Structure and function of the tetrameric restriction endonucleases

It is thought that most of Type II restriction enzymes function as dimmers. However, experimental evidence demonstrates that some of them are arranged and function as tetramers. Crystal structures of the tetrameric restriction enzymes Cfr10I, NgoMIV and Bse634I solved by us will be discussed and correlations between the oligomeric state of enzyme and its catalytic function will be provided.