English
Top

Coreceptor switch in a R5 SHIV infected rhesus macaque

学友会セミナー

学友会セミナー

2006年開催 学友会セミナー

開催日時: 平成18年12月4日(月) 16:00~17:00
開催場所: 白金ホール
講  師: Dr. Cecilia Cheng-Mayer
所  属: Professor, Aaron Diamond AIDS Research Center, New York
演  題: Coreceptor switch in a R5 SHIV infected rhesus macaque
概  要:

The basis for the switch from CCR5 to CXCR4 coreceptor usage seen in ~50% of HIV-1 subtype B infected individuals as disease advances is unknown. Among the hypotheses proposed are target cell limitation and better immune recognition of the CXCR4 (X4)- compared to the CCR5 (R5)-tropic virus. We report the first case of X4 virus evolution in a R5 SHIV infected rhesus macaque. The emergence of X4 virus in a macaque lacking virus-specific humoral and cellular immune responses lends support to a role of antiviral immunity in suppressing HIV-1 coreceptor switch.

世 話 人:  ○岩倉洋一郎
俣野哲朗