2010

Miyake A, Ishida T, Yamagishi M, Hara T, Umezawa K, Watanabe T, Horie R.
Inhibition of active HIV-1 replication by NF-kappaB inhibitor DHMEQ.
Microbes Infect. 2010 Feb 19. [Epub ahead of print]

Iejima D, Minegishi Y, Takenaka K, Siswanto A, Watanabe M, Huang L, Watanabe T, Tanaka F, Kuroda M, Gotoh N.
FRS2beta, a potential prognostic gene for non-small cell lung cancer, encodes a feedback inhibitor of EGF receptor family members by ERK binding.
Oncogene. 2010 Mar 15. [Epub ahead of print]

Chi HT, Vu HA, Iwasaki R, Nagamura F, Tojo A, Watanabe T, Sato Y.
Detection of exon 12 type A mutation of NPM1 gene in IMS-M2 cell line.
Leuk Res. 2010 Feb;34(2):261-2.

2009

Togano T, Sasaki M, Watanabe M, Nakashima M, Tsuruo T, Umezawa K, Higashihara M, Watanabe T, Horie R.
Induction of oncogene addiction shift to NF-kappaB by camptothecin in solid tumor cells.
Biochem Biophys Res Commun. 2009 Dec 4;390(1):60-4.

Chi HT, Vu HA, Iwasaki R, Thao le B, Hara Y, Taguchi T, Watanabe T, Sato Y.
Green tea (-)-epigalocatechin-3-gallate inhibits KIT activity and causes caspase-dependent cell death in gastrointestinal stromal tumor including imatinib-resistant cells.
Cancer Biol Ther. 2009 Oct;8(20):1934-9.

Yamagishi M, Ishida T, Miyake A, Cooper DA, Kelleher AD, Suzuki K, Watanabe T.
Retroviral delivery of promoter-targeted shRNA induces long-term silencing of HIV-1 transcription.
Microbes Infect. 2009 Apr;11(4):500-8.

Thao le B, Vu HA, Yasuda K, Taniguchi S, Yagasaki F, Taguchi T, Watanabe T, Sato Y.
Cas-L was overexpressed in imatinib-resistant gastrointestinal stromal tumor cells.
Cancer Biol Ther. 2009 Apr;8(8):683-8.

Dabaghmanesh N, Matsubara A, Miyake A, Nakano K, Ishida T, Katano H, Horie R, Umezawa K, Watanabe T.
Transient inhibition of NF-kappaB by DHMEQ induces cell death of primary effusion lymphoma without HHV-8 reactivation.
Cancer Sci. 2009 Apr;100(4):737-46.

Miyazaki K, Inoue S, Yamada K, Watanabe M, Liu Q, Watanabe T, Adachi MT, Tanaka Y, Kitajima S.
Differential usage of alternate promoters of the human stress response gene ATF3 in stress response and cancer cells.
Nucleic Acids Res. 2009 Apr;37(5):1438-51.

Shimizu Y, Takamori A, Utsunomiya A, Kurimura M, Yamano Y, Hishizawa M, Hasegawa A, Kondo F, Kurihara K, Harashima N, Watanabe T, Okamura J, Masuda T, Kannagi M.
Impaired Tax-specific T-cell responses with insufficient control of HTLV-1 in a subgroup of individuals at asymptomatic and smoldering stages.
Cancer Sci. 2009 Mar;100(3):481-9.

Iwasaki R, Ito K, Ishida T, Hamanoue M, Adachi S, Watanabe T, Sato Y.
Catechin, green tea component, causes caspase-independent necrosis-like cell death in chronic myelogenous leukemia.
Cancer Sci. 2009 Feb;100(2):349-56.

