*** 2020 *** *** *** *** *** *** *** *** *** ***

Umutoni, D., Iwagawa, T., Baba, Y., Tsuhako, A., Honda, H., Aihara, M, Watanabe, S. (2020) H3K27me3 demethylase UTX regulates the differentiation of a subset of bipolar cells in the mouse retina. Genes to Cells, in press

Mizobuchi, K., Hayashi, T., Katagiri, S., Kim, E., Furukawa, T. , Ishiba, Y., Watanabe, S., Nakano, T. (2020) Improvement of reduced electroretinographic responses in thymoma-associated retinopathy: a case report and literature review. Doc Ophthalmol

Deng, X., Iwagawa, T., Fukushima, M., Watanabe, S. (2020) Characterization of human induced pluripotent stem cells carrying homozygous RB1 gene deletion, Gene to Cells, in press

Chumsakul, O., Wakayama, K. Tsuhako, , A,, Baba, Y., Takai, Y. Kurose, T., Honma, Y., Watanabe, S. (2020) Apigenin regulates activation of microglia and counteracts retinal degeneration, J Ocul Pharmacol Ther, in press

Iwagawa, T., Aihara, Y., Umutoni, D. Baba, Y., Murakami, A. Miyado, K., Watanabe, S. (2020) Cd9 protects photoreceptors from injury and potentiates Edn2 expression, Invest. Ophthalmol. Vis. Sci. in press

*** 2019 *** *** *** *** *** *** *** *** *** ***

Terao, R., Honjo, M., Ueta, T., Obinata, H., Izumi, T., Kurano, M., Yatomi, Y., Koso, H., Watanabe, S., Aihara, M. (2019) Light stress-induced increase of Sphingosine 1-Phosphate in photoreceptors and its relevance to retinal degeneration. Int J Mol Sci., 20 E3670

Poh, B., Koso, H., Momota, H., Komori, T., Yoshida, N., Ino, Y., Todo, T, Watanabe, S. (2019) Foxr2 promotes formation of CNS-embryonal tumor in a Trp53-deficient background, Neuro-Oncology, 21, 993-1004

Baba, Y., Watabe, Y., Sagara, H., Watanabe, S. (2019) Sall1 plays pivotal roles for lens fiber cell differentiation in mouse. Biochem Biophys Res Commun, 512, 927-933

Iwagawa, T., Watanabe, S. (2019) Molecular mechanisms of H3K27me3 and H3K4me3 in retinal development (Review), Neuroscience Research,1 138, 43-48

*** 2018 *** *** *** *** *** *** *** *** *** ***

Koso, H., Tsuhako, A., Matsubara, D., Fujita, Y., Watanabe, S. (2018) Ras activation in retinal progenitor cells induces tumor formation in the eye, Exp Eye Res,180, 39-42

Kawamura, Y., Yamanaka, K., Poh, B., Kuribayashi, K., Koso, H., Watanabe, S. (2018) The role of Zhx2 transcription factor in bipolar cell differentiation during mouse retinal development, Biochem Biophys Res Commun 503, 3023-3030

Kuribayashi, H., Baba, Y., Iwagawa, T,. Arai, E., Murakami, A., Watanabe, S. (2018) Roles of Nmnat1 in the survival of retinal progenitors through the regulation of pro-apoptotic gene expression via histone acetylation, Cell Death and Diseases, 9, 891

Koso, H., Nishinakamura, R., Watanabe, S. (2018) Sall1 regulates microglial morphology cell autonomously in the developing retina, Advances in Experimental Medicine and Biol (Retinal Degenerative Diseases), 1047, 209-215

Iguchi, T., Miyauchi, E., Watanabe, S., Masai, H., Miyatake, S. (2018) A BTB-ZF protein, ANF131, is required for early B cell development. Biochem Biophys Res Commun, 501, 570-575

Iwagawa, T., Watanabe, S., Molecular mechanisms of H3K27me3 and H3K4me3 in retinal development (Review), Neuroscience Researchin press

