Pathophysiological significance of Non B-form DNA/RNA structures in neurobiology
Joint Research Seminar
Event Information
| Date and Time | 22/2/2024(Thu) 16:00 ~ 17:30 |
|---|---|
| Venue | Auditorium |
| Speaker | Norifumi Shioda |
| Affiliation/Position | Kumamoto University, Institute of Molecular Embryology and Genetics. Professor |
| Country | Japan |
| Title | Pathophysiological significance of Non B-form DNA/RNA structures in neurobiology |
| Language | Japanese |
| Organizer | Division of RNA and Gene Regulation Professor Toshifumi Inada |
Overview
The most common form of DNA is a right-handed helix, the B-form DNA. DNA can also adopt a variety of alternative conformations, termed non-B-form DNA secondary structures, including the G-quadruplex (G4). Furthermore, non-canonical RNA G4 secondary structures are also observed. Recent bioinformatics analysis revealed genomic positions of G4. In addition, G4 formation may be associated with various biological functions, including DNA replication, transcription, epigenetic modification, and RNA metabolism. We focus on G4 structures in neuronal functions, which may have important roles reveal mechanisms underlying neurological disorders. I will discuss the potential of G4s as a therapeutic target for neurological diseases.