東京大学医科学研究所

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発表論文解説

Mei Po Chan1、恩地正浩1, 3、福井竜太郎1、川根公樹4、柴田琢磨1,2、齋藤伸一郎1、大戸梅治5、清水敏之5、Glen N. Barber6, 三宅健介1,2
1.東京大学医科学研究所感染遺伝学分野、2,システム疾患モデル研究センター自然免疫研究分野、3.岡山大学大学院医歯薬学総合研究科 消化器・肝臓内科学、4. 京都産業大学総合生命科学部、5.東京大学大学院薬学系研究科 蛋白構造生物学教室、6. Department of Cell Biology and Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine

プライム型多能性幹細胞からナイーブ型多能性幹細胞の新規変換法を開発

Stem Cell Reports Vol. 4, 1-11, January 13, 2015 DOI: 10.1016/j.stemcr.2014.12.003
村山 秀之1、正木 英樹1、佐藤 秀征1、葉山 智工1、山口 智之1、中内 啓光1
1.東京大学医科学研究所・幹細胞治療分野
渡辺登喜子1、2、川上英良2、 Jason E. Shoemaker1、2, Tiago J.S. Lopes2, 松岡由希子2, 冨田有里子1、2, 秦裕子3, 五来武郎1, 桑原朋子1, 武田 瑛司1, 永田 篤史1, 高野量1, 木曽真紀1, 山下誠1, 坂井優子1, 桂廣亮1, 野中 尚輝1, 藤井裕子1, 藤井健2, 杉田 征彦1, 野田岳志1, 五藤秀男1, 福山聡1、2, 渡辺真治2、4, Gabriele Neumann5, 尾山大明3, 北野宏明2, 河岡義裕1、2
(1 東京大学医科学研究所感染免疫部門ウイルス感染分野、2 JST ERATO河岡プロジェクト、3 東京大学医科学研究所疾患プロテオミクスラボラトリー、4 宮崎大学農学部、5 米国ウイスコンシン大学)
秋山 伸子1、新澤 未穂1、宮内 真紀1、箭内 洋見1、立石 涼介1、下茂 佑輔1、大島 大輔1、松尾 光一2、佐々木 泉3、星野 克明4、Guoying Wu5, 八木 慎太郎5, 井上 純一郎1、改正 恒康6、秋山 泰身1
1. 東京大学 医科学研究所 分子発癌分野、2. 慶應義塾大学 医学部 細胞組織学研究、3. 大阪大学、免疫学フロンティア研究センター、4. 香川大学 医学部、5. 東京大学 農学生命科学研究科、6. 和歌山県立医科大学 先端医学研究所

生まれた後の神経と筋肉のつなぎ目を守る新たな仕組み

Proc. Natl. Acd. Sci. USA doi:10.1073/pnas.1408409111
手塚 徹1、井上 茜1、星 太輔1、Scott D. Weatherbee2、Robert W. Burgess3、植田亮1、山梨裕司1
1.東京大学医科学研究所・腫瘍抑制分野、2.Yale大学・Department of Genetics、3.Jackson Laboratory
Yasushi Totoki1, 14, Kenji Tatsuno2, 14, Kyle R. Covington3, 14, Hiroki Ueda2, Chad J. Creighton3, 4, Mamoru Kato1, Shingo Tsuji2, Lawrence A. Donehower5, Betty L. Slagle5, Hiromi Nakamura1, Shogo Yamamoto2, Eve Shinbrot3, Natsuko Hama1, Megan Lehmkuhl3, Fumie Hosoda1, Yasuhito Arai1, Kim Walker3, Mahmoud Dahdouli3, Kengo Gotoh2, Genta Nagae2, Marie-Claude Gingras3, Donna M. Muzny3, Hidenori Ojima6, Kazuaki Shimada7, Yutaka Midorikawa8, John A. Goss9, Ronald Cotton9, Akimasa Hayashi2, 10, Junji Shibahara10, Shumpei Ishikawa10, Jacfranz Guiteau9, Mariko Tanaka10, Tomoko Urushidate1, Shoko Ohashi1, Naoko Okada1, Harsha Doddapaneni3, Min Wang3, Yiming Zhu3, Huyen Dinh3, Takuya Okusaka11, Norihiro Kokudo12, Tomoo Kosuge7, Tadatoshi Takayama8, Masashi Fukayama10, Richard A. Gibbs3, David A. Wheeler3, Hiroyuki Aburatani2, Tatsuhiro Shibata1, 13
1) Division of Cancer Genomics, National Cancer Center Research Institute, 5-1-1, Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan. 2) Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Meguro, Tokyo 153-8904, Japan. 3) Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030. 4) Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030. 5) Department of Molecular Virology & Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030. 6) Division of Molecular Pathology, National Cancer Center Research Institute, 5-1-1, Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan. 7) Hepatoboliary and Pancreatic Surgery Division, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan. 8) Department of Digestive Surgery, Nihon University School of Medicine, 30-1 Oyaguchikami-machi, Itabashi-ku, Tokyo 173-8610, Japan. 9) Department of Surgery, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030. 10) Department of Pathology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. 11) Hepatoboliary and Pancreatic Oncology Division, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan. 12) Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan 13) Laboratory of Molecular Medicine, Human Genome Center, The institute of Medical Science, the University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan
有村 純暢1、岡田 尚巳2、手塚 徹1、千代 智子2、笠原 優子2、吉村 俊朗3、本村 政勝4、吉田 進昭5、David Beeson6、武田 伸一2、山梨裕司1
1.東京大学医科学研究所・腫瘍抑制分野、2.国立精神・神経医療研究センター・遺伝子疾患治療研究部、3.長崎大学・医歯学総合研究科、4.長崎総合科学大学・工学部、5.東京大学医科学研究所・発生工学研究分野、6.オックスフォード大学・Weatherall Institute of Molecular Medicine

