醍醐　弥太郎　プロフィール 

【氏　　名】　醍醐　弥太郎（だいご　やたろう）/ Yataro Daigo, M.D., Ph.D.　

【現　　職】　准教授

【専門分野】分子腫瘍医学・臨床腫瘍学・遺伝医学

【大学院担当専攻】 新領域創成科学研究科 生命科学研究系・メディカルゲノム専攻

【併任】 東京大学医科学研究所附属病院 ゲノム診療部

【職歴・学歴】
平成１０年　３月　山梨医科大学大学院医学研究科博士課程修了（医学博士号取得）
平成１０年　４月　東京大学医科学研究所ヒトゲノム解析センター　
　　　　　　　　　リサーチアソシエイト（日本学術振興会　研究員）
平成１１年　９月　英国ケンブリッジ大学腫瘍学部 研究員（日本学術振興会　海外特別研究員）
　　　　　　　　　英国ケンブリッジ大学アデンブルックス病院臨床腫瘍内科　医員（併任） 
平成１２年　４月　英国ケンブリッジ大学ウルフソンカレッジ　シニア学術員（併任）
平成１４年　１月　東京大学医科学研究所ヒトゲノム解析センター　助手
平成１７年　３月　東京大学医科学研究所先端臨床プロテオミクス共同研究ユニット　特任助教授
平成２０年　４月　東京大学医科学研究所ヒトゲノム解析センター　准教授

【所属学会等】
日本癌学会 (評議員), 日本臨床腫瘍学会 (暫定指導医), 日本がん治療認定医機構 (暫定教育医)
日本癌治療学会, 日本内科学会, 日本肺癌学会,日本消化器病学会, 日本人類遺伝学会

米国癌学会 (AACR Active Member), 米国臨床腫瘍学会 (ASCO Active Member)
米国人類遺伝学会 (ASHG Regular Member)

【受賞】
2000年　Senior Membership 
（Wolfson College, University of Cambridge）
2001年 The Royal Society Research Grant  
 (The Royal Society, UK)
2002年　AACR Scholar-in-Training Awards
（American Association for Cancer Research）
2005年 第18回日本消化器病学会奨励賞
2005年 第24回日本癌学会奨励賞

【論文リスト】

  1. Dunleavy EM, Roche D, Tagami H, Lacoste N, Ray-Gallet D, Nakamura Y, Daigo Y, Nakatani Y, Almouzni-Pettinotti G. HJURP, a key CENP-A-partner for maintenance and deposition of CENP-A at centromeres at late telophase/G1. Cell (2009 in press)

  2. Kamatani Y, Wattanapokayakit S, Ochi H, Kawaguchi T, Takahashi A, Hosono N, Kubo M, Tsunoda T, Kamatani N, Kumada H, Puseenam A, Sura T, Daigo Y, Chayama K, Chantratita W, Nakamura Y, Matsuda K. Identification of association of genetic variations in HLA-DP locus with chronic hepatitis B in Asian population through genome-wide association study. Nature Genetics (2009 in press)

  3. Moriwaki K, Noda K, Furukawa Y, Ohshima K, Uchiyama A, Nakagawa T, Taniguchi N, Daigo Y, Nakamura Y, Hayashi N, Miyoshi E. Deficiency of GMD leads to escape from NK cell-mediated tumor surveillance through modulation of TRAIL signaling. Gastroenterology (2009 in press)

  4. Ueda K, Fukase Y, Katagiri T, Ishikawa N, Irie S, Sato T, Ito H, Nakayama H, Miyagi Y, Tsuchiya E, Kohno N, Shiwa M, Nakamura Y, Daigo Y. Targeted serum glycoproteomics for the discovery of lung cancer-associated glycosylation disorders using lectin-coupled ProteinChip arrays. Proteomics (2009 in press)

  5. Hirata D, Yamabuki T, Ito T, Tsuchiya E, Fujita M, Hosokawa M, Chayama K, Nakamura Y, Daigo Y: Involvement of Epithelial Cell Transforming Sequence 2 (ECT2) Oncoantigen in Lung and Esophageal Cancer Progression. Clin Cancer Res 15: 256-266 (2009)

