Nomura, M., Fukuda, T, Fujii, K., Kawamura, T., Tojo, H., Kihara, M., Bando, Y., Gazdar, A.F., Tsuboi, M., Oshiro, H., Nagao, T., Ohira, T., Ikeda, N., Gotoh, N., Kato, H., Marko-Varga, G. & Nishimura, T.: Preferential expression of potential markers for cancer stem cells in large cell neuroendocrine carcinoma of the lung. Journal of Clinical Bioinformatics, 1; 23, (3 September), 2011.
Yamauchi, M., Yoshino, I., Yamaguchi, R., Shimamura, T., Nagasaki, M., Imoto, S., Niida, A., Koizumi, F., Kohno, T., Yokota, J., Miyano, S. & Gotoh, N.: N-cadherin expression is a potential survival mechanism of gefitinib-resistant lung cancer cells. Am. J. Cancer. Res., 1; 823-833, 2011.
Gotoh, N.: Somatic mutations of the EGF receptor and their signal transducers affect the efficacy of EGF receptor-specific tyrosine kinase inhibitors. Int. J. Clin. Exp. Pathol., 4; 403-409, 2011.
Nasirujjaman K., Kimura-Yoshida, C., Gotoh, N., Hiramatsu, R. and Matsuo I.: A genetic study of the effects of reduced Frs2alpha gene dosage in exostoses development and cartilage abnormalities observed in Ext2 heterozygous mutant mice. Journal of Osaka Medical Center & Research Institute for Maternal & Child Health., 26; 101-108, 2011.
Gotoh,N.:FRS2. In:Encyclopedia of Signaling Molecules.Springer,Heidelberg,Germany.
Hinohara, K. and Gotoh, N.: Inflammatory signaling pathways in self-renewing breast cancer stem cells. Curr. Opin. Pharmacol., 10; 650-654, 2010. (論文の図がこの号の表紙に採用されました)
Kojima, K., Yamaguchi, R., Imoto, S., Yamauchi, M., Nagasaki, M., Yoshida, R., Shimamura, T, Ueno, K., Higuchi, T., , Gotoh, N., Miyano, S.: A state space representation of VAR models with sparse learning for dynamic gene networks. Genome Inform., 22, 56-68, 2010.
Iejima, D., Minegichi, Y., Takenaka, K., Siswanto, A., Watanabe, M., Huang, L., Watanabe, T., Tanaka, F., Kuroda, M. and Gotoh, N.: FRS2b, a potential prognostic gene for non-small cell lung cancer, encodes a feedback inhibitor for EGF receptor family members via ERK binding. Oncogene, 29: 3087-3099, 2010.
Murohashi, M., Hinohara, K., Kuroda, M., Isagawa, T., Tsuji, S., Kobayashi, S., Umezawa, K., Tojo, A., Aburatani, H. and Gotoh, N.: Gene set enrichment analysis provides insight into novel signaling pathways in breast cancer stem cells. British J. Cancer, 102: 206-212, 2010.
Murohashi, M., Nakamura, T., Tanaka, S., Ichise, T., Yoshida, N., Yamamoto, T., Shibuya, M., Schlessinger, J. and Gotoh, N.: An FGF4-FRS2a-Cdx2 axis-in trophoblast stem cells induces BMP4 to regulate proper growth of early mouse embryos. Stem Cells, 28: 113-121, 2010.
Iejima, D. and Gotoh, N.: FRS2b docking/scaffolding adaptor protein. Current research in cancer, Research Media, India,3, 99-107, 2009.
Kameda, Y., Ito, M., Nishimaki, T. and Gotoh, N.: FRS2alpha is required for the separation, migration, and survival of pharyngeal-endoderm derived organs including thyroid, ultimobranchial body, parathyroid, and thymus. Dev. Dyn., 238, 503-513, 2009.
Yamauchi, M., and Gotoh, N.: Molecular mechanisms determining efficacy of EGF receptor-specific tyrosine kinase inhibitors help to identify biomarker candidates. Biomark. Med., 3, 139-151, 2009.
Minegishi, Y., Iwanari, H., Mochizuki, Y., Horii, T., Hoshino, T., Kodama, T., Hamakubo, T. and Gotoh, N.: Prominent expression of FRS2b protein in neural cells and its association with intracellular vesicles. FEBS lett., 583, 807-814, 2009.
Sato T. and Gotoh, N.: The FRS2 family of docking/scaffold adaptor proteins as therapeutic targets of cancer treatment. Expert Opinion on Therapeutic Targets, 13, 689-700, 2009.
