HOME (English Page)　>　Team Nakagwa Member & Research Highlight

Curriculum Vitae

Name: HIDEWAKI NAKAGAWA, M.D., Ph.D.

Birth: 1996 at Osaka, Japan

Citizenship & Sex: Japanese, male

Address:
Laboratory of Molecular Medicine (Prof. Nakamura’s lab.),
Human GenomeCenter,
Institute of Medical Science, The University of Tokyo
4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, JAPAN
Phone: +81-3-5449-5375
FAX: +81-3-5449-5124
E-mail: hidewaki@ims.u-tokyo.ac.jp

• American Association for Cancer Research,Active member
• The Japanese Cancer Association
• The Japan Surgical Society
• The Japanese Society of Gastroenterological Surgery

• Astellas Foundation Fellowship for Research on Metabolic Disorders, 1999
• Medical Research Fellowship from Sumitomo Insurance, 1999
• Research Fellowship from Japan Society for the Promotion of Science, 2001-2002
• The Scholar-in-Training Award for the 2002 American Association of Cancer Research, 2002, April
• The Research Promoting Award for The Japanese Cancer Association Annual Meeting, 2006, September.

• Molecular genetics & biology of prostate cancer, and molecular target for hormone-refractory prostate cancer
• Medical Research Fellowship from Sumitomo Insurance, 1999
• Prostate cancer risk and prevention
• Molecular genetics & biology of pancreatic cancer, and molecular target for pancreatic cancer
• Hereditary colorectal cancer and gene diagnosis

Research Highlight:
Based on the genome-wide gene expression profiles of prostate cancer cells, especially hormone-refractory prostate cancer, we have identified dozens of molecular target for prostate cancer treatment and diagnosis, and are now investigating for their functional analysis on basic research level. Furthermore, collaborating with our venture company, Oncotherapy Science, Inc. (http://www.oncotherapy.co.jp), we are developing innovative anti-cancer medicines, such as antibodies, small molecular compounds, dominant-negative peptides, siRNAs and peptide vaccines, with higher efficacy and a minimum risk of adverse events based on the comprehensive research on cancer genomics and biomedical analysis.

Publications:　（As of Apr,2007）

1. Tamura K, Furihata M, Tsunoda T, Ashida A, Takata R, Obara W, Yoshioka H, Daigo Y, Nasu Y, Kumon H, Konaka H, Namiki M, Tozawa K, Kohri K, Tanji N, Yokoyama M, Shimazui T, Akaza H, Mizutani Y, Miki T, Fujioka T, Shuin T, Nakamura Y, and Nakagawa H. Molecular features of hormone-refractory prostate cancer cells by genome-wide gene-expression profiles. Cancer Res (2007 in press)
   
   
2. Hosokawa M, Takehara A, Matsuda K, Eguchi H, Ohigashi H, Ishikawa O, Shinomura Y, Imai K, Nakamura Y, and Nakagawa H. Oncogenic role of KIAA0101 interacting with PCNA in pancreatic cancer. Cancer Res 67:2568-76 (2007)
   
   
3. Iiizumi M, Hosokawa M, Takehara A, Chung S, Katagiri T, Eguchi E, Ohigashi H, Ishikawa O, Nakamura Y, and Nakagawa H. EphA4 receptor, overexpressed in pancreatic ductal adenocarcinoma, promotes cancer cell growth. Cancer Sci 97: 1211-6 (2006)
   
   
4. Takehara A, Eguchi H, Ohigashi H, Ishikawa O, Kasugai T, Hosokawa M, Katagiri T, Nakamura Y, and Nakagawa H. Novel tumor marker, REG4, detected in serum of patients with resectable pancreatic cancer and feasibility for antibody therapy targeting REG4. Cancer Sci 97: 1191-7 (2006)
   