  6. Kono K, Mizukami Y, Daigo Y, Takano A, Masuda K, Yoshida K, Tsunoda T, Kawaguchi Y, Nakamura Y, Fujii H. Vaccination with Multiple Peptides derived from Novel Cancer-Testis Antigens Can Induce Specific T-Cell Responses and Clinical Responses in Advanced Esophageal cancer. Cancer Sci (2009 in press)

  7. Morioka K, Tanikawa C, Ochi K, Daigo Y, Katagiri T, Kawano H, Kawaguchi H, Myoui A, Yoshikawa H, Naka N, Araki N, Kudawara I, Ieguchi M, Nakamura K, Nakamura Y, Matsuda K. The Orphan Receptor Tyrosine Kinase ROR2 as a Potential Therapeutic Target for Osteosarcoma. Cancer Sci (2009 in press)

  8. Dobashi S, Katagiri T, Hirota E, Ashida S, Daigo Y, Shuin T, Fujioka T, Miki T, Nakamura Y. Involvement of TMEM22 overexpression in the growth of renal cell carcinoma cells. Oncol Rep 21: 305-12 (2009)

  9. Daigo Y, Nakamura Y. From Cancer Genomics to the Thoracic Oncology: Discovery of new biomarkers and therapeutic targets for lung and esophageal carcinomas. Gen Thorac Cardiovasc Surg 56: 43-53 (2008)

  10. Kato T, Sato N, Takano A, Miyamoto M, Nishimura H, Tsuchiya E, Kondo S, Nakamura Y, Daigo Y. Activation of placenta specific transcription factor Distal-less homeobox 5 predicts clinical outcome in primary lung cancer patients. Clin Cancer Res 14: 2363-2370(2008)

  11. Mizukami Y, Kono K, Daigo Y, Takano A, Tsunoda T, Kawaguchi Y, Nakamura Y, Fujii H. Detection of novel Cancer-Testis antigen-specific T-cell responses in TIL, regional lymph nodes and PBL in patients with esophageal squamous cell carcinoma. Cancer Sci 99: 1448-1454 (2008)

  12. Harao M, Hirata S, Irie A, Senju S, Nakatsura T, Komori H, Ikuta Y, Yokomine K, Imai K, Inoue M, Harada K, Mori T, Tsunoda T, Nakatsuru S, Daigo Y, Nomori H, Nakamura Y, Baba H, Nishimura Y. HLA-A2-restricted CTL epitopes of a novel lung cancer-associated cancer testis antigen, cell division cycle associated 1, can induce tumor-reactive CTL. Int J Cancer 123: 2616-2625 (2008)

  13. Leung ACC, Wong VCL, Yang LC, Chan PL, Daigo Y, Nakamura Y, Qi RZ, Miller L, Liu ETB, Wang LD, Li JL, Law S, Tsao SW, Lung ML. Frequent decreased expression of candidate tumor suppressor gene, DEC1, and its anchorage-independent growth properties and impact on global gene expression in esophageal carcinoma. Int J Cancer 122: 587-594 (2008)

  14. Ueda K, Katagiri T, Shimada T Irie S, Sato T, Nakamura Y, Daigo Y. Comparative profiling of serum glycoproteome by sequential purification of glycoproteins and 2-nitrobenzensulfenyl (NBS) stable isotope labeling: a new approach for the novel biomarker discovery for cancer. J Proteome Res 6: 3475-3483 (2007)

  15. Ishikawa N, Takano A, Yasui W, Inai K, Nishimura H, Ito H, Miyagi Y, Nakayama H, Fujita M, Hosokawa M, Tsuchiya E, Kohno N, Nakamura Y, Daigo Y. Cancer-testis antigen lymphocyte antigen 6 complex locus K is a serologic biomarker and a therapeutic target for lung and esophageal carcinomas. Cancer Res 67: 11601-11611 (2007)

  16. Kato T, Sato N, Hayama S, Yamabuki T, Ito T, Miyamoto M, Kondo S, Nakamura Y, Daigo Y. Activation of Holliday junction recognizing protein involved in the chromosomal stability and immortality of cancer cells. Cancer Res 67: 8544-8553 (2007)