Kawamura, Y., Yamanaka, K., Boonmin Poh, Kuribayashi, H., Koso, H., Sumiko Watanabe, S., The role of Zhx2 transcription factor in bipolar cell differentiation during mouse retinal development, Biochem Biophys Res Commun. in press

Kuribayashi, H, Baba, Y, Iwagawa, T, Arai, E, Murakami, A, Watanabe, S, Roles of Nmnat1 in the survival of retinal progenitors through the regulation of pro-apoptotic gene expression via histone acetylation, Cell Death and Diseases, in press

Koso, H., Nishinakamura, R., Watanabe, S. Sall1 regulates microglial morphology cell autonomously in the developing retina, Advances in Experimental Medicine and Biol (Retinal Degenerative Diseases), 1047, 209-215

Iguchi, T., Miyauchi, E., Watanabe, S., Masai, H., Miyatake, S. A BTB-ZF protein, ANF131, is required for early B cell development. Biochem Biophys Res Commun, in press

Suzuki-Kerr, H., Iwagawa, T., Sagara, H., MIzota, A., Suzuki, Y., Watanabe, S., Pivotal roles of Fezf2 in differentiation of cone OFF bipolar cells and functional maturation of cone ON bipolar cells in retina, Exp Eye Res, 171, 142-154

Sumiyoshi, K., Koso, H., Watanabe, S. Spontaneous development of intratumoral heterogeneity in a transposon-induced mouse model of glioma. Cancer Sci., 109, 1513-1523

*** 2017 *** *** *** *** *** *** *** *** *** ***

Shindou, H., Koso, H., Sasaki, J., Nakanishi, H., Sagara, H., Nakagawa, K. M., Takahashi, Y., Hishikawa, D. Iizuka-Hishikawa, Y., Tokumatsu, F., Noguchi, H., Watanabe, S., Sasaki T., Shimizu, T. Docosahexaenoic acid preserves visual function by maintaining correct disc morphology in retinal photoreceptor cells. J. Biol. Chem. 292, 12054-12064

Ueno, K., Iwagawa, T., Ochiai, G., Koso, H., Nakauchi, H., Nagasaki, M., Suzuki, Y., Watanabe, S. Analysis of Muller glia specific genes and their histone modifications using Hes1-promoter driven EGFP expressing mouse. Sci Rep, 7, 3578

Suzuki-Kerr, H., Baba, Y., Tsuhako, A., Koso, H., Dekker, J. D., Tucker, H. O., Kuribayashi, H., Watanabe, S. Forkhead box protein P1 is dispensable for retina but essential for lens development. Invest. Ophthalmol. Vis. Sci. 158, 1916-1929

*** 2016 *** *** *** *** *** *** *** *** *** ***

Kuribayashi, H., Tsuhako, A., Kikuchi, M., Yoshida, N., Koso, H., Watanabe, S. Role of transcription factor Tgif2 in photoreceptor differentiation in the mouse retina. Exp. Eye Res. 152, 34-42

Koso, H., Tsuhako A., Lai, C. Y., Baba, Y., Otsu, M., Ueno, K., Nagasaki, M., Suzuki, Y., Watanabe, S., Conditional rod photoreceptor ablation reveals SAll1 as a microglial marker and regulator of microglial maturation, Glia, 64, 2005-2024

Ueno, K., Iwagawa, T., Kuribayashi, H., Baba, Y., Nakauchi, H, Murakami, A., Nagasaki, M., Suzuki, Y., Watanabe, S., Transition of differentiatial histone H3 methylation in photoreceptors and other retinal cells during retinal differentiation, Sci Rep, 6, 29264

Fujii, T Tsunesumi, S., Sagara, H., Munakata, M. Hisaki, Y., Sekiya, T., Furukawa, Y., Sakamoto, K, Watanabe, S. Smyd5 plays pivotal roles in both primitive and definitive hematopoiesis during zebrafish embryogenesis, Sci Rep,6, 29157

Watanabe, S., Murakami A., Regulation of retinal development via the epigenetic modification of histone H3. Adv Exp Med Biol. 2016;854:635-41. doi: 10.1007/978-3-319-17121-0_84.

