2001 - Now
1991 - 2000
1981 - 1990
1971 - 1980
Review Articles
Proceedings
Chapters of Book
 

(1981-1990)
Takaki, S., A. Tominaga, Y. Hitoshi S. Mita, E. Sonoda, N. Yamaguchi, and K. Takatsu.
Molecular cloning and expression of the murine interleukin 5 receptor. EMBO J. 9:4367-4374, 1990.

Murata, Y., N. Yamaguchi, Y. Hitoshi, A. Tominaga, and K. Takatsu.
Interleukin 5 and interleukin 3 induce serine and tyrosine phosphorylations of several cellular proteins in an interleukin 5-dependent cell line. Biochem. Biophys. Res. Commun. 173:1102-1108, 1990.

Yamaguchi, N., Y. Hitoshi, S. Mita, Y. Hosoya, Y. Murata, Y. Kikuchi, A. Tominaga, and K. Takatsu.
Characterization of the murine interleukin 5 receptor by using a monoclonal antibody. Int. Immunol. 2:181-187, 1990.

Tominaga, A., T. Takahashi, Y. Kikuchi, S. Mita, S. Naomi, N. Harada, N. Yamaguchi, and K. Takatsu.
Role of carbohydrate moiety of IL-5: Effect of tunicamycin on the glycosylation of IL-5 and the biologic activity of deglycosylated IL-5. J. Immunol. 144:1345-1352, 1990.

Taguchi, T., J. R. McGhee, R. L. Coffman, K. W. Beagley, J. H. Eldrige, K. Takatsu, and H. Kiyono.
Detection of individual mouse splenic T cell producing IFNg and IL-5 using the enzyme-linked immunospot (ELISPOT) assay. J. Immunol. Methods 128:65-73, 1990.

Hitoshi, Y., N. Yamaguchi, S. Mita, S. Takaki, A. Tominaga, and K. Takatsu.
Distribution of IL-5 receptor-positive B cells: Expression of IL-5-receptor on Ly-1(CD5)+ B cells. J. Immunol. 53:4218-4325, 1990.

Yamaguchi, Y., T. Suda, J. Suda, Y. Miura, S. Mita Y. Hitoshi A. Tominaga, and K. Takatsu.
Analysis of eosinophil-predominant colonies formed by human hemopoietic precursor cells in the presence of purified interleukin-5. Acta. Hematol. JPN. 144:688-698, 1990.

Yamaguchi, Y., T. Suda, K. Nakano, H. Shiozaki, Y. Miura, Y. Hitoshi, A. Tominaga, K. Takatsu, and T. Kasahara.
Role of IL-5 in IL-2 eosinophilia: In vivo and in vitro expression of IL-5 mRNA by IL-2. J. Immunol. 145:873-877, 1990.

Takahashi, T., N. Yamaguchi, S. Mita, Y. Yamaguchi, T. Suda, A. Tominaga, Y. Miura, and K. Takatsu.
The important role of dimer formation of IL-5 in the expression of its biological activity. Mol. Immunol. 27:911-920, 1990.

Enokihara, H., H. Kajitani, S. Nagashima, S. Tsunogake, N. Takano, K. Saito, S. Furusawa, H. Shishido, Y. Hitoshi, and K. Takatsu.
Interleukin 5 activity in sera from patients with eosinophilia. Brit. J. Hematol. 75:458-462, 1990.

Taguchi, T., J. R. McGhee, R. L. Coffman, K. W. Beagley, J. H. Eldridge, K. Takatsu, and H. Kiyono.
Analysis of Th1 and Th2 cells in murine gut-associated tissues: Frequencies of CD4+ and CD8+ T cells that secrete IFN-g and IL-5. J. Immunol. 145:68-77, 1990.

Kato, S., A. Tominaga, M. Migita, A. Kudo, and K. Takatsu.
Conversion of Ly-1- positive B-lineage cells into Ly-1-positive macrophages in long-term bone marrow cultures. Dev. Immunol. 1:113-126, 1990

Yamaguchi, Y., T. Suda, K. Nakano, H. Shiozaki, Y. Miura, Y. Hitoshi, A. Tominaga, K. Takatsu, and T. Kasahara.
Role of IL-5 in IL-2 eosinophilia: In vivo and in vitro expression of IL-5 mRNA by IL-2. J. Immunol. 145:873-877, 1990.

Blankenstein, T., W. Li, K. Uberla, Z. Qin, A. Tominaga, K. Takatsu, N. Yamaguchi, and T. Diamanstein.
Retroviral interleukin 5 gene transfer into interleukin 5 dependent growing cell lines results in autocrine growth and tumorigenicity. Eur. J. Immunol. 20:2699-2705, 1990.

