Toward clinical practice from advanced stem cell biology.

Our major goals are to understand the mechanism of the intractable disease and establish the therapy of the disease through the several Stem Cells biology.

Current NewsMore News

2020/1/10

Dr.Yamazaki was awarded the AMED (Agency for Medical Research and Development) presidential award.

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2019/5/29

"Long term ex vivo hematopoietic stem cell expansion allows nonconditioned transplantation" was published in "Nature".

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PublicationsMore Publications

Wilkinson AC, Ishida R, Nakauchi H, Yamazaki S.
Long-term ex vivo expansion of mouse hematopoietic stem cells.
Nat Protoc. 2020 Jan

Abstract on PubMed

Nishimura T, Hsu I, Martinez-Krams DC, Nakauchi Y, Majeti R, Yamazaki S, Nakauchi H, Wilkinson AC.
Use of polyvinyl alcohol for chimeric antigen receptor T-cell expansion.
Exp Hematol. 2019 Dec

Abstract on PubMed

Hayashi Y, Goyama S, Liu X, Tamura M, Asada S, Tanaka Y, Fukuyama T, Wunderlich M, O'Brien E, Mizukawa B, Yamazaki S, Matsumoto A, Yamasaki S, Shibata T, Matsuda K, Sashida G, Takizawa H, Kitamura T.
Antitumor immunity augments the therapeutic effects of p53 activation on acute myeloid leukemia.
Nat Commun. 2019 Oct

Abstract on PubMed

Rizk M, Rizq O, Oshima M, Nakajima-Takagi Y, Koide S, Saraya A, Isshiki Y, Chiba T, Yamazaki S, Ma A, Jin J, Iwama A, Mimura N.
Akt inhibition synergizes with polycomb repressive complex 2 inhibition in the treatment of multiple myeloma.
Cancer Sci. 2019 Sep

Abstract on PubMed

Kato Y, Hou LB, Miyagi S, Nitta E, Aoyama K, Shinoda D, Yamazaki S, Kuribayashi W, Isshiki Y, Koide S, Si S, Saraya A, Matsuzaki Y, van Lohuizen M, Iwama A.
Bmi1 restricts the adipogenic differentiation of bone marrow stromal cells to maintain the integrity of the hematopoietic stem cell niche.
Exp Hematol. 2019 Aug

Abstract on PubMed

Ando M, Ando J, Yamazaki S, Ishii M, Sakiyama Y, Harada S, Honda T, Yamaguchi T, Nojima M, Ohshima K, Nakauchi H, Komatsu N.
Long-term eradication of extranodal NK/T cell lymphoma, nasal type, by induced pluripotent stem cell-derived Epstein-Barr virus-specific rejuvenated T cells in vivo.
Haematologica.. 2019 Jul

Abstract on PubMed

Adam C. Wilkinson, Reiko Ishida, Misako Kikuchi, Kazuhiro Sudo, Maiko Morita, Ralph Valentine Crisostomo, Ryo Yamamoto, Kyle M. Loh, Yukio Nakamura, Motoo Watanabe, Hiromitsu Nakauchi, Satoshi Yamazaki
Long term ex vivo hematopoietic stem cell expansion allows nonconditioned transplantation
Nature. 2019 May

Abstract on PubMed

Shiraishi K, Shichino S, Ueha S, Nakajima T, Hashimoto S, Yamazaki S, Matsushima K.
Mesenchymal-Epithelial Interactome Analysis Reveals Essential Factors Required for Fibroblast-Free Alveolosphere Formation.
iScience. 2019 Jan

Abstract on PubMed

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