,

2012年3月まで

2010-2011
2008-2009
2006-2007
2004-2005
2002-2003
2000-2001
1998-1999
1995-1997

 


2010-2011

Sanada T, Kim M, Mimuro H, Suzuki M, Ogawa M, Oyama A, Ashida H, Kobayashi T, Koyama T, Nagai S, Shibata Y, Gohda J, Inoue J, Mizushima T, Sasakawa C. The Shigella flexneri effector OspI deamidates UBC13 to dampen the inflammatory response. (2012) Nature. 483, 623-626.

Fukumatsu M, Ogawa M, Arakawa S, Suzuki M, Nakayama K, Shimizu S, Kim M, Mimuro H, Sasakawa C. Shigella targets epithelial tricellular junctions and uses a noncanonical clathrin-dependent endocytic pathway to spread between cells. (2012) Cell Host Microbe. in press

Ashida, H., Ogawa, M., Kim, M., Mimuro, H., and Sasakawa, C. Bacteria and host interactions in the gut epithelial barrier. (2011) Nature Chem. Biol. 8, 36-45.

Ogawa, M., Yoshikawa, Y., Kobayashi, T., Mimuro, H., Fukumatsu, M., Kiga, K., Piao, Z., Ashida, H., Yoshida, M., Kakuta, S., Koyama, T., Goto, Y., Nagatake, T., Nagai, S., Kiyono, H., Kawalec, M., Reichhart, J.-M., and Sasakawa, C. A tecpr1-dependent selective autophagy pathway targets bacterial pathogens. (2011) Cell Host Microbe. 9, 376-389.

Ashida, H., Kim, M., Schmidt-Supprian, M., Ma, A., Ogawa, M., and Sasakawa, C. A bacterial E3 ubiquitin ligase IpaH9.8 targets NEMO/IKKgamma to dampen the host NF-kappaB-mediated inflammatory response. (2010) Nat. Cell Biol. 12, 66-73.

Kim, M., Ashida, H., Ogawa, M., Yoshikawa, Y., Mimuro, H., and Sasakawa, C. Bacterial interactions with the host epithelium. (2010) Cell Host Microbe. 8, 20-35.

Ashida, H., Mimuro, H., Ogawa, M., Kobayashi, T., Sanada, T., Kim, M., and Sasakawa, C. Host-pathogen interactions: Cell death and infection: A double-edged sword for host and pathogen survival. (2011) J. Cell Biol. 195, 931-942.

Ishijima, N., Suzuki, M., Ashida, H., Ichikawa, Y., Kanegae, Y., Saito, I., Borén, T., Haas, R., Sasakawa, C., and Mimuro, H. BabA-mediated adherence is a potentiator of the Helicobacter pylori Type IV secretion system activity. (2011) J Biol Chem., 286, 25256-25264.

Suzuki, M., Kiga, K., Kersulyte, D., Cok, J., Hooper, C.C., Mimuro, H., Sanada, T., Suzuki, S., Oyama, M., Kozuka-Hata, H., Kamiya, S., Zou, Q.M., Gilman, R.H., Berg, D.E., and Sasakawa, C. Attenuated CagA oncoprotein in Helicobacter pylori from Amerindians in Peruvian Amazon. (2011) J Biol Chem., 286, 29964-29972.

Ashida, H., Ogawa, M., Mimuro, H., Kobayashi, T., Sanada, T., and Sasakawa, C. Shigella are versatile mucosal pathogens that circumvent the host innate immune system. (2011) Curr Opin Immunol. 23, 448-455.

Ashida, H., Ogawa, M., Kim, M., Suzuki, S., Sanada, T., Punginelli, C., Mimuro, H., and Sasakawa, C. Shigella deploy multiple countermeasures against host innate immune responses. (2010) Curr Opin Microbiol. 14, 16-23.

Obata, T., Goto, Y., Kunisawa, J., Sato, S., Sakamoto,.M., Setoyama, H., Matsuki, T., Nonaka, K., Shibata, N., Gohda, M., Kagiyama, Y., Nochi, T., Yuki, Y., Fukuyama, Y., Mukai, A., Shinzaki, S., Fujihashi, K., Sasakawa, C., Iijima, H., Goto, M., Umesaki, Y., Benno, Y., and Kiyono, H. Indigenous opportunistic bacteria inhabit mammalian gut-associated lymphoid tissues and share a mucosal antibody-mediated symbiosis. (2010) Proc Natl Acad Sci U S A. 107, 7419-7424.

Morikawa, H., Kim, M., Mimuro, H., Punginelli, C., Koyama, T., Nagai, S., Miyawaki, A., Iwai, K., and Sasakawa, C. The bacterial effector Cif interferes with SCF ubiquitin ligase function by inhibiting deneddylation of Cullin1. (2010) Biochem Biophys Res Commun. 401, 268-274.

Ogawa, M, and Sasakawa, C. The role of Tecpr1 in selective autophagy as a cargo receptor. (2011) Autophagy. 7(11):1389-1391

Ogawa, M., Yoshikawa, Y., Mimuro, H., Hain, T., Chakraborty, T., and Sasakawa, C. Autophagy targeting of Listeria monocytogenes and the bacterial countermeasure. (2010) Autophagy. 7, 310-314.

