| 氏名 | 坂本 毅治 |
| 長期/短期 | 長期 |
| 派遣先 | オーストリア・ウィーン Institute of Molecular Biotechnology of the Austrian Academy of Sciences |
| 派遣期間 | 平成24年4月8日～平成24年6月8日 （平成24年4月8日～平成24年8月1日のうち） |
| 成果報告書 | |
| 研究課題名 | 新規低酸素関連遺伝子の探索 Exploring novel hypoxia-related genes |
| Aerobic organisms including human need oxygen to generate energy and survive.
Hypoxia is involved in many diseases such as ischemia, chronic inflammation,
and cancer. Therefore, understanding what genes are involved in hypoxic
response and how they regulate are very important for both basic and medical
sciences. Recently, Dr. Penninger’s group of IMBA (Austria) developed mouse
haploid ES mutant cells taking advantage of the gene trap technique (Elling
et al., Cell Stem Cells, 2011). These cells are very powerful tool to identify
novel genes for any purpose. By taking advantage of these cells, in addition
to my techniques and knowledge about hypoxia biology, I plan to identify
novel hypoxia-related genes using haploid ES mutant cells. I have joined the Penninger’s lab in IMBA since April 10th. IMBA is a medium-sized yet well-organized institute, and many core laboratories in this institute support scientists. The Penninger’s lab is the biggest group in IMBA with more than a dozen of Postdocs. Each postdoc or Ph.D student has independent projects that cover many fields of science such as cancer, infectious disease, and neurobiology. With the supports of the lab mates, I have set up the screening condition for hypoxia-related genes, and just started the large-scale screens. |
|
