1st Vaccine Science Seminar
開催日時： 2019 年 12 月 10 日（火）11：00 ～ 12：00
講 師： lliyan D. lliev
所属・職名：Department of Medicine and the Jill Roberts Institute for Research in IBD at Weill Cornell Medicine、Assistant professor
Gut Mycobiome and the Host: when Immunity encounters the Giants
The rapid development of deep sequencing and computational technologies has provided utmost opportunities to explore the structure and functionality of microbial communities associated with our body surfaces. The bacteria have been the primary focus of these efforts. Less data is currently available to similarly characterize the fungal microbiota — the mycobiota. Nevertheless, recent studies have revealed that host-associated fungal populations are also dynamic and responsive to environmental and pathophysiological changes. Here I will discuss how mucosal immunity responds and has been trained to interact with fungi in the gut. I will define specific patterns associated with fungal dysbiosis, point towards fungal species that expand in the human gut during intestinal disease and will discuss mechanisms of intestinal domination by gut-native fungal species. I will further discuss mechanisms of innate immune recognition of intestinal fungi under homeostatic conditions and during inflammation.
連絡先：ワクチン科学分野 石井健 （内線：75314）