Recombinant attenuated Salmonella vaccines for induction of cross-protective immunity and antigen delivery
学友会セミナー
2004年開催 学友会セミナー
開催日時: | 平成16年12月10日(金)14:00~15:30 |
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開催場所: | 新総合研究棟 4F 会議室 |
講 師: | Dr. Motomu Shimaoka |
所 属: | The CBR Institute for Biomedical Research, and Harvard Medical School, U.S.A. |
演 題: | Recombinant attenuated Salmonella vaccines for induction of cross-protective immunity and antigen delivery |
概 要: | Therapeutic antagonists and the conformational regulation of integrin structure and function
Integrins are a structurally elaborate family of adhesion molecules that transmit signals bidirectionally across the plasma membrane by undergoing large scale structural rearrangements. By regulating cell-cell and cell-matrix contacts, integrins participate in a wide-range of biological interactions including development, tissue repair, angiogenesis, inflammation and hemostasis. From a therapeutic standpoint, integrins are probably the most important class of cell adhesion receptors. Recent progress in development of antagonists to integrins has resulted in their clinical application and shed new light on integrin biology. The small molecule antagonists highlight the importance of the structural linkages within and between integrin domains for transmission of the conformational signals and regulation of the overall conformation. |
世 話 人: | 細菌感染分野 笹川 千尋 ○炎症免疫学分野 清野 宏 |