Overview
Profile
Name
Yoshihiro Kawaoka
Zodiac Sign
Scorpio
Place of Birth
Kobe, Japan
Office Address
Division of Virology, Institute of Medical Science
University of Tokyo
4-6-1, Shirokanedai, Minato-ku
Tokyo 108-8639, Japan
Tel: +81 (0)3 5449-5504
Fax: +81 (0)3 5449-5408
PROFESSIONAL APPOINTMENTS
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1980-83
Research Associate, Department of Veterinary Microbiology, Faculty of Agriculture, Tottori University, Japan
1983-85
Postdoctoral Fellow, Department of Virology and Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA
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1985-89
Assistant Member, Department of Virology and Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA
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1989-95
Associate Member, Department of Virology and Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA
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1991-97
Associate Professor, Department of Pathology, University of Tennessee, Memphis, Tennessee, USA
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1996-97
Member, Department of Virology and Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA
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1997 to date
Professor, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, USA
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1999-2021
Professor, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Japan
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2004-08
Visiting Professor, Creative Research Initiative, “Sousei”, Hokkaido University, Japan
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2005-2021
Director, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Japan
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2005 to date
Senior Visiting Scientist, Riken, Japan
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2007-12
Visiting Professor, Kobe University Graduate School of Medicine, Japan
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2010 to date
Visiting Professor, Kyoto University, Japan
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2021 to date
Project Professor, Division of Virology, Institute of Medical Science, University of Tokyo, Japan
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2021 to date
Director, International Virus Infectious Disease Research Center, National Institute of Global Health and Medicine, Japan Institute for Health Security, Japan
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2022 to date
Director, Pandemic Preparedness, Infection and Advanced Research Center, University of Tokyo, Japan
ACADEMIC DEGREES
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1978
D.V.M. The Ministry of Agriculture and Fishery, Japan
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1978
B.S. Hokkaido University, Japan (Veterinary Medicine)
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1980
M.S. Hokkaido University, Japan (Microbiology)
1983
Ph.D. Hokkaido University, Japan (Microbiology)
AWARDS
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1991
Veterinary Science Award
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2002
The Hideo Noguchi Memorial Award for Medicine
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2006
Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology
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2006
Robert Koch Award
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2007
The Takeda Prize for Medical Science
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2010
Japan Prize of Agricultural Science
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2011
The Naito Foundation Merit Award for Advancement of Science
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2011
The 8th Takamine Memorial Daiich-Sankyo Prize
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2011
Medal of Honor (Purple Ribbon) from the Emperor of Japan
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2013
International Member of the United States National Academy of Sciences
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2014
Excellence in Research Award, Association of American Veterinary Medical Colleges
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2015
UNESCO Carlos J. Finlay Prize for Microbiology
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2016
Fellow of the American Academy of Microbiology
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2016
Japan Academy Prize
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2022
Keio Medical Science Prize
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2023
Person of Cultural Merit Award
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2023
Fellow of the National Academy of Inventors
PROFESSIONAL SOCIETY MEMBERSHIPS
- American Society for Microbiology
- American Society for Virology
- American Veterinary Medical Association
- Japanese Society for Virology
- Japanese Society of Veterinary Science
RESEARCH INTEREST
- Pathogenesis of Microorganisms
PROFESSIONAL COMMITTEES
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1999 to 2006
International Committee on Taxonomy of Viruses, Chair, Orthomyxoviridae Study Group
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2002 to date
Influenza Sequence Database, Advisory Board Member
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2002 to 2008
International Union of Microbiological Societies, Virology Division, Advisory Council Member
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2008 to 2011
International Union of Microbiological Societies, Virology Division, Vice Chair
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2011 to 2014
International Union of Microbiological Societies, Virology Division, Chair
PEER REVIEW COMMITTEES
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1992
Special Review Committee, NIH (Grant reviewer)
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07/1994 - 06/1998
Virology Study Section Member, NIH (Grant reviewer)
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10/2001
Virology Study Section Adhoc Member, NIH (Grant reviewer)
JOURNAL EDITORIAL BOARD
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1996 to date
Journal of Virology
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1997 - 2012
Virus Research
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2001 to date
Virology
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1999 - 2001
American Journal of Veterinary Research
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2002 - 2005
Virus Research (Editor)
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2003 - 2006
Journal of General Virology
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2004 - 2005
Journal of Clinical Investigation
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2006 - to date
PLoS Pathogens
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2011 o date
Current Opinion in Virology
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2011 - 2017
Reviews in Medical Virology (Editor)
SELECTED PUBLICATIONS
- Hatta M, Gao P, Halfmann P, Kawaoka Y. Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses.H5N1 influenza A viruses. Science 298:1840-1842. doi:10.1126/science.1062882. 2001.