Ogawa M, Mimuro H, Yoshikawa Y, Ashida H, Sasakawa C. Manipulation of autophagy by bacteria for their own benefit. (2011) Microbiol Immunol. 55, 459-471

Kim, M., Ogawa, M., Mimuro, H., ans Sasakawa, C. Reinforcement of epithelial cell adhesion to basement membrane by a bacterial pathogen as a new infectious stratagem. (2010) Virulence. 1, 52-55.

Sasakawa, C. A new paradigm of bacteria-gut interplay brought through the study of Shigella. (2010) Proc Jpn Acad Ser B Phys Biol Sci. 86, 229-243.

Seyedarabi, A., Sullivan, J.A., Sasakawa, C., and Pickersgill, R.W. A disulfide driven domain swap switches off the activity of Shigella IpaH9.8 E3 ligase. (2010) FEBS Lett. 584, 4163-4168.

 


2008-2009


Kim, M., Ogawa, M., Fujita, Y., Yoshikawa, Y., Nagai, T., Koyama, T., Nagai, S., Lange, A., Fässler, R. and Sasakawa, C. Bacteria hijack integrin-linked kinase to stabilize focal adhesions and block cell detachment. (2009) Nature. 459, 578-582.

Yoshikawa, Y., Ogawa, M., Hain, T., Yoshida, M., Fukumatsu, M., Kim, M., Mimuro, H., Nakagawa, I., Yanagawa, T., Ishii, T., Kakizuka, A., Sztul, E., Chakraborty, T., and Sasakawa, C. Listeria monocytogenes ActA-mediated escape from autophagic recognition. (2009) Nat. Cell Biol.10, 1233-1240.

Ogawa, M., Handa, Y., Ashida, H., Suzuki, M., and Sasakawa, C. The versatility of Shigella effectors. (2008) Nat. Rev. Microbiol. 6, 11-16.

Ashida, H., Ogawa, M., Mimuro, H., and Sasakawa, C. Shigella infection of intestinal epithelium and circumvention of the host innate defense system. (2009) Curr. Top. Microbiol. Immunol. 37, 231-255.

Suzuki, M., Mimuro, H., Kiga, K., Fukumatsu, M., Ishijima, N., Morikawa, H., Nagai, S., Koyasu, S., Gilman, R,H., Kersulyte, D., Berg, D.E., and Sasakawa, C. Helicobacter pylori CagA phosphorylation-independent function in epithelial proliferation and inflammation. (2009) Cell Host Microbe. 5, 23-34.

Ishigame, H., Kakuta, S., Nagai, T., Kadoki, M., Nambu, A., Komiyama, Y., Fujikado, N., Tanahashi, Y., Akitsu, A., Kotaki, H., Sudo, K., Nakae, S., Sasakawa, C., and Iwakura, Y. Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses. (2009) Immunity. 30, 108-119.

Mimuro, H., Berg, D.E., and Sasakawa, C. Control of epithelial cell structure and developmental fate: lessons from Helicobacter pylori (2008) BioEssays. 30, 515-520.

Bronte-Tinkew, D.M., Terebiznik, M., Franco, A., Ang, M., Ahn, D., Mimuro, H., Sasakawa, C., Ropeleski, M.J., Peek, R.M. Jr, and Jones, N.L. Helicobacter pylori cytotoxin-associated gene A activates the signal transducer and activator of transcription 3 pathway in vitro and in vivo. (2009) Cancer Res. 69, 632-639.

Ogawa, M., Nakagawa, I., Yoshikawa, Y., Hain, T., Chakraborty, T., and Sasakawa, C. Streptococcus-, Shigella-, and Listeria-induced autophagy. (2009) Methods Enzymol. 452, 363-381.

Yoshikawa, Y., Ogawa, M., Hain, T., Chakraborty, T., and Sasakawa, C. Listeria monocytogenes ActA is a key player in evading autophagic recognition. (2009) Autophagy. 5, 1220-1221

