東京大学医科学研究所

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学友会セミナー

学友会セミナー:2019年11月15日

開催日時: 2019年11月15日 16:30 ~ 17:30
開催場所:  1号館西側地下1階 B-1E会議室 
講師: Seth Blackshaw
所属: Professor
Department of Neuroscience Johns Hopkins University School of Medicine
演題: Building and rebuilding the retina: one cell at a time
概要:

Abstract: The retina is an accessible system for identifying the molecular mechanisms that control CNS cell fate specification, and is a prime target for regenerative therapies aimed at restoring photoreceptors lost to blinding diseases. I will discuss our recent large-scale single-cell RNA-Seq analysis of multiple vertebrate species – including human, mouse and zebrafish -- that is aimed at identifying gene regulatory networks that drive the acquisition of neuronal and glial identity in the developing retina. I will discuss our identification of transcription factors that control both temporal identity and proliferative quiescence, new tools we and our collaborators have developed to identify both core evolutionarily-conserved and species-specific gene regulatory networks controlling retinal development, and mechanisms controlling injury-induced neurogenic competence in retinal glia.

世話人: 〇渡辺 すみ子 (再生基礎医科学分野)
 谷 憲三朗 (ALA 先端医療学分野)