Matsuo J, Tsukumo Y, Sakurai J, Tsukahara S, Park HR, Shin-Ya K, Watanabe T, Tsuruo T, Tomida A.
Preventing the unfolded protein response via aberrant activation of 4E-binding protein 1 by versipelostatin.
Cancer Sci. 2008 Dec 4. [Epub ahead of print]

Tsukasaki K, Hermine O, Bazarbachi A, Ratner L, Ramos JC, Harrington W, O�fMahony D, Janik JE, Bittencourt AL, Taylor GP, Yamaguchi K, Utsunomiya A, Tobinai K, Watanabe T.
Definition, Prognostic Factors, Treatment and Response Criteria of Adult T-cell Leukemia-Lymphoma: A Proposal from an International Consensus Meeting.
J Clin Oncol. 2009 Jan 20;27(3):453-9.

2008

Uchimaru K, Nakamura Y, Tojo A, Watanabe T, Yamaguchi K.
Factors predisposing to HTLV-1 infection in residents of the greater Tokyo area.
Int J Hematol. 2008 Dec;88(5):565-70.

Watanabe M, Nakashima M, Togano T, Higashihara M, Watanabe T, Umezawa K, Horie R.
Identification of the RelA domain responsible for action of a new NFkappaB inhibitor DHMEQ.
Biochem Biophys Res Commun. 2008 Nov 14;376(2):310-4.

Kurata A, Katayama R, Watanabe T, Tsuruo T, Fujita N.
TUSC4/NPRL2, a novel PDK1-interacting protein, inhibits PDK1 tyrosine phosphorylation and its downstream signaling.
Cancer Sci. 2008 Sep;99(9):1827-34.

Suzuki K, Juelich T, Lim H, Ishida T, Watanabe T, Cooper DA, Rao S, Kelleher AD.
Closed chromatin architecture is induced by an RNA duplex targeting the HIV-1 promoter region.
J Biol Chem. 2008 Aug 22;283(34):23353-63.

Makishi S, Okudaira T, Ishikawa C, Sawada S, Watanabe T, Hirashima M, Sunakawa H, Mori N.
A modified version of galectin-9 induces cell cycle arrest and apoptosis of Burkitt and Hodgkin lymphoma cells.
Br J Haematol. 2008 Aug;142(4):583-94.

Miyake A, Dewan MZ, Ishida T, Watanabe M, Honda M, Sata T, Yamamoto N, Umezawa K, Watanabe T, Horie R.
Induction of apoptosis in Epstein-Barr virus-infected B-lymphocytes by the NF-ƒÈB inhibitor DHMEQ.
Microbes Infect. 2008 Jun;10(7):748-56. Epub 2008 Apr 13.

Saitoh Y, Yamamoto N, Dewan MDZ, Sugimoto H, Martinez VJ, Iwasaki Y, Matsu-bara K, Qi X, Saitoh T, Imoto I, Inazawa J, Utsunomiya A, Watanabe T, MasudaT, Yamamoto N, Yamaoka S.
Overexpressed NF-ƒÈB inducing kinase contributes to the tumorigenesis of adult T-cell leukemia and Hodgkin Reed-Sternberg cells.
Blood. 2008 May 15;111(10):5118-29. Epub 2008 Feb 27.

Watanabe M, Ogawa Y, Itoh K, Koiwa T, Kadin ME, Watanabe T, Okayasu I, Higashihara M, Horie R.
Hypomethylation of CD30 CpG islands with aberrant JunB expression drives CD30 induction in Hodgkin lymphoma and anaplastic large cell lymphoma.
Lab Invest. 2008 Jan;88(1):48-57. Epub 2007 Oct 29.

Franchina M, Woo AJ, Dods J, Karimi M, Ho D, Watanabe T, Spagnolo DV, Abraham LJ.
The CD30 Gene Promoter Microsatellite binds Transcription Factor Yin Yang 1 (YY1) and shows Genetic Instability in Anaplastic Large Cell Lymphoma.
J Pathol. 2008 Jan;214(1):65-74.

