研究業績一覧 (2006年以前)
- Shimada, M. and Nakanishi, M. DNA damage checkpoints and cancer. J. Mol Histol. 37, 253-260 (2006)
- Nakanishi, M., Shimada, M., and Niida, H. Genetic instability in cancer cells by impaired cell cycle checkpoints. Cancer Sci. 97, 984-989 (2006)
- Shiromizu, T., Goto, H., Tomono, Y., Bartek, J., Totsukawa, G., Inoko, A., Nakanishi, M., Matsumura, F., and Inagaki, M. Regulation of mitotic function of Chk1 through phosphorylation at novel sites by cyclin-dependent kinase 1 (Cdk1). Genes Cells. 11, 477-485 (2006)
- Niida, H. and Nakanishi, M. DNA damage checkpoint in mammals. Mutagenesis. 21, 3-9 (2006)
- Shimada, M., Namikawa-Yamada, C., Nakanishi, M., and Murakami, H. Regulation of Cdc2p and Cdc13p is required for cell cycle arrest induced by defective RNA splicing in fission yeast. J. Biol. Chem. 280, 32640-32648 (2005)
- Niida, H., Tsuge, S., Katsuno, Y., Konishi, A., Takeda, N., and Nakanishi, M. Depletion of Chk1 leads to premature activation of cdc2-cyclin B and mitotic catastrophy. J. Biol. Chem. 280, 39246-39252 (2005)
- Tonami, Y., Murakami, H., Shirahige, K., and Nakanishi, M. A checkpoint control linking meiotic S phase and recombination initiation in fission yeast. oc. Natl. Acad. Sci. 102, 5797-5801 (2005)
- Saitoh, T., Yamamoto, M., Miyagi, M., Taira, K., Nakanishi, M., Fujita, T., Akira, S., Yamamoto, N., and Yamaoka, S. A20 is a negative regulator of interferon regulatory factor 3 signaling. J. Immunol. 174, 1507-1512 (2005)
- Sasai, M., Oshiumi, H., Matsumoto, M., Inoue, N., Fujita, F., Nakanishi, M., and Seya T. NF-kappaB-activating kinase (NAK)-associated protein (NAP) 1 participates in Toll-like receptor (TLR)3/Toll-IL-1 homology domain-containing adapter molecule (TICAM)-1-mediated IRF3 activation. J. Immunol. 174, 27-30 (2005)
- Sugimoto, I., Murakami, H., Tonami, Y., Moriyama, A., and Nakanishi, M. DNA replication checkpoint control mediated by the spindle checkpoint protein Mad2p in fission yeast. J. Biol. Chem. 279, 47372-47378 (2004)
- Buscemi, G., Perego, P., Carenini, N., Nakanishi, M., Chessa, L., Chen, J., Khanna, K.K., and Delia, D. Activation of ATM and Chk2 kinases in relation to the amount of DNA strand breaks. Oncogene. 23, 7691-7700 (2004)
- Lu, R., Niida, H., and Nakanishi, M. Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function. J. Biol. Chem. 279, 31164-31170 (2004)
- Matsui, T., Katsuno, Y., Inoue, Y., Fujita, F., Joh, T., Niida, H., Murakami, H., Itoh, M., and Nakanishi, M. Negative regulation of Chk2 expression by p53 is dependent on the CCAAT-binding transcription factor NF-Y. J. Biol. Chem. 279, 25093-25100 (2004)
- Miura, Y., Kataoka, H., Joh, T., Tada, T., Asai, K., Nakanishi, M., Okada, N., and Okada, H. Susceptibility to killer T cells of gastric cancer cells enhanced by Mitomycin-C involves induction of ATBF1 and activation of p21(Waf1/Cip1) promoter. Microbiol Immunol.48, 137-145 (2004)
- Takagi, M., Tsuchida, R., Oguchi, K., Shigeta, T., Nakada, S., Shimizu, K., Ohki, M., Delia, D., Chessa, L., Taya, Y., Nakanishi, M., Tsunematsu, Y., Bessho, F., Isoyama, K., Hayashi, Y., Kudo, K., Okamura, J., and Mizutani, S. Identification and characterization of polymorphic variations of the ataxia telangiectasia mutated (ATM) gene in childhood Hodgkin disease. Blood. 103, 283-290 (2004)
- Fujita, F., Taniguchi, Y., Kato, T., Narita, Y., Furuya, A., Ogawa, T., Sakurai, H., Joh, T., Itoh, M., Delhase, M., Karin, M., and Nakanishi, M. Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling. Mol. Cell. Biol. 23, 7780-7793 (2003)
- Li, S.F., Fujita, F., Hirai, M., Lu, R., Niida, H., and Nakanishi, M. Genomic structure and characterization of the promoter region of the human NAK gene. Gene.304, 57-64 (2003)
- Kobayashi, S., Nagino, M., Komatsu, S., Naruse, Kl., Nimura, Y., Nakanishi, M., and Sokabe, M. Stretch-induced IL-6 secretion from endothelial cells requires NF-kappaB activation. Biochem. Biophys. Res. Commun. 308, 306-312 (2003)
- Ishimi, Y., Komamura, Kohno, Y., Kwon, H.J., Yamada, K., and Nakanishi, M. Identification of MCM4 as a target of the DNA replication block checkpoint system. J. Biol. Chem. 278, 24644-24650 (2003)
- Hayashi, E., Yasui, A., Oda, K., Nagino, M., Nimura, Y., Nakanishi, M., Motoyama, N., Ikeda, K., and Matsuura, A. Loss of p27(Kip1) accelerates DNA replication after partial hepatectomy in mice. J. Surg. Res. 111, 196-202 (2003)
- Takai, H., Naka, K., Okada, Y., Watanabe, M., Harada, N., Saito, S., Anderson, C.W., Appela, E., Nakanishi, M., Suzuki, H., Nagashima, K., Sawa, H., Ikeda, K., and Motoyama, N. Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription. EMBO J. 21, 5195-5205 (2002)
- Murakami, H., Yanow, S.K., Griffiths, D., Nakanishi, M., and Nurse, P. Maintenance of replication forks and the S-phase checkpoint by Cdc18p and Orp1p. Nature Cell Biol. 4, 384-388 (2002)
- Kobayashi, Y., Watanabe, M., Okada, Y., Sawa, H., Takai, H., Nakanishi, M., Kawase, Y., Suzuki, H., Nagashima, K., Ikeda, K., and Motoyama, N. Hydrocephalus, Situs Inversus, Chronic Sinusitis, and Male Infertility in DNA Polymerase lambda-Deficient Mice: Possible Implication for the Pathogenesis of Immotile Cilia Syndrome. ol. Cell. Biol. 22, 2769-2776 (2002)
- Hashimoto, Y., Akita, H., Hibino, M., Kohri, K., and Nakanishi, M. Identification and characterization of Nek6 protein kinase, a potential human homolog of NIMA histone H3 kinase. Biochem. Biophys. Res. Commun. 293, 753-758 (2002)
- Ding, X., Mizokami, M., Ge, X., Orito, E., Iino, S., Ueda R., and Nakanishi, M. Different hepatitis B virus genotype distributions among asymptomatic carriers and patients with liver diseases in Nanning, southern China. Hepatology Res. 22, 37-44 (2002)
- Touitou, R., Richardson, J., Bose, S., Nakanishi, M., Rivett, J., and Allday, M.J. A degradation signal located in the C-terminus of p21WAF1/CIP1 is a binding site for the C8 a-subunit of the 20S proteasome. EMBO J. 20, 2367-2375 (2001)
