東京大学医科学研究所

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発表論文解説

miRNAによる脊髄小脳失調症の遺伝子治療

Science Translational Medicine doi:10.1126
Yu Miyazaki, Xiaofei Du, Shin-ichi Muramatsu, Christopher M. Gomez
Chengjun Li, Masato Hatta, David F. Burke, Jihui Ping, Ying Zhang, Makoto Ozawa, Andrew S. Taft, Subash C. Das, Anthony P. Hanson, Jiasheng Song, Masaki Imai, Peter R. Wilker, Tokiko Watanabe, Shinji Watanabe, Mutsumi Ito, Kiyoko Iwatsuki-Horimoto, Colin A. Russell, Sarah L. James, Eugene Skepner, Eileen A. Maher, Gabriele Neumann, Alexander I. Klimov, Anne Kelso, John McCauley, Dayan Wang, Yuelong Shu, Takato Odagiri, Masato Tashiro, Xiyan Xu, David E. Wentworth, Jacqueline M. Katz, Nancy J. Cox, Derek J. Smith & Yoshihiro Kawaoka
Keisuke Kataoka1†, Yuichi Shiraishi2†, Yohei Takeda3†, Seiji Sakata4, Misako Matsumoto3, Seiji Nagano5, Takuya Maeda5, Yasunobu Nagata1, Akira Kitanaka6, Seiya Mizuno7, Hiroko Tanaka2, Kenichi Chiba2, Satoshi Ito2, Yosaku Watatani1, Nobuyuki Kakiuchi1, Hiromichi Suzuki1, Tetsuichi Yoshizato1, Kenichi Yoshida1, Masashi Sanada8, Hidehiro Itonaga9, Yoshitaka Imaizumi10, Yasushi Totoki11, Wataru Munakata12, Hiromi Nakamura11, Natsuko Hama11, Kotaro Shide6, Yoko Kubuki6, Tomonori Hidaka6, Takuro Kameda6, Kyoko Masuda5, Nagahiro Minato13, Koichi Kashiwase14, Koji Izutsu15, Akifumi Takaori-Kondo16, Yasushi Miyazaki10, Satoru Takahashi7, Tatsuhiro Shibata11,17, Hiroshi Kawamoto5, Yoshiki Akatsuka18,19, Kazuya Shimoda6, Kengo Takeuchi4, Tsukasa Seya3, Satoru Miyano2 and Seishi Ogawa1
1 Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 2Laboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan, 3Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan, 4Pathology Project for Molecular Targets, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan, 5Department of Immunology, Institute for Frontier Medical Science, Kyoto University, Kyoto, Japan, 6Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan, 7Laboratory Animal Resource Center and Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, 8Department of Advanced Diagnosis, Clinical Research Center, Nagoya Medical Center, Nagoya, Japan, 9Department of Hematology, Sasebo City General Hospital, Sasebo, Japan, 10Department of Hematology, Atomic Bomb Disease and Hibakusya Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan, 11Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan, 12Department of Hematology, National Cancer Center Hospital, Tokyo, Japan, 13Department of Immunology and Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 14Department of HLA Laboratory, Japanese Red Cross Kanto-Koshinetsu Block Blood Center, Tokyo, Japan, 15Department of Hematology, Toranomon Hospital, Tokyo, Japan, 16Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 17Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan, 18Department of Hematology, Fujita Health University School of Medicine, Toyoake, Japan, 19Division of Immunology, Aichi Cancer Center Research Institute, Nagoya, Japan, †These authors equally contributed to this study

