Multiomics investigation revealing the characteristics of HIV-1-infected cells in vivo
―Clues for the development of an "HIV-1 cure"―

For eradication of HIV-1 infection, it is important to elucidate the detailed features and heterogeneity of HIV-1-infected cells in vivo. In this study, a hematopoietic stem cell-transplanted humanized mouse model infected with a gene-modified HIV-1 was used to reveal multiple characteristics of HIV-1-producing cells in vivo.

A research group at The Institute of Medical Science, The University of Tokyo (IMSUT) using HIV-1-infected cells performed “multiomics” analyses, which are technologies recently developed to comprehensively investigate the features of biological samples.

 “Our findings describe multiple characteristics of HIV-1-producing cells in vivo, which could provide clues for the development of an HIV-1 cure.”, said the lead scientist, Kei Sato, Associate Professor (Principal Investigator) in the Division of Systems Virology, Department of Infectious Disease Control, IMSUT.

The results of this research were published in "Cell Reports" on July 14, 2020.


Figure 1 : Brief summary of this study
By using the samples obtained from HIV1-GFP-infection in a humanized mouse model, a series of omics analyses were performed.