2001 - Now
1991 - 2000
1981 - 1990
1971 - 1980
Review Articles
Proceedings
Chapters of Book
 


(2006)

Nakajima H, Takatsu K.
Role of Cytokines in Allergic Airway Inflammation.
Int Arch Allergy Immunol. 2006 Nov 22;142(4):265-273

Iwasaki H, Mizuno S, Arinobu Y, Ozawa H, Mori Y, Shigematsu H, Takatsu K, Tenen DG, Akashi K.
The order of expression of transcription factors directs hierarchical specification of hematopoietic lineages.
Genes Dev. 2006 Nov 1;20(21):3010-21.

Horikawa K, Takatsu K.
Interleukin-5 regulates genes involved in B-cell terminal maturation.
Immunology. 2006 Aug;118(4):497-508.

Wakabayashi Y, Kobayashi M, Akashi-Takamura S, Tanimura N, Konno K, Takahashi K, Ishii T, Mizutani T, Iba H, Kouro T, Takaki S, Takatsu K, Oda Y, Ishihama Y, Saitoh S, Miyake K.
A protein associated with toll-like receptor 4 (PRAT4A) regulates cell surface expression of TLR4.
J Immunol. 2006 Aug;177(3):1772-9.

Nagai Y, Garrett KP, Ohta S, Bahrun U, Kouro T, Akira S, Takatsu K, Kincade PW.
Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment.
Immunity. 2006 Jun;24(6):801-12.

Itakura A, Kikuchi Y, Kouro T, Ikutani M, Takaki S, Askenase PW, Takatsu K.
Interleukin 5 plays an essential role in elicitation of contact sensitivity through dual effects on eosinophils and B-1 cells.
Int Arch Allergy Immunol. 2006;140 Suppl 1:8-16.

Takizawa H, Kubo-Akashi C, Nobuhisa I, Kwon SM, Iseki M, Taga T, Takatsu K, Takaki S.
Enhanced engraftment of hematopoietic stem/progenitor cells by the transient inhibition of an adaptor protein, Lnk.
Blood. 2006 Apr 1;107(7):2968-75.

Kikuchi T, Uehara S, Ariga H, Tokunaga T, Kariyone A, Tamura T, Takatsu K.
Augmented induction of CD8+ cytotoxic T-cell response and antitumour resistance by T helper type 1-inducing peptide.
Immunology. 2006 Jan;117(1):47-58.

(2005)

Itakura A, Szczepanik M, Campos RA, Paliwal V, Majewska M, Matsuda H, Takatsu K, Askenase PW.
An hour after immunization peritoneal B-1 cells are activated to migrate to lymphoid organs where within 1 day they produce IgM antibodies that initiate elicitation of contact sensitivity.
J Immunol. 2005 Dec 1;175(11):7170-8.

Tsukamoto Y, Uehara S, Mizoguchi C, Sato A, Horikawa K, Takatsu K.
Requirement of 8-mercaptoguanosine as a costimulus for IL-4-dependent mu to gamma1 class switch recombination in CD38-activated B cells.
Biochem Biophys Res Commun. 2005 Oct 21;336(2):625-33.

Iwasaki H, Mizuno S, Mayfield R, Shigematsu H, Arinobu Y, Seed B, Gurish MF, Takatsu K, Akashi K.
Identification of eosinophil lineage-committed progenitors in the murine bone marrow.
J Exp Med. 2005 Jun 20;201(12):1891-7.

Ema H, Sudo K, Seita J, Matsubara A, Morita Y, Osawa M, Takatsu K, Takaki S, Nakauchi H.
Quantification of self-renewal capacity in single hematopoietic stem cells from normal and Lnk-deficient mice.
Dev Cell. 2005 Jun;8(6):907-14.

Nagai Y, Kobayashi T, Motoi Y, Ishiguro K, Akashi S, Saitoh S, Kusumoto Y, Kaisho T, Akira S, Matsumoto M, Takatsu K, Miyake K.
The radioprotective 105/MD-1 complex links TLR2 and TLR4/MD-2 in antibody response to microbial membranes.
J Immunol. 2005 Jun 1;174(11):7043-9.

Iseki M, Kubo-Akashi C, Kwon SM, Yamaguchi A, Takatsu K, Takaki S.
APS, an adaptor molecule containing PH and SH2 domains, has a negative regulatory role in B cell proliferation.
Biochem Biophys Res Commun. 2005 May 13;330(3):1005-13

Inoue H, Kato R, Fukuyama S, Nonami A, Taniguchi K, Matsumoto K, Nakano T, Tsuda M, Matsumura M, Kubo M, Ishikawa F, Moon BG, Takatsu K, Nakanishi Y, Yoshimura A.
Spred-1 negatively regulates allergen-induced airway eosinophilia and hyperresponsiveness.
J Exp Med. 2005 Jan 3;201(1):73-82.

