東京大学医科学研究所

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学友会セミナー

学友会セミナー:2017年3月21日

開催日時: 2017年3月21日 11:30 ~ 12:30
開催場所: 2号館 大講義室
講師: 新澤 未穂
所属: Experimental Immunology Branch, NCI, NIH ・ Postdoctoral Fellow
演題: FlipFlop mice have a reversed T cell immune system: MHC-I/CD8 Helper and MHC-II/CD4 Cytotoxic T cells
概要:

Almost all of T cells generate in the thymus. In the thymus, the fate of conventional T cells is determined as either CD4 T cells or CD8 T cells, which function mainly helper T cells or killer T cells, respectively, in periphery. To date, mechanisms underlying the fate determination of conventional T cells remain yet to be elucidated.
We recently generated unique “FlipFlop” mice in which both Cd4 and Cd8 gene loci encoded the opposite co-receptor protein. CD4 and CD8 T cells in FlipFlop mice recognize MHC-II and MHC-I ligands, respectively. Importantly, MHC-II/CD4 T cells in FlipFlop mice have cytotoxic function, while MHC-I/CD8 T cells have helper function. Thus, FlipFlop mice have a functionally reversed T cell immune system. As result, we propose that CD4/CD8 T cell lineage fate in the thymus might be determined by Cd4/Cd8 gene loci independently of the co-receptor proteins they encode and regardless of TCR MHC specificity.

世話人: ○井上 純一郎(分子発癌分野)
 吉田 進昭(発生工学研究分野)