|開催日時：||2018年9月19日 17：00 ～ 18 : 00|
|講師：||Thomas P. Zwaka|
|所属：||Professor, Developmental and Regenerative Biology,
Director, Huffington Foundation Center for Cell-Based Research in Parkinson’s Disease, Icahn School of Medicine at Mount Sinai
|演題：||Ronin’s role in creating regulatory DNA structures: blurring the distinction between enhancers and promoters|
Differences in transcription factor binding to enhancers are generally thought to influence development and therefore could bear on the most fundamental questions in biology. How do cells differentiate to form new tissues? And how do these tissues function in a coordinated and flexible manner? Here I will present an entirely novel gene regulatory paradigm in which promoters (and their enhancers) interact with other promoters to potentially regulate key gene expression programs. Adding to this novelty is our choice of a candidate genomic organizer, Ronin, which emerged when a fossil transposon was co-opted by ancient metazoans to achieve a level of functional diversity not seen before in evolution.
|世話人：||〇山田 泰広 （先進病態モデル分野）
武川 陸寛 （分子シグナル制御分野）