1. Watanabe, S., Mui, A.-F., Muto, A., Hayashida, K., Yokota, T., Miyajima, A., and Arai, K. (1993) Reconstituted human granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor transduces growth promoting signals in mouse NIH3T3 cells: Comparison with signalling in BA/F3 proB cells. Mol. Cell. Biol. 13, 1440-1448

2. Watanabe, S., Muto, A., Yokota, T., Miyajima, A. and Arai, K. (1993) Differential regulation of early response genes and cell proliferation through human Granulocyte Macrophage Colony-Stimulating Factor recepter: Selective activation of c-fos promoter by Genistein. Mol. Biol. Cell. 4, 983-992

3. Kondo, M., Takeshita, T. Ihii, N., Nakamura, M., Watanabe, S., Arai, K. and Sugamura, K. (1993) Sharing of the Interleukin-2 (IL-2) Receptor g chain between Receptors for IL-2 and IL-4. Science 262, 1874-1877

4. Watanabe, S., Harada, Y., Yssel, H. and Arai, K. (1994) Effects of prostaglandin E2 on Th0-type human T cell clones: modulation of functions of nuclear proteins involved in cytokine production. Int. Immunol. 6, 523-532

5. Chen, J.-X., Watanabe, S., Arai, K. (1994) Activation of early response genes and cell proliferation by human interleukin-3, GM-CSF, and IL-5 receptors: Comparison with human interleukin-4 receptor signaling. J Allergy Clin. Immunol. 94, 605-611

6. Watanabe, S., Ito, Y., Miyajima, A., Arai, K. (1995) Granulocyte macrophage colony stimulating factor dependent replication of Polyoma virus replicon in hematopoietic cells: Analyses of receptor signals for replication and transcription. J. Biol. Chem. 270, 9615-9621

7. Muto, A., Watanabe, S., Itoh, T., Miyajima, A., Arai, K. (1995) Roles of the cytoplasmic domain of the a subunits of human granulocyte-macrophage colony stimulating factor. J. Allergy Clin. Immunol. 96, 1110-1114

8. Kurata, H., Harada, Y., Watanabe, S., Kanegae, Y., Saito, I., Hirabayashi, Y., Inoue, T. and Arai, K. (1995) Adenovirus-mediated gene transfer: Application to the hematopoietic system. Leukemia

9. Muto, A., Watanabe, S., Miyajima, A., Yokota, T., Arai, K. (1995) High affinity chimeric human granulocyte-macrophage colony-stimulating factor recetor carrying the cytoplasmic domain of the b subunit but not the a subunit transduces growth promoting signals in BA/F3 cells. Biochem. Biophys. Res. Commun. 208, 368-375

10. Watanabe, S., Kondo, M., Takatu, K., Sugamura, K., Arai, K. (1995) Involvement of the IL-2R g subunit in IL-4-dependent activation of mouse hematopoietic cells and splenic B cells. Eur. J. Immunol. 25, 126-131

11. Watanabe, S., Ihida, S., Koike, K., Arai, K. (1995) Characterization of cis-regulatory elements of the c-myc promoter respoding to hman GM-CSF or mouse IL-3 in mouse proB cell line BA/F3 cells expressing the human GM-CSF receptor. Mol. Biol. Cell 6, 627-636

12. Muto, A., Watanabe, S., Miyajima, A., Yokota, T., Arai, K. (1996) The b subunit of human GM-CSF receptor forms a homodimer and is activated via association with the a subunit. J. Exp. Med. 183, 1911-1916

13. Itoh, T., Muto, A., Watanabe, S., Arai, K. (1996) Granulocyte-macrophage colony-stimulating factor provekes RS activation and transcription of c-fos through different modes of signaling. J. Biol. Chem. 271, 7587-7592

14. Watanabe, S., Itoh, T., Arai, K. (1996) Roles of JAK kinases in human GM-CSF receptor signal transduction. J. Allergy Clin. Immunol., S183-191

15. Watanabe, S., Itoh, T., Arai, K. (1996) JAK2 is essential for activation of c-fos and c-myc promoters and cell proliferation through the human granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor in BA/F3 cells. J. Biol. Chem. 271, 12681-12686

16. Harada, Y., Watanabe, S., Yssel, H., Arai, K. (1996) Factors affecting the cytokine production of human T cells stimulated via different modes of activation. J. Allergy Clin. Immunol. 98, S161-173

17. Yasuda, Y., Nishijima, I., Watanabe, S., Arai, K., Zlotonik, A., Moore, T. A. (1997) Intrathymic T cell development in human granulocyte-macrophage colony stimulating factor (hGM-CSF) receptor transgenic mice is inhibited by hGM-CSF. Blood 89, 1349-1356