- Buscemi, G., Savio, C., Zannini, L., Micciche, F., Masnada, D., Nakanishi, M., Tauchi, H., Komatsu, K., Mizutani, S., Khanna, K.K., Chen, P., Concannon, P., Chessa, L., and Delia, D. Nbs1 dependence of Chk2 activation after DNA-damage. Mol. Cell. Biol. 21, 5214-5222 (2001)
- Harris, T.E., Albrecht, J.H., Nakanishi, M., and Darlington, G.J. C/EBPa cooperates with p21 to inhibit cdk2 kinase activity and induces growth arrest independent of DNA binding. J. Biol. Chem. 276, 29200-29209 (2001)
- Yoneda, K., Yamamoto, N., Asai, K., Sobue, K., Fujita, Y., Fujita, M., Mase, M., Yamada, K., Nakanishi, M., Tada, T., Miura, Y., and Kato, T. Regulation of aquaporin-4 expression in astrocytes. Mol. Brain Res. 89, 94-102 (2001)
- Ding, X., Mizokami, M., Yao, G., Xu, G., Orito, E., Ueda, R., and Nakanishi, M. Hepatitis B virus genotype distribution among chronic hepatitis B virus carriers in Shanghai, China. Intervirology 44, 43-47 (2001)
- Tojima, Y., Fujimoto, A., Delhase, M., Chen, Y., Hatakeyama, S., Nakayama, K., Kaneko, Y., Nimura, Y., Motoyama, N., Ikeda, K., Karin, M., Nakanishi, M. NAK is an IkB kinase-activating kinase. Nature 404, 778-782 (2000)
- Takai, H., Tominaga, K., Motoyama, N., Minamishima, Y., Nagahama, H., Tsukiyama, T., Ikeda, K., Nakayama, K., Nakanishi, M., Nakayama, K. Aberrant Cell Cycle Checkpoint Function and Early Embryonic Death in Chk1-/- Mice. Genes & Dev. 14, 1439-1447 (2000)
- Yamamoto, A., Hashimoto, Y., Kohri, K., Ogata, E., Kato, S., Ikeda, K., Nakanishi, M. Cyclin E as a coactivator of the androgen receptor. J. Cell Biol. 150, 873-879 (2000)
- Nagasawa, K., Kitamura, K., Yasui, A., Nimura, Y., Ikeda, K., Hirai, M., Matsukage, A., Nakanishi, M. Identification and characterization of human DNA polymerase b2, a DNA polymerase b-related enzyme. J. Biol. Chem. 275, 31233-31238 (2000)
- Nakanishi, M., Ando, H., Watanabe, N., Kitamura, K., Ito, K., Okayama, H., Miyamoto, T., Agui, T., Sasaki, M. Identification and characterization of human Wee1B, a new member of the Wee1 family of Cdk-inhibitory kinases. Genes to Cells 5, 839-847 (2000)
- Satoh, T., Furuta, K., Tomokiyo, K., Nakatsuka, D., Tanikawa, M., Nakanishi, M., Miura, M., Tanaka, S., Koike, T., Hatanaka, H., Ikuta, K., Suzuki, M., Watanabe, Y. Facilitatory roles of nevel compounds designed from cyclopentenone prostaglandins on neurie outgrowth-promoting acitivities of nerve growth factor. J. Neurochem. 75, 1092-1102 (2000)
- Akita, H., Iizuka, A., Hashimoto, Y., Kohri, K., Ikeda, K., Nakanishi, M. Induction of KAI-1 Expression in Metastatic Cancer Cells by Phorbol Esters. Cancer letters 153, 79-83 (2000)
- Fuse, T., Tanikawa, M., Nakanishi, M., Ikeda, K., Tada, T., Inagaki, H., Asai, K., Kato, T., Yamada, K. p27Kip1 expression by contact inhibition as a prognostic index of human glioma. J. Neurochem. 74, 1393-1399 (2000)
- Takahashi, H., Menjo, M., Kaneko, Y., Ikeda, K., Matsushime, H., Nakanishi, M. Cdk4 activation is dependent on the subunit rearrangement in the complexes. Biochem. Biophys. Res. Commun. 267, 388-393 (2000)