  17. Hayama S, Daigo Y, Yamabuki T, Hirata D, Kato T, Miyamoto M, Ito T, Tsuchiya E, Kondo S, Nakamura Y. Phosphorylation and activation of cell division cycle associated 8 by aurora kinase B plays a significant role in human lung carcinogenesis. Cancer Res 67: 4113-4122 (2007)

  18. Yamabuki T, Takano A, Hayama S, Ishikawa N, Kato T, Miyamoto M, Ito T, Ito H, Miyagi Y, Nakayama H, Fujita M, Hosokawa M, Tsuchiya E, Kohno N, Kondo S, Nakamura Y, Daigo Y. Dickkopf-1 as a novel serologic and prognostic biomarker for lung and esophageal carcinomas. Cancer Res 67: 2517-2525 (2007)

  19. Tamura K, Furihata M, Tsunoda T, Ashida A, Takata R, Obara W, Yoshioka H, Daigo Y, Nasu Y, Kumon H, Konaka H, Namiki M, Tozawa K, Kohri K, Tanji N, Yokoyama M, Shimazui T, Akaza H, Mizutani Y, Miki T, Fujioka T, Shuin T, Nakamura Y, Nakagawa H. Molecular features of hormone-refractory prostate cancer cells by genome-wide gene expression profiles. Cancer Res 67: 5117-25 (2007)

  20. Taniwaki M, Takano A, Ishikawa N, Yasui W, Inai K, Nishimura H, Tsuchiya E, Kohno N, Nakamura Y, Daigo Y. Activation of KIF4A as a prognostic biomarker and therapeutic target for lung cancer. Clin Cancer Res 13: 6624-6631(2007)

  21. Kato T, Hayama S, Yamabuki Y, Ishikawa N, Miyamoto M, Ito T, Tsuchiya E, Kondo S, Nakamura Y, Daigo Y. Increased expression of IGF-II mRNA-binding protein 1 is associated with the tumor progression in patients with lung cancer. Clin Cancer Res 13: 434-442 (2007)

  22. Suzuki C, Takahashi K, Hayama S, Ishikawa N, Kato T, Ito T, Tsuchiya E, Nakamura Y, Daigo Y. Identification of Myc-associated protein with JmjC domain as a novel therapeutic target oncogene for lung cancer. Mol Cancer Ther 6: 542-551 (2007)

  23. Iyer NG, Xian J, Chin SF, Bannister AJ, Daigo Y, Aparicio S, Kouzarides T, Caldas C. p300 is required for orderly G1/S transition in human cancer cells. Oncogene 46: 171-180 (2007)(2006 Nov 10, Epub ahead of print)

  24. Kwong J, Chow LS, Wong AY, Hung WK, Chung GT, To KF, Chan FL, Daigo Y, Nakamura Y, Huang DP, Lo KW. Epigenetic inactivation of the deleted in lung and esophageal cancer 1 gene in nasopharyngeal carcinoma. Genes Chromosomes Cancer 46: 171-180 (2007)

  25. Mano Y, Takahashi, K, Ishikawa N, Takano A, Yasui W, Inai K, Nishimura H, Tsuchiya E, Nakamura Y, Daigo Y. Fibroblast growth factor receptor 1 oncogene partner as a novel prognostic biomarker and therapeutic target for lung cancer. Cancer Sci 98: 1902-1913 (2007)

  26. Suda T, Tsunoda T, Daigo Y, Nakamura Y, Tahara H. Identification of HLA-A24-restricted epitope-peptides derived from gene products up-regulated in lung and esophageal cancers as novel targets for immunotherapy. Cancer Sci 98: 1803-1808 (2007)

  27. Aoki Y, Toyama A, Shimada T, Sugita T, Aoki C, Umino Y, Suzuki A, Aoki D, Daigo Y, Nakamura Y, Sato TA. A novel method for analyzing formalin-fixed paraffin embedded (FFPE) tissue sections by mass spectrometry imaging. Proc Jpn Acad, Ser B, Phys Biol Sci 83: 205-214 (2007)

