2012年3月まで
2010-2011
2008-2009
2006-2007
2004-2005
2002-2003
2000-2001
1998-1999
1995-1997
2010-2011
Sanada T, Kim M, Mimuro H, Suzuki M, Ogawa M, Oyama A, Ashida H, Kobayashi T, Koyama T, Nagai S, Shibata Y, Gohda J, Inoue J, Mizushima T, Sasakawa C. The Shigella flexneri effector OspI deamidates UBC13 to dampen the inflammatory response. (2012) Nature. 483, 623-626.
Fukumatsu M, Ogawa M, Arakawa S, Suzuki M, Nakayama K, Shimizu S, Kim M, Mimuro H, Sasakawa C. Shigella targets epithelial tricellular junctions and uses a noncanonical clathrin-dependent endocytic pathway to spread between cells. (2012) Cell Host Microbe. in press
Ashida, H., Ogawa, M., Kim, M., Mimuro, H., and Sasakawa, C. Bacteria and host interactions in the gut epithelial barrier. (2011) Nature Chem. Biol. 8, 36-45.
Ogawa, M., Yoshikawa, Y., Kobayashi, T., Mimuro, H., Fukumatsu, M., Kiga, K., Piao, Z., Ashida, H., Yoshida, M., Kakuta, S., Koyama, T., Goto, Y., Nagatake, T., Nagai, S., Kiyono, H., Kawalec, M., Reichhart, J.-M., and Sasakawa, C. A tecpr1-dependent selective autophagy pathway targets bacterial pathogens. (2011) Cell Host Microbe. 9, 376-389.
Ashida, H., Kim, M., Schmidt-Supprian, M., Ma, A., Ogawa, M., and Sasakawa, C. A bacterial E3 ubiquitin ligase IpaH9.8 targets NEMO/IKKgamma to dampen the host NF-kappaB-mediated inflammatory response. (2010) Nat. Cell Biol. 12, 66-73.
Kim, M., Ashida, H., Ogawa, M., Yoshikawa, Y., Mimuro, H., and Sasakawa, C. Bacterial interactions with the host epithelium. (2010) Cell Host Microbe. 8, 20-35.
Ashida, H., Mimuro, H., Ogawa, M., Kobayashi, T., Sanada, T., Kim, M., and Sasakawa, C. Host-pathogen interactions: Cell death and infection: A double-edged sword for host and pathogen survival. (2011) J. Cell Biol. 195, 931-942.
Ishijima, N., Suzuki, M., Ashida, H., Ichikawa, Y., Kanegae, Y., Saito, I., Borén, T., Haas, R., Sasakawa, C., and Mimuro, H. BabA-mediated adherence is a potentiator of the Helicobacter pylori Type IV secretion system activity. (2011) J Biol Chem., 286, 25256-25264.
Suzuki, M., Kiga, K., Kersulyte, D., Cok, J., Hooper, C.C., Mimuro, H., Sanada, T., Suzuki, S., Oyama, M., Kozuka-Hata, H., Kamiya, S., Zou, Q.M., Gilman, R.H., Berg, D.E., and Sasakawa, C. Attenuated CagA oncoprotein in Helicobacter pylori from Amerindians in Peruvian Amazon. (2011) J Biol Chem., 286, 29964-29972.
Ashida, H., Ogawa, M., Mimuro, H., Kobayashi, T., Sanada, T., and Sasakawa, C. Shigella are versatile mucosal pathogens that circumvent the host innate immune system. (2011) Curr Opin Immunol. 23, 448-455.
Ashida, H., Ogawa, M., Kim, M., Suzuki, S., Sanada, T., Punginelli, C., Mimuro, H., and Sasakawa, C. Shigella deploy multiple countermeasures against host innate immune responses. (2010) Curr Opin Microbiol. 14, 16-23.
Obata, T., Goto, Y., Kunisawa, J., Sato, S., Sakamoto,.M., Setoyama, H., Matsuki, T., Nonaka, K., Shibata, N., Gohda, M., Kagiyama, Y., Nochi, T., Yuki, Y., Fukuyama, Y., Mukai, A., Shinzaki, S., Fujihashi, K., Sasakawa, C., Iijima, H., Goto, M., Umesaki, Y., Benno, Y., and Kiyono, H. Indigenous opportunistic bacteria inhabit mammalian gut-associated lymphoid tissues and share a mucosal antibody-mediated symbiosis. (2010) Proc Natl Acad Sci U S A. 107, 7419-7424.