Klionsky DJ, Abeliovich H, Agostinis P, Agrawal DK, Aliev G, Askew DS, Baba M, Baehrecke EH, Bahr BA, Ballabio A, Bamber BA, Bassham DC, Bergamini E, Bi X, Biard-Piechaczyk M, Blum JS, Bredesen DE, Brodsky JL, Brumell JH, Brunk UT, Bursch W, Camougrand N, Cebollero E, Cecconi F, Chen Y, Chin LS, Choi A, Chu CT, Chung J, Clarke PG, Clark RS, Clarke SG, Clavé C, Cleveland JL, Codogno P, Colombo MI, Coto-Montes A, Cregg JM, Cuervo AM, Debnath J, Demarchi F, Dennis PB, Dennis PA, Deretic V, Devenish RJ, Di Sano F, Dice JF, Difiglia M, Dinesh-Kumar S, Distelhorst CW, Djavaheri-Mergny M, Dorsey FC, Dröge W, Dron M, Dunn WA Jr, Duszenko M, Eissa NT, Elazar Z, Esclatine A, Eskelinen EL, Fésüs L, Finley KD, Fuentes JM, Fueyo J, Fujisaki K, Galliot B, Gao FB, Gewirtz DA, Gibson SB, Gohla A, Goldberg AL, Gonzalez R, González-Estévez C, Gorski S, Gottlieb RA, Häussinger D, He YW, Heidenreich K, Hill JA, Høyer-Hansen M, Hu X, Huang WP, Iwasaki A, Jäättelä M, Jackson WT, Jiang X, Jin S, Johansen T, Jung JU, Kadowaki M, Kang C, Kelekar A, Kessel DH, Kiel JA, Kim HP, Kimchi A, Kinsella TJ, Kiselyov K, Kitamoto K, Knecht E, Komatsu M, Kominami E, Kondo S, Kovács AL, Kroemer G, Kuan CY, Kumar R, Kundu M, Landry J, Laporte M, Le W, Lei HY, Lenardo MJ, Levine B, Lieberman A, Lim KL, Lin FC, Liou W, Liu LF, Lopez-Berestein G, López-Otín C, Lu B, Macleod KF, Malorni W, Martinet W, Matsuoka K, Mautner J, Meijer AJ, Meléndez A, Michels P, Miotto G, Mistiaen WP, Mizushima N, Mograbi B, Monastyrska I, Moore MN, Moreira PI, Moriyasu Y, Motyl T, Münz C, Murphy LO, Naqvi NI, Neufeld TP, Nishino I, Nixon RA, Noda T, Nürnberg B, Ogawa M, Oleinick NL, Olsen LJ, Ozpolat B, Paglin S, Palmer GE, Papassideri I, Parkes M, Perlmutter DH, Perry G, Piacentini M, Pinkas-Kramarski R, Prescott M, Proikas-Cezanne T, Raben N, Rami A, Reggiori F, Rohrer B, Rubinsztein DC, Ryan KM, Sadoshima J, Sakagami H, Sakai Y, Sandri M, Sasakawa C, Sass M, Schneider C, Seglen PO, Seleverstov O, Settleman J, Shacka JJ, Shapiro IM, Sibirny A, Silva-Zacarin EC, Simon HU, Simone C, Simonsen A, Smith MA, Spanel-Borowski K, Srinivas V, Steeves M, Stenmark H, Stromhaug PE, Subauste CS, Sugimoto S, Sulzer D, Suzuki T, Swanson MS, Tabas I, Takeshita F, Talbot NJ, Tallóczy Z, Tanaka K, Tanaka K, Tanida I, Taylor GS, Taylor JP, Terman A, Tettamanti G, Thompson CB, Thumm M, Tolkovsky AM, Tooze SA, Truant R, Tumanovska LV, Uchiyama Y, Ueno T, Uzcátegui NL, van der Klei I, Vaquero EC, Vellai T, Vogel MW, Wang HG, Webster P, Wiley JW, Xi Z, Xiao G, Yahalom J, Yang JM, Yap G, Yin XM, Yoshimori T, Yu L, Yue Z, Yuzaki M, Zabirnyk O, Zheng X, Zhu X, Deter RL. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. (2008) Autophagy, 4, 151-175.

Nochi, T., Yuki, Y., Katakai, Y., Shibata, H., Tokuhara, D., Mejima, M., Kurokawa, S., Takahashi, Y., Nakanishi, U., Ono, F., Mimuro, H., Sasakawa, C., Takaiwa, F., Terao, K., and Kiyono, H. (2009) A rice-based oral cholera vaccine induces macaque-specific systemic neutralizing antibodies but does not influence pre-existing intestinal immunity. J. Immunol. 183, 6538-6544.

Shifrin Y, Peleg A, Ilan O, Nadler C, Kobi S, Baruch K, Yerushalmi G, Berdichevsky T, Altuvia S, Elgrably-Weiss M, Abe C, Knutton S, Sasakawa C, Ritchie JM, Waldor MK,and Rosenshine I. (2008) Transient shielding of intimin and the type III secretion system of enterohemorrhagic and enteropathogenic Escherichia coli by a group 4 capsule. J. Bacteriol. 190, 5063-5074.

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2006-2007


Iwai, H., Kim, M., Yoshikawa, Y., Ashida, H., Ogawa, M., Fujita, Y., Muller, D., Kirikae, T., Jackson, P.K., Kotani, S., and Sasakawa, C. (2007) A Bacterial Effector Targets Mad2L2, an APC Inhibitor, to Modulate Host Cell Cycling. Cell 130, 611-623.

Yoshida, S., Handa, Y., Suzuki, T., Ogawa, M. Suzuki, M., Tamai, A., Abe, A., Katayama, E., and Sasakawa, C. (2006) Microtubule-Severing Activity of Shigella Is Pivotal for Intercellular Spreading.
Science 314, 985-989.

Handa, Y., Suzuki, M., Ohya, K., Iwai, H., Ishijima, N., Koleske, A. J., Fukui Y., and Sasakawa, C. (2007) Shigella IpgB1 promotes bacterial entry through the ELMO–Dock180 machinery. Nat. Cell Biol. 9, 121-128.

Mimuro, H., Suzuki, T., Nagai, S., Rieder, G., Suzuki, M., Nagai, T., Fujita, Y., Nagamatsu, K., Ishijima, N., Koyasu, S., Haas, R., and Sasakawa, C. (2007) Helicobacter pylori Dampens Gut Epithelial Self-Renewal by Inhibiting Apoptosis, a Bacterial Strategy to Enhance Colonization of the Stomach. Cell Host & Microbe 2, 250-263.