- Kobasa D, Takada A, Shinya K, Hatta M, Halfmann P, Theriault S, Suzuki H, Nishimura H, Mitamura K, Sugaya N, Usui T, Murata T, Maeda Y, Watanabe S, Suresh M, Suzuki T, Suzuki Y, Feldmann H, Kawaoka Y. Enhanced virulence of influenza A viruses with the haemagglutinin of the 1918 pandemic virus. Nature 431:703-707. doi:10.1038/nature02951. 2004.
- Kiso M, Mitamura K, Sakai-Tagawa Y, Shiraishi K, Kawakami C, Kimura K, Hayden FG, Sugaya N, Kawaoka Y. Resistant influenza A viruses in children treated with oseltamivir: Descriptive study. Lancet 364:759-765. doi:10.1016/S0140-6736(04)16934-1. 2004.
- Le QM, Kiso M, Someya K, Sakai YT, Nguyen TH, Nguyen KY, Pham ND, Nguyen HH, Yamada S, Muramoto Y, Takada A, Goto H, Suzuki T, Suzuki Y, Kawaoka Y. Avian flu: isolation of drug-resistant H5N1 virus. Nature 437:1108. doi:10.1038/4371108a. 2005.
- Noda T, Sagara H, Yen A, Takada A, Kida, Cheng RH, Kawaoka Y. Architecture of ribonucleoprotein complexes in influenza A viruses particles. Nature 439:490-492. doi:10.1038/nature04378. 2006.
- Shinya K, Ebina M, Yamada S, Ono, Kasai N, Kawaoka Y. Avian flu: influenza virus receptors in the human airway. Nature 440:435-436. doi:10.1038/440435a. 2006.
- Yamada S, Suzuki Y, Suzuki T, Le MQ, Nidom CA, Sakai-Tagawa Y, Muramoto Y, Ito M, Kiso M, Horimoto T, Shinya K, Sawada T, Kiso K, Usui T, Murata T, Lin Y, Hay A, Haire LF, Stevens DJ, Russell RJ, Gamblin SJ, Skehel JJ, Kawaoka Y. Hemagglutinin mutations responsible for the binding of H5N1 influenza A viruses to human-type receptors. Nature 444:378-382. doi:10.1038/nature05264. 2006.
- Kobasa D, Jones, SM, Shinya K, Kash JC, Copps J, Ebihara H, Hatta Y, Kim JH, Halfmann P, Hatta M, Feldmann F, Alimonti JB, Fernando L, Li Y, Katze MG, Feldmann H, Kawaoka Y. Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus. Nature 445:319-323. doi:10.1038/nature05495. 2007.
- Hatakeyama S, Sugaya N, Ito M, Yamazaki M, Ichikawa M, Kimura K, Kiso M, Shimizu H, Kawakami C, Koike K, Mitamura K, Kawaoka Y. Emergence of influenza B viruses with reduced sensitivity to neuraminidase inhibitors. JAMA 297, 1435-1442. doi:10.1001/jama.297.13.1435. 2007.
- Hao L, Sakurai A, Watanabe T, Sorensen E, Nidom CA, Newton MA, Ahlquist P, Kawaoka Y. Drosophila RNAi screen identifies host genes important for influenza virus replication. Nature 454:890-893. doi:10.1038/nature07151. 2008.
- Itoh Y, Shinya K, Kiso M, Watanabe T, Sakoda Y, Hatta M, Muramoto Y, Tamura D, Sakai-Tagawa Y, Noda T, Sakabe S, Imai M, Hatta Y, Watanabe S, Li C, Yamada S, Fujii K, Murakami S, Imai H, Kakugawa S, Ito M, Takano R, Iwatsuki-Horimoto K, Shimojima M, Horimoto T, Goto H, Takahashi K, Makino A, Ishigaki H, Nakayama M, Okamatsu M, Takahashi K, Warshauer D, Shult PA, Saito R, Suzuki H, Furuta Y, Yamashita M, Mitamura K, Nakano K, Nakamura M, Brockman-Schneider R, Mitamura H, Yamazaki M, Sugaya N, Suresh M, Ozawa M, Neumann G, Gern J, Kida H, Ogasawara K, Kawaoka Y. In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses. Nature 460:1021-1025. doi:10.1038/nature08260. 2009.
