東京大学医科学研究所

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発表論文解説

Kenta Horie, Tamotsu Kato, Takashi Kudo, Hiroki Sasanuma, Maki Miyauchi, Nobuko Akiyama, Takahisa Miyao, Takao Seki, Tatsuya Ishikawa, Yuki Takakura, Masaki Shirakawa, Dai Shiba, Michito Hamada, Hyojung Jeon, Nobuaki Yoshida, Jun-ichiro Inoue, Masafumi Muratani, Satoru Takahashi, Hiroshi Ohno, Taishin Akiyama
Nobuyuki Kakiuchi1,2,3, Kenichi Yoshida1, Motoi Uchino4, Takako Kihara5, Kotaro Akaki6, Yoshikage Inoue1,2,7, Kenji Kawada7, Satoshi Nagayama8, Akira Yokoyama1,9, Shuji Yamamoto3, Minoru Matsuura3,10, Takahiro Horimatsu9, Tomonori Hirano1,2,3, Norihiro Goto3, Yasuhide Takeuchi1,2,11,12, Yotaro Ochi1,2, Yusuke Shiozawa1, Yasunori Kogure1,13, Yosaku Watatani1,2, Yoichi Fujii1,2, Soo Ki Kim1,3, Ayana Kon1,2, Keisuke Kataoka1,13, Tetsuichi Yoshizato1, Masahiro M. Nakagawa1,2, Akinori Yoda1,2, Yasuhito Nanya1,2, Hideki Makishima1,2, Yuichi Shiraishi14, Kenichi Chiba14, Hiroko Tanaka15, Masashi Sanada1,16, Eiji Sugihara17, Taka-aki Sato17, Takashi Maruyama18, Hiroyuki Miyoshi19, Makoto Mark Taketo19, Jun Oishi20, Ryosaku Inagaki1,20, Yutaka Ueda20, Shinya Okamoto21, Hideaki Okajima21,22, Yoshiharu Sakai7, Takaki Sakurai11, Hironori Haga12, Seiichi Hirota5, Hiroki Ikeuchi4, Hiroshi Nakase3,23, Hiroyuki Marusawa3, Tsutomu Chiba3,24, Osamu Takeuchi6, Satoru Miyano14,15, Hiroshi Seno3 & Seishi Ogawa1,2,25
1Department of Pathology and Tumour Biology, Kyoto University, Kyoto, Japan, 2Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto, Japan, 3Department of Gastroenterology and Hepatology, Kyoto University, Kyoto, Japan, 4Department of Inflammatory Bowel Disease, Division of Surgery, Hyogo College of Medicine, Nishinomiya, Japan, 5Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Japan, 6Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 7Department of Surgery, Kyoto University, Kyoto, Japan, 8Gastroenterological Center, Department of Gastroenterological Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan, 9Department of Therapeutic Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 10Department of Gastroenterology and Hepatology, Kyorin University School of Medicine, Tokyo, Japan, 11Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Japan, 12Department of Diagnostic Pathology, Kyoto University, Kyoto, Japan, 13Division of Molecular Oncology, National Cancer Centre Research Institute, Tokyo, Japan, 14Laboratory of DNA Information Analysis, Human Genome Centre, Institute of Medical Science, The University of Tokyo, Tokyo, Japan, 15Laboratory of Sequence Analysis, Human Genome Centre, Institute of Medical Science, The University of Tokyo, Tokyo, Japan, 16Department of Advanced Diagnosis, Clinical Research Centre, National Hospital Organization Nagoya Medical Center, Nagoya, Japan, 17Research and Development Centre for Precision Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan, 18Department of Immunology, Akita University Graduate School of Medicine, Akita, Japan, 19Division of Experimental Therapeutics, Kyoto University, Kyoto, Japan, 20DSP Cancer Institute, Sumitomo Dainippon Pharma Co., Ltd., Osaka, Japan, 21Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 22Department of Paediatric Surgery, Kanazawa Medical University, Ishikawa, JAPAN, 23Department of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Sapporo, Japan, 24Kansai Electric Power Hospital, Osaka, Japan, 25Department of Medicine, Centre for Haematology and Regenerative Medicine, Karolinska Institute, Stockholm, Sweden.
Endo H., Baghdadi M., Ishikawa K., Umeyama Y, Wada H., Asano H., Endo D., Konno Y., Kato T., Watari H., Tozawa A., Suzuki N., Yokose T., Takano A., Kato H., Miyagi Y., Daigo Y., Seino K.-I.

