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Publications

2016 -
(90) Hara T, Murakami Y, Seiki M, Sakamoto T. Mint3 in bone marrow-derived cells promotes lung metastasis in breast cancer model mice. Biochem Biophys Res Commun. 2017 in press

(89) Sakamoto T, Seiki M. Integrated functions of membrane-type 1 matrix metalloproteinase in regulating cancer malignancy: Beyond a proteinase. Cancer Sci. 6: 1095-1100, 2017.

(88) Hara T, Nakaoka HJ, Hayashi T, Mimura K, Hoshino D, Inoue M, Nagamura F, Murakami Y, Seiki M, Sakamoto T. Control of metastatic niche formation by targeting APBA3/Mint3 in inflammatory monocytes. Proc Natl Acad Sci USA. 22: E4416-E4424, 2017.

(87) Fujiki K, Yano S, Ito T, Kumagai Y, Murakami Y, Kamigaito O, Haba H, Tanaka K. A one-pot three-component double-click method for synthesis of [67Cu]-labeled biomolecular radiotherapeutics. Sci Rep. 7: 1912, 2017.

(86) Nakaoka HJ, Tanei Z, Hara T, Weng JS, Kanamori A, Hayashi T, Sato H, Orimo A, Otsuji K, Tada K, Morikawa T, Sasaki T, Fukayama M, Seiki M, Murakami Y, Sakamoto T. Mint3-mediated L1CAM expression in fibroblasts promotes cancer cell proliferation via integrin a5b1 and tumour growth. Oncogenesis. 6: e334, 2017.

(85) Shirakabe K, Omura T, Shibagaki Y, Mihara E, Homma K, Kato Y, Yoshimura A, Murakami Y, Takagi J, Hattori S, Ogawa Y. Mechanistic insights into ectodomain shedding: susceptibility of CADM1 adhesion molecule is determined by alternative splicing and O-glycosylation. Sci Rep. 7: 46174, 2017.

(84) Uematsu T, Fujita T, Nakaoka HJ, Hara T, Kobayashi N, Murakami Y, Seiki M, Sakamoto T. Mint3/Apba3 depletion ameliorates severe murine influenza pneumonia and macrophage cytokine production in response to the influenza virus. Sci Rep. 6: 37815, 2016.

(83) Awano M, Fujiyuki T, Shoji K, Amagai Y, Murakami Y, Furukawa Y, Sato H, Yoneda M, Kai C. Measles virus selectively blind to signaling lymphocyte activity molecule has oncolytic efficacy against nectin-4-expressing pancreatic cancer cells. Cancer Sci. 107: 1647-1652, 2016.

(82) Thang PM, Takano A, Yoshitake Y, Shinohara M, Murakami Y, Daigo Y. Cell division cycle associated 1 as a novel prognostic biomarker and therapeutic target for oral cancer. Int J Oncol. 49: 1385-1393, 2016.

(81) Ito T, Matsubara D, Tanaka I, Makiya K, Tanei Z, Kumagai Y, Shiu SJ, Nakaoka HJ, Ishikawa S, Isagawa T, Morikawa T, Ushiku A, Goto Y, Nakano T, Tsuchiya T, Tsubochi H, Aburatani H, Dobashi Y, Nakajima J, Endo S, Fukayama M, Sekido Y, Niki T, Murakami Y. Loss of YAP1 defines neuroendocrine differentiation of lung tumor. Cancer Sci. 107: 1527-1538, 2016.

(80) Yoshino S, Hara T, Nakaoka HJ, Kanamori A, Murakami Y, Seiki M, Sakamoto T. The ERK-signaling target RNF126 regulates anoikis resistance in cancer cells by changing the mitochondrial metabolic flux. Cell Discov. 2: 16019, 2016.