Koso, H., Yi, H., Scheridan, P., Miyano, S., Miyano, S., Ino, Y., Todo, T., Watanabe, S. Identification of RNA-binding protein LARP4B as a tumor suppressor in glioma. Can Res, 76, 2254-2264

*** 2015 *** *** *** *** *** *** *** ***

Iida, A., Iwagawa, T., Baba, Y., Satoh, S., Mochizuki, Y., Nakauchi, H. Furukawa, T., Koseki, H., Murakami, A., Watanabe, S. Roles Histone H3K27 tri-methylase Ezh2 in retinal proliferation and differentiation, Developmental Neurobiology, 111, 3751-3756

Arai, E., Baba, Y., Iwagawa, T., Kuribayashi, H., Mochizuki, Y., Watanabe, S. Ablation of Kcnj10 expression in retinal explants revealed pivotal roles for Kcnj10 in the proliferation and development of Muller glia. Mol Vis, 21, 148-159

Umebayashi M., Sumita, Y., Kawai, Y, Watanabe, S., Asahina, I. Gene activated-matrix comprised of atelocollagen and plasmid DNA encoding Bmp4 or Runx2 promotes rat cranial bone augmentation. Bio Research Open Access, 4, 64-74

Baba, Y., Aihara, Y., Watanabe, S., MicroRNA-7a regulates Muller glia differentiation by attenuating Notch3 expression, Exp Eye Res, 138:59-65

Kohno, H, Koso, H, Okano, K, Sundermeier, TR, Saito, S., Watanabe, S., Hiroshi Tsuneoka, H., Sakai, T. Expression pattern of Ccr2 and Cx3cr1 in inherited retinal, Journal of Neuroinflammation, in press

*** 2014 *** *** *** *** *** *** *** *** *** ***

Mochizuki, Y., Iida, A., Lyons, E., Kageyama, R., Nakauchi, H., Murakami, A., Watanabe, S. Use of cell type-specific transcriptome to identify genes specifically involved in Müller glia differentiation during retinal development, Dev Neurobiol, 74, 426-437

Koso, H., Tsuhako, A., Lyons, E., Ward, J.M, Rust, A.G., Adams, D.J., Jenkins, N.A., Copeland, N.G., Watanabe, S., Transposon mutagenesis identifies Foxr2 as a putative oncogene in medulloblastoma, Can Res 74, 2351-2361

Iida, A., Iwagawa, T., Kuribayashi, H., Satoh, S., Mochizuki, Y., Baba, Y., Nakauchi, H., Furukawa, T., Koseki, H., Murakami, A., Watanabe, S. Jmjd3 is required for the development of subsets of retinal bipolar cells, Proc.Natl.Acad.Sci.,USA 111, 3751-3756

Kuribayashi, H., Baba, Y., Watanabe, S. BMP signaling participates in late phase differentiation of the retina, party via upregulation of Hey2, Developmental Neurobiology in press

Iida1, A., Tabata, Y., Baba, Y., Fujii, T., and Watanabe,S. Critical Roles of DNase1l3l in Lens Nuclear Degeneration in Zebrafish, Biochimie in press

Abdul Razak, S. A., Baba, Y., Nakauchi, H., Otsu, M., Watanabe, S. (2014) DNA methylation is involved in the expression of miR-142-3p in fibroblasts and induced pluripotent stem cells, Stem Cells International, 101349

*** 2013 *** *** *** *** *** *** *** *** *** ***

Usui, A., Mochizuki, Y., Iida, A., Miyauchi, E., Satoh, S, Sock, E., Nakauchi, H., Aburatani, H., Murakami, A., Wegner, M., Watanabe, S. (2013) The early retinal progenitor-expressed gene Sox11 regulates the timing of the differentiation of retinal cells. Development, 140, 740-750

Usui, A., Iwagata, T., Mochizuki, Y., Iida, A., Wegner, M., Murakami, A., Watanabe, S. (2013) Expression of Sox4 and Sox11 is regulated by multiple mechanisms during retinal development. FEBS Letters, 587, 358-363