(2004)

Tamura T, Ariga H, Kinashi T, Uehara S, Kikuchi T, Nakada M, Tokunaga T, Xu W, Kariyone A, Saito T, Kitamura T, Maxwell G, Takaki S, Takatsu K.
The role of antigenic peptide in CD4+ T helper phenotype development in a T cell receptor transgenic model.
Int Immunol. 2004 Dec;16(12):1691-9. Epub 2004 Oct 11.

Wen X, Zhang D, Kikuchi Y, Jiang Y, Nakamura K, Xiu Y, Tsurui H, Takahashi K, Abe M, Ohtsuji M, Nishimura H, Takatsu K, Shirai T, Hirose S.
Transgene-mediated hyper-expression of IL-5 inhibits autoimmune disease but increases the risk of B cell chronic lymphocytic leukemia in a model of murine lupus.
Eur J Immunol. 2004 Oct;34(10):2740-9.

Tanaka H, Komai M, Nagao K, Ishizaki M, Kajiwara D, Takatsu K, Delespesse G, Nagai H.
Role of interleukin-5 and eosinophils in allergen-induced airway remodeling in mice.
Am J Respir Cell Mol Biol. 2004 Jul;31(1):62-8. Epub 2004 Feb 19.

Moon BG, Takaki S, Miyake K, Takatsu K.
The role of interleukin-5 for mature B-1 cells in homeostatic proliferation, cell survival and Ig production.
J Immunol. 2004 May 15;172(10):6020-9.

Hirano M, Kikuchi Y, Nisitani S, Yamaguchi A, Satoh A, Ito T, Iba H, Takatsu K.
Bruton's tyrosine kinase (Btk) enhances transcriptional co-activation activity of BAM11, a Btk-associated molecule of a subunit of SWI/SNF complexes.
Int Immunol. 2004 May;16(5):747-57.

Moon BG, Takaki S, Nishizumi H, Yamamoto T, Takatsu K.
Abrogation of autoimmune disease in Lyn-deficient mice by the deletion of IL-5 receptor alpha chain gene.
Cell Immunol.
2004 Apr;228(2):110-8.

Iseki M, Kubo C, Kwon SM, Yamaguchi A, Kataoka Y, Yoshida N, Takatsu K, Takaki S.
Increased Numbers of B-1 Cells and Enhanced Responses against TI-2 Antigen in Mice Lacking APS, an Adaptor Molecule Containing PH and SH2 Domains.
Mol Cell Biol. 2004 Mar;24(6):2243-50.

Kubo-Akashi C, Iseki M, Kwon SM, Takizawa H, Takatsu K, Takaki S.
Roles of a conserved family of adaptor proteins, Lnk, SH2-B, and APS, for mast cell development, growth, and functions: APS-deficiency causes augmented degranulation and reduced actin assembly.
Biochem Biophys Res Commun.
2004 Mar 5;315(2):356-62.

Nakamura K, Kouro T, Kincade PW, Malykhin A, Maeda K, Coggeshall KM.
Src homology 2-containing 5-inositol phosphatase (SHIP) suppresses an early stage of lymphoid cell development through elevated interleukin-6 production by myeloid cells in bone marrow.
J Exp Med. 2004 Jan 19;199(2):243-54. Epub 2004 Jan 12.

(2003)

Nobuhisa I, Takizawa M, Takaki S, Inoue H, Okita K, Ueno M, Takatsu K, Taga T.
Regulation of hematopoietic development in the aorta-gonad-mesonephros region mediated by Lnk adaptor protein.
Mol Cell Biol. 2003 Dec;23(23):8486-94.

Minami A, Iseki M, Kishi K, Wang M, Ogura M, Furukawa N, Hayashi S, Yamada M, Obata T, Takeshita Y, Nakaya Y, Bando Y, Izumi K, Moodie SA, Kajiura F, Matsumoto M, Takatsu K, Takaki S, Ebina Y.
Increased insulin sensitivity and hypoinsulinemia in APS knockout mice.
Diabetes. 2003 Nov;52(11):2657-65.

Kariyone A, Tamura T, Kano H, Iwakura Y, Takeda K, Akira S, Takatsu K.
Immunogenicity of Peptide-25 of Ag85B in Th1 development: role of IFN-gamma.
Int Immunol.
2003 Oct;15(10):1183-94.

Takatsu K, Kariyone A.
The immunogenic peptide for Th1 development.
Int Immunopharmacol.
2003 Jun;3(6):783-800.

Suzuki H, Matsuda S, Terauchi Y, Fujiwara M, Ohteki T, Asano T, Behrens TW, Kouro T, Takatsu K, Kadowaki T, Koyasu S.
PI3K and Btk differentially regulate B cell antigen receptor-mediated signal transduction.
Nat Immunol.
2003 Mar;4(3):280-6.

Matsumoto N, Katoh S, Mukae H, Matsuo T, Takatsu K, Matsukura S.
Critical Role of IL-5 in Antigen-Induced Pulmonary Eosinophilia, but Not in Lymphocyte Activation.
Int Arch Allergy Immunol. 2003 Mar;130(3):209-15.

