|開催日時：||2017年11月15日 17：00 ～ 18：00|
|講師：||Anne Van den Broeke|
|所属：||Laboratory of Experimental Hematology, Institut Jules Bordet, ULB, Brussels, Belgium Unit of Animal Genomics, GIGA, University of Liège, Liège・Professor|
|演題：||Combining HTLV-1 and BLV genomic studies towards a better understanding of leukemia progression|
Adult T-cell leukemia (ATL) is an aggressive CD4+ T-cell malignancy caused by the oncogenic retrovirus Human T-cell leukemia virus-1 (HTLV-1). Bovine Leukemia Virus (BLV), a close relative of HTLV-1, induces a similar disease in cattle with tumors affecting the B-cell lineage. Both viruses produce a chronic infection in their respective host that evolves into full-blown leukemia/lymphoma in ~5% of infected individuals after several decades of latency. While not a natural host, it is possible to infect sheep with BLV. In contrast to cattle, all infected sheep develop tumors at an accelerated rate (~20 months), providing a unique model for studying early asymptomatic stages. Historically, research into both viruses has primarily focused on their transcripts/proteins. However, increasing evidence suggests that both the proviral integration site and somatic alterations within the host genome play a critical role, as only a subset of infected individuals, following a long period of asymptomatic infection, develop a tumor.
|世話人：||〇東條 有伸 （分子療法分野）
内丸 薫 （病態医療科学分野）