研究業績一覧 (2006年以前)

  1. Shimada, M. and Nakanishi, M. DNA damage checkpoints and cancer. J. Mol Histol. 37, 253-260 (2006)
  2. Nakanishi, M., Shimada, M., and Niida, H. Genetic instability in cancer cells by impaired cell cycle checkpoints. Cancer Sci. 97, 984-989 (2006)
  3. Shiromizu, T., Goto, H., Tomono, Y., Bartek, J., Totsukawa, G., Inoko, A., Nakanishi, M., Matsumura, F., and Inagaki, M. Regulation of mitotic function of Chk1 through phosphorylation at novel sites by cyclin-dependent kinase 1 (Cdk1). Genes Cells. 11, 477-485 (2006)
  4. Niida, H. and Nakanishi, M. DNA damage checkpoint in mammals. Mutagenesis. 21, 3-9 (2006)
  5. Shimada, M., Namikawa-Yamada, C., Nakanishi, M., and Murakami, H. Regulation of Cdc2p and Cdc13p is required for cell cycle arrest induced by defective RNA splicing in fission yeast. J. Biol. Chem. 280, 32640-32648 (2005)
  6. Niida, H., Tsuge, S., Katsuno, Y., Konishi, A., Takeda, N., and Nakanishi, M. Depletion of Chk1 leads to premature activation of cdc2-cyclin B and mitotic catastrophy. J. Biol. Chem. 280, 39246-39252 (2005)
  7. Tonami, Y., Murakami, H., Shirahige, K., and Nakanishi, M. A checkpoint control linking meiotic S phase and recombination initiation in fission yeast. oc. Natl. Acad. Sci. 102, 5797-5801 (2005)
  8. Saitoh, T., Yamamoto, M., Miyagi, M., Taira, K., Nakanishi, M., Fujita, T., Akira, S., Yamamoto, N., and Yamaoka, S. A20 is a negative regulator of interferon regulatory factor 3 signaling. J. Immunol. 174, 1507-1512 (2005)
  9. Sasai, M., Oshiumi, H., Matsumoto, M., Inoue, N., Fujita, F., Nakanishi, M., and Seya T. NF-kappaB-activating kinase (NAK)-associated protein (NAP) 1 participates in Toll-like receptor (TLR)3/Toll-IL-1 homology domain-containing adapter molecule (TICAM)-1-mediated IRF3 activation. J. Immunol. 174, 27-30 (2005)
  10. Sugimoto, I., Murakami, H., Tonami, Y., Moriyama, A., and Nakanishi, M. DNA replication checkpoint control mediated by the spindle checkpoint protein Mad2p in fission yeast. J. Biol. Chem. 279, 47372-47378 (2004)
  11. Buscemi, G., Perego, P., Carenini, N., Nakanishi, M., Chessa, L., Chen, J., Khanna, K.K., and Delia, D. Activation of ATM and Chk2 kinases in relation to the amount of DNA strand breaks. Oncogene. 23, 7691-7700 (2004)
  12. Lu, R., Niida, H., and Nakanishi, M. Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function. J. Biol. Chem. 279, 31164-31170 (2004)
  13. Matsui, T., Katsuno, Y., Inoue, Y., Fujita, F., Joh, T., Niida, H., Murakami, H., Itoh, M., and Nakanishi, M. Negative regulation of Chk2 expression by p53 is dependent on the CCAAT-binding transcription factor NF-Y. J. Biol. Chem. 279, 25093-25100 (2004)
  14. Miura, Y., Kataoka, H., Joh, T., Tada, T., Asai, K., Nakanishi, M., Okada, N., and Okada, H. Susceptibility to killer T cells of gastric cancer cells enhanced by Mitomycin-C involves induction of ATBF1 and activation of p21(Waf1/Cip1) promoter. Microbiol Immunol.48, 137-145 (2004)