18. Watanabe, S., Kubota, H., Sakamoto, K., Arai, K., (1997) Characterization of cis-acting sequences and trans-acting signals regulating early growth response 1 (egr-1) and c-fos promoters through the granulocyte-macrohpage colony-stimulating factor receptor in BA/F3 cells. Blood 89, 1197-1206

19. Nishijima, I., Nakahata, T., Watanabe, S., Tsuji, K., Tanaka, I., Hirabayashi, Y, Inoue, T., Arai, K. (1997) Hemopoietic and lymphopoietic responses in human GM-CSF receptor transgenic mice injected with human GM-CSF. Blood 90, 1031-1038

20. Liu, R., Itoh, T., Arai, K., Watanabe, S., (1997) Activation of c-Jun N-termial kinase (JNK) by human granulocyte macrophage-colony stimulating factor (hGM-CSF) in BA/F3 cells. Biochem. Biophys. Res. Comm. 234, 611-615

21. Nishijima, I., Watanabe, S., Nakahata, T., Arai, K. (1997) Human granulocyte-macrophage colony stimulating factor (hGM-CSF) dependent in vitro and in vivo proliferation and differentiation of all hematopoietic progenitor cells in hGM-CSF receptor transgenic mice. J. Allergy Clin. Immunol. 100, 79-86

22. Yasuda, Y, Nishijima, I., Watanabe, S., Arai, K. (1997) Thymocyte proliferation and differentiation in human granulocyte-macrophage colony-stimulating factor receptor transgenic mice. J. Allergy Clin. Immunol. 100, 87-96

23. Itoh, T., Liu, R., Yokota, T., Arai, K., Watanabe, S. (1998) Definition of the role of tyrosine residues of the common b subunit regulating multiple signaling pathways of GM-CSF receptor. Mol. Cell. Biol. 18, 742-752

24. Yamashita, Y., Watanabe, S., Miyazato, A., Ohya, K., Ikeda, U., Shimada, K., Komatsu, N., Hatake, K., Miura, Y., Ozawa, K., Mano, H. (1998) Tec and Jak2 kinases cooperate to mediate cytokine-driven activation of c-fos transcription. Blood 91, 1496-1507

25. Sato, T, Watanabe, S., Ishii, E., Tsuji, K., Nakahata, T. (1998) Induction of erythropoietin receptor gene and acquisition of responsiveness to erythropoietin in the presence of stem cell factor in a human leukemic cell line HML/SE. J. Biol. Chem. 273, 16921-16926

26. Yang, F-C., Watanabe, S., Tsuji, K., Xu, M.-J., Kaneko, A., Ebihara, Y., Nakahata, T. (1998) Human G-CSF stimulates the development of primitive multipotential progenitors of human G-CSF receptor-transgenic mice, but does not affect their commitment I vitro and in vivo. Blood 92, 4632-4640

27. Mohi, G., Arai, K., Watanabe, S. (1998) Activation and functional analysis of Jak2 in BA/F3 cells using the coumermycin/GyrB system. Mol. Biol. Cell. 9, 3299-3308

28. Mukasa, R., Homma, T., Ohtsuki, T., Hosono, O., Souta, A., Kitamura, T., Fukuda, M., Watanabe, S., Morimoto, C., (1999) Core 2-containing O-glycans on CD43 are preferentially expressed in the memory subset of human CD4 T cells. Int. Immunol. 11, 259-268

29. Liu, C.-B., Itoh, T., Arai, K., Watanabe, S. (1999) Constitutive activation of JAK2 confers mIL-3-independent survival and proliferation of BA/F3 cells. J. Biol. Chem. 274, 6342-6349

30. Itoh, T., Liu, R., Arai, K., Watanabe, S. (1999) Differential influence of tyrosine residues of the common receptor b subunit on multiple signals induced by human GM-CSF. J. Allergy Cliin. Immunol. 103, 462-470

31. Yang, C.-F., Tsuji, K., Oda, A., Ebihara, Y., Xu, M.-J., Kaneko, A., Hanada, S., Mitsui, T., Kikuchi, A.., Manabe, A., Watanabe, S., Ikeda, Y., Nakahata, T., (1999) Differential effects of human granulocyte colony-stimulating factor (hG-CSF) and thrombopoietin on megakaryopoiesis and platelet function in hG-CSF receptor-transgenic mice. Blood 94, 950-958

32. Liu, R., Itoh, T., Arai, K., Watanabe, S. (1999) JAK2 mediates anti-apoptotic activity of GM-CSF through multiple signaling pathways with different sensitivities to kinase inhibitors. Mol. Biol. Cell. 10, 3959-3970