Iizumi Y, Sagara H, Kabe Y, Azuma M, Kume K, Ogawa M, Nagai T, Gillespie PG, Sasakawa C,and Handa H. (2007) The enteropathogenic E. coli effector EspB facilitates microvillus effacing and antiphagocytosis by inhibiting myosin function. Cell Host & Microbe 2, 383-392.

Nagai, S., Mimuro, H., Yamada, T., Baba, Y., Moro, K., Nochi, T., Kiyono, H., Suzuki, T., Sasakawa, C, and Koyasu, S. (2007) Role of Peyer's patches in the induction of Helicobacter pylori-induced gastritis. Proc Natl Acad Sci U S A 104, 8971-8976.

Suzuki, T., Franchi, L., Toma, C., Ashida, H., Ogawa, M., Yoshikawa, Y., Mimuro, H., Inohara, N., Sasakawa, C., and Nunez, G. (2007) Differential Regulation of Caspase-1 Activation, Pyroptosis, and Autophagy via Ipaf and ASC in Shigella-Infected Macrophages. PLoS Pathog. 3, e111.

Ashida, H., Toyotome, T., Nagai, T. and Sasakawa, C. (2006) Shigella chromosomal IpaH proteins are secreted via the type III secretion system and act as effectors. Mol. Microbiol. 63, 680-693

Suzuki, T., Yoshikawa, Y., Ashida, H., Iwai, H., Toyotome, T., Matsui, H. and Sasakawa, C. (2006) High vaccine efficacy against shigellosis of recombinant noninvasive Shigella mutant that expresses Yersinia invasin. J. Immunol. 177, 4709-4717.

Shim, D. H., Suzuki, T., Chang, S. Y., Park, S. M., Sansonetti, P. J., Sasakawa, C. and Kweon, M. N. (2007) New animal model of shigellosis in the Guinea pig: its usefulness for protective efficacy studies. J. Immunol. 178, 2476-2482.

Morita-Ishihara, T., Ogawa, M., Sagara, H., Yoshida, M., Katayama, E. and Sasakawa, C. (2006) Shigella Spa33 is an essential C-ring component of type III secretion machinery. J. Biol. Chem.281, 599-607.

Ogawa, M. and Sasakawa, C. (2006) Shigella and Autophagy. Autophagy 2, 171-174.

Ogawa, M. and Sasakawa, C. (2006) Intracellular survival of Shigella. Cell. Microbiol. 8, 177-184.

Sasakawa, C. and Hacker, J. (2006) Host-microbe interaction: bacteria. Curr. Opin. Microbiol. 9, 1-4.

Ogawa, M., and Sasakawa, C. (2006) Bacterial evasion of the autophagic defense system. Curr. Opin. Microbiol.9, 62-68.

Marchés, O., Batchelor, M., Shaw, R. K., Patel, A., Cummings, N., Nagai, T., Sasakawa, C., Carlsson, S. R., Cougoule, C., Caron, E., Knutton, S., Connerton, I. and Frankel, G. (2006) EspF of Enteropathogenic Escherichia coli Binds Sorting Nexin 9. J. Bacteriol. 188, 3110-3115.

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2004-2005

Ogawa, M., Yoshimori, T., Suzuki, T., Sagara, H., Mizushima, N. and Sasakawa, C. (2005) Escape of Intracellular Shigella from Autophagy. Science 307, 727-731.

Suzuki, M., Mimuro, H., Suzuki, T., Park, M., Yamamoto, T. and Sasakawa, C. (2005) Interaction of CagA with Crk plays an important role in Helicobacter pylori-induced loss of gastric epithelial cell adhesion. J. Exp. Med. 202, 1235-1247.

Ohya, K., Handa, Y., Ogawa, M., Suzuki, M. and Sasakawa, C. (2005) IpgB1 is a novel Shigella effector protein involved in bacterial invasion of host cells: ITS ACTIVITY TO PROMOTE MEMBRANE RUFFLING VIA RAC1 AND CDC42 ACTIVATION. J. Biol. Chem. 280, 24022-24034.

Suzuki, T., Nakanishi, K., Tsutsui, H., Iwai, H., Akira, S., Inohara, N., Chamaillard, M., Nu´nez, G. and Sasakawa, C. (2005) A novel caspase-1/Toll-like receptor 4-independent pathway of cell death induced by cytosolic Shigella in infected macrophages. J. Biol. Chem. 280, 14042-14050.

Nagai, T., Abe, A. and Sasakawa, C. (2005) Targeting of enteropathogenic Escherichia coli EspF to host mitochondria is essential for the bacterial pathogenesis: critical role of the 16th leucine residue in EspF. J. Biol. Chem. 280, 2998-3011.

Matsuzawa, T., Kuwae, A., Yoshida, S., Sasakawa, C. and Abe, A. (2004) Enteropathogenic Escherichia coli activates the RhoA signaling pathway via the stimulation of GEF-H1. EMBO J. 23, 3570-3582.

Jang, M.H., Kweon, M.N., Iwatani, K., Yamamoto, M., Terahara, K., Sasakawa, C., Suzuki, T., Nochi, T., Yokota, Y., Rennert, P.D., Hiroi, T., Tamagawa, H., Iijima, H., Kunisawa, J., Yuki, Y., and Kiyono, H. (2004) Intestinal villous M cells: an antigen entry site in the mucosal epithelium. Proc Natl Acad Sci U S A 101, 6110-6115.