  15. Takagi, M., Tsuchida, R., Oguchi, K., Shigeta, T., Nakada, S., Shimizu, K., Ohki, M., Delia, D., Chessa, L., Taya, Y., Nakanishi, M., Tsunematsu, Y., Bessho, F., Isoyama, K., Hayashi, Y., Kudo, K., Okamura, J., and Mizutani, S. Identification and characterization of polymorphic variations of the ataxia telangiectasia mutated (ATM) gene in childhood Hodgkin disease. Blood. 103, 283-290 (2004)
  16. Fujita, F., Taniguchi, Y., Kato, T., Narita, Y., Furuya, A., Ogawa, T., Sakurai, H., Joh, T., Itoh, M., Delhase, M., Karin, M., and Nakanishi, M. Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling. Mol. Cell. Biol. 23, 7780-7793 (2003)
  17. Li, S.F., Fujita, F., Hirai, M., Lu, R., Niida, H., and Nakanishi, M. Genomic structure and characterization of the promoter region of the human NAK gene. Gene.304, 57-64 (2003)
  18. Kobayashi, S., Nagino, M., Komatsu, S., Naruse, Kl., Nimura, Y., Nakanishi, M., and Sokabe, M. Stretch-induced IL-6 secretion from endothelial cells requires NF-kappaB activation. Biochem. Biophys. Res. Commun. 308, 306-312 (2003)
  19. Ishimi, Y., Komamura, Kohno, Y., Kwon, H.J., Yamada, K., and Nakanishi, M. Identification of MCM4 as a target of the DNA replication block checkpoint system. J. Biol. Chem. 278, 24644-24650 (2003)
  20. Hayashi, E., Yasui, A., Oda, K., Nagino, M., Nimura, Y., Nakanishi, M., Motoyama, N., Ikeda, K., and Matsuura, A. Loss of p27(Kip1) accelerates DNA replication after partial hepatectomy in mice. J. Surg. Res. 111, 196-202 (2003)
  21. Takai, H., Naka, K., Okada, Y., Watanabe, M., Harada, N., Saito, S., Anderson, C.W., Appela, E., Nakanishi, M., Suzuki, H., Nagashima, K., Sawa, H., Ikeda, K., and Motoyama, N. Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription. EMBO J. 21, 5195-5205 (2002)
  22. Murakami, H., Yanow, S.K., Griffiths, D., Nakanishi, M., and Nurse, P. Maintenance of replication forks and the S-phase checkpoint by Cdc18p and Orp1p. Nature Cell Biol. 4, 384-388 (2002)
  23. Kobayashi, Y., Watanabe, M., Okada, Y., Sawa, H., Takai, H., Nakanishi, M., Kawase, Y., Suzuki, H., Nagashima, K., Ikeda, K., and Motoyama, N. Hydrocephalus, Situs Inversus, Chronic Sinusitis, and Male Infertility in DNA Polymerase lambda-Deficient Mice: Possible Implication for the Pathogenesis of Immotile Cilia Syndrome. ol. Cell. Biol. 22, 2769-2776 (2002)
  24. Hashimoto, Y., Akita, H., Hibino, M., Kohri, K., and Nakanishi, M. Identification and characterization of Nek6 protein kinase, a potential human homolog of NIMA histone H3 kinase. Biochem. Biophys. Res. Commun. 293, 753-758 (2002)
  25. Ding, X., Mizokami, M., Ge, X., Orito, E., Iino, S., Ueda R., and Nakanishi, M. Different hepatitis B virus genotype distributions among asymptomatic carriers and patients with liver diseases in Nanning, southern China. Hepatology Res. 22, 37-44 (2002)
  26. Touitou, R., Richardson, J., Bose, S., Nakanishi, M., Rivett, J., and Allday, M.J. A degradation signal located in the C-terminus of p21WAF1/CIP1 is a binding site for the C8 a-subunit of the 20S proteasome. EMBO J. 20, 2367-2375 (2001)
