|開催日時：||2018年6月14日 16：00 ～ 17：00|
|所属：||Principal Investigator Allergology - Immunology - Inflammation Research Unit Department of Infection and Immunity Luxembourg Institute of Health|
|演題：||Diet-driven interactions of the gut microbiome with the intestinal mucus barrier|
The functional interactions of the human gut microbiome with its host are largely driven by diet, yet the underlying mechanisms have remained poorly understood. By employing a gnotobiotic mouse model—containing a synthetic human gut microbiota composed of 14 commensal bacteria—we recently showed that a dietary fiber-deprived microbiota degrades the colonic mucus layer, which is the first line of defense against invading microorganisms. Furthermore, a fiber-deprived, mucus-eroding microbiota enhances susceptibility to the enteric pathogen Citrobacter rodentium (Desai et al. Cell (2016), 167, 1339–1353). Our follow-up experiments indicate that such deterioration of the colonic mucus barrier is associated with the immunological changes observed in inflammatory bowel disease. In the face of changing Western diets, our results suggest that dietary therapeutics, including next-generation prebiotics, could be utilized to modulate the the gut barrier alterations and to reduce the incidence of colitis.
|世話人：||〇清野 宏 （粘膜免疫学部門）
三宅 健介 （感染遺伝学分野）