Coreceptor switch in a R5 SHIV infected rhesus macaque
学友会セミナー
学友会セミナー
2006年開催 学友会セミナー
開催日時: | 平成18年12月4日(月) 16:00~17:00 |
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開催場所: | 白金ホール |
講 師: | Dr. Cecilia Cheng-Mayer |
所 属: | Professor, Aaron Diamond AIDS Research Center, New York |
演 題: | Coreceptor switch in a R5 SHIV infected rhesus macaque |
概 要: | The basis for the switch from CCR5 to CXCR4 coreceptor usage seen in ~50% of HIV-1 subtype B infected individuals as disease advances is unknown. Among the hypotheses proposed are target cell limitation and better immune recognition of the CXCR4 (X4)- compared to the CCR5 (R5)-tropic virus. We report the first case of X4 virus evolution in a R5 SHIV infected rhesus macaque. The emergence of X4 virus in a macaque lacking virus-specific humoral and cellular immune responses lends support to a role of antiviral immunity in suppressing HIV-1 coreceptor switch. |
世 話 人: | ○岩倉洋一郎 俣野哲朗 |