  27. Buscemi, G., Savio, C., Zannini, L., Micciche, F., Masnada, D., Nakanishi, M., Tauchi, H., Komatsu, K., Mizutani, S., Khanna, K.K., Chen, P., Concannon, P., Chessa, L., and Delia, D. Nbs1 dependence of Chk2 activation after DNA-damage. Mol. Cell. Biol. 21, 5214-5222 (2001)
  28. Harris, T.E., Albrecht, J.H., Nakanishi, M., and Darlington, G.J. C/EBPa cooperates with p21 to inhibit cdk2 kinase activity and induces growth arrest independent of DNA binding. J. Biol. Chem. 276, 29200-29209 (2001)
  29. Yoneda, K., Yamamoto, N., Asai, K., Sobue, K., Fujita, Y., Fujita, M., Mase, M., Yamada, K., Nakanishi, M., Tada, T., Miura, Y., and Kato, T. Regulation of aquaporin-4 expression in astrocytes. Mol. Brain Res. 89, 94-102 (2001)
  30. Ding, X., Mizokami, M., Yao, G., Xu, G., Orito, E., Ueda, R., and Nakanishi, M. Hepatitis B virus genotype distribution among chronic hepatitis B virus carriers in Shanghai, China. Intervirology 44, 43-47 (2001)
  31. Tojima, Y., Fujimoto, A., Delhase, M., Chen, Y., Hatakeyama, S., Nakayama, K., Kaneko, Y., Nimura, Y., Motoyama, N., Ikeda, K., Karin, M., Nakanishi, M. NAK is an IkB kinase-activating kinase. Nature 404, 778-782 (2000)
  32. Takai, H., Tominaga, K., Motoyama, N., Minamishima, Y., Nagahama, H., Tsukiyama, T., Ikeda, K., Nakayama, K., Nakanishi, M., Nakayama, K. Aberrant Cell Cycle Checkpoint Function and Early Embryonic Death in Chk1-/- Mice. Genes & Dev. 14, 1439-1447 (2000)
  33. Yamamoto, A., Hashimoto, Y., Kohri, K., Ogata, E., Kato, S., Ikeda, K., Nakanishi, M. Cyclin E as a coactivator of the androgen receptor. J. Cell Biol. 150, 873-879 (2000)
  34. Nagasawa, K., Kitamura, K., Yasui, A., Nimura, Y., Ikeda, K., Hirai, M., Matsukage, A., Nakanishi, M. Identification and characterization of human DNA polymerase b2, a DNA polymerase b-related enzyme. J. Biol. Chem. 275, 31233-31238 (2000)
  35. Nakanishi, M., Ando, H., Watanabe, N., Kitamura, K., Ito, K., Okayama, H., Miyamoto, T., Agui, T., Sasaki, M. Identification and characterization of human Wee1B, a new member of the Wee1 family of Cdk-inhibitory kinases. Genes to Cells 5, 839-847 (2000)
  36. Satoh, T., Furuta, K., Tomokiyo, K., Nakatsuka, D., Tanikawa, M., Nakanishi, M., Miura, M., Tanaka, S., Koike, T., Hatanaka, H., Ikuta, K., Suzuki, M., Watanabe, Y. Facilitatory roles of nevel compounds designed from cyclopentenone prostaglandins on neurie outgrowth-promoting acitivities of nerve growth factor. J. Neurochem. 75, 1092-1102 (2000)
  37. Akita, H., Iizuka, A., Hashimoto, Y., Kohri, K., Ikeda, K., Nakanishi, M. Induction of KAI-1 Expression in Metastatic Cancer Cells by Phorbol Esters. Cancer letters 153, 79-83 (2000)
  38. Fuse, T., Tanikawa, M., Nakanishi, M., Ikeda, K., Tada, T., Inagaki, H., Asai, K., Kato, T., Yamada, K. p27Kip1 expression by contact inhibition as a prognostic index of human glioma. J. Neurochem. 74, 1393-1399 (2000)
  39. Takahashi, H., Menjo, M., Kaneko, Y., Ikeda, K., Matsushime, H., Nakanishi, M. Cdk4 activation is dependent on the subunit rearrangement in the complexes. Biochem. Biophys. Res. Commun. 267, 388-393 (2000)
