東京大学医科学研究所

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学友会セミナー

学友会セミナー:2018年10月16日

開催日時: 2018年10月16日 15:30 ~ 16:15
開催場所: 総合研究棟8階大セミナー室 (入口にて内線75615, 75617 or 75618に電話下さい。)
講師: Xiang Zhou
所属: Assistant Professor, Department of Biostatistics, University of Michigan
演題: Variability-Preserving Imputation for Accurate Gene Expression Recovery in Single Cell RNA Sequencing Studies
概要:

We develop a method to impute the zero values in single cell RNA sequencing studies to facilitate accurate transcriptome quantification at the single cell level. Our method is based on nonnegative sparse regression models and it is capable of progressively inferring a sparse set of local neighborhood cells that are most predictive of the expression levels of the cell of interest for imputation. A key feature of our method is its ability to preserve gene expression variability across cells after imputation. We illustrate the advantages of our method through several well-designed real data-based analytical experiments.

世話人: 〇宮野 悟 (DNA情報解析分野)
 井元 清哉 (健康医療データサイエンス分野)