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Scientific Papers/Award

Clonal Analysis Unveils Self-Renewing Lineage-Restricted Progenitors Generated Directly from Hematopoietic Stem Cells

Cell Online Edition: 2013/8/30 (Japan time), doi: 10.1016/j.cell.2013.08.007.
Ryo Yamamoto, Yohei Morita, Jun Ooehara, Sanae Hamanaka, Masafumi Onodera, Karl Lenhard Rudolph, Hideo Ema, Hiromitsu Nakauchi
Division of Stem Cell Therapy, Center for Stem Cell Biology and Regeneration Medicine, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan Leibniz Institute for Age Research, Fritz Lipmann Institute, Jena 07745, Germany Japan Science Technology Agency, ERATO, Nakauchi Stem Cell and Organ Regeneration Project, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan Department of Human Genetics, National Research Institute for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo 157-8535, Japan
Yamamoto M, Taguchi Y, Ito-Kureha T, Semba K, Yamaguchi N, Inoue J.
[1] Division of Cellular and Molecular Biology, Department of Cancer Biology, Institute of Medical Science, University of Tokyo, Shirokane-dai, Minato-ku, Tokyo 108-8639, Japan [2] Department of Life Science and Medical Bio-Science, Waseda University, Wakamatsu-cho, Shinjuku-ku, Tokyo 162-8480, Japan.

Rice-based oral antibody fragment prophylaxis and therapy against rotavirus infection

The Journal of Clinical Investigation August 8, 2013, Doi:10.1172/JCI70266
Daisuke Tokuhara1,2, Beatriz ρlvarez3, Mio Mejima1, Tomoko Hiroiwa1, Yuko Takahashi1, Shiho Kurokawa1, Masaharu Kuroda4, Masaaki Oyama5, Hiroko Kozuka-Hata5, Tomonori Nochi1, Hiroshi Sagara5, Farah Aladin6, Harold Marcotte3, Leon G.J. Frenken7, Miren Iturriza-Gómara8, Hiroshi Kiyono1,9, Lennart Hammarström3 and Yoshikazu Yuki1,9
1Division of Mucosal Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, University of Tokyo, Tokyo, Japan. 2Department of Pediatrics, Osaka City University Graduate School of Medicine, Osaka, Japan. 3Division of Clinical Immunology, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden. 4Crop Development Division, NARO Agriculture Research Center, Niigata, Japan. 5Medical Proteomics Laboratory, The Institute of Medical Science, University of Tokyo, Tokyo, Japan. 6Enteric Virus Unit, Virus Reference Department, Health Protection Agency, London, United Kingdom. 7Unilever Research and Development Vlaardingen BV, Vlaardingen, Netherlands. 8Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom. 9International Research and Development Center for Mucosal Vaccine, The Institute of Medical Science, University of Tokyo, Tokyo, Japan.

An essential role for the N-terminal fragment of Toll-like receptor 9 in DNA sensing

Nature Communications 2013 Jun 11;4:1949. doi: 10.1038/ncomms2949
Masahiro Onji1,2, Atsuo Kanno1, Shin-Ichiroh Saitoh1, Ryutaro Fukui1, Yuji Motoi1, Takuma Shibata1,3, Fumi Matsumoto1, Aayam Lamichhane4, Shintaro Sato4, Hiroshi Kiyono4, Kazuhide Yamamoto2 & Kensuke Miyake1,3
1 Division of Innate Immunity, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minatoku, Tokyo 108 8639, Japan. 2 Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700 8558, Japan. 3 Laboratory of Innate Immunity, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minatoku, Tokyo 108 8639, Japan. 4 Division of Mucosal Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minatoku, Tokyo 108 8639, Japan.
Kobayashi T, Ogawa M, Sanada T, Mimuro H, Kim M, Ashida H, Akakura R, Yoshida M, Kawalec M, Reichhart JM, Mizushima T, Sasakawa C.
Department of Microbiology and Immunology, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan; Division of Bacteriology, Department of Infectious Diseases Control, International Research Center for Infectious Diseases, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan.

SAPK pathways and p53 cooperatively regulate PLK4 activity and centrosome integrity under stress

Nature Communications 2013 Apr 30;4:1775. doi: 10.1038/ncomms2752
Nakamura T, Saito H, Takekawa M.
[1] Division of Cell Signaling and Molecular Medicine, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan [2] Department of Cell Signaling and Molecular Medicine, Research Institute of Environmental Medicine, Nagoya University, Nagoya 464-8601, Japan [3] Division of Molecular Cell Signaling, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan [4] Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Tokyo 113-0033, Japan.
Jun Kunisawa, Masashi Gohda, Eri Hashimoto, Izumi Ishikawa, Morio Higuchi, Yuji Suzuki, Yoshiyuki Goto, Casandra Panea, Ivaylo I. Ivanov, Risa Sumiya, Lamichhane Aayam, Taichi Wake, So Tajiri, Yosuke Kurashima, Shiori Shikata, Shizuo Akira, Kiyoshi Takeda & Hiroshi Kiyono
Division of Mucosal Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan
Department of Medical Genome Science, Graduate School of Frontier Science, The University of Tokyo, Chiba 277-8562, Japan
International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan
Laboratory of Vaccine Materials, National Institute of Biomedical Innovation, Osaka 567-0085, Japan
Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Tokyo 102-0075, Japan
Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan
Department of Microbiology and Immunology, Columbia University Medical Center, New York, New York 10032, USA
Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan
Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan

Generation of rejuvenated antigen-specific T cells by reprogramming to pluripotency and redifferentiation

Cell Stem Cell 12 2013, 114-126, doi: http://dx.doi.org/10.1016/j.stem.2012.11.002.
Nishimura T, Kaneko S, Kawana-Tachikawa A, Tajima Y, Goto H, Zhu D, Nakayama-Hosoya K, Iriguchi S, Uemura Y, Shimizu T, Takayama N, Yamada D, Nishimura K, Ohtaka M, Watanabe N, Takahashi S, Iwamoto A, Koseki H, Nakanishi M, Eto K, Nakauchi H.
Division of Stem Cell Therapy, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
Tomida T, Oda S, Takekawa M, Iino Y, Saito H.
1Division of Molecular Cell Signaling, Institute of Medical Science, University of Tokyo

The Receptor LMIR3 Negatively Regulates Mast Cell Activation and Allergic Responses by Binding to Extracellular Ceramide

Immunity 2012 Oct 30. pii: S1074-7613(12)00458-X. doi: 10.1016/j.immuni.2012.08.018
Izawa K, Yamanishi Y, Maehara A, Takahashi M, Isobe M, Ito S, Kaitani A, Matsukawa T, Matsuoka T, Nakahara F, Oki T, Kiyonari H, Abe T, Okumura K, Kitamura T, Kitaura J.
Division of Cellular Therapy, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Department of Immunology, Juntendo University School of Medicine