Okuda, J., Toyotome, T., Kataoka, N., Ohno, M., Abe, H., Shimura, Y., Seyedarabi, A., Pickersgill, R. and Sasakawa, C. (2005) Shigella effector IpaH9.8 binds to a splicing factor U2AF35 to modulate host immune responses. Biochem. Biophys Res. Commun. 333, 531-539.

Takahashi, T., Matsumoto, T., Nakamura, M., Matsui, H., Kiyohara, H., Sasakawa, C., and Yamada, H. (2004) A novel in vitro infection model of Helicobacter pylori using mucin-producing murine gastric surface mucous cells. Helicobacter 9, 302-312.

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2002-2003


Mimuro, H., Suzuki, T., Tanaka, J., Asahi, M., Haas, R. and Sasakawa, C. (2002) Grb2 is a key mediator of Helicobacter pylori CagA protein activities. Mol. Cell 10, 745-755.

Yoshida, S. and Sasakawa, C. (2003) Exploiting host microtubule dynamics: a new aspect of bacterial invasion. Trend. Microbiol. 11, 139-143.

Yoshida, S., Katayama, E., Kuwae, A., Mimuro, H., Suzuki, T. and Sasakawa, C. (2002) Shigella deliver an effector protein to trigger host microtubule destabilization, which promotes Rac1 activity and efficient bacterial internalization. EMBO J. 21, 2923-2935.

Shimizu, Y., Yamamichi, N., Saitoh, K., Watanabe, A., Ito, T., Yamamichi-Nishina, M., Mizutani, M., Yahagi, N., Suzuki, T., Sasakawa, C., Yasugi, S., Ichinose, M. and Iba, H. (2003) Kinetics of v-src-induced epithelial-mesenchymal transition in developing glandular stomach. Oncogene 22, 884-893.

Ogawa, M., Suzuki, T., Tatsuno, I., Abe, H. and Sasakawa, C. (2003) IcsB, secreted via the type III secretion system, is chaperoned by IpgA and required at the post-invasion stage of Shigella pathogenicity. Mol. Microbiol. 48, 913-931.

Tamano, K., Aizawa, S. and Sasakawa, C. (2002) Purification and detection of Shigella type III secretion needle complex. Methods Enzymol. 358, 385-392.

Sasakawa C. (2003) Shigella Invasion. in Bacterial Invasion of Host Cell. (ed. L. Ramont) (Cambridge University Press)

Tanaka, J., Suzuki, T., Mimuro, H. and Sasakawa, C. (2003) Structural definition on the surface of Helicobacter pylori type IV secretion apparatus. Cell. Microbiol. 5, 395-404.

Suzuki, T., Mimuro, H., Suetsugu, S., Miki, H., Takenawa, T. and Sasakawa, C. (2002) Neural Wiskott-Aldrich syndrome protein (N-WASP) is the specific ligand for Shigella VirG among the WASP family and determines the host cell type allowing actin-based spreading. Cell. Microbiol. 4, 223-233.

Tobe, T. and Sasakawa, C. (2002) Species-specific cell adhesion of enteropathogenic Escherichia coli is mediated by type IV bundle-forming pili. Cell. Microbiol. 4, 29-42.

Tatsuno, I., Nagano, K., Taguchi, K., Li, R., Mori, H. and Sasakawa, C. (2003) Hyper Adherence to Caco-2 Cells Caused by Disruption of yhiE and yhiF Genes in Enterohemorrhagic Escherichia coli O157:H7. Infect. Immun. 71, 2598-2606.

Abe, H., Tatsuno, I., Tobe, T., Okutani, A. and Sasakawa, C. (2002) Bicarbonate ion stimulates the expression of locus of enterocyte effacement-encoded genes in enterohemorrhagic Escherichia coli O157:H7. Infect. Immun. 70, 3500-3509.

Tamano, K., Katayama, E., Toyotome, T. and Sasakawa, C. (2002) Shigella Spa32 is an essential secretory protein for functional type III secretion machinery and uniformity of its needle length. J. Bacteriol. 184, 1244-1252.

Biswas, D., Itoh, K., and Sasakawa, C. (2003) Role of microfilaments and microtubules in the invasion of INT-407 cells by Campylobacter jejuni. Microbiol Immunol. 47, 469-473.

Makino, S., Tobe, T., Asakura, H., Watarai, M., Ikeda, T., Takeshi, K. and Sasakawa, C. (2003) Distribution of the secondary type III secretion system locus found in enterohemorrahagic Escherichia coli O157:H7 among Shiga toxin-producing E. coli. J. Clin. Microbiol. 41, 2341-2347.

Honma, Y., Sasakawa, C., Tsuji, T. and Iwanaga, M. (2003) Comparison of antimicrobial susceptibility between invasive and non-invasive Shigella organisms. Int. J. Antimicrob. Agents 21, 262-266.


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2000-2001


Suzuki, T., Mimuro, H., Miki, H., Takenawa, T., Sasaki, T., Nakanishi, H., Takai, Y. and Sasakawa, C. (2000) Rho family GTPase Cdc42 is essential for the actin-based motility of Shigella in mammalian cells. J. Exp. Med. 191, 1905-1920.