  28. Hayama S, Daigo Y, Kato T, Ishikawa N, Yamabuki T, Miyamoto M, Ito T, Tsuchiya E, Kondo S, Nakamura Y. Activation of CDCA1-KNTC2, members of centromere protein complex, involved in pulmonary carcinogenesis. Cancer Res 66: 10339-10348 (2006)

  29. Takahashi K, Furukawa C, Takano A, Ishikawa N, Kato T, Hayama S, Suzuki C, Yasui W, Inai K, Sone S, Ito T, Nishimura H, Tsuchiya E, Nakamura Y, Daigo Y. The neuromedin u-growth hormone secretagogue receptor 1b/neurotensin receptor 1 oncogenic signaling pathway as a therapeutic target for lung cancer. Cancer Res 66: 9408-9419 (2006)

  30. Taniwaki M, Daigo Y, Ishikawa N, Takano A, Tsunoda T, Yasui W, Inai K, Kohno K, Nakamura Y. Gene expression profiles of small-cell lung cancers: Molecular signatures of lung cancer. Int J Oncol 29: 567-575 (2006)

  31. Ishikawa N, Daigo Y, Takano A, Taniwaki M, Kato T, Tanaka S, Yasui W, Takeshima Y, Inai K, Nishimura H, Tsuchiya E, Kohno N, Nakamura Y. Characterization of SEZ6L2 cell-surface protein as a novel prognostic marker for lung cancer. Cancer Sci 97: 737-745 (2006)

  32. Yamabuki T, Daigo Y, Kato T, Hayama S, Tsunoda T, Miyamoto M, Ito T, Fujita M, Hosokawa M, Kondo S, Nakamura Y. Genome-wide gene expression profile analysis of esophageal squamous-cell carcinomas. Int J Oncol 28: 1375-1384 (2006)

  33. Kikuchi T, Daigo Y, Ishikawa N, Katagiri T, Tsunoda T, Yoshida S, Nakamura Y. Expression profiles of metastatic brain tumor from lung adenocarcinomas on cDNA microarray. Int J Oncol 28: 799-805 (2006)

  34. Suzuki C, Daigo Y, Ishikawa N, Kato T, Hayama S, Ito T, Tsuchiya E, Nakamura Y. ANLN plays a critical role in human lung carcinogenesis through the activation of RHOA and by involvement in the phosphoinositide 3-kinase/AKT pathway. Cancer Res 65: 11314-11325 (2005)

  35. Ishikawa N, Daigo Y, Takano A, Taniwaki M, Kato T, Hayama S, Murakami H, Takeshima Y, Inai K, Nishimura H, Tsuchiya E, Kohno N, Nakamura Y. Increases of amphiregulin and transforming growth factor-alpha in serum as predictors of poor response to gefitinib among patients with advanced non-small cell lung cancers. Cancer Res 65: 9176-9184 (2005)

  36. Furukawa C, Daigo Y, Ishikawa N, Kato T, Ito T, Tsuchiya E, Sone S, Nakamura Y. Plakophilin 3 oncogene as prognostic marker and therapeutic target for lung cancer. Cancer Res 65: 7102-7110 (2005)

  37. Kato T, Daigo Y, Hayama S, Ishikawa N, Yamabuki T, Ito T, Miyamoto M, Kondo S, Nakamura Y. A novel human tRNA-dihydrouridine synthase involved in pulmonary carcinogenesis. Cancer Res 65: 5638-5646 (2005)

  38. Callagy G, Pharoah P, Chin SF, Sangan T, Daigo Y, Jackson L, Caldas C. Identification and validation of prognostic markers in breast cancer with the complementary use of array-CGH and tissue microarrays. J Pathol 205: 388-396 (2005)

  39. Yang L, Leung AC, Ko JM, Lo PH, Tang JC, Srivastava G, Oshimura M, Stanbridge EJ, Daigo Y, Nakamura Y, Tang CM, Lau KW, Law S, Lung ML. Tumor suppressive role of a 2.4 Mb 9q33-q34 critical region and DEC1 in esophageal squamous cell carcinoma. Oncogene 24: 697-705 (2005)

  40. Kakiuchi S, Daigo Y, Ishikawa N, Furukawa C, Tsunoda T, Yano S, Nakagawa K, Tsuruo T, Kohno N, Fukuoka M, Sone S, Nakamura Y. Prediction of sensitivity of advanced non-small cell lung cancers to gefitinib. Hum Mol Genet 13: 3029-3043 (2004)

