東京大学医科学研究所

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学友会セミナー

学友会セミナー:2017年5月23日

開催日時: 2017年5月23日 16:00 ~ 17:00
開催場所: 2号館2階 大講義室
講師: Michael Kahn
所属: Co-Director
Center for Molecular Pathways and Drug Discovery,
University of Southern California
演題: From Bench to Bedside: A Tale of Two Coactivators
概要:

From a Wnt signaling phenotypic screen in colorectal cancer cells utilizing a proprietary secondary structure mimetic library that we designed and synthesized, we identified ICG-001. After identification and validation of its molecular target, ICG-001 has become an invaluable tool to examine critical signaling pathways in stem cell biology both in development and disease. A second-generation analog PRI-724, entered Phase I clinical studies in 2011 and continues to be investigated in multiple trials both in oncology and hepatic fibrosis. I will discuss both the fundamental discoveries regarding differential coactivator usage in stem cells and cancer stem cells and the clinical investigations that have evolved over the years from this simple phenotypic screen and the discovery of ICG-001.

世話人: ○古川 洋一(臨床ゲノム腫瘍学)
 武川 睦寛(分子シグナル制御分野)