|開催日時：||2018年7月18日 16：00 ～ 17：00|
|講師：||Paul A Ramsland|
|所属：||School of Science, RMIT University・Principal Research Fellow|
|演題：||Structural and computational studies of glycan targeting in cancer and infection|
Carbohydrates (glycans) on the surface of cells present a complex code that can be recognized by a range of carbohydrate-binding proteins including antibodies and lectins. Blood group related glycans such as Lewis system antigens are often over-expressed by cancer cells and have been associated with tumour progression and invasiveness. On healthy and inflamed tissues similar Lewis glycans can become targets for bacterial adhesion. In this presentation, I will provide an overview of our structural studies using crystallography, automated docking and molecular dynamics that have probed recognition of Lewis system antigens by antibodies and lectins with implications for development of cancer-targeting antibodies and carbohydrate inspired anti-infectives. This work will be contrasted with recent crystal structures we have determined that define how a single antibody can bind a wide range of microbes through recognition of a common core oligosaccharide chain.