Novel and Promising Pancreatic Cancer Organoids for Effective Screening of Anticancer Drugs　

"Incorporation of human iPSC-derived stromal cells creates a pancreatic cancer organoid with heterogeneous cancer-associated fibroblasts"

Cell Reports Online November 12, 2023 doi:10.1016/j.celrep.2023.113420

Kenta Takeuchi¹, Shunsuke Tabe^1,2, Kenta Takahashi^1,3, Kenji Aoshima^1,3, Megumi Matsuo^2,4, Yasuharu Ueno¹, Yoichi Furukawa⁵, Kiyoshi Yamaguchi⁵, Masayuki Ohtsuka², Soichiro Morinaga⁶, Yohei Miyagi⁷, Tomoyuki Yamaguchi⁸, Naoki Tanimizu^1,9,*, and Hideki Taniguchi^1,4,5,*
*Corresponding author

¹ Division of Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
² Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
³ Graduate School of Frontier Sciences, Computational Biology and Medical Science, Kashiwa, Chiba, Japan
⁴ Department of Regenerative Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan
⁵ Division of Clinical Genome Research, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
⁶ Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Kanagawa, Japan
⁷ Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Yokohama, Kangawa, Japan
⁸ School of Life Science, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan
⁹ Lead contact