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Name:Koichi Matsuda, M.D., Ph.D.
Position: Associate Professor

Business Address:
Laboratory of Genome Technology,
Human Genome Center,
Institute of Medical Science,
University of Tokyo,
4-6-1 Shirokanedai
Minato-ku, Tokyo 108-8639, Japan
TEL +81-3-5449-5376
FAX +81-3-5449-5406
E-mail koichima@ims.u-tokyo.ac.jp

Education:
1988-1994 Tokyo University School of Medicine(M.D.)
1999-2003 Tokyo University Graduate School of Medicine(Ph.D.)

Occupation:
1994-1995 The University of Tokyo Hospital ,Orthopaedics, Resident
1995         JR Tokyo General Hospital ,Anesthesiology ,Resident
1995-1996 The Cancer Institute Hospital of JFCR, Orthopaedics ,Resident
1996-1998 Yaizu City Hospital ,Clinical Fellow
1998         Nadogaya Hospital ,Clinical Fellow
1998-1999 The University of Tokyo Hospital ,Orthopaedics,Clinical Fellow
2003-2004 Baylor College of Medicine ,Research Fellow
2004-2009 Institute of Medical Science, The University of Tokyo, Assistant Professor
2009         Institute of Medical Science, The University of Tokyo, Associate Professor

Menberships:
Japanese Cancer Association
The Japanese Orthopaedic association
American Association for Cancer Research

Awards:
2003 Incitement Awards of the Japanese Society for Bone and Mineral Research
2003 Young Investigator Award of the American Society for Bone and Mineral Research

  Publications List:

  1. Kamatani Y, Wattanapokayakit S, Ochi H, Kawaguchi T, Takahashi A, Hosono N, Kubo M, Tsunoda T, Kamatani N, Kumada H, Puseenam A, Sura T, Daigo Y, Chayama K, Chantratita W, Nakamura Y & Matsuda K. A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians. Nature Genetics 41: 591-595 (2009)

  2. Tanikawa C, Ueda K, Nakagawa H, Yoshida N, Nakamura Y & Matsuda K. Regulation of protein Citrullination through p53/PADI4 network in DNA damage response. Cancer Research 69:8761-8769 (2009)

  3. Cui R, Kamatani Y, Takahashi A, Usami M, Hosono N, Kawaguchi T, Tsunoda T, Kamatani N, Kubo M, Nakamura Y & Matsuda K. Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk. Gastroenterology 137:1768-1775 (2009)

  4. Tanikawa C, Furukawa Y, Yoshida N, Arakawa H, Nakamura Y & Matsuda K. XEDAR as a putative colorectal tumor suppressor that mediates p53-regulated anoikis pathway. Oncogene 28:3081-3092 (2009)

  5. Morioka K, Tanikawa C, Ochi K, Daigo Y, Katagiri T, Kawano H, Kawaguchi H, Myoui A, Yoshikawa H, Naka N, Araki N, Kudawara I, Leguchi M, Nakamura K, Nakamura Y & Matsuda K. Orphan receptor tyrosine kinase ROR2 as a potential therapeutic target for osteosarcoma. Cancer Science 100: 1227-1233 (2009)

  6. Tomlinson IP, Dunlop M, Campbell H, Matsuda K, et al. COGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer. Br J Cancer (In press)

  7. Han S Z, Kim-Howard X, Deshmukh H, Kamatani Y, Viswanathan P, Guthridge J M, Thomas K, Kaufman K M, Ojwang J, Rojas-Villarraga A, Baca V, Orozco L, Rhodes B, Choi C B, Gregersen P K, Merrill J T, James J A, Gaffney P M, Moser K L, Jacob C O, Kimberly R P, Harley J B, Bae S C, Anaya J M, Alarcon-Riquelme M E, Matsuda K, Vyse T J & Nath S K. Evaluation of imputation-based association in and around the integrin-alpha-M (ITGAM) gene and replication of robust association between a non-synonymous functional variant within ITGAM and systemic lupus erythematosus (SLE). Human Molecular Genetics 18: 1171-1180 (2009)