  41. Ishikawa N, Daigo Y, Yasui W, Inai K, Nishimura H, Tsuchiya E, Kohno N, Nakamura Y. ADAM8 as a novel serological and histochemical marker for lung cancer. Clin Cancer Res 10: 8363-8370 (2004)

  42. Iyer NG, Chin SF, Ozdag H, Daigo Y, Hu DE, Cariati M, Brindle K, Aparicio S, Caldas C. p300 regulates p53-dependent apoptosis after DNA damage in colorectal cancer cells by modulation of PUMA/p21 levels. Proc Natl Acad Sci U S A 101: 7386-7391 (2004)

  43. Ochi K, Daigo Y, Katagiri T, Nagayama S, Tsunoda T, Myoui A, Naka N, Araki N, Kudawara I, Ieguchi M, Toyama Y, Toguchida J, Yoshikawa H, Nakamura Y. Prediction of response to neoadjuvant chemotherapy for osteosarcoma by gene-expression profiles. Int J Oncol 24: 647-655 (2004)

  44. Daigo Y, Takayama I, Ward SM, Sanders KM. Isolation of novel mouse genes that were differentially expressed in W/WV mouse fundus. J Gastroenterol 39: 238-241 (2004)

  45. Daigo Y, Takayama I, Ponder BAJ, Caldas C, Ward SM, Sanders KM. Novel human, mouse and xenopus genes encoding a member of the RAS superfamily of low-molecular-weight GTP-binding proteins and its down-regulation in W/WV mouse jejunum. J Gastroenterol and Hepatol 19: 211-217 (2004)

  46. Suzuki C, Daigo Y, Kikuchi T, Katagiri T, Nakamura Y. Identification of COX17 as a therapeutic target for non-small cell lung cancer. Cancer Res 63: 7038-7041 (2003)

  47. Chin SF, Daigo Y, Huang HE, Iyer NG, Callagy G, Kranjac T, Gonzalez M, Sargan T, Earl H, Caldas C. A simple and reliable pretreatment protocol facilitates fluorescent in situ hybridisation on tissue microarrays of paraffin wax embedded tumour samples. Mol Pathol 56: 275-279 (2003)

  48. Zembutsu H, Ohnishi Y, Daigo Y, Katagiri T, Kikuchi T, Kakiuchi S, Nishime C, Hirata K, Nakamura Y. Gene-expression profiles of human tumor xenografts in nude mice treated orally with the EGFR tyrosine kinase inhibitor ZD1839. Int J Oncol 23: 29-39 (2003)

  49. Kakiuchi S, Daigo Y, Tsunoda T, Yano S, Sone S, Nakamura Y. Genome-wide analysis of organ-preferential metastasis of human small cell lung cancer in mice. Mol Cancer Res 1: 485-499 (2003)

  50. Daigo Y, Takayama I, Ponder BAJ, Caldas C. Ward SM, Sanders KM: Differential gene expression in the murine gastric fundus lacking interstitial cells of Cajal. BMC Gastroenterol 3: 14 (2003)

  51. Ochi K, Daigo Y, Katagiri T, Saito-Hisaminato A, Tsunoda T, Toyama Y, Matsumoto H, Nakamura Y. Expression profiles of two types of human knee-joint cartilage. J Hum Genet 48: 177-182 (2003)

  52. Kikuchi T, Daigo Y, Katagiri T, Okada K, Kakiuchi S, Zembutsu H, Furukawa Y, Nakamura Y. Expression profiles of non-small cell lung cancers on cDNA microarrays: Identification of genes for prediction of lymph node metastasis and sensitivity to anti-cancer drugs. Oncogene 22: 2192-2205 (2003)

  53. Daigo Y, Takayama I, Ponder BAJ, Caldas C, Ward SM, Sanders KM. Differential gene expression profile in the small Intestines of mice lacking pacemaker interstitial cells of Cajal. BMC Gastroenterol 3: 17 (2003)