- Neumann G, Noda T, Kawaoka Y. Emergence and pandemic potential of H1N1 influenza virus. Nature 459:931-939. doi:10.1038/nature08157. 2009.
- Imai M, Watanabe H, Hatta M, Das SC, Ozawa M, Shinya K, Zhong G, Hanson A, Katsura H, Watanabe S, Li C, Kawakami E, Yamada S, Kiso M, Suzuki Y, Maher EA, Neumann G, Kawaoka Y. Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets. Nature 486:420-428. doi:10.1038/nature10831. 2012.
- Watanabe T, Kiso M, FukuyamaS , Nakajima N, Imai M, Yamada S, Murakami S, Yamayoshi S, Iwatsuki-Horimoto K, Sakoda Y, Takashita E, McBride R, Noda T, Hatta M, Imai H, Zhao D, Kishida N, Shirakura M, de Vries RP, Shichinohe S, Okamatsu M, Tamura T, Tomita Y, Fujimoto N, Goto K, Katsura H, Kawakami E, Ishikawa I, Watanabe S, Ito M, Sakai-Tagawa Y, Sugita Y, Uraki R, Yamaji R, Eisfeld AJ, Zhong G, Fan S, Ping J, Maher EA, Hanson A, Uchida Y, Saito T, Ozawa M, Neumann G, Kida H, Odagiri T, Paulson JC, Hasegawa H, Tashiro M, Kawaoka Y. Characterization of H7N9 influenza A viruses isolated from humans. Nature 501:551-555. doi:10.1038/nature12392. 2013.
- Marzi A, Halfmann P, Hill-Batorski L, Feldmann F, Shupert WL, Neumann G, Feldmann H, Kawaoka Y. An Ebola whole virus vaccine is protective in nonhuman primates. Science 348:439-442. doi:10.1126/science.aaa4919. 2015.
- Halfmann PJ, Hatta M, Chiba S, Maemura T, Fan S, Takeda M, Kinoshita N, Hattori SI, Sakai-Tagawa Y, Iwatsuki-Horimoto K, Imai M, Kawaoka Y. Transmission of SARS-CoV-2 in Domestic Cats. N Engl J Med 383:592-594. doi:10.1056/NEJMc2013400. 2020.
- Takashita E, Kinoshita N, Yamayoshi S, Sakai-Tagawa Y, Fujisaki S, Ito M, Iwatsuki-Horimoto K, Chiba S, Halfmann P, Nagai H, Saito M, Adachi E, Sullivan D, Pekosz A, Watanabe S, Maeda K, Imai M, Yotsuyanagi H, Mitsuya H, Ohmagari N, Takeda M, Hasegawa H, Kawaoka Y. Efficacy of antibodies and antivirals against a SARS-CoV-2 Omicron variant. N Engl J Med 386:995-998 doi:10.1056/NEJMc2119407. 2022.
- Halfmann P, Iida S, Iwatsuki-Horimoto K, Maemura T, Kiso M, Scheaffer S, Darling T, Joshi A, Loeber S, Singh G, Foster S, Ying B, Case J, Chong Z, Whitener B, Moliva J, Floyd K, Ujie M, Nakajima N, Ito M, Wright R, Uraki R, Warang P, Gagne M, Li R, Sakai-Tagawa Y, Liu Y, Larson D, Osorio J, Hernandez-Ortiz J, Henry A, Ciouderis K, Florek K, Patel M, Odle A, Wong LY, Bateman A, Wang Z, Edara VV, Chong Z, Franks J, Jeevan T, Fabrizio T, DeBeauchamp J, Kercher L, Seiler P, Gonzalez-Reiche A, Sordillo E, Chang L, Bakel H, Simon V, PSP study group, Douek D, Sullivan N, Thackray L, Ueki H, Yamayoshi S, Imai M, Perlman S, Webby R, Seder R, Suthar M, Garcia-Sastre A, Schotsaert M, Suzuki T, Boon A, Diamond M, Kawaoka Y. SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters. Nature 603:687-692. doi:10.1038/s41586-022-04441-6. 2022.