Asahi, M., Azuma, T., Ito, S., Ito, Y., Suto, H., Nagai, Y., Tsubokawa, M., Tohyama, Y., Maeda, S., Omata, M., Suzuki, T. and Sasakawa, C. (2000) Helicobacter pylori CagA protein can be tyrosine phosphorylated in the gastric epithelial cells. J. Exp. Med. 191, 593-602.

Tamano, K., Aizaiwa, S., Katayama, E., Nonaka, T., Imajoh-Ohmi, S., Kuwae, A., Nagai, S. and Sasakawa, C. (2000) Supermolecular structure of the Shigella type III secretion machinery: the needle part is changeable in length and essential for delivery of effectors. EMBO J. 19, 3876-3887.

Sekiya, K., Ohishi, M., Ogino, T., Tamano, K., Sasakawa, C. and Abe, A. (2001) Supermolecular structure of the enteropathogenic Escherichia coli type III secretion system and its direct interaction with the EspA-sheath-like structure. Proc. Natl. Acad. Sci. U S A 98, 11638-11643.

Toyotome, T., Suzuki, T., Kuwae, A., Nonaka, T., Fukuda, H., Imajoh-Ohmi, S., Toyofuku, T., Hori, M. and Sasakawa, C. (2001) Shigella protein IpaH(9.8) is secreted from bacteria within mammalian cells and transported to the nucleus. J. Biol. Chem. 276, 32071-32079.

Kuwae, A., Yoshida, S., Tamano, K., Mimuro, H., Suzuki, T. and Sasakawa, C. (2001) Shigella invasion of macrophage requires the insertion of IpaC into the host plasma membrane. Functional analysis of IpaC. J. Biol. Chem. 276, 32230-32239.

Mimuro, H., Suzuki, T., Suetsugu, S., Miki, H., Takenawa, T. and Sasakawa, C. (2000) Profilin is required for sustaining efficient intra- and intercellular spreading of Shigella flexneri. J. Biol. Chem. 275, 28893-28901.

Kanamaru, K., Kanamaru, K., Tatsuno, I., Tobe, T. and Sasakawa, C. (2000) SdiA, an Escherichia coli homologue of quorum-sensing regulators, controls the expression of virulence factors in enterohaemorragic Escherichia coli O157:H7. Mol. Microbiol. 38, 805-816.

Tobe, T. and Sasakawa, C. (2001) Role of bundle-forming pilus of enteropathogenic Escherichia coli in host cell adherence and in microcolony development. Cell. Microbiol. 3, 579-585.

Tatsuno, I., Horie, M., Abe, H., Miki, T., Makino, K., Shinagawa, H., Taguchi, H., Kamiya, S., Hayashi, T. and Sasakawa, C. (2001) toxB gene on pO157 of enterohemorrhagic Escherichia coli O157:H7 is required for full epithelial cell adherence phenotype. Infect. Immun. 69, 6660-6669.

Suzuki, T. and Sasakawa, C. (2001) Molecular basis of the intracellular spreading of Shigella. Infect. Immun. 69, 5959-5966.

Elliott, S. J., Krejany, E. O., Mellies, J. L., Robins-Browne, R. M., Sasakawa, C. and Kaper, J. B. (2001) EspG, a novel type III system-secreted protein from enteropathogenic Escherichia coli with similarities to VirA of Shigella flexneri. Infect. Immun. 69, 4027-4033.

Tatsuno, I., Kimura, H., Okutani, A., Kanamaru, K., Abe, H., Nagai, S., Makino, K., Shinagawa, H., Yoshida, M., Sato, K., Nakamoto, J., Tobe, T. and Sasakawa, C. (2000) Isolation and characterization of mini-Tn5Km2 insertion mutants of enterohemorrhagic Escherichia coli O157:H7 deficient in adherence to Caco-2 cells. Infect. Immun. 68, 5943-5952.

Sakellaris, H., Hannink, K. N., Rajakumar, K., Bulach, D., Hunt, M., Sasakawa, C. and Adler, B. (2000) Curli loci of Shigella spp. Infect. Immun. 68, 3780-3783.

Han, C. G., Shiga, Y., Tobe, T., Sasakawa, C. and Ohtsubo, E. (2001) Structural and functional characterization of IS679 and IS66-family elements. J. Bacteriol. 183, 4296-4304.

Yokoyama, K., Makino, K., Kubota, Y., Watanabe, M., Kimura, S., Yutsudo, C. H., Kurokawa, K., Ishii, K., Hattori, M., Tatsuno, I., Abe, H., Yoh, M., Iida, T., Ohnishi, M., Hayashi, T., Yasunaga, T., Honda, T., Sasakawa, C. and Shinagawa, H. (2000) Complete nucleotide sequence of the prophage VT1-Sakai carrying the Shiga toxin 1 genes of the enterohemorrhagic Escherichia coli O157:H7 strain derived from the Sakai outbreak. Gene 258, 127-139.

Honma, Y., Sasakawa, C., Tsuji, T. and Iwanaga, M. (2001) Enhanced anti-Shigella activity of erythromycin supplemented with sulfadiazine. FEMS Immunol. Med. Microbiol. 32, 43-46.

Honma, Y., Sasakawa, C., Tsuji, T. and Iwanaga, M. (2000) Effect of erythromycin on Shigella infection of Caco-2 cells. FEMS Immunol. Med. Microbiol. 27, 139-145.

