2001 - Now
1991 - 2000
1981 - 1990
1971 - 1980
Review Articles
Chapters of Book


Takaki S, Sauer K, Iritani BM, Chien S, Ebihara Y, Tsuji K, Takatsu K, Perlmutter RM.
Control of B cell production by the adaptor protein lnk. Definition Of a conserved family of signal-modulating proteins. Immunity. 2000 Nov;13(5):599-609.

    Uchino S, Noguchi S, Sato M, Yamashita H, Yamashita H, Watanabe S, Murakami T, Toda M, Ohshima A, Futata T, Mizukoshi T, Koike E, Takatsu K, Terao K, Wakiya S, Nagatomo M, Adachi M.
    Screening of the Men1 gene and discovery of germ-line and somatic mutations in apparently sporadic parathyroid tumors. Cancer Res. 2000 Oct 1;60(19):5553-7.

    Kikuchi Y, Hirano M, Seto M, Takatsu K.
    Identification and characterization of a molecule, BAM11, that associates with the pleckstrin homology domain of mouse Btk. Int Immunol. 2000 Oct;12(10):1397-408.

    Yun J, Lee CK, Chang IM, Takatsu K, Hirano T, Min KR, Lee MK, Kim Y. Differential inhibitory effects of sophoricoside analogs on bioactivity of several cytokines. Life Sci. 2000 Oct 27;67(23):2855-63.

    Kinashi T, Katagiri K, Watanabe S, Vanhaesebroeck B, Downward J, Takatsu K. Distinct mechanisms of alpha 5beta 1 integrin activation by Ha-Ras and R-Ras. J Biol Chem. 2000 Jul 21;275(29):22590-6.

    Tanaka H, Kawada N, Yamada T, Kawada K, Takatsu K, Nagai H.
    Allergen-induced airway inflammation and bronchial responsiveness in interleukin-5 receptor alpha chain-deficient mice. Clin Exp Allergy. 2000 Jun;30(6):874-81.

    Iseki M, Takaki S, Takatsu K.
    Related Articles, Protein, Nucleotide Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins. Biochem Biophys Res Commun. 2000 May 27;272(1):45-54.

    Katagiri K, Hattori M, Minato N, Irie Sk, Takatsu K, Kinashi T.
    Rap1 is a potent activation signal for leukocyte function-associated antigen 1 distinct from protein kinase C and phosphatidylinositol-3-OH kinase. Mol Cell Biol. 2000 Mar;20(6):1956-69.

    Okuda H, Nakanishi T, Takatsu K, Saito A, Hayashi N, Takasaki K, Takenami K, Yamamoto M, Nakano M.
    Serum levels of des-gamma-carboxy prothrombin measured using the revised enzyme immunoassay kit with increased sensitivity in relation to clinicopathologic features of solitary hepatocellular carcinoma. Cancer. 2000 Feb 1;88(3):544-9.

    Kagami Si, Nakajima H, Kumano K, Suzuki K, Suto A, Imada K, Davey HW, Saito Y, Takatsu K, Leonard WJ, Iwamoto I.
    Both stat5a and stat5b are required for antigen-induced eosinophil and T-cell recruitment into the tissue. Blood. 2000 Feb 15;95(4):1370-7.


    Nagai H. Ueda Y. Tanaka H. Hirano Y. Nakamura N. Inagaki N. Takatsu K. Kawada K.
    Effect of overproduction of interleukin 5 on dinitrofluorobenzene-induced allergic cutaneous response in mice. J. Pharmacol. Exp. Ther. 1999 Jan; 288(1): 43-50.

    Hiroi, T., M. Yanagida, H. Iijima, K. Iwatani, T. Yoshida, Takatsu, K., and Kiyono, H.
    Deficiency of IL-5 receptor a chain selectively influences on the development of IgA producing B-1 cell in mucosa associated tissues. J. Immunol. 162: 821-828, 1999.

    Kinashi, T., Asaoka, T., Sagara, H., Setoguchi, R., Hirosawa, K., and Takatsu, K.
    Regulated adhesion by modulating affinity and subcellular localization of integrin VLA-5 (a5b1) in mast cells. J. Immunol. 162: 2850-2857, 1999.