- Ogawa, K., Kimoto, N., Asamoto, M., Nakanishi, M., Satoru Takahashi, Tomoyuki Shirai. Aberrant expression of p27Kip1 is associated with malignant transformation of the rat urinary bladder epithelium. Carcinogenesis 21, 117-121 (2000)
- Morisaki, H., Ando, A., Nagata, Y., Pereira-Smith, O.M., Smith, J.R., Ikeda, K., Nakanishi, M. Complex mechanisms underlying impaired activation of Cdk4 and Cdk2 in replicative senescence: role of p16, p21 and cyclin D1. Exp. Cell Res. 253, 503-510 (1999)
- Mitsui, K., Nakanishi, M., Ohtsuka, S., Norwood, T.H., Obayashi, K., Miyamoto, C., Tanaka, K., Yoshimura, A., Ohtsubo, M. A novel human gene encoding HECT domain and RCC1-like repeats interacts with cyclins and is potentially regulated by the tumor suppressor proteins. Biochem. Biophys. Res. Commun. 266, 115-122 (1999)
- Tominaga, K., Morisaki, H., Kaneko, Y., Fujimoto, A., Tanaka, T., Ohtsubo, M., Hirai, M., Okayama, H., Ikeda, K., Nakanishi, M. Role of human Cds1(Chk2) kinase in DNA damage checkpoint and its regulation by p53. J. Biol. Chem. 274, 31463-13467 (1999)
- Kitamura, K., Takayama, M., Hamajima, N., Nakanishi. M. et al. Characterization of the Human DRP-2 (dihydropyrimidinase-related protein 2) Gene. DNA Research 6, 291-297 (1999)
- Kaneko, Y., Ikeda, K., Nakanishi, M. Phorbol ester inhibits DNA damage-induced apoptosis in U937 cells through activation of protein kinase C. Life Science 65, 2251-2258 (1999)
- Nakanishi, M., Kaneko, Y., Matsuhime, H., Ikeda, K. Direct interaction of p21 cyclin-dependent kinase inhibitor with the retinoblastoma tumor suppressor protein. Biochem. Biophys. Res. Commun. 263, 35-40 (1999)
- Nakanishi, K., Nakanishi, M., Kukita, F. Dual intracellular recording of neocortical neurons in a neuron-glia co-culture system. Brain Res. Protocol. 4, 105-114 (1999)
- Kaneko, Y., Watanabe, N., Morisaki, H., Akita, H., Fujimoto, A., Tominaga, K., Tachibana, A., Ikeda, K., and Nakanishi, M. Cell cycle-dependent and ATM-independent expression of human Chk1in mammalian cells. Oncogene18, 3673-3681 (1999)
- Yanagisawa, K., Kosaka, A., Iwahana H., Nakanishi, M., and Tominaga, S.-I. Opposite regulations of the expression of cyclin-dependent kinase inhibitors during contact inhibition. J. Biochem. 125, 36-40 (1999)
- Menjo, M., Kaneko, Y., Ikeda, K., and Nakanishi, M. Critical role for p27Kip1 in cell cycle arrest after androgen depletion in mouse mammary carcinoma cells (SC-3). Oncogene 17, 2619-2627 (1999)
- Ishikawa, T., Akimaru, K., Nakanishi, M., Tomokiyo K., Furuta, K., Suzuki, M., and Noyori, R. Anticancer prostaglandin-induced cell cycle arrest and its modulation by a GS-X pump inhibitor. Biochemical J. 336, 569-576 (1998)
- Menjo, M., Ikeda, K., and Nakanishi, M. Regulation of G1 cyclin-dependent kinases in liver regeneration. J. Gastro. Hepatol. 13, 100-115 (1998)
- Tanikawa, M., Yamada, K., Tominaga, K., Morisaki, H., Kaneko, Y., Ikeda, K., Suzuki, M., Kiho, T., Tomokiyo, K., Furuta, K., Noyori, R., and Nakanishi, M. Potent prostaglandin A1 analogs that suppress tumor cell growth through induction of p21 and reduction of cyclin E. J. Biol. Chem.