ピロリ菌感染による胃がん発症の鍵となる小さなRNAの発見

Nature Communications 5, Article number: 4497 doi:10.1038/ncomms5497
氣駕 恒太朗1,2*、三室 仁美1*、鈴木 仁人3、牛久 綾4、小林 泰良1、真田 貴人1、金 玟秀5、小川 道永3、岩崎 由香2、嘉陽 啓之2、湯澤 陽子2、八代 正和6、深山 正久4、深尾 太郎2、笹川 千尋3,5,7,8
1 Division of Bacteriology, Department of Infectious Diseases Control, International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. 2 Max-Planck-Institute of Immunobiology and Epigenetics, Stübeweg 51, 79108 Freiburg, Germany. 3 Department of Microbiology and Immunology, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. 4 Department of Pathology, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan. 5 Division of Bacterial Infection Biology, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan. 6 Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan. 7 Nippon Institute for Biological Science, 9-2221-1 Shinmachi, Ome, Tokyo 198-0024, Japan. 8 Medical Mycology Research Center, Chiba University, Chiba 260-8673, Japan. * These authors contributed equally to this work.

自然リンパ球は上皮細胞の糖鎖修飾を調節する

Science 1254009Published online 21 August 2014 [DOI:10.1126/science.1254009]
Yoshiyuki Goto1,2,3, Takashi Obata1,3, Jun Kunisawa1,4,5, Shintaro Sato1,2, Ivaylo I. Ivanov6, Aayam Lamichhane1, Natsumi Takeyama1, Mariko Kamioka1, Mitsuo Sakamoto3, Takahiro Matsuki7, Hiromi Setoyama7, Akemi Imaoka7, Satoshi Uematsu8,9, Shizuo Akira10, Steven E. Domino11, Paulina Kulig12, Burkhard Becher12, Jean-Christophe Renauld13, Chihiro Sasakawa14,15,16, Yoshinori Umesaki7, Yoshimi Benno17, and Hiroshi Kiyono1,2,5
1 Division of Mucosal Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan 2 Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Saitama 332-0012, Japan 3 Microbe Division/Japan Collection of Microorganisms, RIKEN BioResource Center, Tsukuba 305-0074, Japan 4 Laboratory of Vaccine Materials, National Institute of Biomedical Innovation, Osaka 567-0085, Japan 5 Division of Mucosal Immunology, International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan 6 Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032 7 Yakult Central Institute for Microbiological Research, Tokyo 186-8650, Japan 8 Division of Innate Immune Regulation, International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan 9 Department of Mucosal Immunology, School of Medicine, Chiba University, 1-8-1 Inohana, Chuou-ku, Chiba, 260-8670, Japan 10 Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan 11 Department of Obstetrics and Gynecology, Cellular and Molecular Biology Program, University of Michigan Medical Center, Ann Arbor, MI 48109-5617 12 Institute of Experimental Immunology, University of Zürich, Winterthurerstrasse 190, Zürich CH-8057, Switzerland 13 Ludwig Institute for Cancer Research and Université Catholique de Louvain, Brussels B-1200, Belgium 14 Division of Bacterial Infection, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan 15 Medical Mycology Research Center, Chiba University, Chiba 260-8673, Japan 16 Nippon Institute for Biological Science, Tokyo 198-0024, Japan 17 Benno Laboratory, Innovation Center, RIKEN, Saitama 351-0198, Japan
Yuuki Obata1,2,3,4,18 Yukihiro Furusawa1,3,17,18 Takaho A. Endo5, Jafar Sharif6, Daisuke Takahashi7, Koji Atarashi,8,9 Manabu Nakayama10, Satoshi Onawa7, Yumiko Fujimura1,3, Masumi Takahashi7, Tomokatsu Ikawa9,11, Takeshi Otsubo12, Yuki I. Kawamura12, Taeko Dohi12, Shoji Tajima13, Hiroshi Masumoto14, Osamu Ohara5, Kenya Honda8,15, Shohei Hori16, Hiroshi Ohno2,4,7, Haruhiko Koseki6 and Koji Hase1,3,4,9,17.
1. Division of Mucosal Barriology, International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan. 2. Laboratory for immune regulation, Graduate School of Medicine, Chiba University, Chiba, Japan. 3. Laboratory for Bioenvironmental Epigenetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan. 4. Graduate School of Medical Life Science, Yokohama City University, Kanagawa, Japan. 5. Laboratory for Integrative Genomics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan. 6. Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan. 7. Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan. 8. Laboratory for Gut Homeostasis, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan. 9. PRESTO, Japan Science and Technology Agency, Saitama, Japan. 10. Laboratory of Medical Genomics, Department of Human Genome Research, Kazusa DNA Research Institute, Chiba, Japan. 11. Laboratory for Immune Regeneration, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan. 12. Department of Gastroenterology, Research Center for Hepatitis and Immunology, Research Institute, National Center for Global Health and Medicine, Chiba, Japan. 13. Laboratory of Epigenetics, Institute for Protein Research, Osaka University, Osaka, Japan. 14. Laboratory of Cell Engineering, Department of Frontier Research, Kazusa DNA Research Institute, Chiba, Japan. 15. CREST, Japan Science and Technology Agency, Saitama, Japan. 16. Laboratory for Immune Homeostasis, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan. 17. Present address: Department of Biochemistry, Keio University Graduate School of Pharmaceutical Science, Tokyo, Japan. 18. These authors contributed equally to this work.