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IMMUNO-BEHAVIORAL CO-MODULATIONS

学友会セミナー

学友会セミナー

2005年開催 学友会セミナー

開催日時: 平成17年2月21日(月) 16:00~17:00
開催場所: 白金ホール 会議室
講  師: Dr. Mikhail P. Moshkin
所  属: Professor, Institute of Systematics and Ecology of Animals, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia
演  題: IMMUNO-BEHAVIORAL CO-MODULATIONS
概  要:

Since both reproduction and immunocompetence are costly, the negative reciprocal relationships between these functions were predicted by theory of the life history trade-off (Stearns, 1992). Follow to the idea of this theory we studied on the wild and laboratory rodents:

- the correlations between sexual demonstrations and humoral immune response in males of red voles from natural populations;
- influence of the female chemical signals on manifestation of the secondary sexual traits (SST) in male mice;
- aggressiveness and endocrine function of gonads in IL-1 deficient male mice;
- behavioral effects of the T-independent (CpG DNA and LPS) and T-dependent (SRBC) immunogenic challenges.
Taken together our data showed that trade-off between immunocompetence and behavioral sexual demonstrations really exists in mammal populations. Bi-directional links between immune and neuroendocrine systems seem to be charged with the immuno-behavioral trade-off. Immunological changes induced by breeding activity of males lead rather to redistribution than suppression of the immune defense.
世 話 人: ○細胞機能研究分野 岩倉 洋一郎
遺伝子機能研究分野 吉田 進昭