  40. Ogawa, K., Kimoto, N., Asamoto, M., Nakanishi, M., Satoru Takahashi, Tomoyuki Shirai. Aberrant expression of p27Kip1 is associated with malignant transformation of the rat urinary bladder epithelium. Carcinogenesis 21, 117-121 (2000)
  41. Morisaki, H., Ando, A., Nagata, Y., Pereira-Smith, O.M., Smith, J.R., Ikeda, K., Nakanishi, M. Complex mechanisms underlying impaired activation of Cdk4 and Cdk2 in replicative senescence: role of p16, p21 and cyclin D1. Exp. Cell Res. 253, 503-510 (1999)
  42. Mitsui, K., Nakanishi, M., Ohtsuka, S., Norwood, T.H., Obayashi, K., Miyamoto, C., Tanaka, K., Yoshimura, A., Ohtsubo, M. A novel human gene encoding HECT domain and RCC1-like repeats interacts with cyclins and is potentially regulated by the tumor suppressor proteins. Biochem. Biophys. Res. Commun. 266, 115-122 (1999)
  43. Tominaga, K., Morisaki, H., Kaneko, Y., Fujimoto, A., Tanaka, T., Ohtsubo, M., Hirai, M., Okayama, H., Ikeda, K., Nakanishi, M. Role of human Cds1(Chk2) kinase in DNA damage checkpoint and its regulation by p53. J. Biol. Chem. 274, 31463-13467 (1999)
  44. Kitamura, K., Takayama, M., Hamajima, N., Nakanishi. M. et al. Characterization of the Human DRP-2 (dihydropyrimidinase-related protein 2) Gene. DNA Research 6, 291-297 (1999)
  45. Kaneko, Y., Ikeda, K., Nakanishi, M. Phorbol ester inhibits DNA damage-induced apoptosis in U937 cells through activation of protein kinase C. Life Science 65, 2251-2258 (1999)
  46. Nakanishi, M., Kaneko, Y., Matsuhime, H., Ikeda, K. Direct interaction of p21 cyclin-dependent kinase inhibitor with the retinoblastoma tumor suppressor protein. Biochem. Biophys. Res. Commun. 263, 35-40 (1999)
  47. Nakanishi, K., Nakanishi, M., Kukita, F. Dual intracellular recording of neocortical neurons in a neuron-glia co-culture system. Brain Res. Protocol. 4, 105-114 (1999)
  48. Kaneko, Y., Watanabe, N., Morisaki, H., Akita, H., Fujimoto, A., Tominaga, K., Tachibana, A., Ikeda, K., and Nakanishi, M. Cell cycle-dependent and ATM-independent expression of human Chk1in mammalian cells. Oncogene18, 3673-3681 (1999)
  49. Yanagisawa, K., Kosaka, A., Iwahana H., Nakanishi, M., and Tominaga, S.-I. Opposite regulations of the expression of cyclin-dependent kinase inhibitors during contact inhibition. J. Biochem. 125, 36-40 (1999)
  50. Menjo, M., Kaneko, Y., Ikeda, K., and Nakanishi, M. Critical role for p27Kip1 in cell cycle arrest after androgen depletion in mouse mammary carcinoma cells (SC-3). Oncogene 17, 2619-2627 (1999)
  51. Ishikawa, T., Akimaru, K., Nakanishi, M., Tomokiyo K., Furuta, K., Suzuki, M., and Noyori, R. Anticancer prostaglandin-induced cell cycle arrest and its modulation by a GS-X pump inhibitor. Biochemical J. 336, 569-576 (1998)
  52. Menjo, M., Ikeda, K., and Nakanishi, M. Regulation of G1 cyclin-dependent kinases in liver regeneration. J. Gastro. Hepatol. 13, 100-115 (1998)
  53. Tanikawa, M., Yamada, K., Tominaga, K., Morisaki, H., Kaneko, Y., Ikeda, K., Suzuki, M., Kiho, T., Tomokiyo, K., Furuta, K., Noyori, R., and Nakanishi, M. Potent prostaglandin A1 analogs that suppress tumor cell growth through induction of p21 and reduction of cyclin E. J. Biol. Chem.