    Mizoguchi, C., S. Uehara, S. Akira, and K. Takatsu.
    Interleukin-5 Induces IgG1 Isotype Switch Recombination in mouse CD38-Activated sIgD-Positive B Lymphocytes. J. Immunol. 162: 2812-2819, 1999.

    Yasue, T., Baba, M., S. Mori, C. Mizoguchi, S. Uehara, and K. Takatsu.
    IgG1 production by IgD+ splenic B cells and peritoneal B-1 cells in response to IL-5 and CD38 ligatioin. Int. Immunol.1999 June (6); 11: 915-923.

    Sakiyama, T., S. Nishitani, K. Ikuta, K. Takatsu. and T. Honjo.
    Requirement of interelukin-5 for induction of autoimmune hemolytic anemia in the anti-red blood cell autoantibody transgenic mice. Int. Immunol.1999 June (6); 11:995-1000

    Naito, A., S. Azuma, S. Tanaka, T. Miyazaki, S. Takaki, K. Takatsu, K. Nakao, K. Nakamura, M. Katsuki, T. Yamamoto, and J.-I. Inoue.
    Severe osteopetrosis and impaired hematopoietic cell development in TRAF6-/- mice. Genes Cells 1999 July 1 (7); 4: 353-362.

    Chai J-Y, Shin E-H, Takatsu K, Matsumoto, N, Kojima S.
    Eosinophil and IgE responses of IL-5 transgenic mice experimentally infected with Nippostrongylus brasilliensis. Korean J. Parasitol. 1999 June; 37(2):93-99.

    Horikawa, K., H. Nishizumi, H. Umemori, S. Aizawa. K. Takatsu, and T. Yamamoto.
    Distinctive roles of Fyn and Lyn in IgD- and IgM-mediated signal. Int. Immunol. 1999 Sep 1 (9); 11:1441-1449.

    Min, B., S. R Oh, H-K. Lee, K. Takatsu, I-M. Chang, K.P. Ming, and Y. Kim.
    Sophoricoside analogs as the IL-5 inhibitors from Sophora japonica. Planta Med. 65: 408-412, 1999.

    Kariyone, A., K. Higuchi, S. Yamamoto, A. N. Kametaka, M. Harada, A. Takahashi, N. Harada, K. Ogasawara, and K. Takatsu.
    Identification of amino acid _residues of the T-cell epitope of Mycobacteiurm tuberculosis _ antigen critical for Vb11+abTh1 cells. Infect. Immun. 1999 Sep 1; 67(9); 4312-4319.


    Takahashi, K., Miyakawa, K., Wynn, A. A., Nakayama, K-I., Myint, Y. Y., Naito, M., Shiltz, L. D., Tominaga, A., and Takatsu, K.
    Effects of granulocyte/macrophage colony-stimulating factor on the development and differentiation of CD5- positive macrophages and their derivation from a CD5-positive B cell lineage in mice. Am. J. Pathol. 152:445-456, 1998.

    Ogata, N., T. Kouro, A. Yamada, M. Koike, N. Hanai, T. Ishikawa, and K. Takatsu.
    An interleulin 5 (IL-5) receptor a subunit provides a binding site for IL-5 and functional signaling molecules as well. Blood 91:2264-2271, 1998.

    Hirota, J., Baba, M., Matsumoto, M., Furuichi, T., Takatsu, K., and Mikoshiba, K.
    T-cell-receptor signaling in inositol 1,4,5-triphosphate receptor (IP3R) type-1-deficient mice: is IP3R type 1 essential for T-cell-receptor signaling? Biochem. J. 333: 615-619, 1998.

    Setoguchi, R., T. Kinashi, H. Sagara, K. Hirosawa, and K. Takatsu.
    Defective granulation and calcium mobilization of bone-marrow derived mast cells frm Xid and Btk-deficient mice. Immunol. Lett. 64 : 109-118, 1998.


