次世代の独創的な幹細胞研究を目指して

私たちは組織幹細胞である造血幹細胞を中心に様々な“幹細胞”に関する基礎研究を通じて、
新しい再生医療技術の開発を目指します。

最新のお知らせ一覧

2020/1/10

山崎聡特任准教授がAMED理事長賞を受賞いたしました。

詳しくはこちら

2019/5/29

山崎聡特任准教授の論文がNatureに掲載されました。

詳しくはこちら

最近の研究実績一覧

Ishii M, Ando J, Yamazaki S, Toyota T, Ohara K, Furukawa Y, Suehara Y, Nakanishi M, Nakashima K, Ohshima K, Nakauchi H, Ando M.
iPSC-derived neoantigen-specific cytotoxic T-lymphocyte therapy for Ewing sarcoma.
Cancer Immunol Res. 2021 Aug

Abstract on PubMed

Takahashi-Kobayashi M, Usui J, Yaguchi M, Yamazaki S, Kawamura T, Kaneko S, Seshan SV, Yamagata K.
Immunohistological score of transcription factor 21 had a positive correlation with its urinary excretion and proteinuria in immunoglobulin A nephropathy.
Histol Histopathol. 2021 Jul

Abstract on PubMed

Kuribayashi W, Oshima M, Itokawa N, Koide S, Nakajima-Takagi Y, Yamashita M, Yamazaki S, Rahmutulla B, Miura F, Ito T, Kaneda A, Iwama A.
Limited rejuvenation of aged hematopoietic stem cells in young bone marrow niche
J Exp Med. 2021 Mar

Abstract on PubMed

Zhong C, Kayamori K, Koide S, Shinoda D, Oshima M, Nakajima-Takagi Y, Nagai Y, Mimura N, Sakaida E, Yamazaki S, Iwano S, Miyawaki A, Ito R, Tohyama K, Yamaguchi K, Furukawa Y, Lennox W, Sheedy J, Weetall M, Iwama A.
Efficacy of the Novel Tubulin Polymerization Inhibitor PTC-028 for Myelodysplastic Syndrome
Cancer Sci. 2020 Oct

Abstract on PubMed

Omori S, Wang TW, Johmura Y, Kanai T, Nakano Y, Kido T, Susaki EA, Nakajima T, Shichino S, Ueha S, Ozawa M, Yokote K, Kumamoto S, Nishiyama A, Sakamoto T, Yamaguchi K, Hatakeyama S, Shimizu E, Katayama K, Yamada Y, Yamazaki S, Iwasaki K, Miyoshi C, Funato H, Yanagisawa M, Ueno H, Imoto S, Furukawa Y, Yoshida N, Matsushima K, Ueda HR, Miyajima A, Nakanishi M.
Generation of a p16 Reporter Mouse and Its Use to Characterize and Target p16high Cells In Vivo
Cell Metab. 2020 Sep

Abstract on PubMed

Sato R, Reuter T, Hiranuma R, Shibata T, Fukui R, Motoi Y, Murakami Y, Tsukamoto H, Yamazaki S, Liu K, Saitoh SI, Latz E, Miyake K.
The impact of cell maturation and tissue microenvironments on the expression of endosomal Toll-like receptors in monocytes and macrophages
Int Immunol. 2020 Aug

Abstract on PubMed

Izawa K, Yamazaki S, Becker HJ, Bhadury J, Kakegawa T, Sakaguchi M, Tojo A.
Activated HoxB4-induced Hematopoietic Stem Cells from Murine Pluripotent Stem Cells via Long-Term Programming
Exp Hematol. 2020 Aug

Abstract on PubMed

Usui J, Yaguchi M, Yamazaki S, Takahashi-Kobayashi M, Kawamura T, Kaneko S, Seshan SV, Ronco P, Yamagata K.
Transcription factor 21 expression in injured podocytes of glomerular diseases
Sci Rep. 2020 Jul

Abstract on PubMed

Sakurai M, Takemoto H, Mori T, Okamoto S, Yamazaki S.
In vivo expansion of functional human hematopoietic stem progenitor cells by butyzamide
Int J Hematol. 2020 May

Abstract on PubMed

Wilkinson AC, Ishida R, Nakauchi H, Yamazaki S.
Long-term ex vivo expansion of mouse hematopoietic stem cells.
Nat Protoc. 2020 Jan

Abstract on PubMed

Nishimura T, Hsu I, Martinez-Krams DC, Nakauchi Y, Majeti R, Yamazaki S, Nakauchi H, Wilkinson AC.
Use of polyvinyl alcohol for chimeric antigen receptor T-cell expansion.
Exp Hematol. 2019 Dec

Abstract on PubMed

Hayashi Y, Goyama S, Liu X, Tamura M, Asada S, Tanaka Y, Fukuyama T, Wunderlich M, O'Brien E, Mizukawa B, Yamazaki S, Matsumoto A, Yamasaki S, Shibata T, Matsuda K, Sashida G, Takizawa H, Kitamura T.
Antitumor immunity augments the therapeutic effects of p53 activation on acute myeloid leukemia.
Nat Commun. 2019 Oct

Abstract on PubMed

Rizk M, Rizq O, Oshima M, Nakajima-Takagi Y, Koide S, Saraya A, Isshiki Y, Chiba T, Yamazaki S, Ma A, Jin J, Iwama A, Mimura N.
Akt inhibition synergizes with polycomb repressive complex 2 inhibition in the treatment of multiple myeloma.
Cancer Sci. 2019 Sep

Abstract on PubMed

Kato Y, Hou LB, Miyagi S, Nitta E, Aoyama K, Shinoda D, Yamazaki S, Kuribayashi W, Isshiki Y, Koide S, Si S, Saraya A, Matsuzaki Y, van Lohuizen M, Iwama A.
Bmi1 restricts the adipogenic differentiation of bone marrow stromal cells to maintain the integrity of the hematopoietic stem cell niche.
Exp Hematol. 2019 Aug

Abstract on PubMed

Ando M, Ando J, Yamazaki S, Ishii M, Sakiyama Y, Harada S, Honda T, Yamaguchi T, Nojima M, Ohshima K, Nakauchi H, Komatsu N.
Long-term eradication of extranodal NK/T cell lymphoma, nasal type, by induced pluripotent stem cell-derived Epstein-Barr virus-specific rejuvenated T cells in vivo.
Haematologica.. 2019 Jul

Abstract on PubMed

Adam C. Wilkinson, Reiko Ishida, Misako Kikuchi, Kazuhiro Sudo, Maiko Morita, Ralph Valentine Crisostomo, Ryo Yamamoto, Kyle M. Loh, Yukio Nakamura, Motoo Watanabe, Hiromitsu Nakauchi, Satoshi Yamazaki
Long term ex vivo hematopoietic stem cell expansion allows nonconditioned transplantation
Nature. 2019 May

Abstract on PubMed

Shiraishi K, Shichino S, Ueha S, Nakajima T, Hashimoto S, Yamazaki S, Matsushima K.
Mesenchymal-Epithelial Interactome Analysis Reveals Essential Factors Required for Fibroblast-Free Alveolosphere Formation.
iScience. 2019 Jan

Abstract on PubMed

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