2007

Matsuoka M, Watanabe T, Kannagi M, Bangham C, Grassmann R, Marriott SJ, Green P, Jeang K-T.
Meeting Report on the 13th International Conference on Human Retrovirology: Human T-Cell Leukemia Virus Research-30Years after Adult T-Cell Leukemia.
Cancer Res. 2007 Nov 15;67(22):10638-41. Epub 2007 Nov 9. No abstract available.

Han M-Y, Kosako H, Watanabe T, Hattori S.
ERK MAP Kinase Regulates Actin Organization and Cell Motility by Phosphorylating the Actin Cross-Linking Protein EPLIN.
Mol Cell Biol. 2007 Dec;27(23):8190-204. Epub 2007 Sep 17

Katano H, Sato Y, Hoshino S, Tachikawa N, Oka S, Morishita Y, Ishida T, Watanabe T, Rom WN, Mori S, Sata T, Weiden MD, Hoshino Y.
Integration of HIV-1 caused STAT3-associated B cell lymphoma in an AIDS patient.
Microbes Infect. 2007 Nov-Dec;9(14-15):1581-9. Epub 2007 Sep 14.

Ohsugi T, Kumasaka T, Okada S, Ishida T, Yamaguchi K, Horie R, Watanabe T, Umezawa K.
Dehydroxymethylepoxyquinomicin (DHMEQ) therapy reduces tumor formation in mice inoculated with Tax-deficient adult T-cell leukemia-derived cell lines.
Cancer Lett. 2007 Nov 18;257(2):206-15. Epub 2007 Aug 30

Horie R, Ishida T, Maruyama-Nagai M, Ito K, Watanabe M, Yoneyama A, Higashihara M, Kimura S, Watanabe T
TRAF activation of C/EBPƒÀ (NF-IL6) via p38 MAPK induces HIV-1 gene expression in monocytes/macrophages.
Microbes Infect. 2007 May;9(6):721-8. Epub 2007 Feb 24

Watanabe M, Dewan Md. Z, Taira M, Shoda M, Honda M, Sata T, Higashihara M, Kadin ME, Watanabe T, Yamamoto N, Umezawa K, Horie R
IƒÈBƒ¿ independent induction of NF-ƒÈB and its inhibition by DHMEQ in Hodgkin-Reed-Sternberg cells.
Lab Invest. 2007 Apr;87(4):372-82. Epub 2007 Feb 19

2006

Horie R, Watanabe T, Umezawa K.
Blocking NF-kappaB as a potential strategy to treat adult T-cell leukemia/lymphoma.
Drug News Perspect. 2006 May;19(4):201-9

Ishida T, Hamano A, Koiwa T, Watanabe T
5' long terminal repeat (LTR)-selective methylation of latently infected HIV-1 provirus that is demethylated by reactivation signals.
Retrovirology. 2006 Oct 12;3:69

Kamoi K, Yamamoto K, Misawa A, Miyake A, Ishida T, Tanaka Y, Mochizuki M, Watanabe T
SUV39H1 interacts with HTLV-1 Tax and abrogates Tax transactivation of HTLV-1 LTR.
Retrovirology. 2006 Jan 13;3:5

Horie R, Watanabe M, Okamura T, Taira M, Shoda M, Motoji T, Utsunomiya A, Watanabe T, Higashihara M, Umezawa K.
DHMEQ, a new NF-kB inhibitor induces apoptosis of chronic lymphocytic leukemia cells and enhances effect of fludarabine.
Leukemia. 2006 May;20(5):800-6

Miyake A, Ibuki K, Enose Y, Suzuki H, Horiuchi R, Motohara M, Saito N, Nakanose T, Honda M, Watanabe T, Miura T, Hayami M.
Rapid dissemination of a psthogenic siman/human immunodeficiency virus to systemic organs and active replication in lymphoid tissues following intrarectal infection.
J Gen Virol. 2006 May;87(Pt 5):1311-1320

Sugita S, Takase H, Yoshida T, Sugamoto Y, Watanabe T, Mochizuki M.
Intraocular soluble IL-2 receptor alpha in a patient with adult T-cell Leukemia with intraocular invasion.
Br J Ophthalmol. 2006 Sep;90(9):1204-6

