東京大学医科学研究所

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発表論文解説

ピロリ菌感染による胃がん発症の鍵となる小さなRNAの発見

Nature Communications 5, Article number: 4497 doi:10.1038/ncomms5497
氣駕 恒太朗1,2*、三室 仁美1*、鈴木 仁人3、牛久 綾4、小林 泰良1、真田 貴人1、金 玟秀5、小川 道永3、岩崎 由香2、嘉陽 啓之2、湯澤 陽子2、八代 正和6、深山 正久4、深尾 太郎2、笹川 千尋3,5,7,8
1 Division of Bacteriology, Department of Infectious Diseases Control, International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. 2 Max-Planck-Institute of Immunobiology and Epigenetics, Stübeweg 51, 79108 Freiburg, Germany. 3 Department of Microbiology and Immunology, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. 4 Department of Pathology, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan. 5 Division of Bacterial Infection Biology, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan. 6 Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan. 7 Nippon Institute for Biological Science, 9-2221-1 Shinmachi, Ome, Tokyo 198-0024, Japan. 8 Medical Mycology Research Center, Chiba University, Chiba 260-8673, Japan. * These authors contributed equally to this work.

自然リンパ球は上皮細胞の糖鎖修飾を調節する

Science 1254009Published online 21 August 2014 [DOI:10.1126/science.1254009]
Yoshiyuki Goto1,2,3, Takashi Obata1,3, Jun Kunisawa1,4,5, Shintaro Sato1,2, Ivaylo I. Ivanov6, Aayam Lamichhane1, Natsumi Takeyama1, Mariko Kamioka1, Mitsuo Sakamoto3, Takahiro Matsuki7, Hiromi Setoyama7, Akemi Imaoka7, Satoshi Uematsu8,9, Shizuo Akira10, Steven E. Domino11, Paulina Kulig12, Burkhard Becher12, Jean-Christophe Renauld13, Chihiro Sasakawa14,15,16, Yoshinori Umesaki7, Yoshimi Benno17, and Hiroshi Kiyono1,2,5
1 Division of Mucosal Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan 2 Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Saitama 332-0012, Japan 3 Microbe Division/Japan Collection of Microorganisms, RIKEN BioResource Center, Tsukuba 305-0074, Japan 4 Laboratory of Vaccine Materials, National Institute of Biomedical Innovation, Osaka 567-0085, Japan 5 Division of Mucosal Immunology, International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan 6 Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032 7 Yakult Central Institute for Microbiological Research, Tokyo 186-8650, Japan 8 Division of Innate Immune Regulation, International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan 9 Department of Mucosal Immunology, School of Medicine, Chiba University, 1-8-1 Inohana, Chuou-ku, Chiba, 260-8670, Japan 10 Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan 11 Department of Obstetrics and Gynecology, Cellular and Molecular Biology Program, University of Michigan Medical Center, Ann Arbor, MI 48109-5617 12 Institute of Experimental Immunology, University of Zürich, Winterthurerstrasse 190, Zürich CH-8057, Switzerland 13 Ludwig Institute for Cancer Research and Université Catholique de Louvain, Brussels B-1200, Belgium 14 Division of Bacterial Infection, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan 15 Medical Mycology Research Center, Chiba University, Chiba 260-8673, Japan 16 Nippon Institute for Biological Science, Tokyo 198-0024, Japan 17 Benno Laboratory, Innovation Center, RIKEN, Saitama 351-0198, Japan