Morikawa, H., Kim, M., Mimuro, H., Punginelli, C., Koyama, T., Nagai, S., Miyawaki, A., Iwai, K., and Sasakawa, C. The bacterial effector Cif interferes with SCF ubiquitin ligase function by inhibiting deneddylation of Cullin1. (2010) Biochem Biophys Res Commun. 401, 268-274.
Ogawa, M, and Sasakawa, C. The role of Tecpr1 in selective autophagy as a cargo receptor. (2011) Autophagy. 7(11):1389-1391
Ogawa, M., Yoshikawa, Y., Mimuro, H., Hain, T., Chakraborty, T., and Sasakawa, C. Autophagy targeting of Listeria monocytogenes and the bacterial countermeasure. (2010) Autophagy. 7, 310-314.
Ogawa M, Mimuro H, Yoshikawa Y, Ashida H, Sasakawa C. Manipulation of autophagy by bacteria for their own benefit. (2011) Microbiol Immunol. 55, 459-471
Kim, M., Ogawa, M., Mimuro, H., ans Sasakawa, C. Reinforcement of epithelial cell adhesion to basement membrane by a bacterial pathogen as a new infectious stratagem. (2010) Virulence. 1, 52-55.
Sasakawa, C. A new paradigm of bacteria-gut interplay brought through the study of Shigella. (2010) Proc Jpn Acad Ser B Phys Biol Sci. 86, 229-243.
Seyedarabi, A., Sullivan, J.A., Sasakawa, C., and Pickersgill, R.W. A disulfide driven domain swap switches off the activity of Shigella IpaH9.8 E3 ligase. (2010) FEBS Lett. 584, 4163-4168.
2008-2009
Kim, M., Ogawa, M., Fujita, Y., Yoshikawa, Y., Nagai, T., Koyama, T., Nagai, S., Lange, A., Fässler, R. and Sasakawa, C. Bacteria hijack integrin-linked kinase to stabilize focal adhesions and block cell detachment. (2009) Nature. 459, 578-582.
Yoshikawa, Y., Ogawa, M., Hain, T., Yoshida, M., Fukumatsu, M., Kim, M., Mimuro, H., Nakagawa, I., Yanagawa, T., Ishii, T., Kakizuka, A., Sztul, E., Chakraborty, T., and Sasakawa, C. Listeria monocytogenes ActA-mediated escape from autophagic recognition. (2009) Nat. Cell Biol.10, 1233-1240.
Ogawa, M., Handa, Y., Ashida, H., Suzuki, M., and Sasakawa, C. The versatility of Shigella effectors. (2008) Nat. Rev. Microbiol. 6, 11-16.
Ashida, H., Ogawa, M., Mimuro, H., and Sasakawa, C. Shigella infection of intestinal epithelium and circumvention of the host innate defense system. (2009) Curr. Top. Microbiol. Immunol. 37, 231-255.
Suzuki, M., Mimuro, H., Kiga, K., Fukumatsu, M., Ishijima, N., Morikawa, H., Nagai, S., Koyasu, S., Gilman, R,H., Kersulyte, D., Berg, D.E., and Sasakawa, C. Helicobacter pylori CagA phosphorylation-independent function in epithelial proliferation and inflammation. (2009) Cell Host Microbe. 5, 23-34.
Ishigame, H., Kakuta, S., Nagai, T., Kadoki, M., Nambu, A., Komiyama, Y., Fujikado, N., Tanahashi, Y., Akitsu, A., Kotaki, H., Sudo, K., Nakae, S., Sasakawa, C., and Iwakura, Y. Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses. (2009) Immunity. 30, 108-119.
Mimuro, H., Berg, D.E., and Sasakawa, C. Control of epithelial cell structure and developmental fate: lessons from Helicobacter pylori (2008) BioEssays. 30, 515-520.
