Gene analysis technology has been evolving rapidly, starting from Maxam–Gilbert sequencing and Sanger sequencing in the 1970s to current method of DNA microarray and automated next-generation sequence technologies. Recent continuous development of DNA sequencing technologies has reduced the cost of DNA sequencing tremendously, leading to various applications such as gene expression profiling, regulatory element identification, histone modification identification and analysis of environmental sample. It is becoming an essential technology in life science. However, the amount of data produced from the next-generation sequencer becomes enormous, which means that the analysis to interpret the data is time consuming and difficult to perform for most bench scientists. In recent years, joint research between bench scientists and computational scientists has overcome the situation allowing excellent research. In the coming era, human resources with knowledge of both life science and information science will be required to open up uncivilized fields that have been difficult to analyze to date. Our laboratory targets the phenomenon of “immunity”, where a number of unknown territories remain. We promote our studies by making full use of immunological experiments and bioinformatics, and are developing scientists with a double background in both life science and information science.
Currently, our laboratory studies:
- Analysis of gene expression and its regulatory mechanism in immune cells
- Study of gut microbiota and their relationship to immune diseases