A collaborative research group led by Professor Makoto Nakanishi of the Institute of Medical Science, The University of Tokyo (IMSUT), and co-researchers（※）has identified an inhibitor of the glutamate metabolic enzyme GLS1(*1) so that its administration selectively eliminates senescent cells in vivo. They confirmed that the GLS1 inhibitor eliminated senescent cells from various organs and tissues in aged mice, ameliorating age-associated tissue dysfunction and the symptoms of obese diabetes, arteriosclerosis, and NASH. The results of this research were published in "Science" on January 15, 2021.
Abbreviation for glutaminase 1. A type of amidohydrolase enzyme that produces glutamic acid and ammonia from glutamine.
Keiichi Nakayama (Professor, Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University)
Masaki Matsumoto (Professor，Department of Omics and Systems Biology，Niigata University)
Makoto Suematsu (Professor, Department of Biochemistry, Keio University School of Medicine)
Yuki Sugiura (Assistant Professor, Department of Biochemistry, Keio University School of Medicine)
Makoto Arita (Team leader, Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences)
Masataka Sugimoto (Director, Research Institute, National Center for Geriatrics and Gerontology)
Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders
"Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders"
Science Vol. 371, Issue 6526, pp. 265-270 January 15，2021 doi:10.1126/science.abb5916
Yoshikazu Johmura*, Takehiro Yamanaka$, Satotaka Omori$, Teh-Wei Wang$, Yuki Sugiura, Masaki Matsumoto, Narumi Suzuki, Soichiro Kumamoto, Kiyoshi Yamaguchi, Seira Hatakeyama, Tomoyo Takami, Rui Yamaguchi, Eigo Shimizu, Kazutaka Ikeda, Nobuyuki Okahashi, Ryuta Mikawa, Makoto Suematsu, Makoto Arita, Masataka Sugimoto, Keiichi I. Nakayama, Yoichi Furukawa, Seiya Imoto, and Makoto Nakanishi* （*corresponding co-authors, $the second co-authors）