Finding the Synaptic Organizers
学友会セミナー
学友会セミナー
2006年開催 学友会セミナー
| 開催日時： | 平成１８年７月３日（月） １６：００～１７：００ |
|---|---|
| 開催場所： | １号館２階会議室 |
| 講 師： | Hisashi Umemori, M.D. |
| 所 属： | Molecular & Behavioral Neuroscience Institute/ Department of Biological Chemistry/Neuroscience Program University of Michigan Medical School |
| 演 題： | Finding the Synaptic Organizers |
| 概 要： | Neurons analyze and transmit information in our nervous system. Information is transferred from one neuron to another at functional contact sites called synapses. Precise assembly of synapses is critical for proper functioning of the nervous system. Synapses are formed by signaling between the presynaptic and postsynaptic cells. Postsynaptic cell-derived "presynaptic organizers" promote local differentiation of axons into functional nerve terminals at sites of synaptic contact. We purified and identified such presynaptic organizers using clustering of synaptic vesicles in cultured neurons as an assay, and examined their in vivo function using mouse mutants. We show that: (1) In the cerebellum, FGF22 is a critical presynaptic organizer (Umemori et al., Cell 118, 257, 2004).(2) At the Neuromuscular junction, multiple muscle-derived cues act sequentially to organize presynaptic differentiation, with FGF7/10/22, laminin β2, and collagen IV playing predominant roles in induction, maturation, and maintenance of functional motor nerve terminals, respectively. These results help explain how synapses are specifically organized in our nervous system. |
| 世 話 人： | ○山本 雅、真鍋 俊也 |