Biswas, D., Itoh, K. and Sasakawa, C. (2000) Uptake pathways of clinical and healthy animal isolates of Campylobacter jejuni into INT-407 cells. FEMS Immunol. Med. Microbiol. 29, 203-211.

Hayashi, T., Makino, K., Ohnishi, M., Kurokawa, K., Ishii, K., Yokoyama, K., Han, C. G., Ohtsubo, E., Nakayama, K., Murata, T., Tanaka, M., Tobe, T., Iida, T., Takami, H., Honda, T., Sasakawa, C., Ogasawara, N., Yasunaga, T., Kuhara, S., Shiba, T., Hattori, M. and Shinagawa, H. (2001) Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12 (supplement). DNA Res. 8, 47-52.

Hayashi, T., Makino, K., Ohnishi, M., Kurokawa, K., Ishii, K., Yokoyama, K., Han, C. G., Ohtsubo, E., Nakayama, K., Murata, T., Tanaka, M., Tobe, T., Iida, T., Takami, H., Honda, T., Sasakawa, C., Ogasawara, N., Yasunaga, T., Kuhara, S., Shiba, T., Hattori, M. and Shinagawa, H. (2001) Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12. DNA Res. 8, 11-22.

Okutani, A., Tobe, T., Sasakawa, C., Nozu, R., Gotoh, K., Takakura, A., Itoh, T., Miyamoto, Y. and Itoh, K. (2001) Comparison of bacteriological, genetic and pathological characters between Escherichia coli O115a,c:K(B) and Citrobacter rodentium. Exp. Anim. 50, 183-186.

Kanamaru, K., Kanamaru, K., Tatsuno, I., Tobe, T. and Sasakawa, C. (2000) Regulation of virulence factors of enterohemorrhagic Escherichia coli O157:H7 by self-produced extracellular factors. Biosci. Biotechnol. Biochem. 64, 2508-2511.

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1998-1999

Kato, M., Miki, H., Imai, K., Nonoyama, S., Suzuki, T., Sasakawa, C. and Takenawa, T. (1999) Wiskott-Aldrich syndrome protein induces actin clustering without direct binding to Cdc42. J. Biol. Chem. 274: 27225-27230.

Makino, K., Yokoyama, K., Kubota, Y., Yutsudo, H. C., Kimura, S., Kurokawa, K., Ishii, K., Hattori, M., Tatsuno, I., Abe, H., Iida, T., Yamamoto, K., Onishi, M., Hayashi, T., Yasunaga, T., Honda, T., Sasakawa, C. and Shinagawa, H. (1999) Complete nucleotide sequence of the prophage VT2-Sakai carrying the verotoxin 2 genes of the enterohemorrhagic Escherichia coli O157:H7 derived from the Sakai outbreak. Genes Genet. Syst. 74: 227-239.

Tobe, T., Hayashi, T., Han, C-G., Schoolink, G. K., Ohtsubo, E and Sasakawa, C. (1999) Complete DNA sequence and structual analysis of the entro-adeherent factor (EAF) plasmid of enteropathogenic Escherichia coli. Infect. Immun. 67: 5455-5462

Nonaka, T., Kuwae, A., Sasakawa C. and Imajoh-Ohmi, S. (1999) Shigella flexneri YSH6000 induces two types of cell death, apoptosis and oncosis, in the differentiated human monoblastic cell line U937. FEMS Microbiol. Letters. 174: 89-95.

Tobe, T., Tatsuno, I., Katayama, E., Wu, C-Y., Schoolnik, G. K. and Sasakawa, C. (1999) A novel chromosomal locus of enteropathogenic E. coli (EPEC), which encodes a bfpT-regulated chaperone-like protein,TrcA, involved in microcolony formation by EPEC. Mol. Micobiol. 33: 741-752.

Suzuki, T. and Sasakawa, C. (1998) N-WASP is an important protein for the actin-based motility of Shigella flexneri in the infected epithelial cells. Jpn. J. Med. Sci. Biol. 51, suppl. 1 S63 - S68

Okada, N., Tatsuno, I., Hanski, E., Caparon, M. and Sasakawa, C. (1998) Streptococcus pyogenes protein F promotes invasion of HeLa cells. Microbiology 144: 3079-3086

Watarai. M., Sato, T., Kobayashi, M., Shimizu, T., Yamasaki, S., Tobe, T., Sasakawa, C. and Takeda, Y. (1998) Identification and characterization of a newly isolated Shiga toxin-converting phage from Shiga toxin-producing Escherichia coli. Infect. Immun. 66: 4100-4107

Suzuki, T., Miki, H., Takenawa, T. and Sasakawa, C. (1998) Neural Wiskott-Aldrich syndrome protein is implicated in the actin-based motility of Shigella flexneri. EMBO J. 17:2767-2776

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1995-1997

Okada, N., Watarai, M., Ozeri, V., Hanski, E., Caparon, M. and Sasakawa, C. (1997) A matrix form of fibronectin mediates enhanced binding of Streptococcus pyogenes to host tissue. J. Biol. Chem. 272: 26978-26984.

