東京大学医科学研究所

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学友会セミナー

学友会セミナー:2019年8月9日

開催日時: 2019年8月9日 17:00 ~ 18:00
開催場所: 1号館 講堂
講師: 吉田 富
所属: Burke Neurological Institute / Weill Cornell Medicine
Associate Professor
演題: Formation, function, and regeneration of corticospinal circuits underlying skilled movements
「運動系の神経回路の形成、機能、再生」
概要:

We have been interested in understanding the neural circuits underlying locomotor and skilled motor behaviors in mammals. The motor neuron activity integral to these neural circuits is regulated by synaptic inputs from three main pathways: local interneuron circuits, proprioceptive sensory feedback, and descending fibers from the brain, including the corticospinal (CS) tract.
In this presentation, I will particularly focus on CS circuits. CS neurons control motor neuron activity for skilled movements such as reaching and grasping. We found how species-specific CS circuits may be formed during development. Manual dexterity in higher primates is superior to that of other animals. This trait emerged together with the appearance of cortico-motoneuronal (CM) connections during the evolution of the mammalian CS system, and was thought to be unique to higher primates. However, we identified CM connections in early postnatal mice, which are eventually eliminated by Sema6D-PlexA1 signaling. PlexA1 mutant mice maintain CM connections into adulthood, resulting in superior manual dexterity compared to controls. Furthermore, we showed that species-specific regulation of PlexA1 expression by Fezf2 may be crucial to the evolution of enhanced fine motor control in higher primates. We also demonstrated how the activity dependent, non-apoptotic Bax/Bak-caspase pathway regulates reorganization of CS motor circuits during development in mice. Finally, I will talk about how CS neurons in the motor and sensory cortex differentially control skilled movements through distinct spinal interneuron connections as well as our current ongoing projects.
In addition to the formation and function of motor circuits, we are also interested in the regeneration and reorganization of neural circuits following spinal cord injury (SCI). Time permitting, I will briefly talk about our SCI research including roles of semaphorins in inhibition of regeneration of injured CS axons as well as our published study at the end of my talk.
References
1) Gu et al., Science (2017), 357, 400-404.
2) Gu et al., Neuron (2017), 94, 626-641.
3) Ueno et al., Cell Reports (2018), 23, 1286-1300.
4) Ueno et al., Nature Neuroscience (2016), 19, 784-787.

世話人: 〇井上 純一郎 (分子発癌分野)
 山梨 裕司 (腫瘍抑制分野)