  54. Callagy G, Cattaneo E, Daigo Y, Happerfield L, Bobrow LG, Pharoah PDP, Caldas C. Molecular classification of breast carcinomas using tissue microarrays. Diagn Mol Pathol 12: 27-34 (2003)

  55. Daigo Y, Takayama I, Ward SM, Sanders KM. Novel human and mouse genes encoding a Shank-interacting protein and its up-regulation in gastric fundus of W/WV mouse. J Gastroenterol and Hepatol 18: 712-718 (2003)

  56. Ozdag H, Batley SJ, Forsti A, Iyer NG, Daigo Y, Boutell J, Arends MJ, Ponder BAJ, Kouzarides T, Caldas C. Mutation analysis of CBP and PCAF reveals rare inactivating mutations in cancer cell lines but not in primary tumours. Br J Cancer 87: 1162-1165 (2002)

  57. Takayama I*, Daigo Y* (*equal contributors), Ward SM, Sanders KM, Walker RL, Horowitz B. Novel human and mouse genes encoding an acid phosphatase family member and its down regulation in W/Wv mouse jejunum. Gut 50, 790-796 (2002)

  58. Takayama I, Horiguchi K, Daigo Y, Mine T, Ohno S. The interstitial cells of Cajal and a gastrointestinal pacemaker system. Arch Histol Cytol 65, 1-26 (2002)

  59. Daigo Y, Chin SF, Gorringe KL, Bobrow LG, Ponder BAJ, Pharoah PD, Caldas C. Degenerate oligonucleotide primed-polymerase chain reaction-based array comparative genomic hybridization for extensive amplicon profiling of breast cancers: a new approach for the molecular analysis of paraffin-embedded cancer tissue. Am J Pathol 158, 1623-1631 (2001)

  60. Furukawa Y, Kawasoe T, Daigo Y, Nishiwaki T, Ishiguro H, Takahashi M, Kitayama J, Nakamura Y. Isolation of a novel human gene, arhgap9, encoding a rho-gtpase activating protein. Biochem Biophys Res Commun 284, 643-649 (2001)

  61. Takayama I*, Daigo Y* (*equal contributors), Ward SM, Sanders KM. Differential gene expression in the small intestines of wildtype and W/W mice. Neurogastroenterol Motil 13, 163-168 (2001)

  62. Takayama I, Daigo Y. Gastrointestinal pacemaker system. Nippon Shokakibyo Gakkai Zasshi 98, 922-934 (2001)

  63. Gayther SA, Batley SJ, Linger L, Bannister A, Thorpe K, Chin S-F, Daigo Y, Wilson A, Sowter HM, Delhanty JDA, Ponder BAJ, Kouzarides T, Caldas C. Truncating mutations of the EP300 acetylase in human cancers. Nature Genetics 24, 300-303 (2000)

  64. Daigo Y*, Satoh S* (*equal contributors), Furukawa Y, Kato T, Miwa N, Nishiwaki T, Kawasoe T, Ishiguro H, Fujita M, Tokino T, Sasaki Y, Imaoka S, Murata M, Shimano T, Yamaoka Y, Nakamura Y. AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of wild-type Axin. Nature Genetics 24, 245-250 (2000)

  65. Kawasoe T, Furukawa Y, Daigo Y, Nishiwaki T, Ishiguro H, Fujita M, Satoh S, Miwa N, Nagasawa Y, Miyoshi Y, Ogawa M, Nakamura Y. Isolation and characterization of a novel human gene, DRCTNNB1A, the expression of which is down-regulated by beta-catenin. Cancer Res 60, 3354-3358 (2000)

  66. Ishiguro H, Furukawa Y, Daigo Y, Miyoshi Y, Nagasawa Y, Nishiwaki T, Kawasoe T, Fujita M, Satoh S, Miwa N, Fujii Y, Nakamura Y. Isolation and Characterization of Human NBL4, a Gene Involved in the b-Catenin / Tcf Signaling Pathway. Jpn J Cancer Res 91, 597-603 (2000)

  67. Nishiwaki T, Daigo Y, Kawasoe T, Nakamura Y. Isolation and mutational analysis of a novel human cDNA, DEC1 (deleted in esophageal cancer 1), derived from the tumor-suppressor locus on chromosome 9q32. Genes Chromosomes Cancer 27, 169-176 (2000)

