Looking through the Eye: Growth Factor Signaling in Organogenesis

Research in our laboratory is aimed at elucidating the role of secreted signaling molecules and their signaling pathways during embryonic organ formation. One area of our studies is focused on understanding the process of eye development in vertebrates. Our recent studies using transgenic and gene targeting approaches in the mouse have demonstrated essential roles of bone morphogenetic proteins (Bmps), members of the TGFβ superfamily of secreted signaling molecules, in multiple distinct aspects of eye development; ranging from lens induction and differentiation through retinal patterning, growth, and differentiation. Current preliminary studies have also uncovered potential cooperation of Bmp signaling with other signaling pathways, including those of fibroblast growth factors (Fgfs), during eye development. The seminar will summarize recent progress of these studies and their potential significance in understanding of the molecular mechanisms underlying vertebrate eye development.