|開催日時：||2019年1月10日 16：00 ～ 17：00|
|所属：||Department of Neurology, University of Texas Health Science Center at Houston・Postdoctoral Research Fellow|
|演題：||Microbiome-gut-brain axis and its therapeutic manipulation after stroke|
Stroke is a leading cause of mortality in the elderly and exerts systemic effects that extend beyond the brain by triggering a multiphasic immune response in the periphery. Mounting evidence with new sequencing technology revealed that stroke robustly affects distant organs, mainly the gut and its microbiota, the so-called “brain-gut axis”. Stroke altered the makeup of gut microbiota with increased gut permeability (top-down signaling) and activated gut microbiota-involved T cells that control neuro-inflammation in the brain (bottom-up signaling) in experimental mouse models. Recently, we found that preconditioning the aged gut with youthful microbiome using the method of fecal microbiota transplantation (FMT) has a “buffering” effect that leads to improvement in post-stroke recovery. Mice with young biome prior to stroke had decreased mortality and enhanced behavioral outcomes. We also found that short-chain fatty acids (SCFAs) can be a key component for the benefit of young biome. We are now investigating the relevance of young biome to the clinical expression after stroke (i.e., post-stroke FMT). I will discuss our recent findings that transplantation of fecal microbiota from young mice to aged stroke mice has therapeutic benefits by altering both behaviors and immune cell profiles.
|世話人：||〇植松 智 (自然免疫制御分野）
藤橋 浩太郎 (臨床ワクチン学分野)