Migita, M., N. Yamaguchi, S. Kato, S. Mita, R. Matsumoto, E. Sonoda, H. Tsuchiya, I Matsuda, A. Tominaga, and K. Takatsu.
Elevated expression of c-myc proto- oncogene during interleukin 5-induced growth and differentiation of murine B lineage cells. Microbiol. Immunol. 34:937-952, 1990.

Okudaira, H., M. Nogami, G. Matsuzaki, M. Dohi, M. Suko, S. Kasuya, and K. Takatsu.
T-cell-dependent accumulation of eosinophils in the lung and its inhibition by monoclonal anti-interleukin-5. Int. Arch. Allergy Appl. Immunol. 94:171-173, 1990.

Matsumoto, R., M. Matsumoto, S. Mita, Y. Hitoshi, M. Ando, S. Araki, N. Yamaguchi, A. Tominaga, and K. Takatsu. Interleukin 5 induces maturation but not Cclass- switching of surface IgA-positive B cells into IgA-secreting cells. Immunology 66:32-38, 1989.

Tominaga, A., S. Mita, Y. Kikuchi, Y. Hitoshi, S-I.Nishikawa, M. Ogawa, and K. Takatsu.
Establishment of IL-5 dependent early B cell lines by long-term bone marrow cultures. Growth Factors 1:135-146, 1989.

Mita, S., A. Tominaga, Y. Hitoshi, T. Honjo, K. Sakamoto, M. Akagi, Y. Kikuchi, N. Yamaguchi, and K. Takatsu.
Characterization of high-affinity receptors for interleukin-5 on interleukin-5 dependent cell lines. Proc. Natl. Acad. Sci. USA, 86:2311-2315, 1989.

Hitoshi, Y., S. Mita, A. Tominaga, Y. Kikuchi, E. Sonoda, Y. Watanabe, and K. Takatsu.
Interferon-gamma Inhibits the Proliferation but not the Differentiation of Murine B Cells in Response to IL-5. Int. Immunol., 1:185- 190, 1989.

Tsujimoto, R., H. Adachi, S. Kodama, N. Tsuruoka, N. Y. Yamada, S. Tanaka, S. Mita, and K. Takatsu.
Purification and characterization of recombinant Hhuman interleukin 5 expressed in Chinese hamster ovary cell. J. Biochem (Tokyo). 106:23-28, 1989.

Sonoda, E., R. Matsumoto, Y. Hitoshi, S. Mita, T. Ishii, M. Sugimoto, S. Araki, A. Tominaga, N. Yamaguchi, and K. Takatsu.
Transforming growth factor-b induces IgA production and acts additively with IL-5 for IgA production. J. Exp. Med., 170:1415-1420, 1989.

Yamaguchi, N., T. Takahashi, N. Harada, and K. Takatsu.
Mechanisms of the interleukin 5-induced differentiation of B cells. J. Biochem. (Tokyo), 106:837- 843, 1989.

Mita, S., Y. Hosoya, T. Takahashi, I. Kubota, T. Honjo, T. Nishihara, T. Takahashi, and K. Takatsu.
Rapid methods for purification of human recombinant interleukin-5 (IL-5) using the anti-murine IL-5 antibody-coupled immunoaffinity column. J. Immunol. Methods 125:233-241, 1989.

Enokihara, H., S. Furusawa, H. Nakakubo, H. Kajitani, S. Nagashima, K. Saito, H. Shishido, Y. Hitoshi, K. Takatsu, T.
Noma, A. Shimizu, and T. Honjo. T cells from eosinophilic patients produce interleukin 5 with interleukin 2 stimulation. Blood 73:1809-1813, 1989.

Miyazaki, J.-I., S. Takaki, M. Araki, F. Tashiro, A. Tominaga, K. Takatsu, and K. Yamamura.
Expression vector system based on the chicken b-actin promoter directs efficient production of interleukin 5. Gene 79:269-277, 1989.

Koyama, N., N. Harada, T. Takahashi, S. Mita, H. Okamura, A. Tominaga, and K. Takatsu.
Role of recombinant interleukin 1 (IL-1) compared to recombinant T-cell replacing factor/interleukin 5 in B-cell differenti-ation. Immunology 63:277-283, 1988.

Rasmussen, R., K. Takatsu, N. Harada, T. Takahashi, and K. Bottomley.
T cell- dependent hapten-specific and polyclonal B cell responses require release of interleukin 5. J. Immunol. 140:705-712, 1988.

Tominaga, A., M. Matsumoto, N. Harada, T. Takahashi, Y. Kikuchi, and K. Takatsu.
Molecular properties and regulation of mRNA expression for murine T cell- replacing factor/IL-5. J. Immunol. 140:1175-1181, 1988.

Yamaguchi, Y., T. Suda, J. Suda, M. Eguchi, Y. Miura, N. Harada, A. Tominaga, and K. Takatsu.
Purified interleukin-5 supports the terminal differentiation and proliferation of murine eosinophilic precursors. J. Exp. Med. 167:43-56, 1988.