Okada, H., Ishibashi, H., Hayashita-Kinoh, H., Chiyo, T., Nitahara-Kasahara, Y., Baba, Y., Watanabe, S., Takeda, S., and Okada, T. (2013) Robust long-term transduction of common marmoset neuromuscular tissue with rAAV1 and rAAV9. Molecular Therapy - Nucleic Acids, 2, e95

Iwagawa, T, Tanaka, Y, Iida, A., Itoh, T., Watanabe, S. (2013) Enhancer/promoter activities of the long/middle wavelength-sensitive opsins of vertebrates mediated by thyroid hormone receptor β2 and COUP-TFII, Plos One, 8, e72065

Siti Razila Abdul Razak, Ueno, K., Takayama, T, Nariai, N, Nagasaki, M, Saito, R., Koso, H., Lai, C.-Y., Murakami, M, Tsuji, K., Michiue, T., Nakauchi, H, Otsu, M, Watanabe, S. (2013) Profiling of MicroRNA in Human and Mouse ES and iPS Cells Reveals Overlapping but Distinct MicroRNA Expression Patterns. Plos One, 8(9), e73532

*** 2012 *** *** *** *** *** *** *** *** *** ***

Iwagawa, T., Ohuchi, S., Watanabe, S., Nakamura, Y. (2012) Selection of RNA aptamers against mouse embryonic stem cells. Biochimie, 94, 250-257

Iguchi-Ishiguro, H., Ouchi, Y., Watanabe, S., Numabe, Y. (2012) Analysis of syndecan-1 gene promoter during mouse tooth development. Archives of Oral Biology, 57, 531-538

Saito, R., Nakauchi, H., Watanabe, S. (2012) Serine/Threonine kinase Melk regulates proliferation and glial differentiation of retinal progenitor cells. Can. Sci., 103, 42-49

Baba, Y., Satoh, S., Otsu, M., Sasaki, E., Okada, T., and Watanabe, S. (2012) In vitro cell subtype-specific transduction of adeno-associated virus in the mouse and marmoset retinal explant culture, Biochimie,94, 2716-2722 P>

Koso H, Takeda H, Yew C, Ward JM, Nariai N, Ueno K, Nagasaki M, Watanabe S, Rust AG, Adams DJ, Copeland NG, Jenkins NA (2012) Transposon mutagenesis identifies genes that transform neural stem cells intoglioma-initiating cells, Proc.Natl.Acad.Sci.,USA, 10-, 2998-3007

*** 2011 *** *** *** *** *** *** *** *** *** ***

Iida, A., Shinoe, T., Baba, Y., Mano, H., Watanabe, S.(2011) Dicer plays essential roles for retinal development by regulation of survival and differentiation.Invest. Ophthalmol. Vis. Sci, 52, 3008-3017

Ouchi, Y., Baba, Y., KOso, H., Taketo, M.M., Iwamonoto, T., Aburatani, H., Watanabe, S. (2011) BEta catenin signaling regulates the timing of cell differentiation in mouse retinal progenitor cells. Mol. Cell. Neurosci. 46, 770-780

Baba, Y, Iida, A., Watanabe, S. (2011) Sall3 plays essential roles in horizontal cell maturation through regulation of neurofilament expression levels. Biochimie, 93, 1037-1046

Fujii, T., Tsunesumi, S., Yamaguchi, K., Watanabe, S., Furukawa, Y. (2011) Smyd3 is required for the development of cardiac and skeletal muscle in zebrafish. Plos ONE, 6, e23491

Saito, R., Nakauchi, H., Watanabe, S. (2011) Serine/Threonine kinase Melk regulates proliferation and glial differentiation of retinal progenitor cells. Can. Sci., in press (Sep 16)

Watabe, Y., Baba, Y., Nakauchi, H., Mizota, A., Watanabe, S. (2011) The role of Zic family zinc finger transcription factors in the proliferation and differentiation of retinal progenitor cells. Biochem. Biophys. Res. Commun., 415, 42-47