(79) Nakaoka HJ, Hara T, Yoshino S, Kanamori A, Matsui Y, Shimamura T, Sato H, Murakami Y, Seiki M, Sakamoto T. NECAB3 Promotes Activation of Hypoxia-inducible factor-1 during Normoxia and Enhances Tumourigenicity of Cancer Cells. Sci Rep. 6: 22784, 2016.

(78) Dokduang H, Yongvanit P, Namwat N, Pairojkul C, Sangkhamanon S, Sakurai-Yageta M, Murakami Y, Loilome W. Xanthohumol inhibits STAT3 activation pathway leading to growth suppression and apoptosis induction in human cholangiocarcinoma cells. Oncol Rep. 35: 2065-2072, 2016.

(77) Takeuchi A, Badr Mel S, Miyauchi K, Ishihara C, Onishi R, Guo Z, Sasaki Y, Ike H, Takumi A, Tsuji NM, Murakami Y, Katakai T, Kubo M, Saito T. CRTAM determines the CD4+ cytotoxic T lymphocyte lineage. J Exp Med. 213: 123-138, 2016
2013 - 2015

(76) Fujiyuki T, Yoneda M, Amagai Y, Obayashi K, Ikeda F, Shoji K, Murakami Y, Sato H, Kai C. A measles virus selectively blind to signaling lymphocytic activation molecule shows anti-tumor activity against lung cancer cells. Oncotarget. 6: 24895-24903, 2015.

(75) Akashi K, Ebihara Y, Omura G, Saito Y, Yoshida M, Ando M, Asakage T, Yamasoba T, Murakami Y. Frequent copy gain of the MET gene in hypopharyngeal and laryngeal cancer in the Japanese population. J Cancer Therapy. 6: 1093-1102, 2015.

(74) Kogai H, Kikuchi S, Obana T, Tsuboi Y, Maruyama T, Sakurai-Yageta M, Asamura H, Kanai Y, Murakami Y. Promoter methylation of the CADM1 and 4.1B genes occurs independently of the EGFR or the KRAS2 mutation in non-small cell lung cancer. J Cancer Therapy. 6: 273-285, 2015.

(73) Sakurai-Yageta M, Maruyama T, Suzuki T, Ichikawa K, Murakami Y. Dynamic regulation of a cell adhesion protein complex including CADM1 by combinatorial analysis of FRAP with exponential curve-fitting. PLos One. 10: e0116637, 2015.

(72) Matsubara D, Kishaba Y, Yoshimoto T, Sakuma Y, Sakatani T, Tamura T, Endo S, Sugiyama Y, Murakami Y, Niki T. Immunohistochemical analysis of the expression of E-cadherin and ZEB1 in non-small cell lung cancer. Pathol Int. 64: 560-568, 2014.

(71) Mimae T, Ito A, Hagiyama M, Nakanishi J, Hosokawa Y, Okada M, Murakami Y, Kondo T. A novel approach to pseudopodia proteomics: excimer laser etching, two-dimensional difference gel electrophoresis, and confocal imaging. Protoc exch. 2014.007.

(70) Dokduang H, Techasen A, Namwat N, Khuntikeo N, Pairojkul C, Murakami Y, Loilome W, Yongvanit P. STATs profiling reveals predominantly-activated STAT3 in cholangiocarcinoma genesis and progression. J Hepatobiliary Pancreat Sci. 21: 767-776, 2014.

(69) Ibrahim R, Matsubara D, Osman W, Morikawa T, Goto A, Morita S, Ishikawa S, Aburatani H, Takai D, Nakajima J, Fukayama M, Niki T, Murakami Y. Expression of PRMT5 in lung adenocarcinoma and its significance in epithelial-mesenchymal transition. Hum Pathol. 45: 1397-1405, 2014.

(68) Wang F, Akashi K, Murakami Y, Inoue Y, Furuta T, Yamada H, Ohmoto K, Kiryu S. Detection of lung tumors in mice using a 1-tesla compact magnetic resonance imaging system. PLoS One. 9: e94945, 2014.