  8. Tenesa A, Farrington S M, Prendergast J G D, Porteous M E, Walker M, Haq N, Barnetson R A, Theodoratou E, Cetnarskyj R, Cartwright N, Semple C, Clark A J, Reid F J L, Smith L A, Kavoussanakis K, Koessler T, Pharoah P D P, Buch S, Schafmayer C, Tepel J, Schreiber S, Volzke H, Schmidt C O, Hampe J, Chang-Claude J, Hoffmeister M, Brenner H, Wilkening S, Canzian F Capella G, Moreno V, Deary I J, Starr J M, Tomlinson I P M, Kemp Z, Howarth K, Carvajal-Carmona L, Webb E, Broderick P, Vijayakrishnan J, Houlston R S, Rennert G, Ballinger D, Rozek L, Gruber S B, Matsuda K, Kidokoro T, Nakamura Y, Zanke B W, Greenwood C M T, Rangrej J, Kustra R, Montpetit A, Hudson T J, Gallinger S, Campbell H & Dunlop M G. Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. Nature Genetics 40: 631-637 (2008)

  9. Suzuki A, Yamada R, Kochi Y, Sawada T, Okada Y, Matsuda K, Kamatani Y, Mori M, Shimane K, Hirabayashi Y, Takahashi A, Tsunoda T, Miyatake A, Kubo M, Kamatani N, Nakamura Y & Yamamoto K. Functional SNPs in CD244 increase the risk of rheumatoid arthritis in a Japanese population. Nature Genetics 40: 1224-1229 (2008)

  10. Shimo A, Tanikawa C, Nishidate T, Lin M. L, Matsuda K, Park J H, Ueki T, Ohta T, Hirata K, Fukuda M, Nakamura Y & Katagiri T. Involvement of kinesin family member 2C/mitotic centromere-associated kinesin overexpression in mammary carcinogenesis. Cancer Science 99: 62-70 (2008)

  11. Okuma C, Kaketa T, Hikita A, Matsuda K, Nakamura M, Nagase Y, Oshima Y, Iwasawa M, Nakamura Y, Kurosawa H, Nakamura K & Tanaka S. Potential involvement of p53 in ischemia/reperfusion-induced osteonecrosis. Journal of Bone and Mineral Metabolism 26: 576-585 (2008)

  12. Kidokoro T, Tanikawa C, Furukawa Y, Katagiri T, Nakamura Y & Matsuda K. CDC20, a potential cancer therapeutic target, is negatively regulated by p53. Oncogene 27: 1562-1571 (2008)

  13. Oishi T, Iida A, Otsubo S, Kamatani Y, Usami M, Takei T, Uchida K, Tsuchiya K, Saito S, Ohnisi Y, Tokunaga K, Nitta K, Kawaguchi Y, Kamatani N, Kochi Y, Shimane K, Yamamoto K, Nakamura Y, Yumura W & Matsuda K. A functional SNP in the NKX25-binding site of ITPR3 promoter is associated with susceptibility to systemic lupus erythematosus in Japanese population. Journal of Human Genetics 53: 151-162 (2008)

  14. Kamatani Y, Matsuda K, Ohishi T, Ohtsubo S, Yamazaki K, Iida A, Hosono N, Kubo M, Yumura W, Nitta K, Katagiri T, Kawaguchi Y, Kamatani N & Nakamura Y. Identification of a significant association of a single nucleotide polymorphism in TNXB with systemic lupus erythematosus in a Japanese population. Journal of Human Genetics 53: 64-73 (2008)

  15. Kubo M, Hata J, Ninomiya T, Matsuda K, Yonemoto K, Nakano T, Matsushita T, Yamazaki K, Ohnishi Y, Saito S, Kitazono T, Ibayashi S, Sueishi K, Iida M, Nakamura Y & Kiyohara Y. A nonsynonymous SNP in PRKCH (protein kinase C eta) increases the risk of cerebral infarction. Nature Genetics 39: 212-217 (2007)

  16. Hata J, Matsuda K, Ninomiya T, Yonemoto K, Matsushita T, Ohnishi Y, Saito S, Kitazono T, Ibayashi S, Iida M, Kiyohara Y, Nakamura Y & Kubo M. Functional SNP in an Sp1-binding site of AGTRL1 gene is associated with susceptibility to brain infarction. Human Molecular Genetics 16: 630-639 (2007)

  17. Hosokawa M, Takehara A, Matsuda K, Eguchi H, Ohigashi H, Ishikawa O, Shinomura Y, Imai K, Nakamura Y & Nakagawa H. Oncogenic role of KIAA0101 interacting with proliferating cell nuclear antigen in pancreatic cancer. Cancer Research 67: 2568-2576 (2007)

  18. Yang X G, Matsuda K, Bialek P, Jacquot S, Masuoka H C, Schinke T, Li L Z, Brancorsini S, Sassone-Corsi P, Townes T M, Hanauer A & Karsenty G. ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology: Implication for Coffin-Lowry syndrome. Cell 117: 387-398 (2004)

