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Diversity of cytokine-controlled information networks: lessons from cell-specific Stat5 gene knock-out mice

学友会セミナー

学友会セミナー

2005年開催 学友会セミナー

開催日時: 平成17年11月2日(水) 16:00~17:00
開催場所: アムジェンホール大会議室
講  師: Dr. Lothar Hennighausen
所  属: National Institutes of Health/NIDDK
演  題: Diversity of cytokine-controlled information networks: lessons from cell-specific Stat5 gene knock-out mice
概  要:

Cytokines control the diverse physiology of cells upon binding to their respective receptors followed by the activation of receptor-associated signaling molecules. Signal Transducers and Activators of Transcription (STATs) are latent transcription factors residing in the cytoplasm, which are recruited to cytokine receptors and tyrosine phosphorylated by Janus kinases. This leads to the dimerization of STATs, their nuclear translocation and function as bona fide transcription factors. Stat5a and Stat5b are two conserved transcription factors that convey the signals from numerous cytokines, including growth hormone, prolactin, leptin, erythropoietin and several interleukins.

The inactivation of both Stat5 genes results in perinatal lethality, therebyemphasizing the critical role of cytokines in development. In order to obtain insight into cell-specific functions of cytokine-Stat5 signaling and theunderlying mechanisms, we inactivated the two Stat5 genes in specific cell types. These results were compared with mice in which Stat5 was lacking in the entire embryo. Experiments will be presented on the critical role of Stat5 in the physiology of mammary tissue, erythropoiesis, the immune system, hepatic metabolism and energy balance. Moreover, a role for Stat5 in cell proliferation, survival and metabolism will be discussed.

世 話 人: ○細胞療法分野 北村 俊雄
免疫調節分野 高津 聖志