    Numata, F., Y. Hitoshi, S. Uehara, and K. Takatsu.
    B cells with abnormal Btk are responsible for the development of murine aquired immunodeficiency syndrome, MAIDS. Int. Immunol. 9:139-146, 1997.

    Yanagisawa, S., M. Koike, S. Nagai, and K. Takatsu.
    Induction of Vb11+ T cells by stimulation of Mycobacterium-primed cells with synthetic peptide. Int. Immunol. 9:227-238, 1997.

    Tokui, M., I. Takei, F. Tashiro, A. Shimada, A. Kasuga, M. Ishii, T. Ishii, K. Takatsu, T. Saruta, and J.-I. Miyazaki.
    Intramuscular injection of expression plasmid DNA is an effective means of long-term systemic delivery of interleukin-5. Biochem. Biophy. Res. Commun. 233:527-533 1997.

    Takahashi, T., T. Yagi, S. Kakinuma, A. Kurokawa, T. Okada, K. Takatsu, S. Aizawa, and T. Karagiri.
    Suppression of autoimmune disease and of massive lymphadenopathy in MRL/MP-lpr/lpr mice lacking tyrosine kinase fyn (p59fyn). J. Immunol. 159: 2532-2541, 1997.

    Yasue, T., H. Nishizumi, S. Aizawa, T. Yamamoto, K. Miyake, C. Mizoguchi, S. Uehara, Y. Kikuchi, and K Takatsu.
    A critical role of Lyn and Fyn for B cell responses to CD38 ligation and interleukin-5. Proc. natl. Acad. Sci. USA 94: 10307-10312, 1997.

    Baba, M., Y. Kikuchi, S. Mori, M. Kimoto, S. Inui, N. Sakaguchi, T. Takemori, M. Howard, and K. Takatsu.
    The role of CD40 ligation and cytokines in differentiation of mouse germinal center B cells towards antigen-specific antibody-forming cells: functional defects of germinal center B cells of XID mice. Int. Immunol. 9:1463-1473, 1997.

    Gon, S., Saito S., Takeda Y., Miyata H., Takatsu K. and Sendo F.
    Apoptosis and in vivo distribution and clearance of eosinophils in normal and Trichinella spiralis-infected rats. J. Leukoc. Biol. 62: 309-317, 1997.

    Ogata, N., AND K. Takatsu.
    Signal transduction through human IL-5 receptor a chain in eosinophils. Int. Arch. Allergy Immunol. 114 (suppl 1): 24-27, 1997.


Yoshida T, Ikuta K, Sugaya H, Maki K, Takagi M, Kanazawa H, Sunaga S, Kinashi T, Yoshimura K, Miyazaki J, Takaki S, Takatsu K.
Defective B-1 cell development and impaired immunity against Angiostrongylus cantonensis in IL-5R alpha-deficient mice. Immunity. 4:483-94, 1996.

    Shiiba, M., S. Takaki, and K. Takatsu.
    Interleukin-3 (IL-3) and granulocyte- macrophage colony-stimulating factor (GM-CSF) can induce differentiation of chronic B cell leukemia expressing the a subunit of IL-3 and GM-CSF receptor. Int. Arch. Allergy Immunol. 111: 11-14, 1996.

    Sugane, K., Y. Kusama, M. Takamoto, A. Tominaga, and K. Takatsu.
    Eosinophilia, IL-5 level and recovery of larvae in IL-5 transgenic mice infected with Toxocala canis:. J. Helminthol.70:153-158, 1996.

    Ohbo, K., H. Asao, T. Kohro, K. Ohtani, Y. Kikuchi , S,. Takaki, A. Tominaga, M. Nakamura, K. Takatsu, and K. Sugamura.
    Demonstration of a cross-talk between IL-2 and IL-5 in phosphorylation of IL-2 and IL-5 receptor b chain. Int. Immunol. 8: 951-960, 1996.

    Kouro, T., Y. Kikuchi, H. Kanazawa, K. Hirokawa, N. Harada, M. Shiiba, D. Cosman, H. Wakao, S. Takaki, and K. Takatsu.
    Critical residues of cytoplasmic domain of the IL-5 receptor a chain and its function in IL-5-mediated activation of JAK kinase and STAT5. Int. Immunol. 8:237-246, 1996.