  19. Vega R B, Matsuda K, Oh J, Barbosa A C, Yang X L, Meadows E, McAnally J, Pomajzl C, Shelton J M, Richardson J A, Karsenty G & Olson E N. Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis. Cell 119: 5
  20. Saegusa M, Murakami M, Nakatani Y, Yamakawa K, Katagiri M, Matsuda K, Nakamura K, Kudo I & Kawaguchi H. Contribution of membrane-associated prostaglandin E2 synthase to bone resorption. J Cell Physiol 197: 348-356 (2003)

  21. Tanikawa C*, Matsuda K*, Fukuda S, Nakamura Y & Arakawa H. p53RDL1 regulates p53-dependent apoptosis. Nature Cell Biology 5: 216-223 (2003) (*Equally contributed author)

  22. Matsuda K, Yoshida K, Taya Y, Nakamura K, Nakamura Y & Arakawa H. p53AIP1 regulates the mitochondrial apoptotic pathway. Cancer Research 62: 2883-2889 (2002)

  23. Inoue K, Matsuda K, Itoh M, Kawaguchi H, Tomoike H, Aoyagi T, Nagai R, Hori M, Nakamura Y & Tanaka T. Osteopenia and male-specific sudden cardiac death in mice lacking a zinc transporter gene, Znt5. Human Molecular Genetics 11: 1775-1784 (2002)

  24. Goto T, Yokokura S, Kawano H, Yamamoto A, Matsuda K & Nakamura K. Simple curettage without bone grafting for enchondromata of the hand: with special reference to replacement of the cortical window. J Hand Surg Br 27: 446-451 (2002)

  25. Goto T, Kojima T, Iijima T, Yokokura S, Motoi T, Kawano H, Yamamoto A & Matsuda K. Intraosseous lipoma: a clinical study of 12 patients. J Orthop Sci 7: 274-280 (2002)

  26. Goto T, Ishida T, Motoi N, Yokokura S, Kawano H, Yamamoto A, Matsuda K & Yamamoto M. Primary leiomyosarcoma of the femur. J Orthop Sci 7: 267-273 (2002)

  27. Yamaguchi T, Matsuda K, Sagiya Y, Iwadate M, Fujino M A, Nakamura Y & Arakawa H. p53R2-dependent pathway for DNA synthesis in a p53-regulated cell cycle checkpoint. Cancer Research 61: 8256-8262 (2001)

  28. Goto T, Kojima T, Iijima T, Yokokura S, Kawano H, Yamamoto A & Matsuda K. Soft-tissue haemangioma and periosteal new bone formation on the neighbouring bone. Arch Orthop Trauma Surg 121: 549-553 (2001)

  29. Goto T, Kojima T, Iijima T, Yokokura S, Kawano H, Yamamoto A & Matsuda K. Osteofibrous dysplasia of the ulna. J Orthop Sci 6: 608-611 (2001)

  30. Goto T, Kojima T, Iijima T, Yokokura S, Kawano H, Yamamoto A & Matsuda K. Resorption of synthetic porous hydroxyapatite and replacement by newly formed bone. J Orthop Sci 6: 444-447 (2001)

  31. Goto T, Iijima T, Kawano H, Yamamoto A, Arai M, Matsuda K & Yokokura S. Serum acid phosphatase as a tumour marker in giant cell tumour of bone. Arch Orthop Trauma Surg 121: 411-413 (2001)

  32. Shiraishi K, Fukuda S, Mori T, Matsuda K, Yamaguchi T, Tanikawa C, Ogawa M, Nakamura Y & Arakawa H. Identification of fractalkine, a CX3C-type chemokine, as a direct target of p53. Cancer Research 60: 3722-3726 (2000)

  33. Oda K, Arakawa H, Tanaka T, Matsuda K, Tanikawa C, Mori T, Nishimori H, Tamai K, Tokino T, Nakamura Y & Taya Y. p53AlP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53. Cell 102: 849-862 (2000)

  34. Futamura M, Arakawa H, Matsuda K, Katagiri T, Saji S, Miki Y & Nakamura Y. Potential role of BRCA2 in a mitotic checkpoint after phosphorylation by hBUBR1. Cancer Research 60: 1531-1535 (2000)

Copyright © 2009 Yusuke Nakamura's Labo., All rights reserved.
Last update: 2009.12.2

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