Gotoh, N.: Control of stemness by fibroblast growth factor signaling in stem cells and cancer stem cells. Current Stem Cell Research & Therapy, 4, 9-15, 2009.
Kameda, Y., Ito, M., Nishimaki T. and Gotoh, N.: FRS2a2F/2F mutant mice lack the carotid body and exhibit sympathetic ganglia and carotid sinus nerve abnormalities. Dev. Biol., 314, 236-247, 2008.
Gotoh, N. and Tsuchida, N.: Membrane-linked docking protein. Encyclopedia of Cancer, 2nd Edition, Springer, Heidelberg, Germany, 1819-1823, July 4, 2008.
Yamamoto, S., Yoshino, I., Shimazaki, T., Murohashi, M., Hevner, R. F., Lax, I., Okano, H., Shibuya, M., Schlessinger, J. and Gotoh, N.: Essential role of Shp2-binding sites on the docking protein FRS2a for mamalian corticogenesis and for FGF2-dependent proliferation of cultured neural progenitor cells. Proc. Natl. Acad. Sci., USA, 102, 15983-15988, 2005.
Gotoh, N., Manova, K., Tanaka, S., Murohashi, M., Hadari, Y., Lee, A., Hamada, Y., Hiroe, T., Ito, M., Kurihara, T., Nakazato, H., Shibuya, M., Lax, I., Lacy, E. & Schlessinger, J.: The docking protein FRS2a is an essential component of multiple FGF responses during early mouse development. Mol. Cell. Biol, 25, 4105-4116, 2005.
Gotoh, N., Ito, M., Yamamoto, S., Yoshino, I., Song, N., Wang, Y., Lax, I., Schlessinger, J., Shibuya, M. & Lang, R. A.: Tyrosine phosphorylation sites on FRS2a responsible for Shp2 recruitment are critical for induction of lens and retina. Proc. Natl. Acad. Sci. USA, 101, 17144-17149, 2004.
Huang, L., Gotoh, N., Zhang, S., Shibuya, M., Yamamoto, T. & Tsuchida, N.: SNT-2 interacts with ERK2 and negatively regulates ERK2 signaling in response to EGF stimulation. Biochem. Biophys. Res. Commun., 324, 1011-1017, 2004.
Gotoh, N., Laks, S., Nakashima, M., Lax, I. & Schlessinger, J.: FRS2 family docking proteins with overlapping roles in activation of MAP kinase have distinct spatial-temporal patterns of expression of their transcripts. FEBS lett., 564, 14-18, 2004.
Nakamura, T., Komiya, M., Sone, K., Hirose, E., Gotoh, N., Morii, H., Ohta, Y. & Mori, N.: Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and Crk/Crk adapter molecules. Mol. Cell. Biol., 22, 8721-8734, 2002.
Maida, Y., Kyo, S., Kanaya T., Wang, Z., Takakura, M., Yatabe, N., Tanaka, M., Nakamura, M., Hisamoto, K., Ohmichi, M., Gotoh, N. & Inoue, M.: EGF directly activates telomerase via Ets-mediated transactivation of TERT through MAP kinase signaling pathway. Oncogene, 21, 4071-4079, 2002.
Nakamura, T., Komiya, M., Gotoh, N., Koizumi, S., Shibuya, M. & Mori, N.: Discrimination between phosphotyrosine-mediated signaling properties of conventional and neuronal Shc adaptor molecules. Oncogene, 21, 22-31, 2002.
Onishi-Haraikawa, Y., Funaki, M., Gotoh, N., Shibuya, M., Inukai, K., Katagiri, H., Fukushima, Y., Anai, M., Ogihara, T., Sakoda, H., Ono, H., Kikuchi, M., Oka, Y. & Asano, T.: Unique phosphorylation mechanism of Gab1 using PI 3-kinase as an adaptor protein. Biochem. Biophys. Res. Commun., 288, 476-482, 2001.
Hadari, YR., Gotoh, N., Kouhara, H., Lax, I. & Schlessinger, J. : Critical role for docking protein FRS2a in FGF-receptor mediated signal transduction. Proc. Natl. Acad. Sci. USA, 98, 8578-8583, 2001.
Ong, SH., Hadari, YR., Gotoh, N., Guy, GR., Schlessinger, J. & Lax, I.: Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins. Proc. Natl. Acad. Sci. USA, 98, 6074-6079, 2001.