(67) Cortez VS, Cervantes-Barragan L, Song C, Glifillan S, McDonald KG, Tussiwand R, Edelson BT, Murakami Y, Murphy KM, Newberry RD, Sibley LD, Colonna M. CRTAM controls residency of gut CD4+CD8+ T cells in the steady state and maintenance of gut CD4+ Th17 during parasitic infection. J Exp Med. 211: 623-633, 2014.

(66) Ito T, Sakurai-Yageta M, Goto A, Pairojkul C, Yongvanit P, Murakami Y. Genomic and transcriptional alterations of cholangiocarcinoma. J Hepatobiliary Pancreat Sci, 21: 380-387, 2014.

(65) Murakami S, Sakurai-Yageta M, Maruyama T, Murakami Y. Trans-homophilic interaction of CADM1 activates PI3K by forming a complex with MAGuK-family proteins MPP3 and Dlg. PLoS One, 9: e82894, 2014.

(64) Mimae T, Hagiyama M, Inoue T, Yoneshige A, Kato T, Okada M, Murakami Y, Ito A. Increased ectodomain shedding of lung epithelial cell adhesion molecule 1 as a cause of increased alveolar cell apoptosis in emphysema. Thorax, 69: 223-231, 2013.

(63) Matsubara D, Kishaba Y, Ishikawa S, Sakatani T, Oguni S, Tamura T, Hoshino H, Sugiyama Y, Endo S, Murakami Y, Aburatani H, Fukayama M and Niki T. Lung cancer with loss of BRG1/BRM, shows epithelial mesenchymal transition phenotype and distinct histologic and genetic features. Cancer Sci, 104: 266-273, 2013.
2010 - 2012

(62) Matsubara D, Kanai Y, Ishikawa S, Ohara S, Yoshimoto T, Sakatani T, Oguni S, Tamura T, Kataoka H, Endo S, Murakami Y, Aburatani H, Fukayama M. and *Niki T. Identification of CCDC6-RET fusion in the human lung adenocarcinoma cell line, LC-2/ad. J Thorac Oncol, 7: 1872-1876, 2012.

(61) Ishimura M, Sakurai-Yageta M, Maruyama T, Ando T, Fukayama M, Goto A, Murakami Y. Involvement of miR-214 and miR-375 in malign.ant features of non-small-cell lung cancer by down-regulating CADM1. J Cancer Therapy, 3:379-387, 2012.

(60) Ito A, Mimae T, Yamamoto Y-S-Z, Hagiyama M, Nakanishi J, Ito M, Hosokawa Y, Okada M, Murakami Y, and Kondo T. Novel application for pseudopodia proteomics using excimer laser ablation and two-dimensional difference gel electrophoresis. Lab Invest, 92:1374-1385, 2012.

(59) Nakata H, Wakayama T, Adthapanyawanich K, Nishiuchi T, Murakami Y, Takai Y, Iseki S. Compensatory upregulation of myelin protein zero-like 2 expression in spermatogenic cells in cell adhesion molecule-1-deficient mice. Acta Histochem Cytochem, 45:47-56. 2012.

(58) Kikuchi S, Iwai M, Sakurai-Yageta M, Tsuboi Y, Ito T, Masuda T, Tsuda H, Kanai Y, Onizuka M, Sato Y, and Murakami Y. Expression of a splicing variant of the CADM1 specific to small cell lung cancer. Cancer Science, 103, 1051-1057, 2012.

(57) Ito A, Ichiyanagi N, Ikeda Y, Hagiyama M, Inoue T, Kimura KB, Sakurai MA, Hamaguchi K, Murakami Y. Adhesion molecule CADM1 contributes to gap junctional communication among pancreatic islet α-cells and prevents their excessive secretion of glucagon. Islets, in press.