Uchihara JN, Matsuda T, Okudaira T, Ishikawa C, Masuda M, Horie R, Watanabe T, Ohta T, Takasu N, Mori N.
Transactivation of the ICAM-1 gene by CD30 in Hodgkin's Lymphoma.
Int J Cancer. 2006 Mar 1; 118(5): 1098-1107

Ohsugi T, Kumasaka T, Ishida A, Ishida T, Horie R, Watanabe T, Umezawa K, Yamaguchi K.
In vitro and in vivo antitumor activity of the NF-ƒÈB inhibitor DHMEQ in the human T-cell leukemia virus type I-infected cell line, HUT-102.
Leuk Res. 2006 Jan;30(1):90-7. Epub 2005 Jul 5.

2005

Watanabe M, Ohsugi T, Shoda M, Ishida T, Aizawa S, Maruyama-Nagai M, Utsunomiya A, Koga S, Yamada Y, Kamihira S, Okayama A, Kikuchi H, Uozumi K, Yamaguchi K, Higashihara M, Umezawa K, Watanabe T, Horie R
Dual targeting of transformed and untransformed HTLV-1-infected T-cells by DHMEQ, a potent and selective inhibitor of NF-kB, as a strategy for chemoprevention and therapy of adult T cell leukemia.
Blood. 2005 Oct 1;106(7):2462-71.

Watanabe M, Sasaki M, Itoh K, Higashihara M, Umezawa K, Kadin ME, Abraham LJ, Watanabe T, Horie R.
JunB induced by constitutive CD30-ERK1/2 MAPK signaling activates the CD30 promoter in anaplastic large cell lymphoma and Reed-Sternberg cells of Hodgkin lymphoma.
Cancer Res. 2005 Sep 1;65(17):7628-34.

Dewan Md.Z, Watanabe M, Ahmed S, Terashima K, Horiuchi S, Sata T, Honda M, Ito M, Watanabe T, Horie R, Yamamoto N.
Hodgkin's Lymphoma Cells Are Efficiently Engrafted and Expressed Tumor Marker CD30 with Constitutive NF-kB Activity in Unconditioned NOD-SCID/gcnull (NOG) Mice.
Cancer Sci. 2005 Aug;96(8):466-73.

Nonaka M, Horie R, Itoh K, Watanabe T, Yamamoto N, Yamaoka S.
Aberrant NF-kappaB2/p52 expression in Hodgkin/Reed-Sternberg cells and CD30-transformed rat fibroblasts.
Oncogene. 2005 Jun 2;24(24):3976-86.

Ohsugi T, Horie R, Kumasaka T, Ishida A, Ishida T, Yamaguchi K, Watanabe T, Umezawa K, Urano T
In vivo Antitumor Activity of the NF-ƒÈB Inhibitor Dehydroxymethylepoxyquinomicin in a Mouse Model of Adult T-cell Leukemia.
Carcinogenesis. 2005 Aug;26(8):1382-8. Epub 2005 Apr 14.

Watanabe M, Dewan Z, Okamura T, Sasaki M, Itoh K, Higashihara M, Mizoguchi H, Honda M, Sata T, Watanabe T, Yamamoto N, Umezawa K, Horie R
A novel NF-kappaB inhibitor DHMEQ selectively targets constitutive NF-kappaB activity and induces apoptosis of multiple myeloma cells in vitro and in vivo.
Int J Cancer. 2005 Mar 10;114(1):32-8.

Iwata S, Souta-Kuribara A, Sasaki T, Kobayashi H, Yamakawa A, Hosono O, Kawasaki H, Tanaka H, Dang NH, Watanabe T, Arima N, Yamaoka S, Morimoto C
HTLV-I Tax induces and associates with Crk-associated substrate lymphocyte type (Cas-L).
Oncogene. 2005 Feb 10;24(7):1262-71.