Yuuki Obata1,2,3,4,18 Yukihiro Furusawa1,3,17,18 Takaho A. Endo5, Jafar Sharif6, Daisuke Takahashi7, Koji Atarashi,8,9 Manabu Nakayama10, Satoshi Onawa7, Yumiko Fujimura1,3, Masumi Takahashi7, Tomokatsu Ikawa9,11, Takeshi Otsubo12, Yuki I. Kawamura12, Taeko Dohi12, Shoji Tajima13, Hiroshi Masumoto14, Osamu Ohara5, Kenya Honda8,15, Shohei Hori16, Hiroshi Ohno2,4,7, Haruhiko Koseki6 and Koji Hase1,3,4,9,17.
1. Division of Mucosal Barriology, International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan. 2. Laboratory for immune regulation, Graduate School of Medicine, Chiba University, Chiba, Japan. 3. Laboratory for Bioenvironmental Epigenetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan. 4. Graduate School of Medical Life Science, Yokohama City University, Kanagawa, Japan. 5. Laboratory for Integrative Genomics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan. 6. Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan. 7. Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan. 8. Laboratory for Gut Homeostasis, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan. 9. PRESTO, Japan Science and Technology Agency, Saitama, Japan. 10. Laboratory of Medical Genomics, Department of Human Genome Research, Kazusa DNA Research Institute, Chiba, Japan. 11. Laboratory for Immune Regeneration, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan. 12. Department of Gastroenterology, Research Center for Hepatitis and Immunology, Research Institute, National Center for Global Health and Medicine, Chiba, Japan. 13. Laboratory of Epigenetics, Institute for Protein Research, Osaka University, Osaka, Japan. 14. Laboratory of Cell Engineering, Department of Frontier Research, Kazusa DNA Research Institute, Chiba, Japan. 15. CREST, Japan Science and Technology Agency, Saitama, Japan. 16. Laboratory for Immune Homeostasis, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan. 17. Present address: Department of Biochemistry, Keio University Graduate School of Pharmaceutical Science, Tokyo, Japan. 18. These authors contributed equally to this work.
倉島洋介1–4, 網谷岳朗1,2,4,5, 藤澤久美子1,2, 柴田納央子1,2,4,5, 鈴木裕二1, 小暮優太1,4,5, 橋本えり1,4, 大塚篤司6, 椛島健治6, 佐藤慎太郎1,2, 佐藤健1,4,5, 久保允人7,8, 審良静男9, 三宅健介3, 國澤純1,2,4,5,10,11, 清野宏1,2,5,10
1. Division of Mucosal Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan 2. Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Tokyo 102-0075, Japan 3. Division of Innate Immunity, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan 4. Laboratory of Vaccine Materials, National Institute of Biomedical Innovation, Osaka 567-0085, Japan 5. Department of Medical Genome Science, Graduate School of Frontier Science, The University of Tokyo, Chiba 277-8561, Japan 6. Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan 7. Laboratory for Cytokine Regulation, Research Center for Integrative Medical Science, RIKEN Yokohama Institute, Kanagawa 230-0045, Japan 8. Division of Molecular Pathology, Research Institute for Biological Sciences, Tokyo University of Sciences, Chiba 278-0022, Japan. 9. Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan. 10. International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan 11. Department of Microbiology and Immunology, Kobe University School of Medicine, Kobe 650-0017, Japan