   
5. Hampel H, Frankel W, Panescu J, Lockman J, Sotamaa K, Fix D, Comeras I, LaJeunesse J, Nakagawa H, Westman JA, Prior TW, Clendenning M, Penzone P, Lombardi J, Dunn P, Cohn D, Copeland L, Eaton L, Fowler J, Lewandowski G, Vaccarello L, Bell J, Reid G, and de la Chapelle A. Screening for Lynch Syndrome (HNPCC) among endometrial cancer patients. Cancer Res 66: 7810-7 (2006)
   
   
6. Yearsely M, Hampel H, Lehman A, Nakagawa H, de la Chapelle A, and Frankel WL. Histological features distinguish microsatellite high from low and stable colorectal carcinomas, but do not differentiate germline mutations from methylation of the MLH1 promoter. Hum Path 37:831-8 (2006)
   
   
7. Ashida S, Furihata M, Katagiri T, Tamura K, Anazawa Y, Yoshioka H, Miki T, Fujioka T, Shuin T, Nakamura Y, and Nakagawa H. Expression of novel molecules, MICAL2-PVs (MICAL2 prostate cancer variants), increases with high Gleason score and prostate cancer progression. Clin Cancer Res 12: 2767-73 (2006)
   
   
8. Nuovo GJ, Nakagawa H, Sotamaa K, and de la Chapelle A. Hypermethylation of the MLH1 promoter with concomitant absence of transcript and protein occurs in small patches of crypt cell in unaffected mucosa from sporadic MSI colorectal carcinoma. Diagn Mol Pathol 15: 17-23 (2006)
   
   
9. Hampel H, Frankel WL, Martin E, Arnold M, Khanduja K, Kuebler P, Nakagawa H, Sotamaa K, Prior T, Westman J, Panescu J, Fix D, Lockman J, Comeras I, and de la Chapelle A. Population-wide screening for Lynch syndrome (hereditary non-polyposis colorectal cancer). N Engl J Med 352:1851-60 (2005)
   
   
10. Anazawa Y, Nakagawa H, Furihata M, Ashida S, Tamura K, Yoshioka H, Shuin T, Fujioka T, Katagiri T, and Nakamura Y. PCOTH, a novel gene over-expressed in prostate cancers, promotes prostate cancer cell growth through phosphorylation of oncoprotein TAF-Ib/SET. Cancer Res 65: 4578-86 (2005)
    
    
11. Taniuchi K, Nakagawa H, Hosokawa M, Nakamura T, Eguchi H, Ohigashi H, Ishikawa O, Katagiri T, and Nakamura Y. P-cadherin/CDH3 over-expressed in pancreatic cancer promotes cancer cell motility via p120ctn / Rho family GTPases. Cancer Res 65:3092-9 (2005)
    
    
12. Taniuchi K, Nakagawa H, Nakamura T, Eguchi H, Ohigashi H, Ishikawa O, Katagiri T, and Nakamura Y. Down-regulation of RAB6KIFL/KIF20A, a kinesin involved with membrane trafficking of disc large homolog 5, can attenuate growth of pancreatic cancer cells. Cancer Res 65: 105-12 (2005)
    
    
13. Takahashi Y, Kondo K, Hirose T, Nakagawa H, Tsuyuguchi M, Hashimoto M, Sano T, Ochiai A, and Monden Y. Microsatellite instability and protein expression of the DNA mismatch repair gene, hMLH1, of lung cancer in chromate-exposed workers. Mol Carcinog 42: 150-8 (2005)
    
    
14. Anazawa Y, Arakawa H, Nakagawa H, and Nakamura Y. Identification of STAG1 as a key mediator of a p53-dependent apoptotic pathway. Oncogene 23:7621-7 (2004)
    
    
15. Ashida S, Nakagawa H, Katagiri T, Furihata M, Iiizumi M, Anazawa Y, Tsunoda T, Takata R, Kasahara K, Miki T, Fujioka T, Shuin T, and Nakamura Y. Molecular features in the transition from prostatic intraepithelial neoplasia (PIN) to prostate cancer: genome-wide expression profiles in prostate cancers and PINs. Cancer Res　64: 5963-72 (2004)
    