(56) Mimae T, Okada M, Hagiyama M, Miyata Y, Tsutani Y, Inoue T, Murakami Y, Ito A. Notch2 and Six1 are up-regulated during progression of early-stage lung adenocarcinoma and define its unfavorable subset at advanced stages. Clinical Cancer Research, 18, 945-948, 2012.

(55) Nagara Y, Hagiyama M, Hatano, N, Futai, E, Suo S, Takaoka Y, Murakami Y, Ishiura S, and Ito A. Tumor suppressor cell adhesion molecule 1 (CADM1) is cleaved by A disintegrin and metalloprotease 10 (ADAM10) and subsequently cleaved by gamma-secretase complex. Biochem Biophys Res Commun, 417:462-467, 2012.

(54) Ito T, Williams-Nate Y, Iwai M, Tsuboi Y, Hagiyama M, Ito A, Sakurai-Yageta M, Murakami Y. Transcriptional regulation of the CADM1 gene by retinoic acid during the neural differentiation of murine embryonal carcinoma P19 cells. Genes to Cells, 16:791-802, 2011.

(53) Nagata M, Sakurai-Yageta M, Yamada D,Goto A, Ito A, Fukuhara H, Kume H, Morikawa T, Fukayama M, Homma Y, Murakami Y. Aberrations of a cell adhesion molecule CADM4 in renal clear cell carcinoma. Int J Cancer, 130:1329-1337, 2011.

(52) Takahashi Y, Iwai M, Kawai T, Arakawa A, Ito T, Sakurai-Yageta M, Ito A, Goto A, Saito M, Kasumi F, Murakami Y. Aberrant expression of tumor suppressors, CADM1 and 4.1B, in invasive lesions of primary breast cancer. Breast Cancer, 19:242-252, 2011.

(51 ) Hagiyama M, Furuno T, Hosokawa Y, Iino T, Ito T, Inoue T, Nakanishi M, Murakami Y, Ito A. Enhanced nerve-mast cell interaction by a neuronal short isoform of cell adhesion molecule-1. J Immunol, 186(10), 5983-92, 2011.

(50) Mimae T, Tsuta K, Takahashi F, Yoshida A, Kondo T, Murakami Y, Okada M, Takeuchi M, Asamura H, Tsuda H. Steroid Receptor Expression in Thymomas and Thymic Carcinomas. Cancer, 117: 4396-4405, 2011.

(49) Hosokawa Y, Hagiyama M, Iino T, Murakami Y, Ito A. Noncontact estimation of intercellular breaking force using a femtosecond laser impulse quantified by atomic force microscopy. Proc Natl Acad Sci U S A, 108(5), 1777-82, 2011.

(48) Masuda M, Maruyama T, Ohta T, Ito A, Hayashi T, Tsukasaki K, Kamihira S, Yamaoka S, Hoshino H, Yoshida T, Watanabe T, Stanbridge EJ, Murakami Y. CADM1 interacts with Tiam1 and promotes invasive phenotype of human T-cell leukemia virus type I-transformed cells and adult T-cell leukemia cells. J Biol Chem, 285(20), 15511-22, 2010.
2007 - 2009

(47) Sakurai-Yageta M, Masuda M, Tsuboi Y, Ito A, Murakami Y. Tumor suppressor CADM1 is involved in epithelial cell structure. Biochem Biophys Res Commun, 390(3), 977-82, 2009.

(46) Hagiyama M, Ichiyanagi N, Kimura KB, Murakami Y, Ito A. Expression of a soluble isoform of cell adhesion molecule 1 in the brain and its involvement in directional neurite outgrowth. Am J Pathol, 174(6), 2278-89, 2009.

(45) Overmeer RM, Henken FE, Snijders PJ, Claassen-Kramer D, Berkhof J, Helmerhorst TJ, Heideman DA, Wilting SM, Murakami Y, Ito A, Meijer CJ, Steenbergen RD. Association between dense CADM1 promoter methylation and reduced protein expression in high-grade CIN and cervical SCC. J Pathol, 215(4), 388-97, 2008.