TLR3の阻害が致死的な放射線誘導性腸炎を著しく改善させる

Nature Communications 5, 3492 doi:10.1038/ncomms4492
武村直紀1, 川崎拓実2,3,4, 國澤純5,6, 佐藤慎太郎5,7, Aayam Lamichhane5, 小檜山康司8,9, 青枝大貴8,9, 伊東純一10, 水口賢司10, Thangaraj Karuppuchamy2,3, 松永浩太1, 宮武昌一郎11, 森展子12, 辻村亨13, 佐藤荘2,3, 熊谷雄太郎2,3, 河合太郎4, Daron M Standley14, 石井健8,9, 清野宏5,7, 審良静男2,3, 植松智1
1東京大学医科学研究所国際粘膜ワクチン開発研究センター・自然免疫制御分野 2大阪大学WPI免疫学フロンティア研究センター・自然免疫学 3大阪大学微生物病研究所・自然免疫分野 4奈良先端科学技術大学院大学バイオサイエンス研究科・分子免疫制御教室 5東京大学医科学研究所・炎症免疫制御分野 6独立行政法人医薬基盤研究所・ワクチンマテリアルプロジェクト 7科学技術振興機構CREST 8大阪大学WPI免疫学フロンティア研究センター・ワクチン学 10独立行政法人医薬基盤研究所・アジュバント開発プロジェクト 11公益財団法人東京都医学総合研究所 12大阪府立大学大学院理学研究科・生命環境学域 13兵庫医科大学・病理学 14大阪大学WPI免疫学フロンティア研究センター・免疫システム学
Akihisa Shimizu1, Ai Kawana-Tachikawa1, Atsushi Yamagata2, Chung Yong Han1, Dayong Zhu1, Yusuke Sato2, Hitomi Nakamura1, Tomohiko Koibuchi1, Jonathan Carlson3, Eric Martin4, Chanson J. Brumme5, Yi Shi6, George F. Gao6, Zabrina L. Brumme4,5, Shuya Fukai2, *Aikichi Iwamoto1
1東京大学医科学研究所、2東京大学放射光連携研究機構/分子細胞生物学研究所、3マイクロソフト研究所、4サイモンフレーザー大学、5ブリティッシュコロンビアHIV/AIDS研究センター、6中国科学院病原微生物・免疫学重点研究室
Yukihiro Furusawa1,2*, Yuuki Obata1,2,3*, Shinji Fukuda1,4*, Takaho A. Endo1, Gaku Nakato1, Daisuke Takahashi1, Yumiko Nakanishi4, Chikako Uetake1, Keiko Kato1,5, Tamotsu Kato1, Masumi Takahashi1, Noriko N. Fukuda4, Shinnosuke Murakami4, Eiji Miyauchi1, Shingo Hino6, Koji Atarashi1,7, Satoshi Onawa1, Yumiko Fujimura2, Trevor Lockett8, Julie M. Clarke8, David L. Topping8, Masaru Tomita4, Shohei Hori1, Osamu Ohara1, Tatsuya Morita6, Haruhiko Koseki1,3,5, Jun Kikuchi5,9, Kenya Honda1,10, Koji Hase1,2,7* & Hiroshi Ohno1,3,5
1 RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Kanagawa 230-0045, Japan. 2 The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan. 3 Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan. 4 Institute for Advanced Biosciences, Keio University, Yamagata 997-0052, Japan. 5 Graduate School of Medical Life Science, Yokohama City University, Kanagawa 230-0045, Japan. 6 Faculty of Agriculture, Shizuoka University, Shizuoka 422-8529, Japan. 7 PRESTO, Japan Science and Technology Agency, Saitama 332-0012, Japan. 8 Preventative Health National Research Flagship, CSIRO Food and Nutritional Sciences, South Australia 9 RIKEN Center for Sustainable Resource Science, Kanagawa 230-0045, Japan. 10 CREST, Japan Science and Technology Agency, Saitama 332-0012, Japan.
井上大地1、北浦次郎1、戸上勝仁1、西村耕太郎1、榎本豊1、内田智之1、鍵山侑希1、川畑公人1、中原史雄1、伊沢久未1、沖俊彦1、2、前原明絵1、磯部優理1、土屋秋穂1、原田結花3、原田浩徳3、落谷孝弘4、油谷浩幸5、木村宏6、Felicitas Thol7、Michael Heuser7、Ross L. Levine8、Omar Abdel-Wahab8、北村俊雄1、2
1.東京大学医科学研究所・細胞療法分野、2.東京大学医科学研究所・幹細胞シグナル制御部門、3.広島大学・原爆研究所、4.国立がんセンター分子標的研究グループ、5.東京大学先端科学技術研究センターゲノムサイエンス部門、6.大阪大学生命機能研究科細胞核ダイナミクス研究室、7.ハノーバー医科大学血液学、8.スローンケタリング記念がんセンター

意外な血液細胞の発生システムの発見

Cell Online Edition: 2013/8/30 (Japan time), doi: 10.1016/j.cell.2013.08.007.
山本 玲1, 守田 陽平1,4, 大江原 淳1, 濱仲 早苗1,2, 小野寺 雅史3, Karl Lenhard Rudolph4, 依馬 秀夫1#, 中内 啓光1,2
1 東京大学医科学研究所幹細胞治療分野  2 JST, ERATO, 中内幹細胞プロジェクト 3 国立成育医療研究センター研究所 成育遺伝研究部 4 Leibniz Institute for Age Research, Fritz Lipmann Institute, Jena, Germany #現所属 慶応大学医学部 発生・分化生物学

乳腺腫瘍中における癌幹細胞を維持する機能の解明

Nat. Commun. 4:2299 doi: 10.1038/ncomms3299 (2013)
山本瑞生1,2、田口祐1、呉羽拓3、仙波憲太郎2、山口憲孝3、井上純一郎1
1 東京大学医科学研究所 分子発癌分野 2 早稲田大学理工学術院 生命医科学専攻 3 沖縄科学技術大学院大学 細胞シグナルユニット 4 千葉大学大学院薬学研究院 分子細胞生物学