El-Malky M, Maruyama H, Hirabayashi Y, Shimada S, Yoshida A, Amano T, Tominaga A, Takatsu K, Ohta N.
Intraepithelial infiltration of eosinophils and their contribution to the elimination of adult intestinal nematode, Strongyloides venezuelensis in mice.
Parasitol Int.
2003 Mar;52(1):71-9.

Takaki S, Tezuka Y, Sauer K, Kubo C, Kwon SM, Armstead E, Nakao K, Katsuki M, Perlmutter RM, Takatsu K.
Impaired lymphopoiesis and altered B cell subpopulations in mice overexpressing Lnk adaptor protein.
J Immunol. 2003 Jan 15;170(2):703-10.

(2002)

Kaku H, Horikawa K, Obata Y, Kato I, Okamoto H, Sakaguchi N, Gerondakis S, Takatsu K.
NF-kappaB is required for CD38-mediated induction of C(gamma)1 germline transcripts in murine B lymphocytes.
Int Immunol.
2002 Sep;14(9):1055-64.

Ohtsuka S, Takaki S, Iseki M, Miyoshi K, Nakagata N, Kataoka Y, Yoshida N, Takatsu K, Yoshimura A.
SH2-B is required for both male and female reproduction.
Mol Cell Biol. 2002 May;22(9):3066-77.

Saito H, Matsumoto K, Denburg AE, Crawford L, Ellis R, Inman MD, Sehmi R, Takatsu K, Matthaei KI, Denburg JA.
Pathogenesis of murine experimental allergic rhinitis: a study of local and systemic consequences of IL-5 deficiency.
J Immunol.
2002 Mar 15;168(6):3017-23.

Takaki S, Morita H, Tezuka Y, Takatsu K.
Enhanced hematopoiesis by hematopoietic progenitor cells lacking intracellular adaptor protein, Lnk.
J Exp Med.
2002 Jan 21;195(2):151-60.

(2001)

    Horikawa, K., H. Kaku, H. Nakajima, H.W. Davey, L. Henninghausen, I. Iwamoto, T. Yasue, A. Kariyone, and K. Takatsu.
    Essential role of signal transducer and activator of transcription (Stat) 5 for interleukin-5-dependent IgH switch recombination in mouse B cells.
    J. Immunol
    . 167: 5018-5026, 2001.

    Nikawa, T., M. Ikemoto, M. Kano, K. Tokuoka, K. Hirasawa, S. Uehara, K. Takatsu, and K. Kishi.
    Impaired Vitamin A-mediated mucosal IgA response in IL-5 receptor-knockout mice.
    Biolchem. Biophys. Res. Commun.
    285: 546-549, 2001.

    Tamura T, Igarashi O, Hino A, Yamane H, Aizawa S, Kato T, Nariuchi H.
    Impairment in the expression and activity of Fyn during differentiation of naive CD4+ T cells into the Th2 subset.
    J. Immunol. 167: 1962-1969, 2001

    Yamada A*, Takaki S*, Hayashi F, Georgopoulos K, Perlmutter RM, Takatsu K. (*equally contributed authors)
    Identification and characterization of a transcriptional regulator for the lck proximal promoter.
    J. Biol. Chem.
    276:18082-18089, 2001.

    Yun, J., Oh, S.-R., Lee, H-K. Chang, I-M., Takatsu, K., Yun, Y-P., Min, K. R., and Kim, Y.
    Effect of genistein analogs on oxygen radical production in leukocytes stimulated by unopsonized zymosan.
    Planta Med. 67: 274-276, 2001.

    Tanaka, H., Kawada N, Kawada K, Takatsu K, Nagai H.
    Effect of repeated antigen inhalation on airway inflammation and bronchial responsiveness to acetylcholine in interleukin-5 transgenic mice. Allergol. Int. 50: 89-98, 2001.

    Kouro T, Nagata K, Takaki S, Nisitani S, Hirano M, Wahl MI, Witte ON, Karasuyama H, Takatsu K.
    Bruton's tyrosine kinase is required for signaling the CD79b-mediated pro-B to pre-B cell transition.
    Int Immunol. 2001 Apr;13(4):485-493.

    Moon BG, Yoshida T, Shiiba M, Nakao K, Katsuki M, Takaki S, Takatsu K. Functional dissection of the cytoplasmic subregions of the interleukin-5 receptor alpha chain in growth and immunoglobulin G1 switch recombination of B cells.
    Immunology. 2001 Mar;102(3):289-300.

    Miki S, Horikawa K, Nishizumi H, Suemura M, Sato B, Yamamoto M, Takatsu K, Yamamoto T, Miki Y.
    Reduction of atherosclerosis despite hypercholesterolemia in lyn-deficient mice fed a high-fat diet.
    Genes Cells
    . 2001 Jan;6(1):37-42.

    Shin EH, Osada Y, Sagara H, Takatsu K, Kojima S.
    Involvement of complement and fibronectin in eosinophil-mediated damage to Nippostrongylus brasiliensis larvae.
    Parasite Immunol. 2001 Jan;23(1):27-37.