  68. Takayama I, Seto E, Zai H, Ohno S, Tezuka H, Daigo Y. Changes of in vivo gastrointestinal motor pattern in pacemaker-deficient (WsRC-Ws/Ws) rats. Dig Dis Sci 45, 1901-1906 (2000)

  69. Daigo Y, Furukawa Y, Kawasoe T, Fujita T, Ishiguro H, Sugai S, Nakamori S, Liefers GJ, Tollenaar RA, van de Velde CJ, Nakamura Y. Absence of genetic alteration at codon 531 of the human c-src gene in 479 advanced colorectal cancers from Japanese and Caucasian patients. Cancer Res 59, 4222-4224 (1999)

  70. Daigo Y, Isomura M, Nishiwaki T, Suzuki K, Maruyama O, Takeuchi K, Yamane Y, Hayashi R, Minami M, Hojo Y, Uchiyama I, Takagi T, Nakamura Y. Significant differences in the frequency of transcriptional units, types and numbers of repetitive elements, GC content, and the number of CpG islands between a 1,010-kb G-band genomic segment on chromosome 9q31.3 and a 1,200-kb R-band genomic segment on chromosome 3p21.3. DNA Res 6, 227-233 (1999)

  71. Nishiwaki T, Daigo Y, Kawasoe T, Nagasawa Y, Ishiguro H, Fujita M, Furukawa Y, Nakamura Y. Isolation and characterization of a human cDNA homologous to the Xenopus laevis XCAP-C gene belonging to the structural maintenance of chromosomes (SMC) family. J Hum Genet 44, 197-202 (1999)

  72. Daigo Y, Nishiwaki T, Kawasoe T, Tamari M, Tsuchiya E, Nakamura Y. Molecular cloning of a candidate tumor suppressor gene, DLC1, from chromosome 3p21.3. Cancer Res 59, 1966-1972 (1999)

  73. Daigo Y, Isomura M, Tamari M, Nishiwaki T, Ishikawa S, Kai M, Takeuchi K, Yamane Y, Hayashi R, Minami M, Fujino MA, Hojo Y, Uchiyama I, Takagi T, Nakamura Y. Characterization of a 1,200-kb genomic segment on chromosome 3p22-p21.3. DNA Res 6, 37-44 (1999)

  74. Tamari M, Daigo Y, Nakamura Y. Isolation and characterization of a novel serine threonine kinase gene on 3p22-p21.3. J Hum Genet 44, 116-120 (1999)

  75. Nishiwaki T, Daigo Y, Tamari M, Fujii Y, Nakamura Y. Molecular cloning, mappng and characterization of two novel human genes, ORCTL3 and ORCTL4, bearing homology to organic-cation transporters. Cytogenet Cell Genet 83, 251-255 (1998)

  76. Tamari M, Daigo Y, Ishikawa S, Nakamura Y. Genomic structure of a novel human gene (XYLB) on chromosome 3p22-->p21.3 encoding a xylulokinase-like protein. Cytogenet Cell Genet 82, 101-104 (1998)

  77. Ishikawa S, Kai M, Murata Y, Tamari M, Daigo Y, Murano T, Ogawa M, Nakamura Y. Genomic organization and mapping of the human activin receptor type IIB (hActR-IIB) gene. J Hum Genet 43, 132-134 (1998)

  78. Daigo Y, Suzuki K, Maruyama O, Miyoshi Y, Yasuda T, Kabuto T, Imaoka S, Fujiwara T, Takahashi E, Fujino MA, Nakamura Y. Isolation, mapping and mutation analysis of a human cDNA homologous to the doc-1 gene of the Chinese hamster, a candidate tumor suppressor for oral cancer. Genes Chromosomes Cancer 20, 204-207 (1997)

  79. Suzuki K, Daigo Y, Fukuda S, Tokino T, Isomura M, Isono K, Wainwright B, Nakamura Y. No evidence of mutation in the human PTC gene, responsible for nevoid basal cell carcinoma syndrome, in human primary squamous cell carcinomas of the esophagus and lung. Jpn J Cancer Res 88, 225-228 (1997)