Durand, J. M., Bjork, G. R., Kuwae, A., Yoshikawa, M. and Sasakawa, C. (1997) The modified nucleotide-2-methylthio-N6-isopentenyladenosine in tRNA of Shigella flexneri is required for expression of virulence genes. J. Bacteriol. 179: 5777-5782.

Rajakumar, K., Sasakawa, C. and Adler, B. (1997) Use of a novel approach, termed island probing, identifies the Shigella flexneri she pathogenicity island which encodes a homolog of the immunoglobulin a protease-like family of protein. Infect. Immun. 65: 4606-4614.

Nakata, N., Matsuoka, M., Kashiwabara, Y., Okada, N. and Sasakawa, C. (1997) Nucleotide sequence of the Mycobacterium leprae katG region. J. Bacteriol. 179: 3053-3057.

Sasakawa, C. (1997) Early stage of Shigella interaction with host cells. (Review article) J. Infect. Chem.3: 63-72.

Watarai, M., Kamata, Y., Kozaki, S. and Sasakawa, C. (1997) rho, a small GTP-binding protein, is essential for Shigella invasion of epithelial cells. J. Exp. Med. 185: 281-292.

Rajakumar, K., Bulach, A. D., Sasakawa, C. and Adler, B. (1997) Identification of a chromosomal multi-antibiotic resistance locus in Shigella flexneri, which shares sequence and organisational similarity to the resistance region of the plasmid NR1. Plasmid. 37: 159-168.

Rajakumar, K., Luo, F., Sasakawa, C. and Adler, B. (1996) An evolutionary perspective on a composite Shigella flexneri 2a virulence plasmid-borne locus comprising three distinct genetic elements. FEMS Microbiol. Letter. 144: 13-20.

Suzuki, T., Saga, S. and Sasakawa,C. (1996) Functional analysis of Shigella VirG domains essential for interaction with vinculin and actin-based motility. J. Biol. Chem. 271: 21878-21885.

Uchiya, K., Tohsuji, M., Nikai, T, Sugihara, H. and Sasakawa, C. (1996) Identification and characterization of phoN-Sf, a gene on the large plasmid of Shigella flexneri 2a encoding a nonspecific phosphatase. J. Bacteriol. 178: 4548-4554.

Watarai, M., Funato, S. and Sasakawa, C. (1996) Interaction of Ipa proteins of Shigella flexneri with a5b1 integrin promotes entry of the bacteria into mammalian cells. J. Exp. Med. 183: 991-999.

Rajakumar, K., Sasakawa, C. and Adler, B. (1996) A spontaneous 99 kb chromosomal deletion carrying the multi-antibiotic resistance locus results in an attenuation of contact hemolysis in Shigella flexneri 2a. J. Med. Microbiol. 44: 1-12.

MacSiomoin, R., Nakata, N., Murai, T., Yoshikawa, M., Tsuji, H. and Sasakawa, C. (1996) Identification and characterization of ispA, a Shigella flexneri chromosomal gene essential for normal in vivo cell division and intercellular spreading. Mol. Microbiol. 19: 599-609.

Suzuki, T. and Sasakawa, C. (1995) Extracellular transport of VirG protein in Shigella. J. Biol. Chem. 270: 30874-30880.

Watarai, M., Tobe, T., Yoshikawa, M. and Sasakawa, C. (1995) Disulfide oxidoreductase activity of Shigella flexneri is required for release of Ipa proteins and invasion of epithelial cells. Proc. Natl. Acad. Sci. USA. 92: 4927-4931.

Yoshikawa, M., Sasakawa, C., Okada, N., Takasaka, M., Nakayama, M., Yoshikawa, Y., Kohno, A., Danbara, H., Nariuchi, H., Shimada, H. and Toriumi, M. (1995) Construction and evaluation of a virG thyA double mutant of Shigella flexneri 2a as a candidate live-attenuated oral vaccine. Vaccine. 13: 14436-1440.

Uchiya, K., Tobe, T., Komatsu, K., Suzuki, T., Watarai, M., Fukuda, I., Yoshikawa, M. and Sasakawa, C. (1995) Identification of a novel virulence gene, virA, on the large plasmid of Shigella, involved in invasion and intercellular spreading. Mol. Microbiol. 241-250.

Watarai, M., Tobe, T., Yoshikawa, M. and Sasakawa, C. (1995) Contact of Shigella with host cells triggers released of Ipa invasins and is an essential function of invasiveness. EMBO J. 14: 2461-2470.

Fukuda, I., Suzuki, I., Munakata, H., Hayashi, N., Katayama, E., Yoshikawa, M. and Sasakawa, C. (1995) Cleavage of Shigella surface protein VirG occurs at a specific site but the secretion is not essential for intracellular spreading, J. Bacteriol. 177: 1719-1725.

Sasakawa, C. (1995) Molecular basis of pathogenicity of Shigella. Rev. Med. Microbiol. 6: 257-266.

Makino S., Kurazono, T., Okuyama, Y., Shimada, T., Okada, Y. and Sasakawa, C. (1995) Diversity of DNA sequences among Vibrio cholerae O139 Bengal detected by PCR-based DNA fingerprinting. FEMS Microbiol. Letters. 126: 43-48.

Tobe, T., Yoshikawa, M. and Sasakawa, C. (1995) Thermoregulation of virB transcription in Shigella by sensing of changes in local DNA superhelicity. J. Bacteriol. 177: 1094-1097.



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