(44) Wakayama T, Sai Y, Ito A, Kato Y, Kurobo M, Murakami Y, Nakashima E, Tsuji A, Kitamura Y, Iseki S. Heterophilic binding of the adhesion molecules poliovirus receptor and immunoglobulin superfamily 4A in the interaction between mouse spermatogenic and Sertoli cells. Biology Reprod, 76, 1081-1090, 2007.

(43) Kawasaki A, Tsuchiya N, Ohashi J, Murakami Y, Fukazawa T, Kusaoi M, Morimoto S, Matsuda K, Hashimoto H, Takasaki Y, Tokunaga K. Role of APRIL (TNSF13) polymorphisms in the susceptibility to systemic lupus erythematosus in Japanese. Rheumatology, 46, 776-782, 2007..

(42) Ito, A, Hagiyama, M, Oonuma, J, Murakami, Y, Yokozaki, H, Takaki, M. Involvement of the SgIGSF/Necl-2 adhesion molecule in degradation of mesenteric mast cells. J Neuro Immunol, 184, 209-213, 2007.



2004 - 2006

(41) Lung, HL, Kwok, A, Cheung, L, Xie, D, Cheng, Y, Murakami, M, Guan, X-Y, Sham, JS, Chua, D, Protopopov, AI, Zabarovsky, ER, Tsao, SW, Stanbridge, EJ, and Lung, ML. TSLC1 is a tumor suppressor gene associated with metastasis in nasopharyngeal carcinoma. Cancer Res, 66, 9385-9392, 2006.

(40) Yamada, D, Yoshida, M, Williams, YN, Fukami, T, Kikuchi, S, Masuda, Maruyama, M, Ohta, T, Nakae, D, Maekawa, A, Kitamura, T, Murakami, Y. Disruption of spermatogenic cell adhesion and male infertility in mice lacking TSLC1/IGSF4, an immunoglobulin superfamily cell adhesion molecule. Mol Cell Biol, 26, 3610-3624, 2006.

(39) Weyden, LVD, Arends, MJ, Chausiaux, OE, Lange, UC, Surani, MA, Affara, N, Murakami, Y, Adams, DJ, Bradley. A. Loss of TSLC1 causes male infertility due to a defect at the spermatid stage of spermatogenesis, Mol Cell Biol, 26, 3595-3609, 2006.

(38) Kikuchi, S, Yamada, D, Fukami, T, Maruyama, T, Ito, A, Asamura, H, Matsuno, Y, Onizuka, M, Murakami, Y. Hypermethylation of the TSLC1/IGSF4 promoter is associated with tobacco smoking and a poor prognosis in primary non-small cell lung cancer. Cancer, 106, 1751-1758, 2006.

(37) Williams, YN, Masuda, M, Sakurai-Yageta, M, Maruyama, T, Shibuya, M, Murakami, Y. Cell adhesion and prostate tumor suppressor activity of TSLL2/IGSF4C, an immunoglobulin superfamily molecule homologous to TSLC1/IGSF4. Oncogene, 25, 1446-1453, 2006.

(36) Yamada, D, Kikuchi, S, Williams, YN, Sakurai-Yageta, M, Masuda, M, Maruyama, T, Tomita, K, Gutmann, DH, Kakizoe, T, Kitamura, T, Murakami, Y. Promoter Hypermethylation of the Potential Tumor Suppressor DAL-1/4.1B Gene in Renal Clear Cell Carcinoma. Int J Cancer, 118, 916-923, 2006.

(35) Masuda, M, Kikuchi, S, Maruyama, T, Sakurai-Yageta, M, Williams, YN, Ghosh HP, Murakami, Y. TSLC(tumor suppressor in lung cancer)1 suppresses epithelial cell scattering and tubulogenesis. J Biol. Chem, 280, 42164-42171, 2005.