    Koike, M., Y. Kikuchi, A. Tominaga, S. Takaki, K. Akagi, J.-I. Miyazaki, K.-I. Yamamura, and K. Takatsu.
    Defect of IL-5-receptor-mediated signaling in B cells of X-linked immuno-deficient (XID) mice. Int. Immunol. 7:21-30, 1995.

    Takagi, M., T. Hara, M. Ichihara, K. Takatsu, and A. Miyajima.
    Multi-colony stimulating activity of interleukin-5 (IL-5) on hematopoietic progenitors from the transgenic mouse that express IL-5 receptor a subunit constitutively. J. Exp. Med. 181:889-899, 1995.

    Akutsu, I., K. Kojima, A. Kariyone, T. Fukuda, S. Makino, and K. Takatsu.
    Antibody against interleukin-5 prevents antigen-induced eosinophil infiltration and hyperreactivity in the guinea pig airways. Immunol. Lett. 45:109-116,1995.

    Okubo, Y., M. Hossain, R. Kai, E. Sato, T. Honda, M. Sekiguchi, S. Itoh, and K. Takatsu.
    Adhesion molecules on eosinophils in an acute eosinophilic pneumonia. Am. J. Respir. Crit. Care. Med. 151:1259-1262, 1995.

    Yamaguchi, S., Y. Okubo, M. Hossain, K. Fujimoto, T. Honda, T. Kobayashi, M. Sekiguchi, and k. Takatsu.
    IL-5 is predominant in BALF and peripheral blood in a patient with acute eosinophil pneumonia. Intn. Med. 34:65-68, 1995.

    Li, T., S. Tsukada, A. Satterthwaite, H. Park, M. H. Havlik, K. Takatsu, and O. N. Witte.
    Oncogenic activation of Bruton's tyrosine kinase (BTK) by a point mutation in its pleckstrin homology (PH) domain. Immunity 2:451-460, 1995.

    Yamashita, Y., K. Miyake, Y. Kikuchi, K. Takatsu, and M. Kimoto.
    A monoclonal antibody against murine CD38 homologue delivers a signal into B cells for prolongation of survival and protection against apoptosis in vitro: Unresponsiveness of X-linked immunodeficient B cells. Immunology 85:248- 255, 1995.

    Iwamoto, I., and K. Takatsu.
    Evaluation of hyperreactivity in the airways in IL-5 transgenic mouce. Int. Arch. Allergy Immunol., 108 (Suppl):28-30, 1995.

    Korenaga, M., Y. Hitoshi, K. Takatsu, and I. Tada.
    Regulatory effect of anti-IL-5 monoclonal antibody on intestinal worm burden in a primary infection with Strongyloides venezuelensis in mice. J. Parasitol. 69:119-123, 1995.

    Makino, M., K. Yoshimatsu, M. Azuma, Y. Okada, Y. Hitoshi, H. Yagita, K. Takatsu, and K. Komuro.
    Rapid development of murine AIDS is dependent on signals provided by CD54 and CD11a. J. Immunol. 155:974-981, 1995.

    Kinashi, T., J. A. Escobedo, L. T. Williams, K. Takatsu, and T. A. Springer.
    Receptor tyrosine kinase stimulates cell-matrix adhesion by phosphatidylinositol 3- kinase and phospholipase C-g1 pathways. Blood, 86: 2086-2090, 1995.

    Kikuchi, K., T. Yasue, Y. Yamashita, K. Miyake, M. Kimoto, and K. Takatsu.
    CD38 ligation induces Btk activation and enhanced expression of IL-5 receptor a chain. ハProc. Natl. Acad. Sci. USA, 92:10879-10883, 1995.

    Kikuchi, Y., M. Migita, S. Takaki, A. Tominaga, and K. Takatsu.
    Biochemical and functional characterization of soluble form of IL-5 receptor a (sIL-5Ra): Development of ELISA system for detection of sIL-5Ra. J. Immunol. Methods 167:289-298, 1994.

