List of Publications

Main Publications

  1. Shimada, M., Goshima, T., Matsuo, H., Johmura, Y., Haruta, M., Murata, K., Tanaka, H., Ikawa, M., Nakanishi, K., and *Nakanishi, M. Essential role of auto-activation circuitry on Aurora B-mediated H2AX-pS121 in mitosis. Nature Communications 7, 12059 (2016)
  2. Johmura, Y., Sun, J., Kitagawa, K., Nakanishi, K., Kuno, T., Naiki-Ito, A., Sawada, Y., Miyamoto, T., Okabe, A., Aburatani, H., ShengFan, Li., Miyoshi, I., Takahashi, S., Kitagawa, M., and *Nakanishi, M. SCFFbxo22-KDM4A targets methylated p53 for degradation and regulates senescence. Nature Communications7, 10574 (2016)
  3. Johmura Y, Shimada M, Misaki T, Naiki-Ito A, Miyoshi H, Motoyama N, Ohtani N, Hara E, Nakamura M, Morita A, Takahashi S, Nakanishi M. Necessary and sufficient role for a mitosis skip in senescence induction. Mol Cell.55:73-84. 2014
  4. CBP-93872 inhibits NBS1-mediated ATR activation, abrogating maintenance of the DNA double-strand break-specific G2 checkpoint. Hirokawa T, Shiotani B, Shimada M, Murata K, Johmura Y, Haruta M, Tahara H, Takeyama H, Nakanishi M. Cancer Res. 74:3880-9. 2014
  5. Uhrf1-dependent H3K23 ubiquitylation couples maintenance DNA methylation and replication. Nishiyama A, Yamaguchi L, Sharif J, Johmura Y, Kawamura T, Nakanishi K, Shimamura S, Arita K, Kodama T, Ishikawa F, Koseki H, Nakanishi M. Nature 502:249-53. 2013
  6. TANK-binding kinase 1(TBK1) controls cell survival through PAI-2/serpinB2 and transglutaminase 2. Delhase M, Kim SY, Lee H, Naiki-Ito A, Chen Y, Ahn ER, Murata K, Kim SJ, Lautsch N, Kobayashi KS, Shirai T, Karin M, Nakanishi M. Proc Natl Acad Sci USA. 109:E177-86. 2012
  7. Shimada, M., Haruta, M., Niida, H., Sawamoto, K., and *Nakanishi, M. PP1g is a phosphatase responsible for dephosphorylation of histone H3 at threonine 11 after DNA damage. EMBO rep. 11, 883-889 (2010)
  8. Niida, H., Murata, K., Shimada, M., Ogawa, K., Ohta, K., Suzuki, K., Fujigaki, H., Khaw, A.K., Banerjee, B., Hande, P.M., Miyamoto, T., Miyoshi, I., Shirai, T., Motoyama, N., Delhase, M., Appella, E., and *Nakanishi, M. Cooperative functions of Chk1 and Chk2 reduce tumor susceptibility in vivo. EMBO J. 29, 3558-3570 (2010)
  9. Niida, H., Katsuno, Y., Sengoku, M., Shimada, M., Yukawa, M., Ikura, M., Ikura, T., Kohno, K., Shima, H., Suzuki, H., Tashiro, S., and *Nakanishi, M. Essential role of Tip60-dependent recruitment of ribonucleotide reductase at DNA damage sites in DNA repair during G1 phase. Genes and Dev. 24, 333-338 (2010)
  10. Katsuno, Y., Suzuki, A., Sugimura, K., Okumura, K., Zineldeen, D.H., Shimada, M., Niida, H., Mizuno, T., Hanaoka, F., and Nakanishi, M. Cyclin A-Cdk1 regulates the origin firing program in mammalian cells. Proc. Natl. Acad. Sci. 106, 3184-3189 (2009)
  11. Shimada, M., Niida, H., Zineldeen, D.H., Tagami, H., Tanaka, M., Saito, H., and Nakanishi, M. Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression. Cell 132, 221-232 (2008)
  12. Tonami, Y., Murakami, H., Shirahige, K., and Nakanishi, M. A checkpoint control linking meiotic S phase and recombination initiation in fission yeast. oc. Natl. Acad. Sci. 102, 5797-5801 (2005)
  13. Tojima, Y., Fujimoto, A., Delhase, M., Chen, Y., Hatakeyama, S., Nakayama, K., Kaneko, Y., Nimura, Y., Motoyama, N., Ikeda, K., Karin, M., Nakanishi, M. NAK is an IkB kinase-activating kinase. Nature 404, 778-782 (2000)
  14. Takai, H., Tominaga, K., Motoyama, N., Minamishima, Y., Nagahama, H., Tsukiyama, T., Ikeda, K., Nakayama, K., Nakanishi, M., Nakayama, K. Aberrant Cell Cycle Checkpoint Function and Early Embryonic Death in Chk1-/- Mice. Genes & Dev. 14, 1439-1447 (2000)
  15. Yamamoto, A., Hashimoto, Y., Kohri, K., Ogata, E., Kato, S., Ikeda, K., Nakanishi, M. Cyclin E as a coactivator of the androgen receptor. J. Cell Biol. 150, 873-879 (2000)
  16. Nakanishi, M., Adami, G.R., Robetorye, R.S., Noda, A., Venable, S.F., Dimitrov, D., Pereira-Smith, O.M., and Smith, J.R. Exit from G0 and entry into the cell cycle of cells expressing p21Sdi1 antisense RNA. Proc. Natl. Acad. Sci. 92, 4352-4356 (1995)
  17. Nakanishi, M., Robetorye, R.S., Adami, G.R., Pereira-Smith, O.M., and Smith, J.R. Identification of the active region of the DNA synthesis inhibitory gene p21Sdi1/CIP1/WAF1. EMBO J.14, 555-563 (1995)