(34) Sussan, TE, Pletcher, MT, Murakami, Y, Reever, RH. Tumor suppressor in lung cancer 1 (TSLC1) alters tumorigenic growth properties and gene expression. Mol. Cancer, 4, 28, 2005.

(33) Kuroki, K, Tsuchiya, N, Shiroishi, M, Rasubala, L, Yamashita, Y, Matsuta, K, Fukuzawa, T, Kusaoi, M, Murakami, Y, Takiguchi, M, Juji, T, Hashimoto, H, Kohda, D, Maenaka, K, Tokunaga, K. Extensive polymorphisms of LILRB1 (ILT2, LIR1) and their association with HLA-DRB1 shared epitope negative rheumatoid arthritis. Hum Mol Genet, 14, 2469-2480, 2005.

(32) Murakami, Y. Involvement of a cell adhesion molecule, TSLC1/IGSF4, in human oncogenesis. Cancer Sci., 96, 543-552, 2005.

(31) Goto, A, Niki, T, Chi-pin, L, Matsubara, D, Murakami, Y, Funata, N, Fukayama, M. Loss of TSLC expression in lung adencarcinoma: relationships with histological subtypes, gender, and prognostic significance. Cancer Sci, 96, 480-486, 2005.

(30) Kikuchi, S, Yamada, D, Fukami, T, Masuda, M, Sakurai-Yageta, M, Williams, YN, Maruyama, T, Asamura, H, Matsuno, Y, Onizuka, M, Murakami, Y. Promoter methylation of the DAL-1/4.1B predicts poor prognosis in non-small cell lung cancer. Clin. Cancer Res., 11, 2954-2961, 2005.

(29) Mototani, H, Mabuchi, A, Saito, S, Fujioka, M, Iida, A, Takatori, Y, Kotani, A, Kubo, T, Nakamura, K, Sekine, A, Murakami, Y, Tsunoda, T, Notoya, K, Nakamura, Y, Ikegawa, S. A functional single nucleotide polymorphism in the core promoter region of CALM1 is associated with hip osteoarthritis in Japanese. Hum Mol. Genet., 14, 1009-1017, 2005.

(28) Sasaki, H, Nishikata, I, Shiraga, T, Akamatsu, E, Ishida, Y, Fukami, T, Hidaka, T, Kubuki, Y, Okayama, A, Hamada, K, Okabe, H, Murakami, Y, Tsubouchi, H, Morishita, K. Overexpression of a cell adhesion molecule, TSLC1, as a possible molecular marker for acute type of adult T-cell leukemia. Blood, 105:1204-1213, 2005.

(27) Tsuchiya, N., Kuroki, K., Fujimoto, M., Murakami, Y., Tedder, T.F., Tokunaga, K., Takehara, K., Sato, S. Association of functional CD19 polymorphism with susceptibility to systemic sclerosis (scleroderma). Arthritis Rheum., 50:4002-4007, 2004.

(26) Murakami, Y., Isogai, K., Tomita, H., Sakurai-Yageta, M., Maruyama, T., Hidaka, A., Nose, K., Sugano, K., Kaneko A. Detection of allelic imbalance in the gene expression of hMSH2 or RB1 in lymphocytes from pedigrees of hereditary non-polyposis colorectal cancer and retinoblastoma by an RNA difference plot. J. Hum. Genet., 49:635-641, 2004.

(25) Surace, E.I., Murakami, Y., Scheithauer, B.W., Perry, A., Gutmann, D.H. Tumor suppressor in lung cancer-1 (TSLC1) expression is lost in sporadic meningioma. J. Neuropathol. Exp. Neurol., 63:1015-1027, 2004.

(24) Lung, H.L., Cheng, Y., Kumaran, M.K., Liu, E.T.-B., Murakami, Y., Chan, C.Y., Yau, W.L., Stanbridge, E.J., Lung, M.L. Fine mapping of 11q22-23 tumor suppressive region and involvement of TSLC1 in nasopharyngeal carcinoma. Int. J. Cancer, 112:628-635, 2004.