    
16. Nakagawa H, Liyanarachchi S, Davuluri RV, Auer H, Martin EW Jr, de la Chapelle A, and Frankel WL. The role of cancer-associated stromal fibroblasts in metastatic colon cancer to the liver and their expression profiles. Oncogene 23:7366-77 (2004)
    
    
17. Nakagawa H, Lockman JC, Frankel WL, Hampel H, Steenblock K, Burgart LJ, Thibodeau SN, and de la Chapelle A. Mismatch repair gene PMS2: Disease-causing germline mutations occur in patients whose tumors stain negative for PMS2 at immunohistochemistry but paralogous genes obscure mutation detection. Cancer Res 64: 4721-7 (2004)
    
    
18. Nakamura　T, Furukawa Y, Nakagawa H, Tsunoda T, Ohigashi H, Murata M, Ishikawa O, Ohigaki K, Kashimura N, Miyamoto M, Hirano S, Kondo S, Katoh H, Nakamura Y, and Katagiri T. Genome-wide cDNA microarray analysis of gene-expression profiles in pancreatic cancers using populations of tumor cells and normal ductal epithelial cells selected for purity by laser microdissection. Oncogene 23, 2385-400 (2004)
    
    
19. Nakagawa H, Hampel H, and de la Chapelle A. Identification and characterization of genomic rearrangements of MSH2 and MLH1 in Lynch syndrome (HNPCC) by novel techniques. Hum Mut 22: 258 (2003)
    
    
20. Morimoto O, Nagano H, Sakon M, Fujiwara Y, Yamada T, Nakagawa H, Miyamoto A, Kondo M, Arai I, Yamamoto T, Ota H, Dono K, Umeshita K, Nakamori S, Sasaki Y, Ishikawa O, Imaoka S, and Monden M. Diagnosis of intrahepatic metastasis and multicentric carcinogenesis by microsatellite loss of heterozygosity in patients with multiple and recurrent hepatocellular carcinomas. J Hepatol 39: 215-21 (2003)
    
    
21. Pyatt R, Nakagawa H, Hampel H, Sedra M, Fulchik MB, Comeras I, de la Chapelle A, and Proir TW. Identification of a deletion in the mismatch repair gene MSH2 using mouse-human cell hybrids monosomal for chromosome 2. Clin Genet 63: 215-8 (2003)
    
    
22. Wagner A, Barrows A, Wijnen J, van der Klift H, Franken P, Verkuijlen P, Nakagawa H, Geugien M, Jaghmohan-Changur S, Breukel C, Meijers-Heijboer H, Morreau H, de Leeuw W, Burn J, Coronel S, Kinarski Y, Lynch J, de la Chapelle A, Lynch H, and Fodde R. Molecular analysis of Hereditary Non-Polyposis Colorectal Cancer (HNPCC) in the USA: high mutation detection rate at the major mismatch repair genes among clinically selected families and characterization of a founder genomic deletion of the MSH2 gene. Am J Hum Genet 72: 1088-100 (2003)
    
    
23. Yamanaka H, Hashimoto H, Koyama K. Nakagawa H, Nakamura Y, and Noguchi K. Expression of Apc2 during mouse development. Gene Expr Patterns 1: 107-114 (2002)
    
    
24. Nakamura T, Suzuki S, Yokoi Y, Kashiwabara H, Maruyama K, Baba S, Nakagawa H, and Nakamura S. Duodenal cancer in a patient with Peutz-Jeghers syndrome: molecular analysis. J Gastroenterol 37: 376-80 (2002)
    
    
25. Nakagawa H, Yan H, Lockman J, Hampel H, Kinzler KW, Vogelstein B, and de la Chapelle A. Allele separation facilitates interpretation of potential splicing alterations and detection of genomic rearrangements. Cancer Res 62: 4579-82 (2002)
    