Yamaguchi, Y., Y. Hayashi, Y. Sugama, Y. Miura, T. Kasahara, M. Torisu, S. Mita, A. Tominaga, K. Takatsu, and T. Suda.
Highly purified murine interleukin (IL-5) stimulates eosinophil function and prolongs in vitro survival: IL-5 as an eosinophil chemotactic factor. J. Exp. Med. 167:1737-1742, 1988.

Mita, S., N. Harada, S. Naomi, Y. Hitoshi, K. Sakamoto, M. Akagi ,A. Tominaga, and K. Takatsu.
Receptors for T cell-replacing factor/interleukin 5: specificity, quantitation and its implication.J. Exp. Med., 168:863-878, 1988.

Naomi, S., T. Umeda, T. Iwaoka, F. Mirua, M. Ohno, M. Sasaki, S. Oishi, T. Sato, and K. Takatsu.
A sensitive radioimmunoassay of a human atrial natriuretic polypeptide using monoclonal antibody recognizing human form ring structure. Life Sci. 43:761-768,1988.

Matsumoto, M., A. Tominaga, N. Harada and K. Takatsu.
Role of T cell-replacing factor (TRF) in the murine B cell differentiation: Induction of increased levels of expression of secreted type IgM mRNA. J. Immunol. 138:1826-1833, 1987.

Naomi, S., T. Umeda, T. Sato, N. Harada, A. Tominaga, and K. Takatsu.
Production and characterization of monoclonal antibodies against amino-terminus of human a-atrial natriuretic polypeptide. Hybridoma 6:433-437, 1987.

Takatsu, K., Y. Kikuchi, , M. Matsumoto, N. Harada, N. Yamaguchi and A. Tominaga.
Interleukin 5, a T-cell-derived B-cell differentiation factor also induces cytotoxic T lymphocytes. Proc. Natl. Acad. Sci. USA, 84:4234-4238,1987.

Harada, N., T. Takahashi, M. Matsumoto, T. Kinashi, Y. Kikuchi N. Koyama, E. Severinson, Y. Yaoita, T. Honjo, N. Yamaguchi, A. Tominaga, and K. Takatsu.
Production of a monoclonal antibody useful in the molecular characterization of murine T-cell-replacing factor/B-cell growth factor II. Proc. Natl. Acad. Sci. USA, 84:4581-4585, 1987.

Harada, N., M. Matsumoto, N. Koyama, T. Honjo, A. Shimizu, A. Tominaga, and K. Takatsu.
T cell-replacing factor/interleukin 5 induces not only B-cell growth and differentiation, but also increased expression of interleukin-2 Receptor on Activated B-Cells. Immunol. Lett. 15:205-215, 1987.

Loughnan, M. S., K. Takatsu, N. Harada, and G. J. V. Nossal.
T-cell-replacing factor (interleukin 5) induces expression of interleukin 2 receptors on murine splenic B cells. Proc. Natl. Acad. Sci. USA, 84:5399-5403, 1987.

Alderson, M. R., B. L. Pike, N. Harada, A. Tominaga, K. Takatsu, and G. J. V. Nossal.
Recombinant T-cell replacing factor (interleukin 5) acts with antigen to promote the growth and differentiation of single hapten-specific B lymphocytes. J. Immunol. 139: 2656-2660, 1987.

Takatsu, T., Y. Kikuchi, T. Kanatani, K. Okuno, T, Hamaoka, A. Tominaga, and Y. Sano.
Generation of cytotoxic T lymphocytes from thymocyte precursors to trinitrophenyI-modified self antigens. I. Requirement of both killer-helper factor(s) and interleukin 2 for CTL generation from a subpopulation of thymocytes. J. Immunol. 136:61-1170, 1986.

Kikuchi, Y., R. Kato, Y. Sano H. Takahashi T. Kanatatni, and K. Takatsu.
Generation of cytotoxic T lymphocytes from thymocyte precursors to trinitrophenyl-modified self antigens. II. Establishment of a T cell hybrid clone constitutively producing killer-helper factor(s) (KHF) and functional analysis of released KHF. J. Immunol. 136:3553-3560, 1986.

Tominaga, A., M. Matsumoto, T, Takahashi, N. Harada, and K. Takatsu.
Establishment of an assay system for the detection of translated material of T cell-replacing factor mRNA in Xenopus oocytes. Microbiol. Immunol. 30: 689- 698, 1986.

Hashimoto, Y., S, Tsukada, T. Hamaoka, Y. Sano, N. Koyama, and K. Takatsu.
Effect of passive administration of alloantiserum containing antibody against putative acceptor(s) for T cell-replacing factor (TRF) in the neonatal stage on development of B cell activity responsive to TRF. Microbiol. Immunol. 30:49-64, 1986.

