東京大学医科学研究所

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学友会セミナー

学友会セミナー:2019年12月4日

開催日時: 2019年12月4日 13:00 ~ 14:00
開催場所: 4号館3階 国際粘膜ワクチン開発研究センター セミナー室
講師: 吉岡 靖雄 
所属: 大阪大学微生物病研究所 BIKEN次世代ワクチン協働研究所 
特任准教授
演題: For the development of vaccines against infectious diseases
概要:

Vaccines are highly effective at preventing infectious diseases. With continued development of immunological innovations, such as check point therapy for cancer, vaccines likely will become useful therapeutic tools against cancer. The various types of vaccines against infectious diseases include live attenuated vaccines, inactivated whole vaccines, and protein- or peptide-based subunit vaccines. They all have various advantages and disadvantages. For example, subunit vaccines are much safer than live attenuated vaccines and inactivated whole vaccines; however, when used alone, subunit vaccines evoke only weak adaptive immunity. Adaptive immune responses are initiated and regulated by dendritic cells, which acquire antigens and present them to B and T lymphocytes. Therefore, to enhance adaptive immune responses in subunit vaccines, delivering vaccine antigens to dendritic cells with appropriate adjuvants is an attractive approach. In addition, it is important to discover and design optimal vaccine antigens from pathogens. In this presentation, I would like to discuss my recent research for the development of subunit vaccines about 1) dendritic cell-targeting peptide as a vehicle for vaccine antigens, 2) cellular surface receptor of oligonucleotides-based adjuvants for designing novel adjuvants, 3) optimal use of adjuvants for influenza virus vaccine and 4) development of vaccine against Mycoplasma pneumoniae.

世話人: 〇小檜山 康司(ワクチン科学分野)
 古賀 貴子(マラリア免疫学分野)