    Imamura, F., S. Takaki, K. Akagi, J.-I. Miyazaki, K.-I. Yamamura, K. Takatsu, and A. Tominaga.
    Structure of genomic DNA for detection of sIL-5Ra. DNA Cell Biol. 13:283-292, 1994.

    Takaki, S. and K. Takatsu.
    Reconstitution of the functional interleukin-5 receptor: the cytoplasmic domain of alpha-subunit plays an important role in growth signal transduction. Int. Arch. Allergy Immunol. 104:36-38, 1994.

    Miyake, K., Y. Yamashita, Y. Hitoshi, K. Takatsu, and M. Kimoto.
    Murine B cell proliferation and protection from apoptosis with an antibody against a 105- kDa molecule: Unrewsponsiveness of X-linked immunodeficient B cells. J. Exp. Med. 180:1217-1224, 1994.

    Takaki, S., H. Kanazawa, M. Shiiba, and K. Takatsu.
    Critical cytoplasmic domain of the IL-5R a chain and its function in IL-5-mediated growth signal transduction. Mol. Cell. Biol. 12:7404-7413, 1994.

    Satoh, S., T. Katagiri, S. Takaki, Y. Kikuchi, Y. Hitoshi, S. Yonehara, S. Tsukada, D. Kitamura, T. Watanabe, O. N. Witte, and K. Takatsu.
    IL-5 receptor-mediated tyrosine phosphorylation of SH2/SH3-containing proteins and activation of Bruton's tyrosine and JAk2 kinases. J. Exp. Med. 180:2101-2111, 1994.

    Uehara, S., Y. Hitoshi, F. Numata, M. Makino, M. Howard, T. Mizuochi, and K. Takatsu.
    IFN-g-dependent pathway plays a critical role in the pathogenesis of murine immunodeficiency syndrome induced by LP-BM5 murine leukemia virus. Int. Immunol. 6:1937-1947, 1994.

    Hitoshi, Y., Y. Okada, W. Sonoda, A. Tominaga, M. Makino, K. Suzuki, J. Kinoshita, K. Komura, T. Mizuochi, and K. Takatsu.
    Delayed progression of a murine retrovirus-induced acquired immunodeficiency syndrome, MAIDS, in X- linked immunodeficient mice. J. Exp. Med. 177:621-626, 1993.

    Hitoshi, Y., E. Sonoda, Y. Kikuchi, S. Yonehara, H. Nakauchi, and K. Takatsu.
    Interleukin-5 receptor positive B cells, but not eosinophils are functionally and numerically influenced in the mice carried with X-linked immunedeficiency. Int. Immunol. 5:1183-1190, 1993.

    Corrigan, C. J., A. Haczku, V. Gemou-Engesaeth, S. Doi, Y. Kikuchi, K. Takatsu, S. R. Durham, and A. B. Kay.
    CD4-T lymphocyte activation in asthma is accompanied by increased serum concentrations of interleukin-5: Effect of glucocorticoid therapy. Am. Rev. Resp. Dis. 147:540-547, 1993.

    Takaki, S., Y. Murata, T. Kitamura, A. Miyajima, A. Tominaga, and K. Takatsu.
    Reconstitution of the functional receptors for murine and human interleukin 5. J. Exp. Med. 177:1523-1529, 1993.

    Katoh, S., M. M. Bendig, Y. Kanai, L. D. Schultz, Y. Hitoshi, K. Takatsu, and A. Tominaga.
    Maintenance of CD5+ B cells at early developmental stage by interleukin-5: Evidence from immunoglobulin gene usage in interleukin-5 transgenic mice. DNA Cell. Biol., 5:481-491, 1993.

    Mita, S., S. Takaki, A. Tominaga, and K. Takatsu.
    Comparative analysis of kinetic binding, internalization, and degradation of IL-5 receptors of high- and low- affinity. J. Immunol. 151:6924-6932, 1993.

    Motojima, S., I. Akutsu, T. Fukuda, S. Makino, and K. Takatsu.
    Clinical significance of mearing levels of sputum and serum ECP and serum IL-5 in bronchial asthma. Allergy 48:98-106, 1993.