    
26. Nakagawa H, Nuovo GJ, Zervos EE, Martin EW Jr., Salovaara R, Aaltonen LA, and de la Chapelle A. Age-related hypermethylation of the 5’ region of MLH1 in normal colonic mucosa is associated with microsatellite-unstable colorectal cancer development. Cancer Res 61: 6991-5 (2001)
    
    
27. Nakagawa H, Chadwick RB, Peltomäki P, Plass C, Nakamura Y, and de la Chapelle A. Loss of imprinting of IGF2 occurs by biallelic methylation in a core region of H19 associated CTCF-binding sites in colorectal cancer. Proc Natl Acad Sci USA 98: 591-596 (2001)
    
    
28. Nishioka K, Doki Y, Shiozaki H, Yamamoto H, Tamura S, Yasuda T, Fujiwara Y, Yano M, Miyata H, Kishi K, Nakagawa H, Shamma A, and Monden M. Clinical significance of CDC25A and CDC25B expression in squamous cell carcinomas of the oesophagus. Br J Cancer 85: 412-21 (2001)
    
    
29. Tono T, Ohzato H, Fukunaga M, Hasuike Y, Nakagawa H, Monden T, Okamura J, Kikkawa N, and Takatsuka Y. Surgical treatment of hepatic caudate lobe metastases originating from colorectal primaries. Int Surg 85: 237-42 (2000)
    
    
30. Oyama T, Miyoshi Y, Koyama K, Nakagawa H, Yamori T, Ito T, Matsuda H, Arakawa H, and Nakamura Y. Isolation of a novel gene on 8p21.3-22 whose expression is reduced significantly in human colorectal cancers with liver metastasis. Genes, Chromosome & Cancer 29: 9-15 (2000)
    
    
31. Nakagawa H, Koyama K, Murata Y, Monden M, Akiyama T, and Nakamura Y. EB3, a novel member of the EB1 family preferentially expressed in the central nervous system, binds to a CNS-specific APC homologue. Oncogene 19: 210-6 (2000)
    
    
32. Nakagawa H, Koyama K, Murata Y, Monden M, Akiyama T, and Nakamura Y. APCL, a central nervous system-specific homologue of adenomatous polyposis coli tumor suppressor, binds to p53-binding protein 2 and translocates it to the perinucleus. Cancer Res 60: 101-5 (2000)
    
    
33. Nakagawa H, Koyama K, Monden M, and Nakamura Y. Analysis of APCL, a brain-specific adenomatous polyposis coli homologue, for mutations and expression in brain tumors. J Jpn Cancer Res 90: 982-986 (1999)
    
    
34. Nakagawa H, Koyama K, Nakamori S, Kameyama M, Imaoka S, Monden M, and Nakamura Y. Frameshift mutation of the STK11 gene in a sporadic gastrointestinal cancer with microsatellite instability. J Jpn Cancer Res 90: 633-637 (1999)
    
    
35. Nakagawa H, Murata Y, Koyama K, Fujiyama A, Miyoshi Y, Monden M, Akiyama T, and Nakamura Y. Identification of a brain-specific APC homologue, APCL, and its interaction with b-catenin. Cancer Res 58: 5176-81 (1998)
    
    
36. Nakagawa H, Koyama K, Miyoshi Y, Ando H, Baba S, Yasutomi M, Matsuura N, Monden M, and Nakamura Y. Nine novel germline mutations of STK11 in ten families with Peutz-Jeghers syndrome. Hum Genet 103: 168-172 (1998)
    
    
37. Nakagawa H, Koyama K, Tanaka T, Miyoshi Y, Ando H, Baba S, Yasutomi M, Monden M, and Nakamura Y. Localization of the gene responsible for Peutz-Jeghers syndrome within a 6-cM region of chromosome 19p13.3. Hum Genet 102: 203-206 (1998)
    
    

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Last update: 2007.4.9

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