インフルエンザウイルスゲノムの核内動態に関わる宿主タンパク質を同定

Nature Microbiology 5月16日オンライン版 DOI番号:10.1038/nmicrobiol.2016.62
Tomomi Ando, Seiya Yamayoshi, Yuriko Tomita, Shinji Watanabe, Tokiko Watanabe & Yoshihiro Kawaoka
Akihiro Fujimoto, Mayuko Furuta, Yasushi Totoki, Tatsuhiko Tsunoda, Mamoru Kato, Yuichi Shiraishi, Hiroko Tanaka, Hiroaki Taniguchi, Yoshiiku Kawakami, Masaki Ueno, Kunihito Gotoh, Shun-ichi Ariizumi, Christopher P Wardell, Shinya Hayami, Toru Nakamura, Hiroshi Aikata, Koji Arihiro, Keith A Boroevich, Tetsuo Abe, Kaoru Nakano, Kazuhiro Maejima, Aya Sasaki-Oku, Ayako Ohsawa, Tetsuo Shibuya, Hiromi Nakamura, Natsuko Hama, Fumie Hosoda, Yasuhito Arai, Shoko Ohashi, Tomoko Urushidate, Genta Nagae, Shogo Yamamoto, Hiroki Ueda, Kenji Tatsuno, Hidenori Ojima, Nobuyuki Hiraoka, Takuji Okusaka, Michiaki Kubo, Shigeru Marubashi, Terumasa Yamada, Satoshi Hirano, Masakazu Yamamoto, Hideki Ohdan, Kazuaki Shimada, Osamu Ishikawa, Hiroki Yamaue, Kazuaki Chayama, Satoru Miyano, Hiroyuki Aburatani, Tatsuhiro Shibata, and Hidewaki Nakagawa
James Y. Chen1(スタンフォード大学), Masanori Miyanishi1(スタンフォード大学, Sean K. Wang1(スタンフォード大学), Satoshi Yamazaki(東京大学医科学研究所), Rahul Sinha(スタンフォード大学, Kevin S. Kao(スタンフォード大学, Hiromitsu Nakauch(スタンフォード大学、東京大学医科学研究所), Irving L. Weissman(スタンフォード大学)
Keisuke Kataoka1, Yasunobu Nagata1,25, Akira Kitanaka2,25, Yuichi Shiraishi3,25, Teppei Shimamura4,25, Jun-ichirou Yasunaga5,25, Yasushi Totoki6,25, Kenichi Chiba3, Aiko Sato-Otsubo1, Genta Nagae7, Ryohei Ishii8, Satsuki Muto9, Shinichi Kotani1, Yosaku Watatani1, June Takeda1, Masashi Sanada1,10, Hiroko Tanaka3, Hiromichi Suzuki1, Yusuke Sato1, Yusuke Shiozawa1, Tetsuichi Yoshizato1, Kenichi Yoshida1, Hideki Makishima1, Masako Iwanaga11, Guangyong Ma5, Kisato Nosaka12, Masakatsu Hishizawa13, Hidehiro Itonaga14, Yoshitaka Imaizumi15, Wataru Munakata16, Hideaki Ogasawara17, Toshitaka Sato17, Ken Sasai17, Kenzo Muramoto17, Marina Penova18, Takahisa Kawaguchi18, Hiromi Nakamura6, Natsuko Hama6, Kotaro Shide2, Yoko Kubuki2, Tomonori Hidaka2, Takuro Kameda2, Tsuyoshi Nakamaki19, Ken Ishiyama20, Shuichi Miyawaki21, Sung-Soo Yoon22, Kensei Tobinai16, Yasushi Miyazaki15, Akifumi Takaori-Kondo13, Fumihiko Matsuda18, Kengo Takeuchi23, Osamu Nureki8, Hiroyuki Aburatani7, Toshiki Watanabe9, Tatsuhiro Shibata6,24, Masao Matsuoka5, Satoru Miyano3, Kazuya Shimoda2,26, & Seishi Ogawa1,26
1 Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan 2 Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan 3 Laboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan 4 Division of Systems Biology, Center for Neurological Disease and Cancer, Graduate School of Medicine, Nagoya University, Aichi, Japan 5 Laboratory of Virus Control, Institute for Virus Research, Kyoto University, Kyoto, Japan 6 Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan 7 Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan 8 Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan 9 Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan 10 Department of Advanced Diagnosis, Clinical Research Center, Nagoya Medical Center, Aichi, Japan 11 Department of Frontier Life Science, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan 12 Department of Hematology, Kumamoto University School of Medicine, Kumamoto, Japan 13 Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan 14 Department of Hematology, Sasebo City General Hospital, Sasebo, Japan 15 Department of Hematology, Atomic Bomb Disease and Hibakusya Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan 16 Department of Hematology, National Cancer Center Hospital, Tokyo, Japan 17 KAN Research Institute, Inc., Kobe, Japan 18 Center for Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan 19 Division of Hematology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan 20 Department of Hematology and Oncology, Kanazawa University Hospital, Kanazawa, Japan 21 Division of Hematology, Department of Internal Medicine, Tokyo Metropolitan Ohtsuka Hospital, Tokyo, Japan 22 Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea 23 Pathology Project for Molecular Targets, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan. 24 Laboratory of Molecular Medicine, Human Genome Center, The institute of Medical Science, The University of Tokyo, Tokyo, Japan 25 These authors equally contributed to this study. 26 These authors jointly directed this work.

腸管B細胞の分化に伴うエネルギー代謝経路とビタミンB1依存性の変化

Cell Reports (米国東部時間9月24日のオンライン版)
國澤純、杉浦悠毅、和氣太一、長竹貴広、鈴木英彦、永澤莉沙、四方紫織、本多 久楽々、橋本えり、鈴木祐二、瀬藤光利、末松誠、清野宏
Jihui Ping1, Tiago J.S. Lopes1,2, Chairul A. Nidom3, Elodie Ghedin4,5, Catherine A. Macken6, Adam Fitch5, Masaki Imai1, Eileen A. Maher1, Gabriele Neumann1 & Yoshihiro Kawaoka1,2
1. ウイスコンシン大学、2. 東京大学医科学研究所、3. エアランガ大学、4. ニューヨーク大学、5. ピッツバーグ大学、6. オークランド大学

安全なiPS細胞由来T細胞療法の実現へ ~有効で安全な免疫細胞治療へ大きな一歩~

Stem Cell Reports 2015年8月27日Advanced Online版で掲載、10月号に本掲載予定 DOI 番号:Stem Cell Reports (2015), http://dx.doi.org/10.1016/j.stemcr.2015.07.011
安藤 美樹1,西村 聡修1,11、山崎 聡 1、山口 智之1、立川(川名) 愛2,10、葉山 智工1、中内 祐介1、安藤 純5、大田 泰徳3、高橋 聡4、西村 健6、大高 真奈美7、中西 真人7、John J Miles8、 Scott R Burrows8、 Malcolm K Brenner9、中内 啓光1,11
1. 東京大学医科学研究所・幹細胞治療研究センター・幹細胞治療分野、 2. 東京大学医科学研究所・先端医療研究センター・感染症部門、 3.東京大学医科学研究所附属病院病理部 、 4. 東京大学医科学研究所・先端医療研究センター・分子療法分野、 5. 順天堂大学医学部血液内科、 6. 筑波大学医学医療系遺伝子制御学、 7. 産業技術総合研究所・創薬基盤研究部門、 8. QIMR Berghofer Medical Research Institute、9. Center for Cell and Gene Therapy, Baylor College of Medicine、10. 国立感染症研究所・エイズ研究センター第二室、11. Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine