The role of BRCA1 and BRCA2 in breast and ovarian cancer, and even in pancreatic and prostate cancer, presents a paradox. BRCA1 and BRCA2 are expressed in all tissues and are critical to homologous recombination repair, which is a universal process. So why are only some tissues vulnerable to cancer as the result of loss of BRCA1 or BRCA2 gene function? Rachel Klevit and I explored this question together. Our results suggest that the BRCA1/BARD1 heterodimer plays a role in estrogen metabolism and that this critical function establishes a link between steroid hormone dependence and pathogenesis of BRCA-related cancers.
Inherited Breast and Ovarian Cancer and the Resolution of a Paradox
学友会セミナー
開催情報
| 開催日時 | 2023年5月22日（月）16：00～17：00 |
|---|---|
| 開催場所 | 1号館講堂 |
| 講師 | Mary-Claire King 博士 |
| 所属・職名 | American Cancer Society Professor, Departments of Medicine and Genome Sciences, University of Washington, Seattle |
| 国名 | 米国 |
| 演題 | Inherited Breast and Ovarian Cancer and the Resolution of a Paradox |
| 使用言語 | 英語 |
| 世話人 | 主たる世話人：中西 真（癌防御シグナル分野） 世話人：古川 洋一（臨床ゲノム腫瘍学分野） |