Bronte-Tinkew, D.M., Terebiznik, M., Franco, A., Ang, M., Ahn, D., Mimuro, H., Sasakawa, C., Ropeleski, M.J., Peek, R.M. Jr, and Jones, N.L. Helicobacter pylori cytotoxin-associated gene A activates the signal transducer and activator of transcription 3 pathway in vitro and in vivo. (2009) Cancer Res. 69, 632-639.
Ogawa, M., Nakagawa, I., Yoshikawa, Y., Hain, T., Chakraborty, T., and Sasakawa, C. Streptococcus-, Shigella-, and Listeria-induced autophagy. (2009) Methods Enzymol. 452, 363-381.
Yoshikawa, Y., Ogawa, M., Hain, T., Chakraborty, T., and Sasakawa, C. Listeria monocytogenes ActA is a key player in evading autophagic recognition. (2009) Autophagy. 5, 1220-1221
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Nochi, T., Yuki, Y., Katakai, Y., Shibata, H., Tokuhara, D., Mejima, M., Kurokawa, S., Takahashi, Y., Nakanishi, U., Ono, F., Mimuro, H., Sasakawa, C., Takaiwa, F., Terao, K., and Kiyono, H. (2009) A rice-based oral cholera vaccine induces macaque-specific systemic neutralizing antibodies but does not influence pre-existing intestinal immunity. J. Immunol. 183, 6538-6544.
Shifrin Y, Peleg A, Ilan O, Nadler C, Kobi S, Baruch K, Yerushalmi G, Berdichevsky T, Altuvia S, Elgrably-Weiss M, Abe C, Knutton S, Sasakawa C, Ritchie JM, Waldor MK,and Rosenshine I. (2008) Transient shielding of intimin and the type III secretion system of enterohemorrhagic and enteropathogenic Escherichia coli by a group 4 capsule. J. Bacteriol. 190, 5063-5074.
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2006-2007
Iwai, H., Kim, M., Yoshikawa, Y., Ashida, H., Ogawa, M., Fujita, Y., Muller, D., Kirikae, T., Jackson, P.K., Kotani, S., and Sasakawa, C. (2007) A Bacterial Effector Targets Mad2L2, an APC Inhibitor, to Modulate Host Cell Cycling. Cell 130, 611-623.
Yoshida, S., Handa, Y., Suzuki, T., Ogawa, M. Suzuki, M., Tamai, A., Abe, A., Katayama, E., and Sasakawa, C. (2006) Microtubule-Severing Activity of Shigella Is Pivotal for Intercellular Spreading.
Science 314, 985-989.
Handa, Y., Suzuki, M., Ohya, K., Iwai, H., Ishijima, N., Koleske, A. J., Fukui Y., and Sasakawa, C. (2007) Shigella IpgB1 promotes bacterial entry through the ELMO–Dock180 machinery. Nat. Cell Biol. 9, 121-128.
Mimuro, H., Suzuki, T., Nagai, S., Rieder, G., Suzuki, M., Nagai, T., Fujita, Y., Nagamatsu, K., Ishijima, N., Koyasu, S., Haas, R., and Sasakawa, C. (2007) Helicobacter pylori Dampens Gut Epithelial Self-Renewal by Inhibiting Apoptosis, a Bacterial Strategy to Enhance Colonization of the Stomach. Cell Host & Microbe 2, 250-263.
Iizumi Y, Sagara H, Kabe Y, Azuma M, Kume K, Ogawa M, Nagai T, Gillespie PG, Sasakawa C,and Handa H. (2007) The enteropathogenic E. coli effector EspB facilitates microvillus effacing and antiphagocytosis by inhibiting myosin function. Cell Host & Microbe 2, 383-392.
Nagai, S., Mimuro, H., Yamada, T., Baba, Y., Moro, K., Nochi, T., Kiyono, H., Suzuki, T., Sasakawa, C, and Koyasu, S. (2007) Role of Peyer's patches in the induction of Helicobacter pylori-induced gastritis. Proc Natl Acad Sci U S A 104, 8971-8976.
Suzuki, T., Franchi, L., Toma, C., Ashida, H., Ogawa, M., Yoshikawa, Y., Mimuro, H., Inohara, N., Sasakawa, C., and Nunez, G. (2007) Differential Regulation of Caspase-1 Activation, Pyroptosis, and Autophagy via Ipaf and ASC in Shigella-Infected Macrophages. PLoS Pathog. 3, e111.
Ashida, H., Toyotome, T., Nagai, T. and Sasakawa, C. (2006) Shigella chromosomal IpaH proteins are secreted via the type III secretion system and act as effectors. Mol. Microbiol. 63, 680-693
Suzuki, T., Yoshikawa, Y., Ashida, H., Iwai, H., Toyotome, T., Matsui, H. and Sasakawa, C. (2006) High vaccine efficacy against shigellosis of recombinant noninvasive Shigella mutant that expresses Yersinia invasin. J. Immunol. 177, 4709-4717.
Shim, D. H., Suzuki, T., Chang, S. Y., Park, S. M., Sansonetti, P. J., Sasakawa, C. and Kweon, M. N. (2007) New animal model of shigellosis in the Guinea pig: its usefulness for protective efficacy studies. J. Immunol. 178, 2476-2482.
Morita-Ishihara, T., Ogawa, M., Sagara, H., Yoshida, M., Katayama, E. and Sasakawa, C. (2006) Shigella Spa33 is an essential C-ring component of type III secretion machinery. J. Biol. Chem.281, 599-607.
Ogawa, M. and Sasakawa, C. (2006) Shigella and Autophagy. Autophagy 2, 171-174.
Ogawa, M. and Sasakawa, C. (2006) Intracellular survival of Shigella. Cell. Microbiol. 8, 177-184.
Sasakawa, C. and Hacker, J. (2006) Host-microbe interaction: bacteria. Curr. Opin. Microbiol. 9, 1-4.
Ogawa, M., and Sasakawa, C. (2006) Bacterial evasion of the autophagic defense system. Curr. Opin. Microbiol.9, 62-68.
Marchés, O., Batchelor, M., Shaw, R. K., Patel, A., Cummings, N., Nagai, T., Sasakawa, C., Carlsson, S. R., Cougoule, C., Caron, E., Knutton, S., Connerton, I. and Frankel, G. (2006) EspF of Enteropathogenic Escherichia coli Binds Sorting Nexin 9. J. Bacteriol. 188, 3110-3115.
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2004-2005
Ogawa,
M., Yoshimori, T., Suzuki, T., Sagara, H., Mizushima, N. and Sasakawa,
C. (2005) Escape of Intracellular Shigella from Autophagy.
Science 307, 727-731.
Suzuki, M., Mimuro, H., Suzuki, T., Park, M., Yamamoto, T. and Sasakawa, C. (2005) Interaction of CagA with Crk plays an important role in Helicobacter pylori-induced loss of gastric epithelial cell adhesion. J. Exp. Med. 202, 1235-1247.
Ohya, K., Handa, Y., Ogawa, M., Suzuki, M. and Sasakawa, C. (2005) IpgB1 is a novel Shigella effector protein involved in bacterial invasion of host cells: ITS ACTIVITY TO PROMOTE MEMBRANE RUFFLING VIA RAC1 AND CDC42 ACTIVATION. J. Biol. Chem. 280, 24022-24034.
Suzuki,
T., Nakanishi, K., Tsutsui, H., Iwai, H., Akira, S., Inohara,
N., Chamaillard, M., Nu´nez, G. and Sasakawa, C. (2005) A novel
caspase-1/Toll-like receptor 4-independent pathway of cell death
induced by cytosolic Shigella in infected macrophages. J. Biol. Chem. 280, 14042-14050.
Nagai,
T., Abe, A. and Sasakawa, C. (2005) Targeting of enteropathogenic
Escherichia coli EspF to host mitochondria is essential
for the bacterial pathogenesis: critical role of the 16th leucine
residue in EspF. J. Biol. Chem. 280, 2998-3011.
Matsuzawa,
T., Kuwae, A., Yoshida, S., Sasakawa, C. and Abe, A. (2004) Enteropathogenic
Escherichia coli activates the RhoA signaling pathway via
the stimulation of GEF-H1. EMBO J. 23, 3570-3582.
Jang, M.H., Kweon, M.N., Iwatani, K., Yamamoto, M., Terahara,
K., Sasakawa, C., Suzuki, T., Nochi, T., Yokota, Y., Rennert,
P.D., Hiroi, T., Tamagawa, H., Iijima, H., Kunisawa, J., Yuki,
Y., and Kiyono, H. (2004) Intestinal villous M cells: an
antigen entry site in the mucosal epithelium. Proc Natl
Acad Sci U S A 101, 6110-6115.
Okuda, J., Toyotome, T., Kataoka, N., Ohno, M., Abe, H., Shimura, Y., Seyedarabi, A., Pickersgill, R. and Sasakawa, C. (2005) Shigella effector IpaH9.8 binds to a splicing factor U2AF35 to modulate host immune responses. Biochem. Biophys Res. Commun. 333, 531-539.
Takahashi, T., Matsumoto, T., Nakamura, M., Matsui, H., Kiyohara,
H., Sasakawa, C., and Yamada, H. (2004) A novel in vitro infection
model of Helicobacter pylori using mucin-producing murine
gastric surface mucous cells. Helicobacter 9, 302-312.
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2002-2003
Mimuro, H., Suzuki, T., Tanaka, J., Asahi, M., Haas, R. and Sasakawa,
C. (2002) Grb2 is a key mediator of Helicobacter pylori
CagA protein activities. Mol. Cell 10, 745-755.
Yoshida, S. and Sasakawa, C. (2003) Exploiting host microtubule
dynamics: a new aspect of bacterial invasion. Trend. Microbiol.
11, 139-143.
Yoshida, S., Katayama, E., Kuwae, A., Mimuro, H., Suzuki, T. and
Sasakawa, C. (2002) Shigella deliver an effector protein
to trigger host microtubule destabilization, which promotes Rac1
activity and efficient bacterial internalization. EMBO J.
21, 2923-2935.
Shimizu, Y., Yamamichi, N., Saitoh, K., Watanabe, A., Ito, T.,
Yamamichi-Nishina, M., Mizutani, M., Yahagi, N., Suzuki, T., Sasakawa,
C., Yasugi, S., Ichinose, M. and Iba, H. (2003) Kinetics of v-src-induced
epithelial-mesenchymal transition in developing glandular stomach.
Oncogene 22, 884-893.
Ogawa, M., Suzuki, T., Tatsuno, I., Abe, H. and Sasakawa, C. (2003)
IcsB, secreted via the type III secretion system, is chaperoned
by IpgA and required at the post-invasion stage of Shigella
pathogenicity. Mol. Microbiol. 48, 913-931.
Tamano, K., Aizawa, S. and Sasakawa, C. (2002) Purification and
detection of Shigella type III secretion needle complex.
Methods Enzymol. 358, 385-392.
Sasakawa C. (2003) Shigella Invasion. in Bacterial Invasion
of Host Cell. (ed. L. Ramont) (Cambridge University Press)
Tanaka, J., Suzuki, T., Mimuro, H. and Sasakawa, C. (2003) Structural
definition on the surface of Helicobacter pylori type IV
secretion apparatus. Cell. Microbiol. 5, 395-404.
Suzuki, T., Mimuro, H., Suetsugu, S., Miki, H., Takenawa, T. and
Sasakawa, C. (2002) Neural Wiskott-Aldrich syndrome protein (N-WASP)
is the specific ligand for Shigella VirG among the WASP
family and determines the host cell type allowing actin-based
spreading. Cell. Microbiol. 4, 223-233.
Tobe, T. and Sasakawa, C. (2002) Species-specific cell adhesion
of enteropathogenic Escherichia coli is mediated by type
IV bundle-forming pili. Cell. Microbiol. 4, 29-42.
Tatsuno, I., Nagano, K., Taguchi, K., Li, R., Mori, H. and Sasakawa,
C. (2003) Hyper Adherence to Caco-2 Cells Caused by Disruption
of yhiE and yhiF Genes in Enterohemorrhagic Escherichia
coli O157:H7. Infect. Immun. 71, 2598-2606.
Abe, H., Tatsuno, I., Tobe, T., Okutani, A. and Sasakawa, C. (2002)
Bicarbonate ion stimulates the expression of locus of enterocyte
effacement-encoded genes in enterohemorrhagic Escherichia coli
O157:H7. Infect. Immun. 70, 3500-3509.
Tamano, K., Katayama, E., Toyotome, T. and Sasakawa, C. (2002)
Shigella Spa32 is an essential secretory protein for functional
type III secretion machinery and uniformity of its needle length.