Tanaka G, Okayama A, Watanabe T, Aizawa S, Stuver S, Mueller N, Hsieh C-C, Tsubouchi H
The clonal expansion of HTLV-1 infected cells: A comparison between seroconverters and long-term carriers.
J Infect Dis. 2005 Apr 1;191(7):1140-7. Epub 2005 Mar 1.

Higuchi M, Matsuda T, Mori N, Yamada Y, Horie R, Watanabe T, Takahashi M, Oie M, Fujii M
Elevated expression of CD30 in adult T-cell leukemia cell lines:possible role in constitutive NF-ƒÈB activation.
Retrovirology. 2005 May 6;2:29.

2004

Ohsugi T, Yamaguchi K, Kumasaka T, Ishida T, Horie R, Watanabe T, Sakio N, Fujimoto T, Sakamoto N, Urano T.
Rapid Tumor Death Model for Evaluation of New Therapeutic Agents for Adult T-cell Leukemia.
Lab Invest. 2004 Feb;84(2):263-6.

Habelhah H, Takahashi S, Cho SG, Kadoya T, Watanabe T, Ronai Z
Ubiquitination-dependent translocation of TRAF2 to the insoluble cellular fraction is required for its activation of JNK but not of p38 or NF-kappaB.
EMBO J. 2004 Jan 28;23(2):322-32. Epub 2004 Jan 8.

Horie R, Watanabe M, Ishida T, Koiwa T, Aizawa S, Itoh K, Higashihara M, Kadin ME, Watanabe T.
The NPM-ALK oncoprotein abrogates CD30 signaling and constitutive NF-kappaB activation in anaplastic large cell lymphoma.
Cancer Cell. 2004 Apr;5(4):353-64.

Dewan MZ, Watanabe M, Terashima K, Aoki M, Sata T, Honda M, Ito M, Yamaoka S, Watanabe T, Horie R, Yamamoto N.
Prompt tumor formation and maintenance of constitutive NF-kappaB activity of multiple myeloma cells in NOD/SCID/gammacnull mice.
Cancer Sci. 2004 Jul;95(7):564-8.

2003

Tanaka J, Ishida T, Choi B-I, Watanabe T, Yasuda J, Iwakura Y.
Latent HIV-1 reactivation in transgenic mice requires cell cycle-dependent demethylation of CREB/ATF sites in the LTR.
AIDS. 2003 Jan 24;17(2):167-75.

Watanabe M, Ogawa Y, Ito K, Higashihara M, Kadin ME, Abraham LJ, Watanabe T, Horie R
AP-1 mediated relief of repressive activity of the CD30 promoter microsatellite in Hodgkin and Reed-Sternberg cells.
Am J Pathol. 2003 Aug;163(2):633-41.

2002

Satoh M, Toma H, Sugahara K, Etoh K, Shiroma Y, Kiyuna S, Takara M, Matsuoka M, Yamaguchi K, Nakada K, Fujita K, Kojima S, Hori E, Kamihira S, Sato Y, Tanaka Y, Watanabe T.
Involvement of IL-2/IL-2R system activation by parasite antigen in polyclonal expansion of CD4+25+ HTLV-1-infected T-cells in human carriers of both HTLV-1 and S. stercoralis.
Oncogene. 2002 Apr 11;21(16):2466-75.

Horie R, Watanabe T, Morishita Y, Ito K, Ishida T, Kanegae Y, Saito I, Higashihara M, Mori S, Kadin ME, Watanabe T.
Ligand-independent signaling by overexpressed CD30 drives NF-kappaB activation in Hodgkin-Reed Sternberg cells.
Oncogene. 2002 Apr 11;21(16):2493-503.

Horie R, Watanabe T, Ito K, Morisita Y, Watanabe M, Ishida T, Higashihara M, Kadin M, Watanabe T.
Cytoplasmic aggregation of TRAF2 and TRAF5 proteins in the Hodgkin-Reed-Sternberg cells.
Am J Pathol. 2002 May;160(5):1647-54.