    Murata, Y., S. Takaki, M Migita, Y. Kikuchi, A. Tominaga, and K. Takatsu.
    Molecular cloning and expression of the human interleukin 5 receptor. J. Exp. Med. 175:341-351, 1992.

    Sonoda, E., Y. Hitoshi, N. Yamaguchi, T. Ishii, A. Tominaga, S. Araki, and K. Takatsu.
    Differential regulation of IgA production by TGF-b and IL-5: TGF-b induces surface IgA-positive B cells bearing IL-5 receptor, whereas IL-5 promotes their survival and maturation into IgA-secreting cells. Cell. Immunol. 144:1132-1139, 1992.

    Iwamoto, I., S. Tomoe, H. Tomioka, K. Takatsu, and S. Yoshida.
    Role of CD4+ T lymphocytes and interleukin-5 in antigen-induced eosinophil recruitment into the site of cutaneous late-phase reaction in mice. J. Leukoc. Biol. 52:572- 578, 1992.

    Nakajima, H., I. Iwamoto, S. Tomoe, R. Matsumura, H. Tomioka, K. Takatsu, and S. Yoshida.
    CD4+ T-lymphocytes and interleukin-5 mediate antigen-induced eosinophil infiltration into the mouse trachea. Amr. Rev. Respir. Dis. 146:374-377, 1992.

    Matsumoto, R., M. Ando, S. Araki, and K. Takatsu.
    Interleukin-5 levels of pleural fluid and serum samples in a patient with PIE syndrome. Chest 102:1296-1298, 1992.

    Isobe, M., Y. Kumura, Y. Murata, S. Takaki, A. Tominaga, K. Takatsu, and Z. Ogita.
    Localization of the gene encoding human interleukin-5 receptor (IL-5R) chromosome region, 3p24-3p26. Genomics 14:755-758, 1992.

    Tominaga, A., S. Takaki, N. Koyama, S. Katoh, R. Matsumoto, M. Migita, Y. Hitoshi, Y. Hosoya, S. Yamauchi, Y. Kanai, J. Miyazaki, G. Usuku, K. Yamaura, and K. Takatsu.
    Transgenic mice expressing a B cell growth and differentiation factor gene (interleukin 5) develop eosinophilia and autoantibody production. J. Exp. Med. 173: 429-438, 1991.

    Migita, M., N. Yamaguchi, S. Mita, Y. Hitoshi, S. Higuchi, Y. Yoshida, I. Matsuda, M. Tomonaga, and K. Takatsu. Cell Immunol. 133:484-497,1991. Hitoshi, Y., N. Yamaguchi, M. Korenaga, S. Mita, A. Tominaga, and K. Takatsu.
    In vivo administration of antibody to murine IL-5 receptor inhibits eosinophilia of IL-5 transgenic mice. Int. Immunol. 3:135-139, 1991.

    Mita, S., S. Takaki, Y. Hitoshi, A. G. Rolink, A. Tominaga, N. Yamaguchi, and K. Takatsu.
    Molecular characterization of the b chain of the murine interleukin 5 (IL-5) receptor. Int. Immunol. 3:665-672, 1991.

    Yamaguchi, N., Y. Hitoshi, S. Takaki, Y. Murata, M. Migita, T. Kamiya, J. Minowada, A. Tominaga, and K. Takatsu.
    Murine interleukin 5 receptor isolated by immunoaffinity chromatogr-aphy: comparison of determined N- terminal sequence and deduced primary sequence from cDNA and implication of a role of the intracytoplasmic domain. Int. Immunol. 3:889- 898, 1991.

    Takaki, S., S. Mita, T. Kitamura, S. Yonehara, A. Tominaga, N. Yamaguchi, A. Miyajima, and K. Takatsu.
    Identification of the second subunit of the murine interleukin 5 receptor: interleukin-3 receptor-like protein, AIC2B is a component of the high affinity interleukin-5 receptor EMBO J. 10:2833-2838, 1991.