東京大学医科学研究所

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学友会セミナー

学友会セミナー:2019年1月10日

開催日時: 2019年1月10日 16:00 ~ 17:00
開催場所: 総合研究棟4階 会議室
講師: Juneyoung Lee
所属: Department of Neurology, University of Texas Health Science Center at Houston・Postdoctoral Research Fellow
演題: Microbiome-gut-brain axis and its therapeutic manipulation after stroke
概要:

Stroke is a leading cause of mortality in the elderly and exerts systemic effects that extend beyond the brain by triggering a multiphasic immune response in the periphery. Mounting evidence with new sequencing technology revealed that stroke robustly affects distant organs, mainly the gut and its microbiota, the so-called “brain-gut axis”. Stroke altered the makeup of gut microbiota with increased gut permeability (top-down signaling) and activated gut microbiota-involved T cells that control neuro-inflammation in the brain (bottom-up signaling) in experimental mouse models. Recently, we found that preconditioning the aged gut with youthful microbiome using the method of fecal microbiota transplantation (FMT) has a “buffering” effect that leads to improvement in post-stroke recovery. Mice with young biome prior to stroke had decreased mortality and enhanced behavioral outcomes. We also found that short-chain fatty acids (SCFAs) can be a key component for the benefit of young biome. We are now investigating the relevance of young biome to the clinical expression after stroke (i.e., post-stroke FMT). I will discuss our recent findings that transplantation of fecal microbiota from young mice to aged stroke mice has therapeutic benefits by altering both behaviors and immune cell profiles.

世話人: 〇植松 智 (自然免疫制御分野)
 藤橋 浩太郎  (臨床ワクチン学分野)