Kinashi, T., N. Harada, E. Severinson, T. Tanabe, P. Sideras, M. Konishi, C. Azuma, A. Tominaga, S. Bergstedt-Lindqvist, M. Takahashi, F. Matsuda, Y. Yaoita, K. Takatsu, and T. Honjo.
Cloning of complementary DNA for T-cell replacing factor and identity with B-cell growth factor II. Nature 324:70-73, 1986.

Azuma, C., T. Tanabe, M. Konishi, T. Kinashi, T. Noma, R. Matsuda, Y. Yaoita, K. Takatsu, L. Hammarstrom, E. Severinson, L. I. E. Smith, and T. Honjo.
Cloning of cDNA encoding human T-cell replacing factor (Interleukin-5) and comparison with the murine homologue. Nucleic Acids Res. 14:9149-9158, 1986.

Okuno, K., Y. Kikuchi, T, Tsuchida, T. Hamaoka, T. Igarashi, R. Kato, and K. Takatsu.
The role of I-region associated antigen (Ia)-bearing accessory cells in the generation of cytotoxic T cells in a subpopulation of thymocytes. Gann 77:711-721, 1986.

Takatsu, K., N. Harada, Y. Hara, Y. Takahama, G. Yamada, K. Dobashi and T. Hamaoka.
Purification and physicochemical characterization of murine T cell-replacing factor, (TRF). J. Immunol. 134:382-389, 1985.

Harada, N., Y. Kikuchi, A. Tominaga, S. Takaki, and K. Takatsu.
BCGFII activity on activated B cells of a purified murine T cell-replacing factor (TRF) from a T cell hybridoma (B151K12). J. Immunol. 134:3944-3951, 1985.

Sano, Y., N. Harada, and K. Takatsu.
Three functionally distinct helper T-cell clones: The roles for antigen non-specific helper factors in B-cell activation through two different pathways. Immunology 56:585-596, 1985.

Hashimoto, N., K. Takatsu, Y. Masuho, K. Kishida, T. Hara, and T. Hamaoka.
Selective elimination of a B cell subset having acceptor site(s) for T cell- replacing factor (TRF) with biotinylated antibody to the acceptor site(s) and avidin ricin-A chain conjugate. J. Immunol. 132:129-135, 1984.

Sano, Y., G. Yamada, K. Dobashi, T. Mizuochi, T. Hamaoka, and K. Takatsu.
Establishment of three PPD-reactive helper T cell clones with distinct functions in B cell activation. J. Immuol. 133:629-635, 1984.

Okuno, K., K. Takatsu, Y. Takahama, Y. Kitayama, and T. Hamaoka.
Interleukin-1 restores the impaired cytotoxic T lymphocyte generation in beige mutant mouse. Gann 75:824-832, 1984.

Nakanishi, K., M. Howard, A. Muraguchi, J. Farrar, K. Takatsu, T. Hamaoka, and W. E. Paul.
Soluble factors involved in B cell differentiation: Identification of two distinct T cell-replacing factors (TRF). J. Immunol. 130:2219-2224, 1983.

Takatsu, K., Y. Sano, S. Tomita, N. Hashimoto, and T. Hamaoka
Acceptor site(s) for T cell-replacing factor (TRF) on B lymphocytes. I. TRF substituting activity of anti-TRF acceptor site(s) antibody in the triggering of B cells. J. Immunol. 128:2575-2580, 1982.

Tominaga, A., K. Takatsu, and T. Hamaoka.
Acceptor site(s) for T cell replacing factor (TRF) on B lymphocytes II. Activation of B cells by cross-linkage or aggregation of the TRF acceptor molecule. J. Immunol. 128:2581-2585, 1982.

Howard, M., J. Farrar, M. Hilfiker, B. Johnson, K. Takatsu, T. Hamaoka and W. E. Paul.
Identification of a T cell growth factor distinct from interleukin 2. J. Exp. Med. 155:914-923, 1982.

Hamaoka, T., K. Takatsu, K. Okuno, and T. Tsuchida.
Functional characterization of the killer-helper factor responsible for the induction of cytotoxic T lymphocytes from thymocytes, and evidence for the nature of this factor as distinct from T cell-replacing factor (TRF) in regards to B cell triggering. J. Immunol. 126:659-665, 1981.

Takatsu, K., Y. Sano, S. Tomita, N. Hashimoto, and T. Hamaoka.
Antibody against T cell-replacing factor acceptor site(s) augments in vivo primary IgM responses to suboptimal doses of heterologous erythrocytes. Nature 292:360- 362, 1981.

Takatsu, K., A, Tominaga, and T, Hamaoka.
X-Linked recessive inheritance of a defective responsiveness to T-cell-replacing factor in DBA/2Ha mice. Immunol. Lett. 3:137-143, 1981.