J. Bacteriol. 184, 1244-1252.
Biswas, D., Itoh, K., and Sasakawa, C. (2003) Role of microfilaments
and microtubules in the invasion of INT-407 cells by Campylobacter
jejuni. Microbiol Immunol. 47, 469-473.
Makino, S., Tobe, T., Asakura, H., Watarai, M., Ikeda, T., Takeshi,
K. and Sasakawa, C. (2003) Distribution of the secondary type
III secretion system locus found in enterohemorrahagic Escherichia
coli O157:H7 among Shiga toxin-producing E. coli. J.
Clin. Microbiol. 41, 2341-2347.
Honma, Y., Sasakawa, C., Tsuji, T. and Iwanaga, M. (2003) Comparison
of antimicrobial susceptibility between invasive and non-invasive
Shigella organisms. Int. J. Antimicrob. Agents
21, 262-266.
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Suzuki, T., Mimuro, H., Miki, H., Takenawa, T., Sasaki, T., Nakanishi,
H., Takai, Y. and Sasakawa, C. (2000) Rho family GTPase Cdc42
is essential for the actin-based motility of Shigella in
mammalian cells. J. Exp. Med. 191, 1905-1920.
Asahi, M., Azuma, T., Ito, S., Ito, Y., Suto, H., Nagai, Y., Tsubokawa,
M., Tohyama, Y., Maeda, S., Omata, M., Suzuki, T. and Sasakawa,
C. (2000) Helicobacter pylori CagA protein can be tyrosine
phosphorylated in the gastric epithelial cells. J. Exp. Med.
191, 593-602.
Tamano, K., Aizaiwa, S., Katayama, E., Nonaka, T., Imajoh-Ohmi,
S., Kuwae, A., Nagai, S. and Sasakawa, C. (2000) Supermolecular
structure of the Shigella type III secretion machinery:
the needle part is changeable in length and essential for delivery
of effectors. EMBO J. 19, 3876-3887.
Sekiya, K., Ohishi, M., Ogino, T., Tamano, K., Sasakawa, C.
and Abe, A. (2001) Supermolecular structure of the enteropathogenic
Escherichia coli type III secretion system and its direct
interaction with the EspA-sheath-like structure. Proc. Natl.
Acad. Sci. U S A 98, 11638-11643.
Toyotome, T., Suzuki, T., Kuwae, A., Nonaka, T., Fukuda, H.,
Imajoh-Ohmi, S., Toyofuku, T., Hori, M. and Sasakawa, C. (2001)
Shigella protein IpaH(9.8) is secreted from bacteria
within mammalian cells and transported to the nucleus. J.
Biol. Chem. 276, 32071-32079.
Kuwae, A., Yoshida, S., Tamano, K., Mimuro, H., Suzuki, T. and
Sasakawa, C. (2001) Shigella invasion of macrophage requires
the insertion of IpaC into the host plasma membrane. Functional
analysis of IpaC. J. Biol. Chem. 276, 32230-32239.
Mimuro, H., Suzuki, T., Suetsugu, S., Miki, H., Takenawa, T.
and Sasakawa, C. (2000) Profilin is required for sustaining
efficient intra- and intercellular spreading of Shigella
flexneri. J. Biol. Chem.
275, 28893-28901.
Kanamaru, K., Kanamaru, K., Tatsuno, I., Tobe, T. and Sasakawa,
C. (2000) SdiA, an Escherichia coli homologue of quorum-sensing
regulators, controls the expression of virulence factors in
enterohaemorragic Escherichia coli O157:H7. Mol. Microbiol.
38, 805-816.
Tobe, T. and Sasakawa, C. (2001) Role of bundle-forming pilus
of enteropathogenic Escherichia coli in host cell adherence
and in microcolony development. Cell. Microbiol. 3,
579-585.
Tatsuno, I., Horie, M., Abe, H., Miki, T., Makino, K., Shinagawa,
H., Taguchi, H., Kamiya, S., Hayashi, T. and Sasakawa, C. (2001)
toxB gene on pO157 of enterohemorrhagic Escherichia
coli O157:H7 is required for full epithelial cell adherence
phenotype. Infect. Immun. 69, 6660-6669.
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Kato,
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