- Takashita E, Kinoshita N, Yamayoshi S, Sakai-Tagawa Y, Fujisaki S, Ito M, Iwatsuki-Horimoto K, Halfmann P, Watanabe S, Maeda K, Imai M, Mitsuya H, Ohmagari N, Takeda M, Hasegawa H, Kawaoka Y. Efficacy of Antiviral Agents against the SARS-CoV-2 Omicron Subvariant BA.2. N Engl J Med 386(15):1475-1477. doi: 10.1056/NEJMc2201933. 2022.
- Uraki R, Kiso M, Iida S, Imai M, Takashita E, Kuroda M, Halfmann P, Loeber S, Maemura T, Yamayoshi S, Fujisaki S, Wang Z, Ito M, Ujie M, Iwatsuki-Horimoto K, Furusawa Y, Wright R, Chong Z, Ozono S, Yasuhara A, Ueki H, Sakai Y, Li R, Liu Y, Larson D, Koga M, Tsutsumi T, Adachi E, Saito M, Yamamoto S, Hagihara M, Mitamura K, Sato T, Hojo M, Hattori SI, Maeda K, Valdez R, ISAO study team, Okuda M, Murakami J, Duong C, Godbole S, Douek D, Maeda K, Watanabe S, Gordon A, Ohmagari N, Yotsuyanagi H, Diamond M, Hasegawa H, Mitsuya H, Suzuki T, Kawaoka Y. Characterization and antiviral susceptibility of SARS-CoV-2 Omicron/BA.2. Nature 607:119-127. doi: 10.1038/s41586-022-04856-1. 2022.
- Takashita E, Yamayoshi S, Simon V, van Bakel H, Sordillo EM, Pekosz A, Fukushi S, Suzuki T, Maeda K, Halfmann P, Sakai-Tagawa Y, Ito M, Watanabe S, Imai M, Hasegawa H, Kawaoka Y. Efficacy of Antibodies and Antiviral Drugs against Omicron BA.2.12.1, BA.4, and BA.5 Subvariants. N Engl J Med 387(5):468-470. doi: 10.1056/NEJMc2207519. 2022.
- Uraki R, Halfmann PJ, Iida S, Yamayoshi S, Furusawa Y, Kiso M, Ito M, Iwatsuki-Horimoto K, Mine S, Kuroda M, Maemura T, Sakai-Tagawa Y, Ueki H, Li R, Liu Y, Larson D, Fukushi S, Watanabe S, Maeda K, Pekosz A, Kandeil A, Webby RJ, Wang Z, Imai M, Suzuki T, Kawaoka Y. Characterization of SARS-CoV-2 Omicron BA.4 and BA.5 isolates in rodents. Nature 612(7940):540-545. doi: 10.1038/s41586-022-05482-7. 2022.
- Takashita E, Yamayoshi S, Fukushi S, Suzuki T, Maeda K, Sakai-Tagawa Y, Ito M, Uraki R, Halfmann P, Watanabe S, Takeda M, Hasegawa H, Imai M, Kawaoka Y. Efficacy of Antiviral Agents against the Omicron Subvariant BA.2.75. N Engl J Med 387(13):1236-1238. doi:10.1056/NEJMc2209952. 2022.
- Takashita E, Yamayoshi S, Halfmann P, Wilson N, Ries H, Richardson A, Bobholz M, Vuyk W, Maddox R, Baker DA, Friedrich TC, O'Connor DH, Uraki R, Ito M, Sakai-Tagawa Y, Adachi E, Saito M, Koga M, Tsutsumi T, Iwatsuki-Horimoto K, Kiso M, Yotsuyanagi H, Watanabe S, Hasegawa H, Imai M, Kawaoka Y. In Vitro Efficacy of Antiviral Agents against Omicron Subvariant BA.4.6. N Engl J Med 387:2094-2097. doi:10.1056/NEJMc2211845. 2022.
- Imai M, Ito M, Kiso M, Yamayoshi S, Uraki R, Fukushi S, Watanabe S, Suzuki T, Maeda K, Sakai-Tagawa Y, Iwatsuki-Horimoto K, Halfmann P, Kawaoka Y. Efficacy of Antiviral Agents against Omicron BQ.1.1 and XBB Subvariants. N Engl J Med 388:89-91. doi:10.1056/NEJMc2214302. 2023.
In the Media
- Profile: Yoshihiro Kawaoka.
Nature Medicine 12, 489 doi: 10.1038/nm0506-489. 2006 - Centenary of 1918 influenza pandemic -
Snapshot: Yoshi Kawaoka.
Microbiology Community from Springer Nature http://go.nature.com/2CWy88c. 2018