(23) Saino, M., Maruyama, T., Sekiya, T., Kayama, T., Murakami, Y. Inhibition of angiogenesis in human glioma cell lines by antisense RNA from the soluble guanylate cyclase genes, GUCY1A3 and GUCY1B3. Oncol. Rep., 12:47-52, 2004.

(22) Sugano, K., Yoshida, T., Izumi, H., Umezawa S., Ushiama M., Ichikawa, A., Hidaka, A., Murakami, Y., Kodama, T., Suzuki, S., Kaneko, A. Outpatient clinic for genetic counseling and gene testing of retinoblastoma. Int. J. Clin. Oncol., 9:25-30, 2004.

2001 - 2003

(21) Fukami, T., Satoh, H., Williams, YN., Masuda, M., Fukuhara, H., Maruyama, T., Yageta, M., Kuramochi, M., Takamoto, S., Murakami, Y. Isolation of the mouse Tsll1 and Tsll2 genes, orthologues of the human TSLC1-like genes 1 and 2 (TSLL1 and TSLL2). Gene, 323:11-18, 2003.

(20) Mao, X., Seidlitz, E., Ghosh, K., Murakami, Y., Ghosh, H.P. The cytoplasmic domain is critical to the tumour suppressor activity of TSLC1 in non-small cell lung cancer. Cancer Res., 63:7979-7985, 2003.

(19) Ito, T., Shimada, Y., Hashimoto, Y., Kaganoi, J., Kan, T., Watanabe, G., Murakami, Y., Imamura, M. Involvement of TSLC1 in progression of esophageal squamous cell carcinoma. Cancer Res., 63:6320-6326, 2003.

(18) Fukuhara, H., Masuda, M., Yageta, M., Fukami, T., Kuramochi, M., Maruyama, T., Kitamura, T., Murakami, Y. Association of a lung tumor suppressor TSLC1 with MPP3, a human homologue of drosophila tumor suppressor Dlg. Oncogene, 22:6160-6165, 2003.

(17) Fukami, F., Fukuhara, H., Kuramochi, M., Maruyama, T., Isogai, K., Sakamoto, M., Takamoto, S., Murakami, Y. Promoter methylation of the TSLC1 gene in advanced lung tumors and various cancer cell lines. Int. J. Cancer, 107:53-59, 2003.

(16) Murakami, Y. Functional cloning of a tumor suppressor gene, TSLC1, in human non-small cell lung cancer. Oncogene, 21:6936-6948, 2002.

(15) Yageta, M., Kuramochi, M., Masuda, M., Fukami, T., Fukuhara, H., Maruyama, T., Shibuya, T., Murakami, Y. Direct association of TSLC1 and DAL-1, two distinct tumor suppressor proteins in lung cancer. Cancer Res., 62:5129-5133, 2002.

(14) Fukami, F., Fukuhara, H., Kuramochi, 53) Fukami, T., Satoh, H., Maruyama, T., Fukuhara, H., Kuramochi, M., Takamoto, S., Momoi, T., Murakami, Y. Identification of the Tslc1 gene, a mouse orthologue of the human tumor suppressor TSLC1 gene. Gene, 295:7-12, 2002.

(13) Masuda, M., Yageta, M., Fukuhara, H., Kuramochi, M., Maruyama, T., Nomoto, A., Murakami, Y. The tumor suppressor protein TSLC1 is involved in cell-cell adhesion. J Biol. Chem., 277:31014-31019, 2002.

(12) Honda, T., Tamura, G., Waki, T., Jin, Z., Sato, K., Motoyama, T., Kawata, S., Kimura, W., Nishizuka, S., Murakami, Y. Hypermethylation of the TSLC1 gene promoter in primary gastric cancers and gastric cancer cell lines. Jpn. J. Cancer Res., 93:857-860, 2002.