  54. Suzuki, M., Kiho, T., Tomokiyo, K., Furuta, K., Fukushima, S., Takeuchi, Y., Nakanishi, M., and Noyori, R. Rational design of antitumor prostaglandins with high biological stability. J. Med. Chem. 41, 3084-3090 (1998)
  55. Hashimoto, Y., Kohri, K., Kaneko, Y., Morisaki, Y., Kato, T., Ikeda, K., and Nakanishi, M. Critical role for the 310 helix region of p57 in Cdk2 inhibition and growth suppression. J. Biol. Chem. 273, 16544-16550 (1998)
  56. Akimaru, K., Nakanishi, M., Suzuki, M., Furuta, K., Noyori, R., and Ishikawa, T. Cell growth inhibition by antitumor prostaglandin and its modulation by MRP/GS-X pump. Adv. Exp. Med. Biol. 407, 387-391 (1997)
  57. Nakanishi, M., Kagawa, Y., Takahashi, H., and Matsushime, H. Two different bindings of p21 CKI to cyclin/Cdk complex. Leukemia 11, 356-357 (1997)
  58. Morisaki, H., Fujimoto, A., Ando, A., Nagata, Y., Ikeda, K., and Nakanishi, M. Cell cycle-dependent phosphorylation of p27 cyclin-dependent kinase (Cdk) inhibitor by cyclin E/Cdk2. Biochem. Biophys. Res. Commun. 240, 386-390 (1997)
  59. Hashimoto, Y., Kohri, K., Akita, H., Mitani, K., Ikeda, K., and Nakanishi, M. Efficient transfer of genes into senescent cells by adenovirus vectors via highly expressed alpha v beta 5 integrin. Biochem. Biophys. Res. Commun. 240, 88-92 (1997)
  60. Fuse, T., Yamada, K., Asai, K., Kato, T., and Nakanishi, M. Heat shock-mediated cell cycle arrest is accompanied by induction of p21 CKI. Biochem. Biophys. Res. Commun. 225, 759-763 (1996)
  61. Dimri, G.P., Nakanishi, M., Desprez, P.Y., Smith, J.R., and Campisi, J. Inhibition of E2F activity by the cyclin-dependent protein kinase inhibitor p21 in cells expressing or lacking a functional retinoblastoma protein. Mol Cell Biol 16, 2987-2997 (1996)
  62. Timchenko, N.A., Wilde, M. Nakanishi, M., Smith, J.R., and Darlington, G.J. CCAAT/enhancer-binding protein alpha (C/EBP alpha) inhibits cell proliferation through the p21 (WAF-1/CIP-1/SDI-1) protein. Genes Dev. 10, 804-815 (1996)
  63. Smith, J.R., Nakanishi, M., Robetorye, R.S., Venable, S.F., and Pereira-Smith, O.M. Studies demonstrating the complexity of regulation and action of the growth inhibitory gene SDI1. Exp. Gerontol. 31, 327-335 (1996)
  64. Nakanishi, M., Robetorye, R.S., Pereira-Smith, O.M., and Smith, J.R. The C-terminal region of p21SDI1/WAF1/CIP1 is involved in proliferating cell nuclear antigen binding but does not appear to be required for growth inhibition. J. Biol. Chem. 270, 17060-17063 (1995)
  65. Nakanishi, M., Adami, G.R., Robetorye, R.S., Noda, A., Venable, S.F., Dimitrov, D., Pereira-Smith, O.M., and Smith, J.R. Exit from G0 and entry into the cell cycle of cells expressing p21Sdi1 antisense RNA. Proc. Natl. Acad. Sci. 92, 4352-4356 (1995)
  66. Nakanishi, M., Robetorye, R.S., Adami, G.R., Pereira-Smith, O.M., and Smith, J.R. Identification of the active region of the DNA synthesis inhibitory gene p21Sdi1/CIP1/WAF1. EMBO J.14, 555-563 (1995)