Nakamura, Y., He, X., Kato, H., Wakitani, S., Kobayashi, T., Watanabe, S., Iida, A., Tahara, H., Warman, M. L., Watanapokasin, R., Postlethwait, J. H. (2011) Sox9 is upstream of microRNA-140 in cartilage. Appl. Biochem. Biotechnol. 166, 64-71

*** 2010 *** *** *** *** *** *** *** *** *** ***

Inoue, M., Iida, A., Satoh, S., Kodama, T., Watanabe, S. (2010) COUP-TFI and -TFII nuclear receptors are expressed in amacrine cells and play roles in regulating the differentiation of retinal progenitor cells., Exp. Eye. Res., 90, 49-56

Shinoe, T., Kuribayashi, H., Saya, H., Seiki, M., Aburatni, H., Watanabe, S. (2010) Identiication of CD44 as a cell surface marker for Mueller glia precursor cells. J. Neurochem, 115, 1633-1642

Mori, K., Akiba, H., Saitoh, M., Watanabe, S. (2010) Induction of differentiation of murine iPS cells into dendritic cells, Juntendo Medical Journal, 56, 260-267

*** 2009 *** *** *** *** *** *** *** *** *** ***

Nakada, C., Iida, A Tabata, Y., Watanabe, S. (2009) The forkhead transcription factor foxe1 regulates chondrogenesis in zebrafish. J. Exp. Zool. B Mol. Dev. Evol. 312, 827-840

Muto, A., Watanabe, S. (2009) Group E Sox genes, Sox8 and Sox9, are regulated by Notch signaling and required for the Mueller glia development in mouse retina. Exp. Eye. Res, 89, 549-558

Koso, H., Minami, C., Tabata, Y., Inoue, M., Sasaki, E., Satoh, S., Watanabe, S. (2009) CD73 is a novel cell surface antigen characterizes retinal photoreceptor precursor cells. Invest. Ophthalmol. Vis. Sci, 50, 5411-5418

Satoh, S.,Tang, K., .....Kodama T., Tsai, S., Tsai, M.-J., Furuta, Y., Watanabe, S. (2009) The spatial patterning of mouse cone opsin expression is regulted by BMP signaling through downstream effector COUP-TF nucelear reeptors. J. Neurosci, 29, 12401-12411

*** 2008 *** *** *** *** *** *** *** *** *** ***

Zhao, J., Iida, A., Ouchi, Y., Satoh, S., Watanabe, S. (2008) M6a regulates neurite extension in the murine neural retina. Exp. Eye. Res. 14, 1623-1630

Koso, H., Taketo, M.M., Watanabe, S. (2008) CD138/syndecan-1 and SSEA-1 mark distinct populations of developing ciliary epithelium that are regulated differentially by Wnt signal. Stem Cells, 26, 3162-3171

Lin, Y., Ouchi, Y., Satoh, S., and Watanabe, S. (2008) The HMG-transcription factor Sox2 is sufficient for the induction of amacrine cells in mouse retina. Inv.Ophtahl.Vis. Sci, 50, 68-74

Satoh, S., Watanabe, S. (2008) TGIF, a homeodomain transcription factor, regulates retinal progenitor cell differentiation. Exp. Eye. Res, 87, 571-579

Koso, H., Satoh, S., Watanabe, S. (2007) c-kit marks late retinal progenitor cells and regulates their differentiation in developing mouse retina. Dev. Biol. 301, 141-154

Muto, A., Aoki, Y., Watanabe, S. (2007) Mouse Rab11-FIP4 regulates proliferation and differentiation of retinal progenitors in a Rab11-independent manner, Dev. Dyn. 236, 214-225

Zho, J., Izumi, T., Nunomura, K., Satoh, S., Watanabe, S. (2007) MARCKS-like protein, a membrane protein identified for its experession in developing neural retina, plays a role in regulating retinal cell proliferation. Biochemical J. 408, 51-59