- Suzuki, M., Kiho, T., Tomokiyo, K., Furuta, K., Fukushima, S., Takeuchi, Y., Nakanishi, M., and Noyori, R. Rational design of antitumor prostaglandins with high biological stability. J. Med. Chem. 41, 3084-3090 (1998)
- Hashimoto, Y., Kohri, K., Kaneko, Y., Morisaki, Y., Kato, T., Ikeda, K., and Nakanishi, M. Critical role for the 310 helix region of p57 in Cdk2 inhibition and growth suppression. J. Biol. Chem. 273, 16544-16550 (1998)
- Akimaru, K., Nakanishi, M., Suzuki, M., Furuta, K., Noyori, R., and Ishikawa, T. Cell growth inhibition by antitumor prostaglandin and its modulation by MRP/GS-X pump. Adv. Exp. Med. Biol. 407, 387-391 (1997)
- Nakanishi, M., Kagawa, Y., Takahashi, H., and Matsushime, H. Two different bindings of p21 CKI to cyclin/Cdk complex. Leukemia 11, 356-357 (1997)
- Morisaki, H., Fujimoto, A., Ando, A., Nagata, Y., Ikeda, K., and Nakanishi, M. Cell cycle-dependent phosphorylation of p27 cyclin-dependent kinase (Cdk) inhibitor by cyclin E/Cdk2. Biochem. Biophys. Res. Commun. 240, 386-390 (1997)
- Hashimoto, Y., Kohri, K., Akita, H., Mitani, K., Ikeda, K., and Nakanishi, M. Efficient transfer of genes into senescent cells by adenovirus vectors via highly expressed alpha v beta 5 integrin. Biochem. Biophys. Res. Commun. 240, 88-92 (1997)
- Fuse, T., Yamada, K., Asai, K., Kato, T., and Nakanishi, M. Heat shock-mediated cell cycle arrest is accompanied by induction of p21 CKI. Biochem. Biophys. Res. Commun. 225, 759-763 (1996)
- Dimri, G.P., Nakanishi, M., Desprez, P.Y., Smith, J.R., and Campisi, J. Inhibition of E2F activity by the cyclin-dependent protein kinase inhibitor p21 in cells expressing or lacking a functional retinoblastoma protein. Mol Cell Biol 16, 2987-2997 (1996)
- Timchenko, N.A., Wilde, M. Nakanishi, M., Smith, J.R., and Darlington, G.J. CCAAT/enhancer-binding protein alpha (C/EBP alpha) inhibits cell proliferation through the p21 (WAF-1/CIP-1/SDI-1) protein. Genes Dev. 10, 804-815 (1996)
- Smith, J.R., Nakanishi, M., Robetorye, R.S., Venable, S.F., and Pereira-Smith, O.M. Studies demonstrating the complexity of regulation and action of the growth inhibitory gene SDI1. Exp. Gerontol. 31, 327-335 (1996)
- Nakanishi, M., Robetorye, R.S., Pereira-Smith, O.M., and Smith, J.R. The C-terminal region of p21SDI1/WAF1/CIP1 is involved in proliferating cell nuclear antigen binding but does not appear to be required for growth inhibition. J. Biol. Chem. 270, 17060-17063 (1995)
- Nakanishi, M., Adami, G.R., Robetorye, R.S., Noda, A., Venable, S.F., Dimitrov, D., Pereira-Smith, O.M., and Smith, J.R. Exit from G0 and entry into the cell cycle of cells expressing p21Sdi1 antisense RNA. Proc. Natl. Acad. Sci. 92, 4352-4356 (1995)
- Nakanishi, M., Robetorye, R.S., Adami, G.R., Pereira-Smith, O.M., and Smith, J.R. Identification of the active region of the DNA synthesis inhibitory gene p21Sdi1/CIP1/WAF1. EMBO J.14, 555-563 (1995)