  67. Nakanishi, M., Kagawa, Y., Narita, Y., and Hirata, H. Purification and reconstitution of an intestinal Na(+)-dependent neutral L-alpha-amino acid transporter. J. Biol. Chem. 269, 9325-9329 (1994)
  68. Niwa, K., Yaginuma, A., Nakanishi, M., Wada, Y., Sugo, T., Asakura, S., Watanabe, N., and Matsuda, M. Fibrinogen Mitaka II: a hereditary dysfibrinogen with defective thrombin binding caused by an A alpha Glu-11 to Gly substitution. Blood 82, 3658-3663 (1993)
  69. Nakanishi, M., Tetsuka, T., Kagawa, Y., Moriyama, A., Sasaki, M., and Hirata, H. Solubilization and reconstitution of high- and low-affinity Na(+)-dependent neutral L-alpha-amino acid transporters from rabbit small intestine. Biochim. Biophys. Acta.1151, 193-200 (1993)
  70. Wada, Y., Niwa, K., Maekawa, H., Asakura, S., Sugo, T., Nakanishi, M., Auerswald, G., Popp, M., and Matsuda, M. A new type of congenital dysfibrinogen, fibrinogen Bremen, with an A alpha Gly-17 to Val substitution associated with hemorrhagic diathesis and delayed wound healing. Thromb Haemost. 70, 397-403 (1993)
  71. Matsuda, C., Endo, H., Hirata, H., Morosawa, H., Nakanishi, M., and Kagawa, Y. Tissue-specific isoforms of the bovine mitochondrial ATP synthase gamma-subunit. FEBS Lett. 325, 281-284 (1993)
  72. Yamasaki, S., Nakanishi, M., Hamamoto, T., Hirata, H., Ebihara, A., Tokue, A., and Kagawa, Y. Expression of human metallothionein-II fusion protein in Escherichia coli. Biochem. Int. 28, 451-460 (1992)
  73. Ohta, T., Noguchi, S., Nakanishi, M., Mutoh, Y., Hirata, H., Kagawa, Y., and Kawamura, M. The 'lysine cluster' in the N-terminal region of Na+/K(+)-ATPase alpha-subunit is not involved in ATPase activity. Biochim. Biophys. Acta. 1059, 157-164 (1991)
  74. Sasaki, M., Nakanishi, M., and Moriyama, A. Human liver aminopeptidase M and its regulation by bile acids. Biol. Chem. Hoppe. Seyler. 371, 321-326 (1990)
  75. Narita, Y., Moriyama, A., Nakanishi, M., Hayakawa, T., Katagiri, K., and Sasaki, M. A novel diisopropylphosphofluoridate-sensitive phenylalanine arylamidase in human liver. Biochem. Int. 20, 89-98 (1990)
  76. Nakanishi, M., Moriyama, A., Narita, Y., and Sasaki, M. Aminopeptidase M from human liver. II. Kinetic analysis of inhibition of the enzyme by bile acids. J. Biochem. 106, 826-830 (1989)
  77. Nakanishi, M., Moriyama, A., Narita, Y., and Sasaki, M. Aminopeptidase M from human liver. I. Solubilization, purification, and some properties of the enzyme. J. Biochem. 106, 818-825 (1989)
  78. Moriyama, A., Nakanishi, M., Takenaka. O., and Sasaki, M. Porcine muscle prolyl endopeptidase: limited proteolysis of tryptic peptides from hemoglobin beta-chains at prolyl and alanyl bonds. Biochim. Biophys. Acta. 956, 151-155 (1988)
  79. Moriyama, A., Nakanishi, M., and Sasaki, M. Porcine muscle prolyl endopeptidase and its endogenous substrates. J. Biochem. 104, 112-117 (1988)
  80. Nakanishi, M., Hirata, H., Moriyama, A., Kagawa, Y., and Sasaki, M. Partial purification of alanine carrier from rabbit small intestine brush border membrane and its functional reconstitution into proteoliposomes. Biochem. Biophys. Res. Commun. 152, 1158-1164 (1988)