*** 2006 *** *** *** *** *** *** *** *** *** ***

Koso, H., Ouchi, Y., Tabata, Y., Aoki, Y., Satoh, S., Arai, K., Watanabe, S., (2006) SSEA-1 marks regionally restricted immature subpopulations of embryonic retinal progenitor cells that are regulated by the Wnt signaling pathway. Dev. Biol. 292, 265-276

Muto, A., Arai, K., Watanabe, S., (2006) Rab11-FIP4 is predominantly expressed in neural tissues and involved in proliferation as well as differentiation during zebrafish retinal development. Dev. Biol. 292, 90-201

Niikura, Y., Tabata, Y., Tajima, A., Inoue, I., Arai, K., Watanabe, S. (2006) Zebrafish numb homologue: phylogenetic evolution and involvement in regulation of left-right asymmetry. Mech. Dev. 123, 407-414

Goishi, K., Shimizu, A., Najarro, G., Watanabe, S., Rogers, R., Zon, L. I., Klagsbrun, M. (2006) alphaA-crystallin expression prevents gamma-crystallin insolubility and cataract formation in the zebrafish cloche mutant lens. Development 144, 2585-2593

Nakada, C., Satoh, S., Tabata, Y., Arai, K. and Watanabe, S. (2006) Transcriptional repressor foxl1 regulates CNS development by suppressing shh expression in zebrafish. Mol. Cell. Biol. 26, 7246-7257

*** 2005 *** *** *** *** *** *** *** *** *** ***

Kubota, Y., Oike, Y., Satoh, S., Tabata, Y., Niikura, Y., Morisada, T., Akao, M., Urano, T., Ito, Y., Miyamoto, T., Yasunaga, K., Watanabe, S., Suda, T. (2005) Isolation and expression patterns of three angiopoietin-related proteins in zebrafish. Gene Expr Patterns. 5, 679-85.

Saito, R., Tabata, Y., Muto, A., Arai, K., Watanabe, S. (2005) Melk-like kinase plays a role in haematopoiesis in the zebrafish. Mol. Cell. Biol. 25, 6682-6693

Ouchi, Y., Tabata, Y., Arai, K. Watanabe, S., (2005) Negative regulation of retinal-neurite extension by Wnt-Lef-1 signalling pathway. J. Cell Sci. 118, 4473-4483

Ohtsuka Y, Manabe A, Kawasaki H, Hasegawa D, Zaike Y, Watanabe S, Tanizawa T, Nakahata T, Tsuji K. (2005) RAS-blocking bisphosphonate zoledronic acid inhibits the abnormal proliferation and differentiation of juvenile myelomonocytic leukemia cells in vitro. Blood.106, 3134-3141

Kubota, Y., Oike, Y., Satoh, S., Tabata, Y., Niikura, Y., Morisada, T., Akao, M., Urano, T., Ito, Y., Miyamoto, T., Nagai, N., Watanabe, S., Suda, T., (2005) Cooperative interaction of angiopoietin-like proteins, 1 and 2 on the vascular development of zebrafish. Proc. Natl. Acad. Sci. USA 102, 13502-13507

Kurita, R., Tabata, Y., Sagara, H., Arai, K., Watanabe, S. (2004) A novel smoothelin-like actin-binding proteins required for choroidal fissure in zebrafish. Biochem. Biophys. Res. Comm. 13, 1092-1100

Tabata, Y., Ouchi, Y., Kamiya, H., Manabe, T., Arai, K., Watanabe, S., (2004) Retinal fate specification of mouse embryonic stem cells by ectopic expression of Rx/rax, a homeobox gene. Mol. Cell. Biol. 24, 4513-4521

Muto, H. Tabata, Y., Taneda, T., Aoki, Y., Muto, A., Arai, K., Watanabe, S. (2004) Identification and characterization of Veph, a novel gene encoding a PH domain-containing protein expressed in the developing central nervous system of vertebrates. Biochimie, 86, 523-531

Satoh, S., Arai, K., Watanabe, S. (2004) Identification of a novel splicing form of zebrafish p73 having strong transcriptional activity. Biohem. Biophys. Res. Comm. 325, 835-842