- Nakanishi, M., Kagawa, Y., Narita, Y., and Hirata, H. Purification and reconstitution of an intestinal Na(+)-dependent neutral L-alpha-amino acid transporter. J. Biol. Chem. 269, 9325-9329 (1994)
- Niwa, K., Yaginuma, A., Nakanishi, M., Wada, Y., Sugo, T., Asakura, S., Watanabe, N., and Matsuda, M. Fibrinogen Mitaka II: a hereditary dysfibrinogen with defective thrombin binding caused by an A alpha Glu-11 to Gly substitution. Blood 82, 3658-3663 (1993)
- Nakanishi, M., Tetsuka, T., Kagawa, Y., Moriyama, A., Sasaki, M., and Hirata, H. Solubilization and reconstitution of high- and low-affinity Na(+)-dependent neutral L-alpha-amino acid transporters from rabbit small intestine. Biochim. Biophys. Acta.1151, 193-200 (1993)
- Wada, Y., Niwa, K., Maekawa, H., Asakura, S., Sugo, T., Nakanishi, M., Auerswald, G., Popp, M., and Matsuda, M. A new type of congenital dysfibrinogen, fibrinogen Bremen, with an A alpha Gly-17 to Val substitution associated with hemorrhagic diathesis and delayed wound healing. Thromb Haemost. 70, 397-403 (1993)
- Matsuda, C., Endo, H., Hirata, H., Morosawa, H., Nakanishi, M., and Kagawa, Y. Tissue-specific isoforms of the bovine mitochondrial ATP synthase gamma-subunit. FEBS Lett. 325, 281-284 (1993)
- Yamasaki, S., Nakanishi, M., Hamamoto, T., Hirata, H., Ebihara, A., Tokue, A., and Kagawa, Y. Expression of human metallothionein-II fusion protein in Escherichia coli. Biochem. Int. 28, 451-460 (1992)
- Ohta, T., Noguchi, S., Nakanishi, M., Mutoh, Y., Hirata, H., Kagawa, Y., and Kawamura, M. The 'lysine cluster' in the N-terminal region of Na+/K(+)-ATPase alpha-subunit is not involved in ATPase activity. Biochim. Biophys. Acta. 1059, 157-164 (1991)
- Sasaki, M., Nakanishi, M., and Moriyama, A. Human liver aminopeptidase M and its regulation by bile acids. Biol. Chem. Hoppe. Seyler. 371, 321-326 (1990)
- Narita, Y., Moriyama, A., Nakanishi, M., Hayakawa, T., Katagiri, K., and Sasaki, M. A novel diisopropylphosphofluoridate-sensitive phenylalanine arylamidase in human liver. Biochem. Int. 20, 89-98 (1990)
- Nakanishi, M., Moriyama, A., Narita, Y., and Sasaki, M. Aminopeptidase M from human liver. II. Kinetic analysis of inhibition of the enzyme by bile acids. J. Biochem. 106, 826-830 (1989)
- Nakanishi, M., Moriyama, A., Narita, Y., and Sasaki, M. Aminopeptidase M from human liver. I. Solubilization, purification, and some properties of the enzyme. J. Biochem. 106, 818-825 (1989)
- Moriyama, A., Nakanishi, M., Takenaka. O., and Sasaki, M. Porcine muscle prolyl endopeptidase: limited proteolysis of tryptic peptides from hemoglobin beta-chains at prolyl and alanyl bonds. Biochim. Biophys. Acta. 956, 151-155 (1988)
- Moriyama, A., Nakanishi, M., and Sasaki, M. Porcine muscle prolyl endopeptidase and its endogenous substrates. J. Biochem. 104, 112-117 (1988)
- Nakanishi, M., Hirata, H., Moriyama, A., Kagawa, Y., and Sasaki, M. Partial purification of alanine carrier from rabbit small intestine brush border membrane and its functional reconstitution into proteoliposomes. Biochem. Biophys. Res. Commun. 152, 1158-1164 (1988)