Koiwa T, Hamano-Usami A, Ishida T, Okayama A, Yamaguchi K, Kamihira S, Watanabe T.
5'-LTR-selective CpG methylation of latent HTLV-1 provirus in vitro and in vivo.
J Virol. 2002 Sep;76(18):9389-97.

Reviews and Textbook

Yoshida M, Seiki M, Hattori S, Watanabe T.
Genome structure of human T-cell leukemia virus and its involvement in the development of adult T-cell leukemia/lymphoma.
In "Human T-cell Leukemia/Lymphoma Viruses", eds. Gallo RC, Essex ME and Gross L. Cold Spring Harbor Laboratory, N. Y., pp 141-148, 1984

Yoshida M, Hattori S, Kiyokawa T, Watanabe T, Seiki M.
The molecular biology of human T-cell leukemia virus.
In "Symposium of the Society for General Microbiology. Viruses and Cancer", eds. Rigby PWJ and Wilkie NM, Cambridge University Press, 1984

Yoshida M, Kiyokawa T, Watanabe T, Hattori S, Fujisawa J and Seiki M.
Human T-cell leukemia virus type 1: Molecular biology and its implications in Adult T-cell Leukemia.
In "Retroviruses in Human Lymphoma/Leukemia", eds. Miwa M, et al., Japan Science Society Press, Tokyo University Press, Utrecht, pp39-47, 1985

Takatsuki k, Yamaguchi K, Watanabe T, Mochizuki M, Kiyokawa T, Mori S, Miyata N.
Adult T-cell Leukemia and HTLV-1 related Diseases.
in "Gann Monograph on Cancer Research 39", eds. Takatsuki K, Hinuma Y and Yoshida M.
Jpn Scientific Society Press, Tokyo, CRC Press, Boca Raton Ann Arbor London Tokyo. pp1-15, 1992.

Yamaguchi K, Mochizuki M, Watanabe T.
Human T-lymphotropic virus type 1 uveitis.
Leukemia 8, Suppl. 1: 88-90, 1994

Mochizuki M, Watanabe T, Yamaguchi K, Tajima K.
"Human T-lymphotropic virus type I associated diseases" in Ocular Infection and Immunity.
Edited by Pepose J S, Holland G N and Wilhelmus K R. Mosby, 1995, pp1366- 1387.

Mochizuki M, Ono A, Ikeda E, Hikita N, Watanabe T, Yamaguchi K, Sagawa K, Ito K.
HTLV-1 uveitis.
J AIDS Hum Retro 13. (Supl 1): S50-56, 1996

Watanabe T, Mochizuki M, Yamaguchi K.
HTLV-1 uveitis (HU).
Leukemia. 11 (Suppl 3): 582-584, 1997

Watanabe, T.
HTLV-1-associated diseases.
Int J Hematol. 66: 257-278, 1997

Horie R, Watanabe T.
CD30: Expression and function in health and disease.
Sem Immunol, 10: 457-470, 1998

Horie R, Higashihara M, Watanabe T.
Hodgkin's Lymphoma and CD30 signal transduction.
Int J Hematol. 77:37-47, 2003

Tobinai K, Watanabe T, Jaffe E.
"HTLV-1-associated adult T-cell leukemia-lymphoma" in Non-Hodgkin Lymphomas.
Edited by Mauch PM, Armitage JO, Harris NL, Dalla-Favera R, Coiffier B. Lippincott Williams &Wilkins, 2003

Tobinai K and Watanabe T.
"Chapter 114. Adult T-cell Leukemia-Lymphoma" in Clinical Oncology 3rd Ed.
Edited by Abeloff MD, Armitage JO, Kastan M, Niederhuber JE. W.B. Saunders, 2003

Yamaguchi K, Watanabe T.
Human T lymphotropic virus type-I and adult T-cell leukemia in Japan.
Int J Hematol. 76 (Suppl 2):240-245, 2002.