IMS logo Department of Cancer Biology
The Institute of Medical Science
The University of Tokyo
IMSUT Home Page
  Department of Cancer Biology English / Japanese

ChairMasabumi Shibuya

Formation and developement of cancer are multi-step that involves alteration of structure adn function of various genes that are relevant to cell growth, differentiation, and to cell-cell communication, the genes include oncogenes, tumor suppressor genes, and their related genes. In the Department of Cancer Biology, we try to establish molecular mechaminsms of tumor formation and development basing on the function of these gene products.
Our goal is to understand
(1) how the cell growth and differentiation are regulated,
(2) molecular basis of angiogenesis,
(3) molecular meachanisms of invasion and metastasis of cancer,
(4) mechanisms of malignant transformation by tumor viruses,
and their pathogenic mechanisms of human cancer.

On going researches are as follows:

  1. Structure, expression, and function of cancer related genes including oncogenes and tumor suppressor genes
  2. Studies on signal transduction and gene expression involved in cell growth and differentiation
  3. Studies on inositol-phospholipid signaling
  4. Studies on cell-cell interaction, cell motility, and cytoskelton
  5. Molecular mechanisms of tumor angiogenesis, cancer cell invasion, and metastasis
  6. Molecular pathogenesis of malignant lymphomas, other solid tumors, and retrovirus-associated neoplasms

 Division of Oncology Head   Tadashi Yamamoto  
Professor Tadashi Yamamoto Division of Oncology Home Page 3rd Bldg. 4F South
Research Associate Toru Tezuka
Research Associate Toru Suzuki
Research Associate Miho Ohsugi
Research Associate Takanobu Nakazawa
 Division of Cancer Cell Research Head   Motoharu Seiki  
Professor Motoharu Seiki Division of Cancer Cell Research Home Page 3rd Bldg. 3F South
Lecturer Ikuo Yana
Research Associate Isamu Gotoh  
Research Associate Naohiko Koshikawa
Research Associate
 Division of Cancer Genomics Head    
Professor   Division of Cancer Genomics Home Page Ex-SNPs Bldg. 1F
Associate Professor Hiroaki Miki
Research Associate Kei Takenaka
  Division of Cellular and Molecular Biology Head    
Professor Jun'ichiro Inoue Division of Cellular and Molecular Biology Home Page 2nd Bldg. 3F East
Associate Professor Kentaro Semba
Lecturer Taishin Akiyama  
Research Associate Jin Gouda
Research Associate
 Division of Biochemistry Head   Tadaomi Takenawa  
Professor Tadaomi Takenawa Division of Biochemistry Home Page 3rd Bldg. 1F North
Associate Professor
Research Associate Toshiki Itoh
Research Associate Shiro Suetsugu
Research Associate Takeshi Ijuin
     
Associate Professor Seiichi Takasaki   2nd Bldg. 2F West
  Division of Genetics Head   Masabumi Shibuya  
Professor Masabumi Shibuya Division of Genetics Home Page General Research Bldg. 5F South
Associate Professor
Lecturer Noriko Goto
Research Associate Yoshiko Sakurai
Research Associate Masato Murakami

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