ほ乳類とレトロウイルスの進化的軍拡競争の網羅的描出

Proceedings of the National Academy of Sciences of the United States of America 12月17日オンライン版 DOI番号:10.1073/pnas.1914183116
伊東 潤平, Robert J. Gifford, 佐藤 佳*
Makoto Hirata, Naofumi Asano, Kotoe Katayama, Akihiko Yoshida, Yusuke Tsuda, Masaya Sekimizu, Sachiyo Mitani, Eisuke Kobayashi, Motokiyo Komiyama, Hiroyuki Fujimoto, Takahiro Goto, Yukihide Iwamoto, Norifumi Naka, Shintaro Iwata, Yoshihiro Nishida, Toru Hiruma, Hiroaki Hiraga, Hirotaka Kawano, Toru Motoi, Yoshinao Oda, Daisuke Matsubara, Masashi Fujita, Tatsuhiro Shibata, Hidewaki Nakagawa, Robert Nakayama, Tadashi Kondo, Seiya Imoto, Satoru Miyano, Akira Kawai, Rui Yamaguchi, Hitoshi Ichikawa, and Koichi Matsuda

新しいゲノム編集ツールCRISPR-Cas3の開発に成功

Nature Communications オンライン DOI番号 10.1038/s41467-019-13226-x
Hiroyuki Morisaka#, Kazuto Yoshimi#, Yuya Okuzaki #, Peter Gee, Yayoi Kunihiro, Ekasit Sonpho, Huaigeng Xu, Noriko Sasakawa, Yuki Naito, Shinichiro Nakada, Takashi Yamamoto, Shigetoshi Sano, Akitsu Hotta*, Junji Takeda* and Tomoji Mashimo*(同等貢献、 * 責任著者)

患者から分離されたゾフルーザ耐性インフルエンザウイルスの特性を解明

Nature Microbiology 11月25日オンライン版 DOI番号:10.1038/s41564-019-0609-0
今井 正樹1、山下 誠1、坂井(田川) 優子1、岩附(堀本) 研子1、木曽 真紀1、村上 樹里佳1、安原 敦洋1、 高田 光輔1、伊藤 睦美1、中島 典子2、高橋 健太2、Tiago J. S. Lopes1,3、Jayeeta Dutta4、Zenab Khan4、Divya Kriti4、Harm van Bakel4、時田 章史5、萩原 温久5、泉田 直己5、黒木 春郎6, 西野 多聞5、和田 紀之5、古賀 道子7、 安達 英輔8、十菱大介1、長谷川 秀樹2、河岡義裕1,3
1.東京大学医科学研究所・ウイルス感染分野、2国立感染症研究所、3.米国ウィスコンシン大学、4.米国マウントサイナイ医科大学、5東京小児科医会公衆衛生委員会、6外房こどもクリニック、7東京大学医科学研究所・感染症分野、8東京大学医科学研究所付属病院
Munemasa Mori1, Kazuhiro Furuhashi2, Jennifer A. Danielsson3, Yuichi Hirata2, Miwako Kakiuchi2, Chyuan-Sheng Lin4, Mayu Ohta5, Paul Riccio5, Yusuke Takahashi6,7, Xinjing Xu8, Charles W. Emala3, Chao Lu8, Hiromitsu Nakauchi9,10, Wellington V. Cardoso11,12
1.Columbia Center for Human Development and Division of Pulmonary, Allergy, Critical Care, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA. mm4452@cumc.columbia.edu. 2.Columbia Center for Translational Immunology, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA. 3.Department of Anethesiology, Columbia University Irving Medical Center, New York, NY, USA. 4.Bernard and Shirlee Brown Glaucoma Laboratory, Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA. 5.Columbia Center for Human Development and Division of Pulmonary, Allergy, Critical Care, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA. 6.Institute for Stem Cell Biology and Regenerative Medicine, Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA. 7.Division of Stem Cell Therapy, Distinguished Professor Unit, The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo, Japan. 8.Department of Genetics and Development and Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA. 9.Institute for Stem Cell Biology and Regenerative Medicine, Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA. nakauchi@stanford.edu. 10Division of Stem Cell Therapy, Distinguished Professor Unit, The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo, Japan. nakauchi@stanford.edu. 11.Columbia Center for Human Development and Division of Pulmonary, Allergy, Critical Care, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA. wvc2104@cumc.columbia.edu. 12.Department of Genetics and Development and Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA. wvc2104@cumc.columbia.edu.
Hideo Negishi, Nobuyasu Endo, Yuki Nakajima, Tatsuaki Nishiyama, Yuichiro Tabunoki, Junko Nishio, Ryuji Koshiba, Atsushi Matsuda, Kosuke Matsuki, Tomohisa Okamura, Takako Negishi-Koga, Takeshi Ichinohe, Shunji Takemura, Hiroyuki Ishiwata, Shun-ichiro Iemura, Tohru Natsume, Takaya Abe, Hiroshi Kiyonari, Takeshi Doi, Sho Hangai, Hideyuki Yanai, Keishi Fujio, Kazuhiko Yamamoto and Tadatsugu Taniguchi*
Chikashi Terao, Yukihide Momozawa, Kazuyoshi Ishigaki, Eiryo Kawakami, Masato Akiyama, Po Ru Loh, Giulio Genovese, Hiroki Sugishita, Tazro Ohta, Makoto Hirata, John R.B Perry, Koichi Matsuda, Yoshinori Murakami, Michiaki Kubo, Yoichiro Kamatani