(11) Fukuhara, H., Kuramochi, M., Fukami, T., Kasahara, K., Furuhata, M., Nobukuni, T., Maruyama, T., Isogai, K., Sekiya, T., Shuin, T., Kitamura, T., Reeves, R.H., Murakami, Y. Promoter methylation of the TSLC1 and tumor suppression by its gene product in human prostate cancer. Jpn. J. Cancer Res., 93:605-609, 2002.

(10) Tamura, K., Miwa, W., Maruyama, T., Sekiya, T., Murakami, Y. Homozygous deletion on the chromosomal region 5q12.3 in human lines of small-cell lung cancers. J Hum. Genet., 47:348-354, 2002.

(9) Fukuhara, H., Kuramochi. M., Nobukuni, T., Fukami, T., Saino, M., Maruyama, T., Nomura, N., Sekiya, T., Murakami, Y. Isolation of the TSLL1 and TSLL2 genes, members of the tumor suppressor TSLC1 gene family encoding transmembrane proteins. Oncogene, 20:5401-5407, 2001.

(8) Pletcher, M.T., Nobukuni, T., Fukuhara, H., Kuramochi, M., Maruyama, T., Sekiya, T., Sussan, T., Isomura, M., Murakami, Y., Reeves, R.H. Identification of tumor suppressor candidate genes by physical and sequence mapping of the TSLC1 region of human chromosome 11q23. Gene, 273:181-189, 2001.

(7) Kuramochi, M., Fukuhara, H., Nobukuni, T., Kanbe, T., Maruyama, T., Ghosh, H.P., Pletcher, M., Isomura, M., Onizuka, M., Kitamura, T., Sekiya, T., Reeves, R.H., Murakami, Y. TSLC1 is a tumor suppressor gene in human non-small cell lung cancer. Nat. Genet., 27:427-430, 2001.

(6) Kanbe, T., Nobukuni, T., Kawasaki, H., Sekiya, T., Murakami, Y. Four single-nucleotide polymorphisms in the human BUB1 gene. J Hum. Genet., 46:150-151, 2001.

(5) Nishimoto, A., Miura, N., Horikawa, I., Kugoh, H., Murakami, Y., Hirohashi, S., Kawasaki, H., Barrett, C.J., Gazdar, A.F., Shay, J.W., Oshimura, M. Evidence for a telomerase repressor gene on human chromosome 10p15.1. Oncogene, 20:828-835, 2001

- 2000 (representative publications)

(4) Murakami, Y., Uejima, H., Fukuhara, H., Maruyama, T., Oshimura, M., Sekiya, T. Construction of human-rodent hybrids containing fragments of human chromsome 10p. J Hum. Genet., 45:370-373, 2000.

(3) Kanamori, M., Kon, H., Nobukuni, T., Nomura, S., Sugano, K., Mashiyama, S., Kumabe, T., Yoshimoto, T., Meuth, M., Sekiya, T., Murakami, Y. Microsatellite instability and the PTEN1 gene mutation in a subset of early onset gliomas carrying germline mutation or promoter methylation of the hMLH1 gene. Oncogene, 19:1564-1571, 2000.

(2) Kuchiki, H., Saino, M., Nobukuni, T, Yasuda, J., Maruyama, T., Kayama, Y, Murakami, Y., Sekiya, T. Detection of amplification of a chromosomal fragment at 6p21 including the Cyclin D3 gene in a glioblastoma cell line by arbitrarily primed polymerase chain reaction. Int. J Cancer, 85:113-116, 2000.

(1) Murakami, Y., Nobukuni, T., Tamura, K., Maruyama, T., Sekiya, T., Arai, Y., Gomyou, H., Tanigami, A., Ohki, M., Cabin, D., Frischmyer, P., Hunt, P., Reeves, R.H. Localization of tumor suppressor activity important in non-small cell lung carcinoma on chromosome 11q. Proc. Natl. Acad. Sci. USA, 95:8153-8158, 1998.