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SCT in IMSUT Hospital
Annual SCT Cases in IMSUT Hospital
Clinical Study of Adult CBT A Total of 117 Cases between Aug.1998 and Dec.2004 Transplant for Pts Under 16 (N= 6)* 2nd or 3rd Transplant (N= 9)* Multi-units Transplant (N= 2) Non-myeloablative Conditioning (N= 10)* Acute Irradiation Injury (N= 1) Transplant since October 2004 (N=9)* *Partially overlapped. 82 Adult Cases of 1st Translant with Myeloablative Conditioning (Final observation : January 1, 2005)
Patient Characteristics (N=82) Age : 36 (16­53) years Body Weight : 55 (36­76) Kg Gender : Male 50⁄Femail 32 Disease : * AML 46 * ALL 18 * CML 6* * MDS 9 * NHL 4* (*1Pt = CML&NHL) Status of Transplant * Standard Risk Group 32 * High Risk Group 50 Interval between Diagnosis and Transplant : 17 (2­148) months Interval between CB Search and Transplant : 3 (1­36) months Follow-up Periods 644 (13­2319) days Infused Cell Number 2.44 (1.10­5.29) × 107⁄kg Infused CD34 + Cell Number : 0.93 (0.15 - 8.97) × 105⁄kg 0.93（0.15−8.97）ｘ 105⁄kg HLA Disparity * 5⁄6 19 * 4⁄6 43 * 3⁄6 18 * 2⁄6 2
Method of Transplant Conditioning TBI（12Gy）＋AraC（12g⁄m2） ＋CY（120mg⁄kg） For myeloid leukemia and MDS, continuous infusion of G−CSF (5mg⁄kg⁄d) is combined with AraC GVHD Prophylaxis CsA (3mg⁄kg⁄d) + MTX (D1 : 15mg⁄m2； D3, D6 : 10mg⁄m2) Infection Prophylaxis ST (4T⁄d), TFLX (300mg⁄d), FCZ (200mg⁄d), ACV (1000mg⁄d), G−CSF (5mg⁄kg⁄d), γ−globulin (in case of IgG<500, 10g⁄2w）
Engraftment Failure 82 cases exclude 3 cases of early death (within 4 weeks after transplant). 79 cases Engraftment Failure : 5 cases * Infection * Relapse * 2nd transplant * Autologous Recovery 1 1 1 2
Engraftment Rate (− Neutrophil>500⁄mm3） Days after Transplant
Incidence of aGVHD Days after Transplant
Incidence of cGVHD Days after Transplant
Relapse Rate − according to the risk − Days after Transplant
Disease Free Survival − according to the risk − Days after Transplant
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Last update : 27 September, 2005 Reproduction or republication is strictly prohibited without prior written permission.